The Mechanism of Nrf2/ARE Signaling Pathway in Periodontitis with Atherosclerosis
Wan-Yun Lin,
Lin-Han Wu,
Xiang-Qiong Chen,
Hai-Long Zheng,
Zheng-Rou Wang,
Pin-Xin Zhan,
Sunchuri Diwas,
Zhu-Ling Guo
Issue:
Volume 11, Issue 1, January 2022
Pages:
1-5
Received:
14 December 2021
Accepted:
31 December 2021
Published:
8 January 2022
Abstract: Background Periodontitis is a high prevalence disease, affecting up to 80% of the world's population. Recently studies have shown a connection between periodontal disease and cardiovascular disease, as oxidative stress plays an important role in chronic inflammatory diseases such as periodontal disease and cardiovascular disease. Nuclear factor erythroid 2 - related factor 2 (Nrf2) is the core transcriptional regulator of endogenous antioxidant system and plays a cellular defense role in antioxidant, anti-inflammatory and immune response. Objective To explore Nrf2/antioxidant responsive element (ARE) signaling pathway in periodontitis or periodontitis complicated with atherosclerosis. Method With "Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2), Periodontitis, Atherosclerosis, Oxidative Stress" as the search terms, the authors searched related articles published during 2016-2021 in PubMed, CNKI, Science Direct and other databases by computer, and made the following review through screening, induction and summary. Result & Conclusion Nrf2/ARE signaling pathway is one of the important mechanisms connecting chronic periodontitis and atherosclerosis. Nrf2 can slow down the occurrence and development of periodontitis by promoting osteoblast differentiation, inhibiting osteoclast activation, regulating mesenchymal stem cell proliferation, differentiation and apoptosis. However, inhibition of Nrf2/ARE signaling pathway may increase the risk of periodontitis with atherosclerosis by destroying the integrity of vascular endothelium, increasing lipid accumulation and promoting inflammation.
Abstract: Background Periodontitis is a high prevalence disease, affecting up to 80% of the world's population. Recently studies have shown a connection between periodontal disease and cardiovascular disease, as oxidative stress plays an important role in chronic inflammatory diseases such as periodontal disease and cardiovascular disease. Nuclear factor ery...
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SPECT Ioflupane123I (DaTscan), 99mTc (TRODAT) and Ioflupane with Myocardial Scintigraphy 123I (MIBG) for Diagnosis of Parkinson’s Disease
Jaber Abdulwahab Asiri,
Sami Ahmed Kulaybi,
Fatimah Ahmed Daghas,
Ali Ibrahim Aamry
Issue:
Volume 11, Issue 1, January 2022
Pages:
6-12
Received:
17 February 2022
Accepted:
4 March 2022
Published:
9 March 2022
Abstract: Parkinson’s disease (PD) is one of the most common neurological disorder diseases which takes place when brain cells gradually die. PD is considered a challengeable disease because of the similarities between PD and other brain disorders. For this reason, there are several ways to diagnose PD. Nuclear medicine can be a solution to distinguish the similarities between some brain disorders and PD. The aim of this review is to understand the differences between three radiopharmaceuticals used to diagnose PD and to list the advantages and disadvantages of using each radiopharmaceutical. This review includes studies from 2014 to 2019. Every study published before 2014 was excluded. The database used for this search was found in PubMed. English filters and best matches were used to minimize the outcomes. The comparison between PD nuclear medicine agents was established according to three main points: availability and the length of the scan, sensitivity and specificity, and visual evolution. It would appear that using TRODAT 99mTc can be helpful for some departments that other agents cannot offer, especially 123I. However, using MIBG as a biomarker increases the specificity in some studies. MIBG 123I can be used with TRODAT 99mTc as a biomarker. Moreover, applying PET/CT agents can be studied and researched along with nuclear medicine agents. More research studies are needed to understand the relation between cardiac uptake and PD.
Abstract: Parkinson’s disease (PD) is one of the most common neurological disorder diseases which takes place when brain cells gradually die. PD is considered a challengeable disease because of the similarities between PD and other brain disorders. For this reason, there are several ways to diagnose PD. Nuclear medicine can be a solution to distinguish the s...
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