Analysis of Drug Resistance of 157 Strains of Multidrug Resistant Mycobacterium Tuberculosis in Jilin Province

Zhang Lifu; Zhang Wei Yu; Yang Xiujun; Liu Xin; Ma Yingcong; Wang Hui

doi:doi:10.11648/j.ijcems.20220805.11

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Analysis of Drug Resistance of 157 Strains of Multidrug Resistant Mycobacterium Tuberculosis in Jilin Province

Zhang Lifu, Zhang Wei Yu, Yang Xiujun, Liu Xin, Ma Yingcong, Wang Hui

Published in International Journal of Clinical and Experimental Medical Sciences (Volume 8, Issue 5)

Received: 2 August 2022 Accepted: 26 August 2022 Published: 16 September 2022

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Abstract

Objective: Through the analysis of drug resistance of 157 strains of multidrug resistant Mycobacterium tuberculosis in Jilin Province, the drug resistance spectrum of multi drug resistant Mycobacterium tuberculosis in Jilin Province was preliminarily established to provide the basis for the treatment of patients with multi drug resistant tuberculosis in the future. Methods: Anti-tuberculosis streptomycin (SM), ethambutol (EMB), of loxacin (OFX) and kanamycin (KM) were tested by L-J ratio. Results: The SM resistance rate in 157 MDR M. tuberculosis strains was 56.05%, EMB The resistance rate 38.85%, OFX The resistance rate 64.97%, KM The resistance rate 14.65%. The XDR resistance rate was 14.01%. The results of drug resistance analysis in different characteristic populations show that second-line drugs OFX and KM drug resistance rates Female patients Higher than male, and statistically significant (P < 0.05), the resistance rate of OFX relapse patients was significantly higher than that in naive patients, and was statistically significant (P < 0.05). Conclusion: The resistance rate of tuberculosis patients in Jilin Province to the first-line and second-line anti-tuberculosis drugs is at a relatively high level, and the situation of tuberculosis prevention and control is not optimistic. The management of patients should be strengthened in the prevention and treatment strategies, and the use of anti-tuberculosis drugs should be standardized, At the same time, strengthen the ability of tuberculosis laboratory to detect drug-resistant Mycobacterium tuberculosis is strengthened.

Published in	International Journal of Clinical and Experimental Medical Sciences (Volume 8, Issue 5)
DOI	10.11648/j.ijcems.20220805.11
Page(s)	65-68
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Mycobacterium Tuberculosis, Multidrug Resistance, Drug Resistance Rate

References

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[6]	Word Health Oraanization. Anti-tuberculos is Drug Resistance in The word, Fourth Global Report. The WHO/IUATLD Global Project on Anti-tuberculos is Drug Resistance Surveillance [J]. Geneva WHO 2008.
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[8]	Ministry of Health, PRC. The National Baseline TB Drug Resistance Survey Report (2007-2008). Beijing: People's Health Publishing House, 2010.
[9]	Zhang Weiyu, Yang Xiujun, Wang Bo, et al. Analysis of drug susceptibility results of 238 multidrug-resistant M. tuberculosis strains in Jilin Province [J]. Health Engineering in China, 2015, 014 (006): 540-541.
[10]	Zhang Zhijian et al. Prevalence and molecular characterization of fluoroquinolone-resistant Mycobacterium tuberculosis isolates in China. [J]. Antimicrobial agents and chemotherapy, 2014, 58 (1): 364-9.
[11]	Che Yang, Yang Tianchi, Pingguohua, et al. Epidemic of Beijing genotype of MDR-Mycobacterium tuberculosis and its relationship with quinolone resistance in Ningbo, Zhejiang Province [J]. Disease surveillance, 2017, 32 (12): 962-965.
[12]	Zhao Wei, Liu Sijie, Li Kewei, et al. Analysis of the resistance of 894 M. tuberculosis strains to first-line anti-tuberculosis drugs [J]. Chinese Tuberculosis magazine, 2019, 41 (3): 364-368.
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APA Style

Zhang Lifu, Zhang Wei Yu, Yang Xiujun, Liu Xin, Ma Yingcong, et al. (2022). Analysis of Drug Resistance of 157 Strains of Multidrug Resistant Mycobacterium Tuberculosis in Jilin Province. International Journal of Clinical and Experimental Medical Sciences, 8(5), 65-68. https://doi.org/10.11648/j.ijcems.20220805.11

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ACS Style

Zhang Lifu; Zhang Wei Yu; Yang Xiujun; Liu Xin; Ma Yingcong, et al. Analysis of Drug Resistance of 157 Strains of Multidrug Resistant Mycobacterium Tuberculosis in Jilin Province. Int. J. Clin. Exp. Med. Sci. 2022, 8(5), 65-68. doi: 10.11648/j.ijcems.20220805.11

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AMA Style

Zhang Lifu, Zhang Wei Yu, Yang Xiujun, Liu Xin, Ma Yingcong, et al. Analysis of Drug Resistance of 157 Strains of Multidrug Resistant Mycobacterium Tuberculosis in Jilin Province. Int J Clin Exp Med Sci. 2022;8(5):65-68. doi: 10.11648/j.ijcems.20220805.11

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@article{10.11648/j.ijcems.20220805.11,
  author = {Zhang Lifu and Zhang Wei Yu and Yang Xiujun and Liu Xin and Ma Yingcong and Wang Hui},
  title = {Analysis of Drug Resistance of 157 Strains of Multidrug Resistant Mycobacterium Tuberculosis in Jilin Province},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {8},
  number = {5},
  pages = {65-68},
  doi = {10.11648/j.ijcems.20220805.11},
  url = {https://doi.org/10.11648/j.ijcems.20220805.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20220805.11},
  abstract = {Objective: Through the analysis of drug resistance of 157 strains of multidrug resistant Mycobacterium tuberculosis in Jilin Province, the drug resistance spectrum of multi drug resistant Mycobacterium tuberculosis in Jilin Province was preliminarily established to provide the basis for the treatment of patients with multi drug resistant tuberculosis in the future. Methods: Anti-tuberculosis streptomycin (SM), ethambutol (EMB), of loxacin (OFX) and kanamycin (KM) were tested by L-J ratio. Results: The SM resistance rate in 157 MDR M. tuberculosis strains was 56.05%, EMB The resistance rate 38.85%, OFX The resistance rate 64.97%, KM The resistance rate 14.65%. The XDR resistance rate was 14.01%. The results of drug resistance analysis in different characteristic populations show that second-line drugs OFX and KM drug resistance rates Female patients Higher than male, and statistically significant (P < 0.05), the resistance rate of OFX relapse patients was significantly higher than that in naive patients, and was statistically significant (P < 0.05). Conclusion: The resistance rate of tuberculosis patients in Jilin Province to the first-line and second-line anti-tuberculosis drugs is at a relatively high level, and the situation of tuberculosis prevention and control is not optimistic. The management of patients should be strengthened in the prevention and treatment strategies, and the use of anti-tuberculosis drugs should be standardized, At the same time, strengthen the ability of tuberculosis laboratory to detect drug-resistant Mycobacterium tuberculosis is strengthened.},
 year = {2022}
}

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TY  - JOUR
T1  - Analysis of Drug Resistance of 157 Strains of Multidrug Resistant Mycobacterium Tuberculosis in Jilin Province
AU  - Zhang Lifu
AU  - Zhang Wei Yu
AU  - Yang Xiujun
AU  - Liu Xin
AU  - Ma Yingcong
AU  - Wang Hui
Y1  - 2022/09/16
PY  - 2022
N1  - https://doi.org/10.11648/j.ijcems.20220805.11
DO  - 10.11648/j.ijcems.20220805.11
T2  - International Journal of Clinical and Experimental Medical Sciences
JF  - International Journal of Clinical and Experimental Medical Sciences
JO  - International Journal of Clinical and Experimental Medical Sciences
SP  - 65
EP  - 68
PB  - Science Publishing Group
SN  - 2469-8032
UR  - https://doi.org/10.11648/j.ijcems.20220805.11
AB  - Objective: Through the analysis of drug resistance of 157 strains of multidrug resistant Mycobacterium tuberculosis in Jilin Province, the drug resistance spectrum of multi drug resistant Mycobacterium tuberculosis in Jilin Province was preliminarily established to provide the basis for the treatment of patients with multi drug resistant tuberculosis in the future. Methods: Anti-tuberculosis streptomycin (SM), ethambutol (EMB), of loxacin (OFX) and kanamycin (KM) were tested by L-J ratio. Results: The SM resistance rate in 157 MDR M. tuberculosis strains was 56.05%, EMB The resistance rate 38.85%, OFX The resistance rate 64.97%, KM The resistance rate 14.65%. The XDR resistance rate was 14.01%. The results of drug resistance analysis in different characteristic populations show that second-line drugs OFX and KM drug resistance rates Female patients Higher than male, and statistically significant (P < 0.05), the resistance rate of OFX relapse patients was significantly higher than that in naive patients, and was statistically significant (P < 0.05). Conclusion: The resistance rate of tuberculosis patients in Jilin Province to the first-line and second-line anti-tuberculosis drugs is at a relatively high level, and the situation of tuberculosis prevention and control is not optimistic. The management of patients should be strengthened in the prevention and treatment strategies, and the use of anti-tuberculosis drugs should be standardized, At the same time, strengthen the ability of tuberculosis laboratory to detect drug-resistant Mycobacterium tuberculosis is strengthened.
VL  - 8
IS  - 5
ER  -

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Author Information

Zhang Lifu

Jilin Province Health Testing and Inspection Center, Changchun, China
Zhang Wei Yu

Jilin Provincial Center for Disease Control and Prevention (Jilin Provincial Institute of Public Health), Changchun, China
Yang Xiujun

Jilin Province Health Testing and Inspection Center, Changchun, China
Liu Xin

Jilin Provincial Research Institute of Tuberculosis Prevention and Control (Affiliated Hospital), Changchun, China
Ma Yingcong

Jilin Provincial Research Institute of Tuberculosis Prevention and Control (Affiliated Hospital), Changchun, China
Wang Hui

Jilin Provincial Center for Disease Control and Prevention (Jilin Provincial Institute of Public Health), Changchun, China

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APA Style

Zhang Lifu, Zhang Wei Yu, Yang Xiujun, Liu Xin, Ma Yingcong, et al. (2022). Analysis of Drug Resistance of 157 Strains of Multidrug Resistant Mycobacterium Tuberculosis in Jilin Province. International Journal of Clinical and Experimental Medical Sciences, 8(5), 65-68. https://doi.org/10.11648/j.ijcems.20220805.11

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ACS Style

Zhang Lifu; Zhang Wei Yu; Yang Xiujun; Liu Xin; Ma Yingcong, et al. Analysis of Drug Resistance of 157 Strains of Multidrug Resistant Mycobacterium Tuberculosis in Jilin Province. Int. J. Clin. Exp. Med. Sci. 2022, 8(5), 65-68. doi: 10.11648/j.ijcems.20220805.11

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AMA Style

Zhang Lifu, Zhang Wei Yu, Yang Xiujun, Liu Xin, Ma Yingcong, et al. Analysis of Drug Resistance of 157 Strains of Multidrug Resistant Mycobacterium Tuberculosis in Jilin Province. Int J Clin Exp Med Sci. 2022;8(5):65-68. doi: 10.11648/j.ijcems.20220805.11

Copy | Download

@article{10.11648/j.ijcems.20220805.11,
  author = {Zhang Lifu and Zhang Wei Yu and Yang Xiujun and Liu Xin and Ma Yingcong and Wang Hui},
  title = {Analysis of Drug Resistance of 157 Strains of Multidrug Resistant Mycobacterium Tuberculosis in Jilin Province},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {8},
  number = {5},
  pages = {65-68},
  doi = {10.11648/j.ijcems.20220805.11},
  url = {https://doi.org/10.11648/j.ijcems.20220805.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20220805.11},
  abstract = {Objective: Through the analysis of drug resistance of 157 strains of multidrug resistant Mycobacterium tuberculosis in Jilin Province, the drug resistance spectrum of multi drug resistant Mycobacterium tuberculosis in Jilin Province was preliminarily established to provide the basis for the treatment of patients with multi drug resistant tuberculosis in the future. Methods: Anti-tuberculosis streptomycin (SM), ethambutol (EMB), of loxacin (OFX) and kanamycin (KM) were tested by L-J ratio. Results: The SM resistance rate in 157 MDR M. tuberculosis strains was 56.05%, EMB The resistance rate 38.85%, OFX The resistance rate 64.97%, KM The resistance rate 14.65%. The XDR resistance rate was 14.01%. The results of drug resistance analysis in different characteristic populations show that second-line drugs OFX and KM drug resistance rates Female patients Higher than male, and statistically significant (P < 0.05), the resistance rate of OFX relapse patients was significantly higher than that in naive patients, and was statistically significant (P < 0.05). Conclusion: The resistance rate of tuberculosis patients in Jilin Province to the first-line and second-line anti-tuberculosis drugs is at a relatively high level, and the situation of tuberculosis prevention and control is not optimistic. The management of patients should be strengthened in the prevention and treatment strategies, and the use of anti-tuberculosis drugs should be standardized, At the same time, strengthen the ability of tuberculosis laboratory to detect drug-resistant Mycobacterium tuberculosis is strengthened.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Analysis of Drug Resistance of 157 Strains of Multidrug Resistant Mycobacterium Tuberculosis in Jilin Province
AU  - Zhang Lifu
AU  - Zhang Wei Yu
AU  - Yang Xiujun
AU  - Liu Xin
AU  - Ma Yingcong
AU  - Wang Hui
Y1  - 2022/09/16
PY  - 2022
N1  - https://doi.org/10.11648/j.ijcems.20220805.11
DO  - 10.11648/j.ijcems.20220805.11
T2  - International Journal of Clinical and Experimental Medical Sciences
JF  - International Journal of Clinical and Experimental Medical Sciences
JO  - International Journal of Clinical and Experimental Medical Sciences
SP  - 65
EP  - 68
PB  - Science Publishing Group
SN  - 2469-8032
UR  - https://doi.org/10.11648/j.ijcems.20220805.11
AB  - Objective: Through the analysis of drug resistance of 157 strains of multidrug resistant Mycobacterium tuberculosis in Jilin Province, the drug resistance spectrum of multi drug resistant Mycobacterium tuberculosis in Jilin Province was preliminarily established to provide the basis for the treatment of patients with multi drug resistant tuberculosis in the future. Methods: Anti-tuberculosis streptomycin (SM), ethambutol (EMB), of loxacin (OFX) and kanamycin (KM) were tested by L-J ratio. Results: The SM resistance rate in 157 MDR M. tuberculosis strains was 56.05%, EMB The resistance rate 38.85%, OFX The resistance rate 64.97%, KM The resistance rate 14.65%. The XDR resistance rate was 14.01%. The results of drug resistance analysis in different characteristic populations show that second-line drugs OFX and KM drug resistance rates Female patients Higher than male, and statistically significant (P < 0.05), the resistance rate of OFX relapse patients was significantly higher than that in naive patients, and was statistically significant (P < 0.05). Conclusion: The resistance rate of tuberculosis patients in Jilin Province to the first-line and second-line anti-tuberculosis drugs is at a relatively high level, and the situation of tuberculosis prevention and control is not optimistic. The management of patients should be strengthened in the prevention and treatment strategies, and the use of anti-tuberculosis drugs should be standardized, At the same time, strengthen the ability of tuberculosis laboratory to detect drug-resistant Mycobacterium tuberculosis is strengthened.
VL  - 8
IS  - 5
ER  -

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