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Association of Triglyceride/Glucose Index with CRP and Ferritin Among Different Obesity Phenotypes of Non-diabetic Adult Bangladeshi

Received: 23 August 2024     Accepted: 13 September 2024     Published: 26 September 2024
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Abstract

Introduction: Obesity is an alarming problem worldwide and it antedates insulin resistance (IR) as well as inflammation. Considering financial condition of Bangladesh, TyG index can be used for assessment of insulin resistance. As CRP and ferritin usually respond to any inflammatory condition, they are expected to be raised in obesity. Early detection of association between TyG index and inflammatory markers (CRP & ferritin) can help in prediction of severity of obesity induced health risks. Materials and Methods: A cross sectional analytical study was conducted in the Department of Biochemistry and Molecular Biology, (BSMMU) from March, 2022 to February, 2023. BMI was calculated, and individuals were classified into three obesity phenotypes: phenotype A (obese BMI, non-obese WC), phenotype B (non-obese BMI, obese WC), and phenotype C (obese BMI, obese WC). The Triglyceride-Glucose (TyG) index, serum ferritin, and CRP were assessed, and their correlations were analyzed across different obesity phenotypes. Results: TyG index was significantly higher in phenotype C compared to A & B. Plasma CRP and ferritin level were found to be highest in phenotype C in comparison to phenotype A and phenotype B. A moderate positive correlation was found between TyG index and serum ferritin but not with CRP in subjects belonging phenotype B. Very low positive correlation was found between CRP and ferritin in subjects of phenotype C. Conclusion: A significant association was shown between TyG index and serum ferritin among phenotype B. Plasma CRP showed no significant association with TyG index among different obesity phenotypes.

Published in Advances in Biochemistry (Volume 12, Issue 3)
DOI 10.11648/j.ab.20241203.14
Page(s) 112-117
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

TyG Index, Plasma CRP, Serum Ferritin, Obesity Phenotypes, Non-Diabetic Adult

References
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    Brishti, T. W., Hoque, M., Moyenullah, M., Alam, A. (2024). Association of Triglyceride/Glucose Index with CRP and Ferritin Among Different Obesity Phenotypes of Non-diabetic Adult Bangladeshi. Advances in Biochemistry, 12(3), 112-117. https://doi.org/10.11648/j.ab.20241203.14

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    ACS Style

    Brishti, T. W.; Hoque, M.; Moyenullah, M.; Alam, A. Association of Triglyceride/Glucose Index with CRP and Ferritin Among Different Obesity Phenotypes of Non-diabetic Adult Bangladeshi. Adv. Biochem. 2024, 12(3), 112-117. doi: 10.11648/j.ab.20241203.14

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    AMA Style

    Brishti TW, Hoque M, Moyenullah M, Alam A. Association of Triglyceride/Glucose Index with CRP and Ferritin Among Different Obesity Phenotypes of Non-diabetic Adult Bangladeshi. Adv Biochem. 2024;12(3):112-117. doi: 10.11648/j.ab.20241203.14

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  • @article{10.11648/j.ab.20241203.14,
      author = {Tanha Waheed Brishti and Mozammel Hoque and Mohammad Moyenullah and Azmeri Alam},
      title = {Association of Triglyceride/Glucose Index with CRP and Ferritin Among Different Obesity Phenotypes of Non-diabetic Adult Bangladeshi
    },
      journal = {Advances in Biochemistry},
      volume = {12},
      number = {3},
      pages = {112-117},
      doi = {10.11648/j.ab.20241203.14},
      url = {https://doi.org/10.11648/j.ab.20241203.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20241203.14},
      abstract = {Introduction: Obesity is an alarming problem worldwide and it antedates insulin resistance (IR) as well as inflammation. Considering financial condition of Bangladesh, TyG index can be used for assessment of insulin resistance. As CRP and ferritin usually respond to any inflammatory condition, they are expected to be raised in obesity. Early detection of association between TyG index and inflammatory markers (CRP & ferritin) can help in prediction of severity of obesity induced health risks. Materials and Methods: A cross sectional analytical study was conducted in the Department of Biochemistry and Molecular Biology, (BSMMU) from March, 2022 to February, 2023. BMI was calculated, and individuals were classified into three obesity phenotypes: phenotype A (obese BMI, non-obese WC), phenotype B (non-obese BMI, obese WC), and phenotype C (obese BMI, obese WC). The Triglyceride-Glucose (TyG) index, serum ferritin, and CRP were assessed, and their correlations were analyzed across different obesity phenotypes. Results: TyG index was significantly higher in phenotype C compared to A & B. Plasma CRP and ferritin level were found to be highest in phenotype C in comparison to phenotype A and phenotype B. A moderate positive correlation was found between TyG index and serum ferritin but not with CRP in subjects belonging phenotype B. Very low positive correlation was found between CRP and ferritin in subjects of phenotype C. Conclusion: A significant association was shown between TyG index and serum ferritin among phenotype B. Plasma CRP showed no significant association with TyG index among different obesity phenotypes.
    },
     year = {2024}
    }
    

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  • TY  - JOUR
    T1  - Association of Triglyceride/Glucose Index with CRP and Ferritin Among Different Obesity Phenotypes of Non-diabetic Adult Bangladeshi
    
    AU  - Tanha Waheed Brishti
    AU  - Mozammel Hoque
    AU  - Mohammad Moyenullah
    AU  - Azmeri Alam
    Y1  - 2024/09/26
    PY  - 2024
    N1  - https://doi.org/10.11648/j.ab.20241203.14
    DO  - 10.11648/j.ab.20241203.14
    T2  - Advances in Biochemistry
    JF  - Advances in Biochemistry
    JO  - Advances in Biochemistry
    SP  - 112
    EP  - 117
    PB  - Science Publishing Group
    SN  - 2329-0862
    UR  - https://doi.org/10.11648/j.ab.20241203.14
    AB  - Introduction: Obesity is an alarming problem worldwide and it antedates insulin resistance (IR) as well as inflammation. Considering financial condition of Bangladesh, TyG index can be used for assessment of insulin resistance. As CRP and ferritin usually respond to any inflammatory condition, they are expected to be raised in obesity. Early detection of association between TyG index and inflammatory markers (CRP & ferritin) can help in prediction of severity of obesity induced health risks. Materials and Methods: A cross sectional analytical study was conducted in the Department of Biochemistry and Molecular Biology, (BSMMU) from March, 2022 to February, 2023. BMI was calculated, and individuals were classified into three obesity phenotypes: phenotype A (obese BMI, non-obese WC), phenotype B (non-obese BMI, obese WC), and phenotype C (obese BMI, obese WC). The Triglyceride-Glucose (TyG) index, serum ferritin, and CRP were assessed, and their correlations were analyzed across different obesity phenotypes. Results: TyG index was significantly higher in phenotype C compared to A & B. Plasma CRP and ferritin level were found to be highest in phenotype C in comparison to phenotype A and phenotype B. A moderate positive correlation was found between TyG index and serum ferritin but not with CRP in subjects belonging phenotype B. Very low positive correlation was found between CRP and ferritin in subjects of phenotype C. Conclusion: A significant association was shown between TyG index and serum ferritin among phenotype B. Plasma CRP showed no significant association with TyG index among different obesity phenotypes.
    
    VL  - 12
    IS  - 3
    ER  - 

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