Analysis of a Case of Soft Tissue Infection Caused by Mycobacterium Fortuitum

Zhenyu Yang; Xiaosheng Chen; Qingqi Meng

doi:doi:10.11648/j.ijcems.20220805.12

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Analysis of a Case of Soft Tissue Infection Caused by Mycobacterium Fortuitum

Zhenyu Yang, Xiaosheng Chen, Qingqi Meng

Published in International Journal of Clinical and Experimental Medical Sciences (Volume 8, Issue 5)

Received: 2 September 2022 Accepted: 12 September 2022 Published: 27 September 2022

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Abstract

Background: Mycobacterium fortuitum complex (MTC) is a group of rapidly growing nontuberculous mycobacteria (NTM) that often develop in immunocompromised patients, while local NTM disease is most common in postoperative wound infections or invasion of the skin from wounds. Clinical case reports are rare, which often lead to tissue abscess and ulceration, and natural resistance to anti-tuberculosis drugs, difficult to control, long treatment process, mostly lasting more than half a year or even a year, and the therapeutic effect is relatively poor. The incidence of NTM-associated infections is increasing and is emerging as a global public health concern. Objective: To introduce the diagnosis and treatment of a case of soft tissue infection caused by Mycobacterium fortuitum in order to improve clinicians' understanding of the disease and deepen the understanding of bacteriological characteristics of the bacterium by microbiological examination personnel. Methods: Bacterial culture was performed in wound secretion, and MRI was performed to examine soft tissue infection. Result: Mass spectrometry analysis of bacterial culture of wound secretion showed Mycobacterium fortuitum infection. MR showed soft tissue infection and sinus formation in the posterolateral aspect of the right ankle. After diagnosis, the antibiotic regimen was adjusted to levofloxacin, amikacin, and rifampicin for triple anti-infection. One month later, the patient was discharged from the hospital for oral treatment with levofloxacin tablets, clarithromycin tablets and rifampicin capsules for 1 year and followed up for 1.5 years without recurrence. Conclusion: This paper can provide reference for etiological diagnosis, identification and treatment of non-tuberculous mycobacteria-related soft tissue infection.

Published in	International Journal of Clinical and Experimental Medical Sciences (Volume 8, Issue 5)
DOI	10.11648/j.ijcems.20220805.12
Page(s)	69-72
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Non-Tuberculous Mycobacteria, Mycobacterium Fortuitum, Orthopaedic, Rapidly Growing Mycobacteria

References

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[4]	Haworth, C. S., et al., British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD). Thorax, 2017. 72 (Suppl 2): p. ii1-ii64.
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[6]	Lai CC, Tan CK, Chou CH, et al. Increasing incidence of nontuberculous mycobacteria, Emerg Infect Dis, 2010, 16 (6): 294-296.
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[10]	Piersimoni, C. and C. Scarparo, Extrapulmonary infections associated with nontuberculous mycobacteria in immunocompetent persons. Emerg Infect Dis, 2009. 15 (9): p. 1351-8; quiz 1544.
[11]	Lin Yayan et al., Clinical analysis of four cases of cutaneous nontuberculous mycobacterial infection. Chinese Journal of Dermatology, 2018. 51 (06): 463-464.
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[15]	Tebruegge, M., et al., Nontuberculous Mycobacterial Disease in Children - Epidemiology, Diagnosis & Management at a Tertiary Center. PLoS One, 2016. 11 (1): p. e0147513.
[16]	Griffith, D. E., et al., An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med, 2007. 175 (4): p. 367-416.
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APA Style

Zhenyu Yang, Xiaosheng Chen, Qingqi Meng. (2022). Analysis of a Case of Soft Tissue Infection Caused by Mycobacterium Fortuitum. International Journal of Clinical and Experimental Medical Sciences, 8(5), 69-72. https://doi.org/10.11648/j.ijcems.20220805.12

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ACS Style

Zhenyu Yang; Xiaosheng Chen; Qingqi Meng. Analysis of a Case of Soft Tissue Infection Caused by Mycobacterium Fortuitum. Int. J. Clin. Exp. Med. Sci. 2022, 8(5), 69-72. doi: 10.11648/j.ijcems.20220805.12

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AMA Style

Zhenyu Yang, Xiaosheng Chen, Qingqi Meng. Analysis of a Case of Soft Tissue Infection Caused by Mycobacterium Fortuitum. Int J Clin Exp Med Sci. 2022;8(5):69-72. doi: 10.11648/j.ijcems.20220805.12

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@article{10.11648/j.ijcems.20220805.12,
  author = {Zhenyu Yang and Xiaosheng Chen and Qingqi Meng},
  title = {Analysis of a Case of Soft Tissue Infection Caused by Mycobacterium Fortuitum},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {8},
  number = {5},
  pages = {69-72},
  doi = {10.11648/j.ijcems.20220805.12},
  url = {https://doi.org/10.11648/j.ijcems.20220805.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20220805.12},
  abstract = {Background: Mycobacterium fortuitum complex (MTC) is a group of rapidly growing nontuberculous mycobacteria (NTM) that often develop in immunocompromised patients, while local NTM disease is most common in postoperative wound infections or invasion of the skin from wounds. Clinical case reports are rare, which often lead to tissue abscess and ulceration, and natural resistance to anti-tuberculosis drugs, difficult to control, long treatment process, mostly lasting more than half a year or even a year, and the therapeutic effect is relatively poor. The incidence of NTM-associated infections is increasing and is emerging as a global public health concern. Objective: To introduce the diagnosis and treatment of a case of soft tissue infection caused by Mycobacterium fortuitum in order to improve clinicians' understanding of the disease and deepen the understanding of bacteriological characteristics of the bacterium by microbiological examination personnel. Methods: Bacterial culture was performed in wound secretion, and MRI was performed to examine soft tissue infection. Result: Mass spectrometry analysis of bacterial culture of wound secretion showed Mycobacterium fortuitum infection. MR showed soft tissue infection and sinus formation in the posterolateral aspect of the right ankle. After diagnosis, the antibiotic regimen was adjusted to levofloxacin, amikacin, and rifampicin for triple anti-infection. One month later, the patient was discharged from the hospital for oral treatment with levofloxacin tablets, clarithromycin tablets and rifampicin capsules for 1 year and followed up for 1.5 years without recurrence. Conclusion: This paper can provide reference for etiological diagnosis, identification and treatment of non-tuberculous mycobacteria-related soft tissue infection.},
 year = {2022}
}

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TY  - JOUR
T1  - Analysis of a Case of Soft Tissue Infection Caused by Mycobacterium Fortuitum
AU  - Zhenyu Yang
AU  - Xiaosheng Chen
AU  - Qingqi Meng
Y1  - 2022/09/27
PY  - 2022
N1  - https://doi.org/10.11648/j.ijcems.20220805.12
DO  - 10.11648/j.ijcems.20220805.12
T2  - International Journal of Clinical and Experimental Medical Sciences
JF  - International Journal of Clinical and Experimental Medical Sciences
JO  - International Journal of Clinical and Experimental Medical Sciences
SP  - 69
EP  - 72
PB  - Science Publishing Group
SN  - 2469-8032
UR  - https://doi.org/10.11648/j.ijcems.20220805.12
AB  - Background: Mycobacterium fortuitum complex (MTC) is a group of rapidly growing nontuberculous mycobacteria (NTM) that often develop in immunocompromised patients, while local NTM disease is most common in postoperative wound infections or invasion of the skin from wounds. Clinical case reports are rare, which often lead to tissue abscess and ulceration, and natural resistance to anti-tuberculosis drugs, difficult to control, long treatment process, mostly lasting more than half a year or even a year, and the therapeutic effect is relatively poor. The incidence of NTM-associated infections is increasing and is emerging as a global public health concern. Objective: To introduce the diagnosis and treatment of a case of soft tissue infection caused by Mycobacterium fortuitum in order to improve clinicians' understanding of the disease and deepen the understanding of bacteriological characteristics of the bacterium by microbiological examination personnel. Methods: Bacterial culture was performed in wound secretion, and MRI was performed to examine soft tissue infection. Result: Mass spectrometry analysis of bacterial culture of wound secretion showed Mycobacterium fortuitum infection. MR showed soft tissue infection and sinus formation in the posterolateral aspect of the right ankle. After diagnosis, the antibiotic regimen was adjusted to levofloxacin, amikacin, and rifampicin for triple anti-infection. One month later, the patient was discharged from the hospital for oral treatment with levofloxacin tablets, clarithromycin tablets and rifampicin capsules for 1 year and followed up for 1.5 years without recurrence. Conclusion: This paper can provide reference for etiological diagnosis, identification and treatment of non-tuberculous mycobacteria-related soft tissue infection.
VL  - 8
IS  - 5
ER  -

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Author Information

Zhenyu Yang

Department of Orthopedics, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China
Xiaosheng Chen

Department of Orthopedics, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China
Qingqi Meng

Department of Orthopedics, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China

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APA Style

Zhenyu Yang, Xiaosheng Chen, Qingqi Meng. (2022). Analysis of a Case of Soft Tissue Infection Caused by Mycobacterium Fortuitum. International Journal of Clinical and Experimental Medical Sciences, 8(5), 69-72. https://doi.org/10.11648/j.ijcems.20220805.12

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ACS Style

Zhenyu Yang; Xiaosheng Chen; Qingqi Meng. Analysis of a Case of Soft Tissue Infection Caused by Mycobacterium Fortuitum. Int. J. Clin. Exp. Med. Sci. 2022, 8(5), 69-72. doi: 10.11648/j.ijcems.20220805.12

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AMA Style

Zhenyu Yang, Xiaosheng Chen, Qingqi Meng. Analysis of a Case of Soft Tissue Infection Caused by Mycobacterium Fortuitum. Int J Clin Exp Med Sci. 2022;8(5):69-72. doi: 10.11648/j.ijcems.20220805.12

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@article{10.11648/j.ijcems.20220805.12,
  author = {Zhenyu Yang and Xiaosheng Chen and Qingqi Meng},
  title = {Analysis of a Case of Soft Tissue Infection Caused by Mycobacterium Fortuitum},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {8},
  number = {5},
  pages = {69-72},
  doi = {10.11648/j.ijcems.20220805.12},
  url = {https://doi.org/10.11648/j.ijcems.20220805.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20220805.12},
  abstract = {Background: Mycobacterium fortuitum complex (MTC) is a group of rapidly growing nontuberculous mycobacteria (NTM) that often develop in immunocompromised patients, while local NTM disease is most common in postoperative wound infections or invasion of the skin from wounds. Clinical case reports are rare, which often lead to tissue abscess and ulceration, and natural resistance to anti-tuberculosis drugs, difficult to control, long treatment process, mostly lasting more than half a year or even a year, and the therapeutic effect is relatively poor. The incidence of NTM-associated infections is increasing and is emerging as a global public health concern. Objective: To introduce the diagnosis and treatment of a case of soft tissue infection caused by Mycobacterium fortuitum in order to improve clinicians' understanding of the disease and deepen the understanding of bacteriological characteristics of the bacterium by microbiological examination personnel. Methods: Bacterial culture was performed in wound secretion, and MRI was performed to examine soft tissue infection. Result: Mass spectrometry analysis of bacterial culture of wound secretion showed Mycobacterium fortuitum infection. MR showed soft tissue infection and sinus formation in the posterolateral aspect of the right ankle. After diagnosis, the antibiotic regimen was adjusted to levofloxacin, amikacin, and rifampicin for triple anti-infection. One month later, the patient was discharged from the hospital for oral treatment with levofloxacin tablets, clarithromycin tablets and rifampicin capsules for 1 year and followed up for 1.5 years without recurrence. Conclusion: This paper can provide reference for etiological diagnosis, identification and treatment of non-tuberculous mycobacteria-related soft tissue infection.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Analysis of a Case of Soft Tissue Infection Caused by Mycobacterium Fortuitum
AU  - Zhenyu Yang
AU  - Xiaosheng Chen
AU  - Qingqi Meng
Y1  - 2022/09/27
PY  - 2022
N1  - https://doi.org/10.11648/j.ijcems.20220805.12
DO  - 10.11648/j.ijcems.20220805.12
T2  - International Journal of Clinical and Experimental Medical Sciences
JF  - International Journal of Clinical and Experimental Medical Sciences
JO  - International Journal of Clinical and Experimental Medical Sciences
SP  - 69
EP  - 72
PB  - Science Publishing Group
SN  - 2469-8032
UR  - https://doi.org/10.11648/j.ijcems.20220805.12
AB  - Background: Mycobacterium fortuitum complex (MTC) is a group of rapidly growing nontuberculous mycobacteria (NTM) that often develop in immunocompromised patients, while local NTM disease is most common in postoperative wound infections or invasion of the skin from wounds. Clinical case reports are rare, which often lead to tissue abscess and ulceration, and natural resistance to anti-tuberculosis drugs, difficult to control, long treatment process, mostly lasting more than half a year or even a year, and the therapeutic effect is relatively poor. The incidence of NTM-associated infections is increasing and is emerging as a global public health concern. Objective: To introduce the diagnosis and treatment of a case of soft tissue infection caused by Mycobacterium fortuitum in order to improve clinicians' understanding of the disease and deepen the understanding of bacteriological characteristics of the bacterium by microbiological examination personnel. Methods: Bacterial culture was performed in wound secretion, and MRI was performed to examine soft tissue infection. Result: Mass spectrometry analysis of bacterial culture of wound secretion showed Mycobacterium fortuitum infection. MR showed soft tissue infection and sinus formation in the posterolateral aspect of the right ankle. After diagnosis, the antibiotic regimen was adjusted to levofloxacin, amikacin, and rifampicin for triple anti-infection. One month later, the patient was discharged from the hospital for oral treatment with levofloxacin tablets, clarithromycin tablets and rifampicin capsules for 1 year and followed up for 1.5 years without recurrence. Conclusion: This paper can provide reference for etiological diagnosis, identification and treatment of non-tuberculous mycobacteria-related soft tissue infection.
VL  - 8
IS  - 5
ER  -

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