Biostable Composite Materials Filled with Silver-Containing Silica Nanocomposites with Antibacterial Properties

Tetiana Vislohuzova; Rita Rozhnova; Nataliia Galatenko

doi:doi:10.11648/j.ajpst.20220803.11

| Peer-Reviewed

Biostable Composite Materials Filled with Silver-Containing Silica Nanocomposites with Antibacterial Properties

Tetiana Vislohuzova, Rita Rozhnova, Nataliia Galatenko

Published in American Journal of Polymer Science and Technology (Volume 8, Issue 3)

Received: 15 July 2022 Accepted: 1 August 2022 Published: 15 August 2022

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

The ability of biodegradation and the expression of biological activity in vitro are among the most important characteristics of polymers for medical purposes, which will make it possible to predict the behavior of polymers in vivo. Therefore, this article is devoted to the study of the biodegradability of composite materials based on PUU filled with silver-containing silica nanocomposites of various compositions (02AgCu, AgCu, 01Ag) in different amounts (0.1, 0.5, and 1.0 wt.%) under the influence of biological medium 199 (BM 199) for 1, 3 and 6 months as potential biopolymers and the study of their antibacterial properties. The biodegradation ability was assessed by changes in structure, physical-mechanical, thermophysical and thermogravimetric characteristics. The results of IR spectroscopic studies demonstrate the absence of changes in the absorption bands of functional groups before and after incubation in BM 199, which indicates the stability of polymer materials under the influence of BM 199. According to physical-mechanical studies after 6 months of incubation in BM 199 the strength values are greater than the control values, and the values of relative elongation at break does not undergo significant changes compared to the control values. It also allows us to conclude about the biostability of composite materials for 6 months. According to the results of tests by the DSC method, after 6 months of incubation in BM 199 the values of T_g and ΔC_p at the glass-transition temperature do not undergo significant changes, which also indicates the biostability of the studied materials. Using the TGA method, it was established that after incubation in BM 199 composite materials in vitro remain heat-resistant materials. According to the results of microbiological studies, all filled film materials have antibacterial properties against the most common gram-positive and gram-negative bacteria, which are manifested by the formation of zones of bacterial growth retardation with a diameter of 14-31 mm. Thus, composite materials filled with silver-containing silica nanocomposites are biostable for 6 months without significant changes in their structure and properties under the influence of biological medium for a long period of time and exhibit antibacterial activity. This makes it possible to use them as biologically active polymer materials of long-term use in various branches of medicine.

Published in	American Journal of Polymer Science and Technology (Volume 8, Issue 3)
DOI	10.11648/j.ajpst.20220803.11
Page(s)	38-45
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Composite Materials, Silver-Containing Silica Nanocomposites, Biodegradation, Biological Medium 199

References

[1]	Vislohuzova T. V., Galatenko N. A., Rozhnova R. A., Bogatyrov V. M., Galaburda M. V. Composite materials based on polyurethane with fragments of poly(vinyl butyral-vinyl acetate-vinyl alcohol) copolymer in their structure filled with silver-containing silica. Chemistry, Physics and Technology of Surface. 2022, 13 (3), in press.
[2]	Vislohuzova T. V., Rozhnova R. A., Bogatyrov V. M. Film materials filled with biocidal silver-containing silica nanocomposites. Ukrainian Conference with International Participation “Chemistry, physics and technology of surface”, Kyiv, Ukraine, October 21-23, 2020, P. 190.
[3]	Vislohuzova T. V., Kuliesh D. V., Rozhnova R. A., Galatenko N. A., Narazhayko L. F. Study of biocompatibility of composite materials filled with silver-containing silica nanocomposite. Bulletin of problems biology and medicine, 2022, in press.
[4]	Makadia H. K., Siegel S. J. Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier. Polymers (Basel), 2011, 3 (3), 1377–1397. https://doi.org/10.3390/polym3031377
[5]	Visan A. I., Popescu-Pelin G., Socol G. Degradation behavior of polymers used as coating materials for drug delivery — A Basic Review. Polymers (Basel), 2021, 13 (8), 1272. https://doi.org/10.3390/polym13081272
[6]	Siegel S. J., Kahn J. B., Metzger K., Winey K. I., Werner K., Dan N. Effect of drug type on the degradation rate of PLGA matrices. European Journal of Pharmaceutics and Biopharmaceutics, 2006, 64 (3), 287-293. https://doi.org/10.1016/j.ejpb.2006.06.009
[7]	Vislohuzova T., Rozhnova R., Galatenko N., Narazhayko L., RudenkoA. Study of biodegradation, biocompatibility and bactericidal activity of film materials with tiamulinfumarate based on polyurethaneurea. Chemistry & Chemical Technology, 2020, 14 (3), 318–326. https://doi.org/10.23939/chcht14.03.318
[8]	Rozhnova R. A., Ostapenko S. M., Galatenko N. A. Investigationof biodegradation of biological active block-copolyurethane with amizon in vitro. Naukovi Zapysky NaUKMa, 2010, Vol. 105, 32-36.
[9]	Bogatyrov V. M., Gun’ko V. M., Galaburda M. V., Oranska O. I., Petryk I. S., Tsyganenko K. S., SavchukYa. I., Chobotarov A. Yu., Rudenchyk T. V., Rozhnova R. A., Galatenko N. A. The effect of photoactivated transformations of Ag+ and AgO in silica fillers on their biocidal activity. Research on Chemical Intermediates, 2019, 45 (8), 3985-4001. https://doi.org/10.1007/s11164-019-03885-2
[10]	Tsyganenko K. S., Galaburda M. V., Savchuk Y. I., Yusypchuk V. I., Zaichenko O. M., Bogatyrev V. M. Patent UA 118518. The method of obtaining a nanocomposite with antifungal properties based on silver, copper and silica. Publ. 2017.
[11]	Bogatyrov V. M., Oranska O. I., Galaburda M. V., Gerashchenko I. I., Osolodchenko Т. P., Yusypchuk V. I. Silica nanocomposites doped with silver, copper, or zinc compound and their antimicrobial properties. Chemistry, Physics and Technology of Surface, 2016, 7 (1), 44-58. https://doi.org/10.15407/hftp07.01.044
[12]	Stashenko K. V., Vislohuzova T. V., Galatenko N. A., Rozhnova R. A. Development of composite materials based on polyurethane ureas with fragments of a copolymer of poly(vinyl butyral, vinyl acetate and vinyl alcohol) and lysozyme. Polymer journal, 2020, № 2, 126-136. https://doi.org/10.15407/polymerj.42.02.136
[13]	Pretsch E., Bёllmann P., Affolter C. Structure determination of organic compounds. Tables of Spectral Data. Springer-Verlag Berlin Heidelberg New York. 2000.
[14]	European Standard EN ISO 527-3: 2019. Plastics - Determination of tensile properties - Part 3: Test conditions for films and sheets (ISO 527-3:2018).
[15]	Lipatova Т. Е., Pkhakadze G. A. Polymers in arthroplasty, Naukova dumka, Kyiv, 1983.

Cite This Article

Plain Text BibTeX RIS

APA Style

Tetiana Vislohuzova, Rita Rozhnova, Nataliia Galatenko. (2022). Biostable Composite Materials Filled with Silver-Containing Silica Nanocomposites with Antibacterial Properties. American Journal of Polymer Science and Technology, 8(3), 38-45. https://doi.org/10.11648/j.ajpst.20220803.11

Copy | Download

ACS Style

Tetiana Vislohuzova; Rita Rozhnova; Nataliia Galatenko. Biostable Composite Materials Filled with Silver-Containing Silica Nanocomposites with Antibacterial Properties. Am. J. Polym. Sci. Technol. 2022, 8(3), 38-45. doi: 10.11648/j.ajpst.20220803.11

Copy | Download

AMA Style

Tetiana Vislohuzova, Rita Rozhnova, Nataliia Galatenko. Biostable Composite Materials Filled with Silver-Containing Silica Nanocomposites with Antibacterial Properties. Am J Polym Sci Technol. 2022;8(3):38-45. doi: 10.11648/j.ajpst.20220803.11

Copy | Download

@article{10.11648/j.ajpst.20220803.11,
  author = {Tetiana Vislohuzova and Rita Rozhnova and Nataliia Galatenko},
  title = {Biostable Composite Materials Filled with Silver-Containing Silica Nanocomposites with Antibacterial Properties},
  journal = {American Journal of Polymer Science and Technology},
  volume = {8},
  number = {3},
  pages = {38-45},
  doi = {10.11648/j.ajpst.20220803.11},
  url = {https://doi.org/10.11648/j.ajpst.20220803.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpst.20220803.11},
  abstract = {The ability of biodegradation and the expression of biological activity in vitro are among the most important characteristics of polymers for medical purposes, which will make it possible to predict the behavior of polymers in vivo. Therefore, this article is devoted to the study of the biodegradability of composite materials based on PUU filled with silver-containing silica nanocomposites of various compositions (02AgCu, AgCu, 01Ag) in different amounts (0.1, 0.5, and 1.0 wt.%) under the influence of biological medium 199 (BM 199) for 1, 3 and 6 months as potential biopolymers and the study of their antibacterial properties. The biodegradation ability was assessed by changes in structure, physical-mechanical, thermophysical and thermogravimetric characteristics. The results of IR spectroscopic studies demonstrate the absence of changes in the absorption bands of functional groups before and after incubation in BM 199, which indicates the stability of polymer materials under the influence of BM 199. According to physical-mechanical studies after 6 months of incubation in BM 199 the strength values are greater than the control values, and the values of relative elongation at break does not undergo significant changes compared to the control values. It also allows us to conclude about the biostability of composite materials for 6 months. According to the results of tests by the DSC method, after 6 months of incubation in BM 199 the values of Tg and ΔCp at the glass-transition temperature do not undergo significant changes, which also indicates the biostability of the studied materials. Using the TGA method, it was established that after incubation in BM 199 composite materials in vitro remain heat-resistant materials. According to the results of microbiological studies, all filled film materials have antibacterial properties against the most common gram-positive and gram-negative bacteria, which are manifested by the formation of zones of bacterial growth retardation with a diameter of 14-31 mm. Thus, composite materials filled with silver-containing silica nanocomposites are biostable for 6 months without significant changes in their structure and properties under the influence of biological medium for a long period of time and exhibit antibacterial activity. This makes it possible to use them as biologically active polymer materials of long-term use in various branches of medicine.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Biostable Composite Materials Filled with Silver-Containing Silica Nanocomposites with Antibacterial Properties
AU  - Tetiana Vislohuzova
AU  - Rita Rozhnova
AU  - Nataliia Galatenko
Y1  - 2022/08/15
PY  - 2022
N1  - https://doi.org/10.11648/j.ajpst.20220803.11
DO  - 10.11648/j.ajpst.20220803.11
T2  - American Journal of Polymer Science and Technology
JF  - American Journal of Polymer Science and Technology
JO  - American Journal of Polymer Science and Technology
SP  - 38
EP  - 45
PB  - Science Publishing Group
SN  - 2575-5986
UR  - https://doi.org/10.11648/j.ajpst.20220803.11
AB  - The ability of biodegradation and the expression of biological activity in vitro are among the most important characteristics of polymers for medical purposes, which will make it possible to predict the behavior of polymers in vivo. Therefore, this article is devoted to the study of the biodegradability of composite materials based on PUU filled with silver-containing silica nanocomposites of various compositions (02AgCu, AgCu, 01Ag) in different amounts (0.1, 0.5, and 1.0 wt.%) under the influence of biological medium 199 (BM 199) for 1, 3 and 6 months as potential biopolymers and the study of their antibacterial properties. The biodegradation ability was assessed by changes in structure, physical-mechanical, thermophysical and thermogravimetric characteristics. The results of IR spectroscopic studies demonstrate the absence of changes in the absorption bands of functional groups before and after incubation in BM 199, which indicates the stability of polymer materials under the influence of BM 199. According to physical-mechanical studies after 6 months of incubation in BM 199 the strength values are greater than the control values, and the values of relative elongation at break does not undergo significant changes compared to the control values. It also allows us to conclude about the biostability of composite materials for 6 months. According to the results of tests by the DSC method, after 6 months of incubation in BM 199 the values of Tg and ΔCp at the glass-transition temperature do not undergo significant changes, which also indicates the biostability of the studied materials. Using the TGA method, it was established that after incubation in BM 199 composite materials in vitro remain heat-resistant materials. According to the results of microbiological studies, all filled film materials have antibacterial properties against the most common gram-positive and gram-negative bacteria, which are manifested by the formation of zones of bacterial growth retardation with a diameter of 14-31 mm. Thus, composite materials filled with silver-containing silica nanocomposites are biostable for 6 months without significant changes in their structure and properties under the influence of biological medium for a long period of time and exhibit antibacterial activity. This makes it possible to use them as biologically active polymer materials of long-term use in various branches of medicine.
VL  - 8
IS  - 3
ER  -

Copy | Download

Author Information

Tetiana Vislohuzova

Department of Polymers of Medical Appointment, Institute of Macromolecular Chemistry of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
Rita Rozhnova

Department of Polymers of Medical Appointment, Institute of Macromolecular Chemistry of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
Nataliia Galatenko

Department of Polymers of Medical Appointment, Institute of Macromolecular Chemistry of the National Academy of Sciences of Ukraine, Kyiv, Ukraine

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Tetiana Vislohuzova, Rita Rozhnova, Nataliia Galatenko. (2022). Biostable Composite Materials Filled with Silver-Containing Silica Nanocomposites with Antibacterial Properties. American Journal of Polymer Science and Technology, 8(3), 38-45. https://doi.org/10.11648/j.ajpst.20220803.11

Copy | Download

ACS Style

Tetiana Vislohuzova; Rita Rozhnova; Nataliia Galatenko. Biostable Composite Materials Filled with Silver-Containing Silica Nanocomposites with Antibacterial Properties. Am. J. Polym. Sci. Technol. 2022, 8(3), 38-45. doi: 10.11648/j.ajpst.20220803.11

Copy | Download

AMA Style

Tetiana Vislohuzova, Rita Rozhnova, Nataliia Galatenko. Biostable Composite Materials Filled with Silver-Containing Silica Nanocomposites with Antibacterial Properties. Am J Polym Sci Technol. 2022;8(3):38-45. doi: 10.11648/j.ajpst.20220803.11

Copy | Download

@article{10.11648/j.ajpst.20220803.11,
  author = {Tetiana Vislohuzova and Rita Rozhnova and Nataliia Galatenko},
  title = {Biostable Composite Materials Filled with Silver-Containing Silica Nanocomposites with Antibacterial Properties},
  journal = {American Journal of Polymer Science and Technology},
  volume = {8},
  number = {3},
  pages = {38-45},
  doi = {10.11648/j.ajpst.20220803.11},
  url = {https://doi.org/10.11648/j.ajpst.20220803.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpst.20220803.11},
  abstract = {The ability of biodegradation and the expression of biological activity in vitro are among the most important characteristics of polymers for medical purposes, which will make it possible to predict the behavior of polymers in vivo. Therefore, this article is devoted to the study of the biodegradability of composite materials based on PUU filled with silver-containing silica nanocomposites of various compositions (02AgCu, AgCu, 01Ag) in different amounts (0.1, 0.5, and 1.0 wt.%) under the influence of biological medium 199 (BM 199) for 1, 3 and 6 months as potential biopolymers and the study of their antibacterial properties. The biodegradation ability was assessed by changes in structure, physical-mechanical, thermophysical and thermogravimetric characteristics. The results of IR spectroscopic studies demonstrate the absence of changes in the absorption bands of functional groups before and after incubation in BM 199, which indicates the stability of polymer materials under the influence of BM 199. According to physical-mechanical studies after 6 months of incubation in BM 199 the strength values are greater than the control values, and the values of relative elongation at break does not undergo significant changes compared to the control values. It also allows us to conclude about the biostability of composite materials for 6 months. According to the results of tests by the DSC method, after 6 months of incubation in BM 199 the values of Tg and ΔCp at the glass-transition temperature do not undergo significant changes, which also indicates the biostability of the studied materials. Using the TGA method, it was established that after incubation in BM 199 composite materials in vitro remain heat-resistant materials. According to the results of microbiological studies, all filled film materials have antibacterial properties against the most common gram-positive and gram-negative bacteria, which are manifested by the formation of zones of bacterial growth retardation with a diameter of 14-31 mm. Thus, composite materials filled with silver-containing silica nanocomposites are biostable for 6 months without significant changes in their structure and properties under the influence of biological medium for a long period of time and exhibit antibacterial activity. This makes it possible to use them as biologically active polymer materials of long-term use in various branches of medicine.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Biostable Composite Materials Filled with Silver-Containing Silica Nanocomposites with Antibacterial Properties
AU  - Tetiana Vislohuzova
AU  - Rita Rozhnova
AU  - Nataliia Galatenko
Y1  - 2022/08/15
PY  - 2022
N1  - https://doi.org/10.11648/j.ajpst.20220803.11
DO  - 10.11648/j.ajpst.20220803.11
T2  - American Journal of Polymer Science and Technology
JF  - American Journal of Polymer Science and Technology
JO  - American Journal of Polymer Science and Technology
SP  - 38
EP  - 45
PB  - Science Publishing Group
SN  - 2575-5986
UR  - https://doi.org/10.11648/j.ajpst.20220803.11
AB  - The ability of biodegradation and the expression of biological activity in vitro are among the most important characteristics of polymers for medical purposes, which will make it possible to predict the behavior of polymers in vivo. Therefore, this article is devoted to the study of the biodegradability of composite materials based on PUU filled with silver-containing silica nanocomposites of various compositions (02AgCu, AgCu, 01Ag) in different amounts (0.1, 0.5, and 1.0 wt.%) under the influence of biological medium 199 (BM 199) for 1, 3 and 6 months as potential biopolymers and the study of their antibacterial properties. The biodegradation ability was assessed by changes in structure, physical-mechanical, thermophysical and thermogravimetric characteristics. The results of IR spectroscopic studies demonstrate the absence of changes in the absorption bands of functional groups before and after incubation in BM 199, which indicates the stability of polymer materials under the influence of BM 199. According to physical-mechanical studies after 6 months of incubation in BM 199 the strength values are greater than the control values, and the values of relative elongation at break does not undergo significant changes compared to the control values. It also allows us to conclude about the biostability of composite materials for 6 months. According to the results of tests by the DSC method, after 6 months of incubation in BM 199 the values of Tg and ΔCp at the glass-transition temperature do not undergo significant changes, which also indicates the biostability of the studied materials. Using the TGA method, it was established that after incubation in BM 199 composite materials in vitro remain heat-resistant materials. According to the results of microbiological studies, all filled film materials have antibacterial properties against the most common gram-positive and gram-negative bacteria, which are manifested by the formation of zones of bacterial growth retardation with a diameter of 14-31 mm. Thus, composite materials filled with silver-containing silica nanocomposites are biostable for 6 months without significant changes in their structure and properties under the influence of biological medium for a long period of time and exhibit antibacterial activity. This makes it possible to use them as biologically active polymer materials of long-term use in various branches of medicine.
VL  - 8
IS  - 3
ER  -

Copy | Download