Retinopathy (ophthalmopathy) of premature infants (ROP) continues to be one of the complex and unresolved problems of pediatric ophthalmology, giving a high percentage of visual disability. ROP is a vasoproliferative disease and occurs in premature infants with a frequency of 16 to 40% of cases. Every year, about 15 million premature babies are born in the world, while 32,300 of them remain blind or with residual vision due to ROP. Despite the success of pediatric ophthalmology, every 5 children with retinopathy of prematurity have low vision or blindness. Moreover, some patients by the age of 25-35 also lose their eyesight from the effects of retinopathy of prematurity. The power of the proliferative process in retinopathy, the speed and irreversibility of its development often plunges pediatric ophthalmic surgeons into despondency and pessimism. The lack of sufficient knowledge still keeps this problem important for ophthalmology. It's time to call retinopathy of prematurity a «tragedy of our time». Today, there are two phases in the course of retinopathy of prematurity: 1) active and 2) regressive or scarring. We propose to single out the first preclinical angiospastic phase of ROP development, which is not deservedly forgotten by ophthalmologists. Most ophthalmologists focus on the active or scar phase of ROP, but the preclinical phase (РР), which lasts about 1 month, attracts almost little attention of ophthalmologists. Meanwhile, during the first month of a premature baby's life, ophthalmologists usually take a wait-and-see attitude and do not carry out treatment, although at this time there are crisis morphofunctional changes in the eye. In the first preclinical, angiospastic phase, the pathogenesis of pathological angiogenesis is formed and new mechanisms of ROP prevention are determined. A thorough study of it will allow a radical revision of the strategy and tactics of diagnosis and treatment will enable early detection and treatment of ROP by stages. The lack of due attention to this phase delays the development of screening informative research schemes during this period, the search for the most significant risk factors for the development of ROP, the search for new methods of prevention and treatment.
| Published in | International Journal of Clinical and Experimental Medical Sciences (Volume 7, Issue 6) |
| DOI | 10.11648/j.ijcems.20210706.12 |
| Page(s) | 165-169 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Retinopathy of Prematurity, The First Preclinical Phase of ROP, Autoregulation of Retinal Vessels, Hypoxic and Hypercapnic Drives
| [1] | Sidorenko E. I. Oxygen therapy in ophthalmology. Moscow. 1995 (in Russian). |
| [2] | Bunin A. Ya. Ocular hemodynamics and methods of its research. Moscow: Medicine, 1971 (in Russian). |
| [3] | Kornilovskiy I. M. The role of disorders of autoregulation of intraocular circulation in the development of dystrophic changes in the tissues of the eye. Ovtal'mologitscheckij zhurnal; 1982; 8; 477-480 (in Russian). |
| [4] | Alm A., Bill A. The oxygen supply to the retina. Effects of high intraocular pressure and of increased arterial carbon diod tension on uveal and retinal blood flow in cats/ Acta Phisiol. Scansd., 1972, p. 84-306, |
| [5] | Ernst J. T. Autoregulation of blood flow in the Distal Segment of the Optic Nerve/ Glaucoma Upda e. International Glaucoma Symposium. Nara Japan. May 7-11, 1978, p. 93-99. |
| [6] | Hayrech Sohan S. Patogenesis of Optic Nerve Damage and Visual Feld Defect. Glaucoma. Conceptions of a Disease. Pathogenesis/ Diagnosis/ Therapi. Stittgert. 1978, 104-138/ (1978) (1, 2. 3). |
| [7] | Saltzman G. L., Kuchuk G. A. Gurgenidze A. G.- Fundamentals of hyperbaric physiology. Moscow, 1979. |
| [8] | Dollery C. T., Buljutt C. J., Kohner E. M.- Oxygen Supply to the Retinal Choroidal at Normal and Increased Arterial Oxygen Tensions/ Invest. Ophthal., 1969, 8, 6, 588-594. |
| [9] | Sidorenko E. I., Koctotschkina I. A. Zernova I. P. Change in hemodynamics of the eye with inhalation of oxygen and carbogen in the experiment. Ovtal'mologitscheckij zhurnal; (In Russ). |
| [10] | Sidorenko E. I., Zernova I. P. Koctotschkina I. A Carboxytherapy in ophthalmology. Annals of ophthalmology [Vestnik oftal'mologii]. - 1979; 2: 51 (in Russian). |
| [11] | Sidorenko E. I., Parzchalawa M. A. Hyperbaric oxygenation in ophthalmology. Annals of ophthalmology [Vestnik oftal'mologii]; 1979; 4: 42-44 (in Russian). |
| [12] | Sidorenko E. I., Kenarskaya E. E. Carboxytherapy in children with high myopia. Annals of ophthalmology [Vestnik oftal'mologii]; 2004; 120 (3): 16-18 (in Russian). |
| [13] | Sidorenko E. I., Nicolaeva G. V. Biochemical autoregulation of the eye vessels as a risk factor of retinopathy of prematurity. Russian ophthalmology of children [Rossiiskaya detskaya oftal'mologiya]. - 2007; 4: 7-10 (in Russian). |
| [14] | Nikolaeva GV, Sidorenko EI, Guseva MR, Babak OA. The study of biochemical autoregulation of blood flow in the vascular basin of the inner carotid artery in premature children. Zh Nevrol Psikhiatr Im S S Korsakova. 2014; 114 (10): 90-3 (in Russian). |
| [15] | Nikolayeva G. V., Sidorenko E. I. The role of blood flow changes in the ophthalmic artery in the pathogenesis of retinopathy of prematurity. Russian ophthalmology of children [Rossiiskaya detskaya oftal'mologiya] 2015; 4: 20-25 (in Russian). |
| [16] | Sidorenko E. I. New mechanisms of pathogenesis of retinopathy of prematurity. Archive of Ophthalmology of Ukraine, 2015, vol. 3, No. 2, pp. 54-58. |
APA Style
Evgeny Ivanovich Sidorenko. (2021). The First Preclinical Angiospastic Phase of Retinopathy (Оphthalmopathy) of Prematurity. International Journal of Clinical and Experimental Medical Sciences, 7(6), 165-169. https://doi.org/10.11648/j.ijcems.20210706.12
ACS Style
Evgeny Ivanovich Sidorenko. The First Preclinical Angiospastic Phase of Retinopathy (Оphthalmopathy) of Prematurity. Int. J. Clin. Exp. Med. Sci. 2021, 7(6), 165-169. doi: 10.11648/j.ijcems.20210706.12
Share This Article
Twitter
Linked In
Facebook
Copy
Download@article{10.11648/j.ijcems.20210706.12,
author = {Evgeny Ivanovich Sidorenko},
title = {The First Preclinical Angiospastic Phase of Retinopathy (Оphthalmopathy) of Prematurity},
journal = {International Journal of Clinical and Experimental Medical Sciences},
volume = {7},
number = {6},
pages = {165-169},
doi = {10.11648/j.ijcems.20210706.12},
url = {https://doi.org/10.11648/j.ijcems.20210706.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20210706.12},
abstract = {Retinopathy (ophthalmopathy) of premature infants (ROP) continues to be one of the complex and unresolved problems of pediatric ophthalmology, giving a high percentage of visual disability. ROP is a vasoproliferative disease and occurs in premature infants with a frequency of 16 to 40% of cases. Every year, about 15 million premature babies are born in the world, while 32,300 of them remain blind or with residual vision due to ROP. Despite the success of pediatric ophthalmology, every 5 children with retinopathy of prematurity have low vision or blindness. Moreover, some patients by the age of 25-35 also lose their eyesight from the effects of retinopathy of prematurity. The power of the proliferative process in retinopathy, the speed and irreversibility of its development often plunges pediatric ophthalmic surgeons into despondency and pessimism. The lack of sufficient knowledge still keeps this problem important for ophthalmology. It's time to call retinopathy of prematurity a «tragedy of our time». Today, there are two phases in the course of retinopathy of prematurity: 1) active and 2) regressive or scarring. We propose to single out the first preclinical angiospastic phase of ROP development, which is not deservedly forgotten by ophthalmologists. Most ophthalmologists focus on the active or scar phase of ROP, but the preclinical phase (РР), which lasts about 1 month, attracts almost little attention of ophthalmologists. Meanwhile, during the first month of a premature baby's life, ophthalmologists usually take a wait-and-see attitude and do not carry out treatment, although at this time there are crisis morphofunctional changes in the eye. In the first preclinical, angiospastic phase, the pathogenesis of pathological angiogenesis is formed and new mechanisms of ROP prevention are determined. A thorough study of it will allow a radical revision of the strategy and tactics of diagnosis and treatment will enable early detection and treatment of ROP by stages. The lack of due attention to this phase delays the development of screening informative research schemes during this period, the search for the most significant risk factors for the development of ROP, the search for new methods of prevention and treatment.},
year = {2021}
}
TY - JOUR T1 - The First Preclinical Angiospastic Phase of Retinopathy (Оphthalmopathy) of Prematurity AU - Evgeny Ivanovich Sidorenko Y1 - 2021/11/10 PY - 2021 N1 - https://doi.org/10.11648/j.ijcems.20210706.12 DO - 10.11648/j.ijcems.20210706.12 T2 - International Journal of Clinical and Experimental Medical Sciences JF - International Journal of Clinical and Experimental Medical Sciences JO - International Journal of Clinical and Experimental Medical Sciences SP - 165 EP - 169 PB - Science Publishing Group SN - 2469-8032 UR - https://doi.org/10.11648/j.ijcems.20210706.12 AB - Retinopathy (ophthalmopathy) of premature infants (ROP) continues to be one of the complex and unresolved problems of pediatric ophthalmology, giving a high percentage of visual disability. ROP is a vasoproliferative disease and occurs in premature infants with a frequency of 16 to 40% of cases. Every year, about 15 million premature babies are born in the world, while 32,300 of them remain blind or with residual vision due to ROP. Despite the success of pediatric ophthalmology, every 5 children with retinopathy of prematurity have low vision or blindness. Moreover, some patients by the age of 25-35 also lose their eyesight from the effects of retinopathy of prematurity. The power of the proliferative process in retinopathy, the speed and irreversibility of its development often plunges pediatric ophthalmic surgeons into despondency and pessimism. The lack of sufficient knowledge still keeps this problem important for ophthalmology. It's time to call retinopathy of prematurity a «tragedy of our time». Today, there are two phases in the course of retinopathy of prematurity: 1) active and 2) regressive or scarring. We propose to single out the first preclinical angiospastic phase of ROP development, which is not deservedly forgotten by ophthalmologists. Most ophthalmologists focus on the active or scar phase of ROP, but the preclinical phase (РР), which lasts about 1 month, attracts almost little attention of ophthalmologists. Meanwhile, during the first month of a premature baby's life, ophthalmologists usually take a wait-and-see attitude and do not carry out treatment, although at this time there are crisis morphofunctional changes in the eye. In the first preclinical, angiospastic phase, the pathogenesis of pathological angiogenesis is formed and new mechanisms of ROP prevention are determined. A thorough study of it will allow a radical revision of the strategy and tactics of diagnosis and treatment will enable early detection and treatment of ROP by stages. The lack of due attention to this phase delays the development of screening informative research schemes during this period, the search for the most significant risk factors for the development of ROP, the search for new methods of prevention and treatment. VL - 7 IS - 6 ER -
Information
Email: