Investigating and Comparing the Effect of Portulaca oleracea, Vaccinium myrtillus, and Berberis vulgaris on Oral Squamous Cell Carcinoma in an Vitro Study
Sara Pourshahidi,
Mohaddeseh Davari,
Naghmeh Bahrami,
Roja Rahimi
Issue:
Volume 6, Issue 3, September 2021
Pages:
41-48
Received:
23 May 2021
Accepted:
5 July 2021
Published:
15 July 2021
Abstract: Background and Aim: Oral squamous cell carcinoma (OSCC) is a growing health problem worldwide, for which standard treatment strategies have failed to increase its recovery rate significantly. In recent decades, many studies have investigated herbal or natural compounds for the prevention and treatment of OSCC. The present study was performed to investigate the effects of the extract of Portulaca oleracea seed, Berberis vulgaris, and Vaccinium myrtillus fruit on the OSCC. Experimental procedure: Firstly, the herbal samples were purchased from the medicinal plant market and each one of the samples was extracted. Afterward, SCC-15 cells were purchased from the Iranian Biological Resource Center. MTT test was used to evaluate cell proliferation and to measure the transcription rate of ki67, miR-4492, and miR-877-5p genes using Real-time PCR. Finally, the western blot test was used to measure the translation rate of b-cell lymphoma 2 and matrix metalloproteinase-2 genes. Quantitative variables of the present study were described as mean and standard deviation and the three-way ANOVA was used via SPSS ver. 25. an independent t-test was used. P-value< 0.05 was considered a statistically significant level. Results and Conclusion: Briefly, the findings of the present study showed that all three extracts had significant effects on growth suppression, apoptosis induction, and OSCC metastasis. Also, the triple (PVB) combination and Portulaca-Berberis (PB) combination were shown to be the most effective. This result indicates the anti-cancer synergistic effect of these extracts especially P and B, on suppressing OSCC, which should be confirmed in future animal and human studies.
Abstract: Background and Aim: Oral squamous cell carcinoma (OSCC) is a growing health problem worldwide, for which standard treatment strategies have failed to increase its recovery rate significantly. In recent decades, many studies have investigated herbal or natural compounds for the prevention and treatment of OSCC. The present study was performed to inv...
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Rehabilitation Nursing Care of a Child with Congenital Heart Disease with Cerebral Infarction After Valve Replacement: A Case Report
Issue:
Volume 6, Issue 3, September 2021
Pages:
49-52
Received:
11 September 2021
Accepted:
27 September 2021
Published:
29 September 2021
Abstract: Background: Cerebral infarction is a chronic and rare complication for children who regularly take warfarin after valve surgery of congenital heart disease, which affects their health and quality of life. There are few reports on the rehabilitation nursing experience of children with cerebral infarction after congenital heart valve surgery. Objective: We reported on an 11-year-old child who was diagnosed with cerebral infarction and had undergone rehabilitation care for congenital heart disease and valve replacement. Method: During the period of hospitalization and discharge, rehabilitation care of the children such as functional exercises, language, cognition, daily living ability training and psychological counseling were carried out. Result: In this case, through rehabilitation nursing, the patient's vital signs were stable. His blood pressure fluctuates between 101-124/68-91 mmHg. The weakness of the right limb was relieved compared with the previous one, and the aphasia was improved compared with the previous one. The skin was intact and no bleeding occurred. After 28 days in hospital, the patient was discharged. Conclusion: We summarized the experience of rehabilitation nursing, to provide effective guidance and suggestions for the rehabilitation nursing of children with cerebral infarction after valve replacement.
Abstract: Background: Cerebral infarction is a chronic and rare complication for children who regularly take warfarin after valve surgery of congenital heart disease, which affects their health and quality of life. There are few reports on the rehabilitation nursing experience of children with cerebral infarction after congenital heart valve surgery. Objecti...
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