Association Between the Level of Homocysteine and Diabetic Retinopathy Among Type 2 Diabetic Patients: A Systemic Review and Meta-analysis

Lu Xin; Zhao-Xing Xing; Chen-Wen Jun; Wang Yuan; Yi-En Hui; Zhang-Yi Ping; Yu Lu; Du-Zhao Jiang

doi:doi:10.11648/j.ijovs.20220703.11

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Association Between the Level of Homocysteine and Diabetic Retinopathy Among Type 2 Diabetic Patients: A Systemic Review and Meta-analysis

Lu Xin, Zhao-Xing Xing, Chen-Wen Jun, Wang Yuan, Yi-En Hui, Zhang-Yi Ping, Yu Lu, Du-Zhao Jiang

Published in International Journal of Ophthalmology & Visual Science (Volume 7, Issue 3)

Received: 10 July 2022 Accepted: 25 July 2022 Published: 4 August 2022

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Abstract

Aim: To examine the relationship between homocysteine and diabetic retinopathy in patients with type 2 diabetes mellitus. Methods: A search of PubMed, EMBASE, and the Cochrane Library was conducted for controlled clinical trials examining the association between homocysteine and diabetic retinopathy in type 2 diabetic patients. The retrieval of all available relevant studies as of January 15, 2022. The Newcastle-Ottawa scale was used to evaluate the quality of included studies. Using Review Manager 5.4, an analysis is conducted on the relevant data. Results: Hcy levels were higher in DR patients compared to NDR patients (total MD: 1.78, 95% CI: 1.02 to 2.54, Z = 4.60, P < 0.01). In addition, the meta-analysis of the studies revealed similar results in the PDR versus NPDR group (total MD: 1.85, 95%CI: 0.70 to 3.00, P < 0.01) and the NPDR vs NDR group (total MD: 0.59, 95% CI 0.33 to 0.85, P = 0.21). Still evident was heterogeneity in the majority of subgroup analyses (I² ≥ 50%, P < 0.1). Forest plots from various subgroups revealed a slight increase in Hcy between the DR and NDR, PDR and NPDR, and NPDR and NDR time periods. A funnel plot demonstrated that publication bias was significant. Conclusions: Our meta-analysis revealed that elevated Hcy is significantly associated with DR and likely plays an important role in its progression.

Published in	International Journal of Ophthalmology & Visual Science (Volume 7, Issue 3)
DOI	10.11648/j.ijovs.20220703.11
Page(s)	83-94
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Diabetic Retinopathy, Homocysteine, Type 2 Diabetes Mellitus, Meta-analysis

References

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APA Style

Lu Xin, Zhao-Xing Xing, Chen-Wen Jun, Wang Yuan, Yi-En Hui, et al. (2022). Association Between the Level of Homocysteine and Diabetic Retinopathy Among Type 2 Diabetic Patients: A Systemic Review and Meta-analysis. International Journal of Ophthalmology & Visual Science, 7(3), 83-94. https://doi.org/10.11648/j.ijovs.20220703.11

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ACS Style

Lu Xin; Zhao-Xing Xing; Chen-Wen Jun; Wang Yuan; Yi-En Hui, et al. Association Between the Level of Homocysteine and Diabetic Retinopathy Among Type 2 Diabetic Patients: A Systemic Review and Meta-analysis. Int. J. Ophthalmol. Vis. Sci. 2022, 7(3), 83-94. doi: 10.11648/j.ijovs.20220703.11

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AMA Style

Lu Xin, Zhao-Xing Xing, Chen-Wen Jun, Wang Yuan, Yi-En Hui, et al. Association Between the Level of Homocysteine and Diabetic Retinopathy Among Type 2 Diabetic Patients: A Systemic Review and Meta-analysis. Int J Ophthalmol Vis Sci. 2022;7(3):83-94. doi: 10.11648/j.ijovs.20220703.11

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@article{10.11648/j.ijovs.20220703.11,
  author = {Lu Xin and Zhao-Xing Xing and Chen-Wen Jun and Wang Yuan and Yi-En Hui and Zhang-Yi Ping and Yu Lu and Du-Zhao Jiang},
  title = {Association Between the Level of Homocysteine and Diabetic Retinopathy Among Type 2 Diabetic Patients: A Systemic Review and Meta-analysis},
  journal = {International Journal of Ophthalmology & Visual Science},
  volume = {7},
  number = {3},
  pages = {83-94},
  doi = {10.11648/j.ijovs.20220703.11},
  url = {https://doi.org/10.11648/j.ijovs.20220703.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20220703.11},
  abstract = {Aim: To examine the relationship between homocysteine and diabetic retinopathy in patients with type 2 diabetes mellitus. Methods: A search of PubMed, EMBASE, and the Cochrane Library was conducted for controlled clinical trials examining the association between homocysteine and diabetic retinopathy in type 2 diabetic patients. The retrieval of all available relevant studies as of January 15, 2022. The Newcastle-Ottawa scale was used to evaluate the quality of included studies. Using Review Manager 5.4, an analysis is conducted on the relevant data. Results: Hcy levels were higher in DR patients compared to NDR patients (total MD: 1.78, 95% CI: 1.02 to 2.54, Z = 4.60, P 2  ≥ 50%,  P < 0.1). Forest plots from various subgroups revealed a slight increase in Hcy between the DR and NDR, PDR and NPDR, and NPDR and NDR time periods. A funnel plot demonstrated that publication bias was significant. Conclusions: Our meta-analysis revealed that elevated Hcy is significantly associated with DR and likely plays an important role in its progression.},
 year = {2022}
}

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TY  - JOUR
T1  - Association Between the Level of Homocysteine and Diabetic Retinopathy Among Type 2 Diabetic Patients: A Systemic Review and Meta-analysis
AU  - Lu Xin
AU  - Zhao-Xing Xing
AU  - Chen-Wen Jun
AU  - Wang Yuan
AU  - Yi-En Hui
AU  - Zhang-Yi Ping
AU  - Yu Lu
AU  - Du-Zhao Jiang
Y1  - 2022/08/04
PY  - 2022
N1  - https://doi.org/10.11648/j.ijovs.20220703.11
DO  - 10.11648/j.ijovs.20220703.11
T2  - International Journal of Ophthalmology & Visual Science
JF  - International Journal of Ophthalmology & Visual Science
JO  - International Journal of Ophthalmology & Visual Science
SP  - 83
EP  - 94
PB  - Science Publishing Group
SN  - 2637-3858
UR  - https://doi.org/10.11648/j.ijovs.20220703.11
AB  - Aim: To examine the relationship between homocysteine and diabetic retinopathy in patients with type 2 diabetes mellitus. Methods: A search of PubMed, EMBASE, and the Cochrane Library was conducted for controlled clinical trials examining the association between homocysteine and diabetic retinopathy in type 2 diabetic patients. The retrieval of all available relevant studies as of January 15, 2022. The Newcastle-Ottawa scale was used to evaluate the quality of included studies. Using Review Manager 5.4, an analysis is conducted on the relevant data. Results: Hcy levels were higher in DR patients compared to NDR patients (total MD: 1.78, 95% CI: 1.02 to 2.54, Z = 4.60, P 2  ≥ 50%,  P < 0.1). Forest plots from various subgroups revealed a slight increase in Hcy between the DR and NDR, PDR and NPDR, and NPDR and NDR time periods. A funnel plot demonstrated that publication bias was significant. Conclusions: Our meta-analysis revealed that elevated Hcy is significantly associated with DR and likely plays an important role in its progression.
VL  - 7
IS  - 3
ER  -

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Author Information

Lu Xin

Department of Ophthalmology, Xi'an Central Hospital, Xi'an, China
Zhao-Xing Xing

Department of Ophthalmology, Xi'an Central Hospital, Xi'an, China
Chen-Wen Jun

Department of Ophthalmology, Xi'an Central Hospital, Xi'an, China
Wang Yuan

Department of Ophthalmology, Xi'an Central Hospital, Xi'an, China
Yi-En Hui

Department of Ophthalmology, Xi'an Central Hospital, Xi'an, China
Zhang-Yi Ping

Department of Ophthalmology, Xi'an Central Hospital, Xi'an, China
Yu Lu

Department of Ophthalmology, Xi'an Central Hospital, Xi'an, China
Du-Zhao Jiang

Department of Ophthalmology, Xi'an Central Hospital, Xi'an, China

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APA Style

Lu Xin, Zhao-Xing Xing, Chen-Wen Jun, Wang Yuan, Yi-En Hui, et al. (2022). Association Between the Level of Homocysteine and Diabetic Retinopathy Among Type 2 Diabetic Patients: A Systemic Review and Meta-analysis. International Journal of Ophthalmology & Visual Science, 7(3), 83-94. https://doi.org/10.11648/j.ijovs.20220703.11

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ACS Style

Lu Xin; Zhao-Xing Xing; Chen-Wen Jun; Wang Yuan; Yi-En Hui, et al. Association Between the Level of Homocysteine and Diabetic Retinopathy Among Type 2 Diabetic Patients: A Systemic Review and Meta-analysis. Int. J. Ophthalmol. Vis. Sci. 2022, 7(3), 83-94. doi: 10.11648/j.ijovs.20220703.11

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AMA Style

Lu Xin, Zhao-Xing Xing, Chen-Wen Jun, Wang Yuan, Yi-En Hui, et al. Association Between the Level of Homocysteine and Diabetic Retinopathy Among Type 2 Diabetic Patients: A Systemic Review and Meta-analysis. Int J Ophthalmol Vis Sci. 2022;7(3):83-94. doi: 10.11648/j.ijovs.20220703.11

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@article{10.11648/j.ijovs.20220703.11,
  author = {Lu Xin and Zhao-Xing Xing and Chen-Wen Jun and Wang Yuan and Yi-En Hui and Zhang-Yi Ping and Yu Lu and Du-Zhao Jiang},
  title = {Association Between the Level of Homocysteine and Diabetic Retinopathy Among Type 2 Diabetic Patients: A Systemic Review and Meta-analysis},
  journal = {International Journal of Ophthalmology & Visual Science},
  volume = {7},
  number = {3},
  pages = {83-94},
  doi = {10.11648/j.ijovs.20220703.11},
  url = {https://doi.org/10.11648/j.ijovs.20220703.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20220703.11},
  abstract = {Aim: To examine the relationship between homocysteine and diabetic retinopathy in patients with type 2 diabetes mellitus. Methods: A search of PubMed, EMBASE, and the Cochrane Library was conducted for controlled clinical trials examining the association between homocysteine and diabetic retinopathy in type 2 diabetic patients. The retrieval of all available relevant studies as of January 15, 2022. The Newcastle-Ottawa scale was used to evaluate the quality of included studies. Using Review Manager 5.4, an analysis is conducted on the relevant data. Results: Hcy levels were higher in DR patients compared to NDR patients (total MD: 1.78, 95% CI: 1.02 to 2.54, Z = 4.60, P 2  ≥ 50%,  P < 0.1). Forest plots from various subgroups revealed a slight increase in Hcy between the DR and NDR, PDR and NPDR, and NPDR and NDR time periods. A funnel plot demonstrated that publication bias was significant. Conclusions: Our meta-analysis revealed that elevated Hcy is significantly associated with DR and likely plays an important role in its progression.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Association Between the Level of Homocysteine and Diabetic Retinopathy Among Type 2 Diabetic Patients: A Systemic Review and Meta-analysis
AU  - Lu Xin
AU  - Zhao-Xing Xing
AU  - Chen-Wen Jun
AU  - Wang Yuan
AU  - Yi-En Hui
AU  - Zhang-Yi Ping
AU  - Yu Lu
AU  - Du-Zhao Jiang
Y1  - 2022/08/04
PY  - 2022
N1  - https://doi.org/10.11648/j.ijovs.20220703.11
DO  - 10.11648/j.ijovs.20220703.11
T2  - International Journal of Ophthalmology & Visual Science
JF  - International Journal of Ophthalmology & Visual Science
JO  - International Journal of Ophthalmology & Visual Science
SP  - 83
EP  - 94
PB  - Science Publishing Group
SN  - 2637-3858
UR  - https://doi.org/10.11648/j.ijovs.20220703.11
AB  - Aim: To examine the relationship between homocysteine and diabetic retinopathy in patients with type 2 diabetes mellitus. Methods: A search of PubMed, EMBASE, and the Cochrane Library was conducted for controlled clinical trials examining the association between homocysteine and diabetic retinopathy in type 2 diabetic patients. The retrieval of all available relevant studies as of January 15, 2022. The Newcastle-Ottawa scale was used to evaluate the quality of included studies. Using Review Manager 5.4, an analysis is conducted on the relevant data. Results: Hcy levels were higher in DR patients compared to NDR patients (total MD: 1.78, 95% CI: 1.02 to 2.54, Z = 4.60, P 2  ≥ 50%,  P < 0.1). Forest plots from various subgroups revealed a slight increase in Hcy between the DR and NDR, PDR and NPDR, and NPDR and NDR time periods. A funnel plot demonstrated that publication bias was significant. Conclusions: Our meta-analysis revealed that elevated Hcy is significantly associated with DR and likely plays an important role in its progression.
VL  - 7
IS  - 3
ER  -

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