Nitrous oxide abuse is increasingly common among young people. It's a gas consumed at parties, where access is easy and less expensive. It can cause vitamin deficiencies, leading to neurological and non-neurological clinical manifestations. The aim of this study was to establish the blood biology profile of patients hospitalized for neurological disorders in the context of nitrous oxide abuse. Methodology, we conducted a retrospective and prospective descriptive study from January 2021 to April 2023. We studied frequency of consumption, inhaled dose and time of exposure to nitrous oxide. Blood levels of vitamin B12 and B9 were measured. Methylmalonic acid and homocysteine were also measured in the blood. Results include 15 patients recruited during the study period. 7 of the 15 patients used nitrous oxide daily. One patient consumed 9600 grams per week. Ten patients had a delay in toxicity beyond one year. Vitamin B12 blood levels were normal in 8 of 15 patients. On average, vitamin B12 levels were normal at 207.57 pmol/l. Vitamin B9 was not routinely measured in 9 patients. Blood homocysteine levels were elevated in 12 of 13 patients, with a high mean of 83.36 µmol/l. In conclusion, blood homocysteine levels are a more reliable marker than vitamin B12 for demonstrating biological disturbances associated with laughing gas abuse.
| Published in | Advances in Biochemistry (Volume 12, Issue 3) |
| DOI | 10.11648/j.ab.20241203.12 |
| Page(s) | 99-104 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Homocysteine, Neurology, Nitrous Oxide, Vitamin B12
Patients | Consumption frequency | Average consumption (grams/week) | Toxicity time |
|---|---|---|---|
1 | 3-6 times a week | Not specified | 6 months |
2 | 1 time a week | 80 | Less than 1 month |
3 | 2times a week | 160 | More than 12 months |
4 | Daily | Not specified | More than12 months |
5 | Daily | 1600 | More than 6 months |
6 | Daily | 3200 | More than12 months |
7 | Daily | 1600 | More than12 months |
8 | Daily | 4000 | More than12 months |
9 | Daily | 2400 | More than12 months |
10 | Daily | 3200 | More than12 months |
11 | 2 times a week | 3200 | 6 months |
12 | 4 times a week | 6400 | 2 months |
13 | 4 times a week | 9600 | More than12 months |
14 | 3 times a week | 4800 | More than12months |
15 | 3 times a week | Not specified | More than12 months |
Patients | Vitamin B12 assay (pmol/l) | Vitamin B9 assay (nmol/l) |
|---|---|---|
1 | 213 (normal) | 11 (limit of normal) |
2 | 231 (normal) | 11.7 (limit of normal) |
3 | 254 (normal) | 10.1 (deficiency) |
4 | <109 (deficiency) | 11.3 (limit of normal) |
5 | 289 (normal) | 13.4 (normal) |
6 | 124 (deficiency) | 15.8 (normal) |
7 | 172 (deficiency) | Not realized |
8 | 278 (normal) | Not realized |
9 | 186 (limit of normal) | Not realized |
10 | <109 (deficiency) | 17.9 (normal) |
11 | 342 (normal) | Not realized |
12 | 363 (normal) | Not realized |
13 | 123 (deficiency) | Not realized |
14 | Not realized | Not realized |
15 | 113 (deficiency) | 8.6 (deficiency) |
Average | 207.57 (normal) | 12.47 (normal) |
Patients | Homocysteine assay (µmol/l) | Determination of methylmalonic acid (µmol/l)) |
|---|---|---|
1 | 120.67 (increased) | Not realized |
2 | 17(increased slightly) | 29.1 (normal) |
3 | 110.91 (increased) | 840 (increased) |
4 | 2 (normal) | 17 (normal) |
5 | 56.4 (increased) | 134.5 (normal) |
6 | 61.39 (increased) | Not realized |
7 | 152.14 (increased) | Not realized |
8 | 146.85 (increased) | Not realized |
9 | 101.37 (increased) | Not realized |
10 | 21.23 (increased) | Not realized |
11 | 46.24 (increased) | 132.1 (normal) |
12 | 126.31(increased) | Not realized |
13 | 121.23(increased) | Not realized |
14 | Not realized | Not realized |
15 | Not realized | Not realized |
Average | 83.36 (increased) | 230.5 (normal) |
N2O | Nitrous Oxide |
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APA Style
Koffi, Y. T., Yeo, S. N., Pottier, C., Niclot, P. (2024). Disturbances in Biological Parameters in Patients Exposed to Nitrous Oxide Abuse Experience of the Rene Dubos Hospital Centre in Pontoise. Advances in Biochemistry, 12(3), 99-104. https://doi.org/10.11648/j.ab.20241203.12
ACS Style
Koffi, Y. T.; Yeo, S. N.; Pottier, C.; Niclot, P. Disturbances in Biological Parameters in Patients Exposed to Nitrous Oxide Abuse Experience of the Rene Dubos Hospital Centre in Pontoise. Adv. Biochem. 2024, 12(3), 99-104. doi: 10.11648/j.ab.20241203.12
AMA Style
Koffi YT, Yeo SN, Pottier C, Niclot P. Disturbances in Biological Parameters in Patients Exposed to Nitrous Oxide Abuse Experience of the Rene Dubos Hospital Centre in Pontoise. Adv Biochem. 2024;12(3):99-104. doi: 10.11648/j.ab.20241203.12
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Download@article{10.11648/j.ab.20241203.12,
author = {Yannick Thibaut Koffi and Samuel Nawa Yeo and Corinne Pottier and Philippe Niclot},
title = {Disturbances in Biological Parameters in Patients Exposed to Nitrous Oxide Abuse Experience of the Rene Dubos Hospital Centre in Pontoise
},
journal = {Advances in Biochemistry},
volume = {12},
number = {3},
pages = {99-104},
doi = {10.11648/j.ab.20241203.12},
url = {https://doi.org/10.11648/j.ab.20241203.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20241203.12},
abstract = {Nitrous oxide abuse is increasingly common among young people. It's a gas consumed at parties, where access is easy and less expensive. It can cause vitamin deficiencies, leading to neurological and non-neurological clinical manifestations. The aim of this study was to establish the blood biology profile of patients hospitalized for neurological disorders in the context of nitrous oxide abuse. Methodology, we conducted a retrospective and prospective descriptive study from January 2021 to April 2023. We studied frequency of consumption, inhaled dose and time of exposure to nitrous oxide. Blood levels of vitamin B12 and B9 were measured. Methylmalonic acid and homocysteine were also measured in the blood. Results include 15 patients recruited during the study period. 7 of the 15 patients used nitrous oxide daily. One patient consumed 9600 grams per week. Ten patients had a delay in toxicity beyond one year. Vitamin B12 blood levels were normal in 8 of 15 patients. On average, vitamin B12 levels were normal at 207.57 pmol/l. Vitamin B9 was not routinely measured in 9 patients. Blood homocysteine levels were elevated in 12 of 13 patients, with a high mean of 83.36 µmol/l. In conclusion, blood homocysteine levels are a more reliable marker than vitamin B12 for demonstrating biological disturbances associated with laughing gas abuse.
},
year = {2024}
}
TY - JOUR T1 - Disturbances in Biological Parameters in Patients Exposed to Nitrous Oxide Abuse Experience of the Rene Dubos Hospital Centre in Pontoise AU - Yannick Thibaut Koffi AU - Samuel Nawa Yeo AU - Corinne Pottier AU - Philippe Niclot Y1 - 2024/08/20 PY - 2024 N1 - https://doi.org/10.11648/j.ab.20241203.12 DO - 10.11648/j.ab.20241203.12 T2 - Advances in Biochemistry JF - Advances in Biochemistry JO - Advances in Biochemistry SP - 99 EP - 104 PB - Science Publishing Group SN - 2329-0862 UR - https://doi.org/10.11648/j.ab.20241203.12 AB - Nitrous oxide abuse is increasingly common among young people. It's a gas consumed at parties, where access is easy and less expensive. It can cause vitamin deficiencies, leading to neurological and non-neurological clinical manifestations. The aim of this study was to establish the blood biology profile of patients hospitalized for neurological disorders in the context of nitrous oxide abuse. Methodology, we conducted a retrospective and prospective descriptive study from January 2021 to April 2023. We studied frequency of consumption, inhaled dose and time of exposure to nitrous oxide. Blood levels of vitamin B12 and B9 were measured. Methylmalonic acid and homocysteine were also measured in the blood. Results include 15 patients recruited during the study period. 7 of the 15 patients used nitrous oxide daily. One patient consumed 9600 grams per week. Ten patients had a delay in toxicity beyond one year. Vitamin B12 blood levels were normal in 8 of 15 patients. On average, vitamin B12 levels were normal at 207.57 pmol/l. Vitamin B9 was not routinely measured in 9 patients. Blood homocysteine levels were elevated in 12 of 13 patients, with a high mean of 83.36 µmol/l. In conclusion, blood homocysteine levels are a more reliable marker than vitamin B12 for demonstrating biological disturbances associated with laughing gas abuse. VL - 12 IS - 3 ER -
Neurology Department, Bouake University Hospital Centre, Bouake, Ivory Coast
Neurology Department, Bouake University Hospital Centre, Bouake, Ivory Coast
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