Evaluation of the Binding Property of Some Binders in Metronidazole Tablet Formulation
Akodu Busayo Odunayo,
Fasuba Ilesanmi Kayode,
Akawa Ayodeji Benjamin,
Adu Isaac Adekola,
Olasehinde Oluwaseun Ruth
Issue:
Volume 7, Issue 2, March 2021
Pages:
22-30
Received:
17 February 2021
Accepted:
9 March 2021
Published:
30 March 2021
Abstract: The binding property of five (5) commonly used binders in metronidazole granule and tablet formulations was studied. The binders studied included gelatin, polyvinylpyrrolidone (PVP), carboxymethylcellulose (CMC), maize starch and guar gum. The binders were incorporated as 5%w/w of tablet weight in each case. The granules were formulated by the wet granulation technique while the tablets were prepared by compression. The properties of granules evaluated included flow rate, angle of repose, bulk and tapped densities, Hausner’s ratio, Carr’s index and moisture content. Tablet properties studied included weight uniformity, hardness, friability, thickness and diameter, disintegration time and dissolution rate. Results indicated that granules containing guar gum or PVP possessed flow properties superior to those of other binders, while those containing gelatin possessed the least flow property. In terms of packing characteristics, granules containing CMC were better than others. The mechanical strength of tablets containing gelatin, PVP or CMC was superior to those made with either guar gum or maize starch. In terms of release of metronidazole, tablets containing PVP, gelatin or guar gum were more efficient in releasing the drug, while those made with CMC was the least. On the basis of these, good metronidazole tablets could be formulated using PVP, gelatin or guar gum. On the other hand, maize starch or CMC may not be recommended as a binder for metronidazole tablets because of high friability or poor release respectively.
Abstract: The binding property of five (5) commonly used binders in metronidazole granule and tablet formulations was studied. The binders studied included gelatin, polyvinylpyrrolidone (PVP), carboxymethylcellulose (CMC), maize starch and guar gum. The binders were incorporated as 5%w/w of tablet weight in each case. The granules were formulated by the wet ...
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Development and Validation of a UV/vis Spectrometric Method for Determination of Cefixim Trihydrate in Raw Materials (Pure) and Tablet Forms
Mavanga Mabaya Timothy,
Mankulu Kakumba Jocelyn,
Mayangi Makola Mannix,
Mbenza Puati Adelard,
Mana Kialengila Didi,
Mavar Tayey Mbay Jean,
Mbinze Kindenge Jeremi
Issue:
Volume 7, Issue 2, March 2021
Pages:
31-36
Received:
13 March 2021
Accepted:
30 March 2021
Published:
13 April 2021
Abstract: A Cefixim Trihydrate method was developed and validated for determination of Cefixim in raw materials and tablets. This was to enable quantification of the compound using an available and less expensive analytical method for those forms. Henceforth, this study aimed to develop and validate a fast, simple and economical Ultraviolet-visible (UV/vis) spectrophotometric method for the quantitative estimation of Cefixim in pure state and in tablet forms. The predicted wavelength for maximal absorption to perform with this method was 286 nm with 0.1N HCl as solvent and blank. This gave useful results for the following steps. Linearity, precision, accuracy, specificity, robustness, limit of detection (LOD) and limit of quantification (LOQ) were evaluated for the method validation according to the International Conference on Harmonization (ICH) requirements. The developed method was used for the quantitative determination of Cefixim tablets marketed on the local market. The calibration data showed a better correlation (R2=1) over the range of concentrations used (2.5-15µg / ml) and the regression equation was Y=0.0511X. The limits of detection (LOD) and quantification (LOQ) determined were 0.275 µg/ml and 0.919 µg/ml, respectively. The accuracy study carried out at three concentration levels (80%, 100%, and 120%) gave respective recovery rate averages of 97.25%, 97.56% and 97.44% at which the relative standard deviations (RSD) were all less than 2%. The intra and inter-day precision, specificity and robustness were also satisfactory.
Abstract: A Cefixim Trihydrate method was developed and validated for determination of Cefixim in raw materials and tablets. This was to enable quantification of the compound using an available and less expensive analytical method for those forms. Henceforth, this study aimed to develop and validate a fast, simple and economical Ultraviolet-visible (UV/vis) ...
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