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Peripheral Ischemia and Necrosis Revealing Buerger's Disease in an Internal Medicine Department

Received: 11 September 2024     Accepted: 29 September 2024     Published: 18 October 2024
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Abstract

Buerger's disease is a systemic vasculitis strongly correlated with tobacco use. It entails a heavy socio-occupational impact. We report the case of a 26-year-old patient with ischemia of the lower limbs revealing Buerger’s disease. He is known smoker with passive exposure to Indian hemp. He was seen for ischemic foot pain that had been progressing for a year. Involvement began in the left big toe. Subsequently, hyperalgesic necrotic lesions were observed on the 3rd, 4th and 5th toes of the foot. Biological investigations revealed an inflammatory syndrome with normocytic anemia and increased C-reactive protein. Retroviral, syphilitic, Hepatitis B and C viruses and SARS-CoV-2 serologies were negative. Antinuclear antibodies were initially borderline at 100 IU with speckled fluorescence, then negative on control. Neutrophil cytoplasmic antibodies and antiphospholipid antibodies were negative. Investigation of thrombophilia was non-contributory, notably factor V mutation testing, antithrombin III assay, proteins C and S and fibrinogen. An arterial ultrasound revealed extensive arterial thrombosis with thickening of the femoral arterial vessel walls. Thromboangiitis obliterans was confirmed and the patient was put on corticosteroids and adjuvant therapy. Surgical treatment was performed 4 months later. Buerger's disease is a serious vascular disorder which must be diagnosed very early in order to prevent complications. Early smoking cessation leads to remission in the early phase.

Published in American Journal of Internal Medicine (Volume 12, Issue 5)
DOI 10.11648/j.ajim.20241205.12
Page(s) 74-77
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Thromboangiitis Obliterans, Buerger's, Tobacco, Amputation

References
[1] Klein-weigel PF, Richter JG. Thromboangiitis obliterans (Buerger's disease). Vasa. 2014; 43 (5): 337-346.
[2] Fernandes U, Vasconcelos J, Marques R, and al. Buerger's Disease - A Clinical Case. Port J Card Thorac Vasc Surg. 2023 Jul 7; 30(2): 59-61.
[3] Puéchal X, Fiessinger JN. Thromboangiitis obliterans or Buerger's disease: challenges for the rheumatologist. Rheumatol (Oxford). 2007; 46(2): 192-199.
[4] Rivera-Chavarría IJ, Brenes-Gutiérrez JD. Thromboangiitis obliterans (Buerger's disease). Ann Med Surg (Lond). 2016 Mar 29; 7: 79-82.
[5] Shionoya S. Buerger's disease: diagnosis and management. Cardiovasc Surg. 1993; 1(3): 207-214.
[6] Laidoudi A, Hamadane A, Salah M, et al. La maladie de Leo-Buerger: une cause rare et grave d’artériopathie oblitérante. Rev med int. 2016; 37: A167-8.
[7] Ratbi MI, Abissegue GY, Tarchouli M, et al. Severe mesenteric infarction by superior mesenteric artery occlusion in a patient suffering from Buerger’s disease. Pan Afr Med J. 2014; 19: 322.
[8] Pouye A, Ka MM, N'dongo S, Diallo S, Fall S, Diop SB, Coume M, Leye A, Diop-Moreira T. Possible confusion between Buerger's disease and Hansen's disease in the tropics: a case report. Rev med int. 2004; 25(8): 606-7. https://doi.org/10.1016/j.revmed.2004.04.014
[9] Ndongo S, Diallo S, Tiendrebeogo J, and al. Systemic vasculitis: study of 27 cases in Senegal. Tropical med. 2010; 70(3): 264-266. PMID: 20734595.
[10] Bura-Riviere A, Rossignol P. Thromboangéite oblitérante ou maladie de Buerger. EMC Cardio Angio. 2005; 2(4): 498-503.
[11] Broner J, Arnaud E. Colite ischémique révélant une thromboangéite oblitérante: à propos d’un cas. Rev med int. 2017; 38(S1): A145.
Cite This Article
  • APA Style

    Mansour, D. B., Ndour, J. N., Yanidou, N., Faye, F. F. A., Diop, M. M., et al. (2024). Peripheral Ischemia and Necrosis Revealing Buerger's Disease in an Internal Medicine Department. American Journal of Internal Medicine, 12(5), 74-77. https://doi.org/10.11648/j.ajim.20241205.12

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    ACS Style

    Mansour, D. B.; Ndour, J. N.; Yanidou, N.; Faye, F. F. A.; Diop, M. M., et al. Peripheral Ischemia and Necrosis Revealing Buerger's Disease in an Internal Medicine Department. Am. J. Intern. Med. 2024, 12(5), 74-77. doi: 10.11648/j.ajim.20241205.12

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    AMA Style

    Mansour DB, Ndour JN, Yanidou N, Faye FFA, Diop MM, et al. Peripheral Ischemia and Necrosis Revealing Buerger's Disease in an Internal Medicine Department. Am J Intern Med. 2024;12(5):74-77. doi: 10.11648/j.ajim.20241205.12

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  • @article{10.11648/j.ajim.20241205.12,
      author = {Diallo Bachir Mansour and Jean Noel Ndour and Ndiaye Yanidou and Faye Fulgence Abdou Faye and Moustapha Mbacke Diop and Aboubakry Sow and Nana Mamoudou Baba and Wade Adama and Mbaye Serigne Abdou Khadr and Diack Mamadou and Berthé Adama and Touré Papa Souleymane and Diop Madoky Magatte and Ka Mamadou Mourtalla},
      title = {Peripheral Ischemia and Necrosis Revealing Buerger's Disease in an Internal Medicine Department
    },
      journal = {American Journal of Internal Medicine},
      volume = {12},
      number = {5},
      pages = {74-77},
      doi = {10.11648/j.ajim.20241205.12},
      url = {https://doi.org/10.11648/j.ajim.20241205.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20241205.12},
      abstract = {Buerger's disease is a systemic vasculitis strongly correlated with tobacco use. It entails a heavy socio-occupational impact. We report the case of a 26-year-old patient with ischemia of the lower limbs revealing Buerger’s disease. He is known smoker with passive exposure to Indian hemp. He was seen for ischemic foot pain that had been progressing for a year. Involvement began in the left big toe. Subsequently, hyperalgesic necrotic lesions were observed on the 3rd, 4th and 5th toes of the foot. Biological investigations revealed an inflammatory syndrome with normocytic anemia and increased C-reactive protein. Retroviral, syphilitic, Hepatitis B and C viruses and SARS-CoV-2 serologies were negative. Antinuclear antibodies were initially borderline at 100 IU with speckled fluorescence, then negative on control. Neutrophil cytoplasmic antibodies and antiphospholipid antibodies were negative. Investigation of thrombophilia was non-contributory, notably factor V mutation testing, antithrombin III assay, proteins C and S and fibrinogen. An arterial ultrasound revealed extensive arterial thrombosis with thickening of the femoral arterial vessel walls. Thromboangiitis obliterans was confirmed and the patient was put on corticosteroids and adjuvant therapy. Surgical treatment was performed 4 months later. Buerger's disease is a serious vascular disorder which must be diagnosed very early in order to prevent complications. Early smoking cessation leads to remission in the early phase.
    },
     year = {2024}
    }
    

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    AU  - Diallo Bachir Mansour
    AU  - Jean Noel Ndour
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    AU  - Aboubakry Sow
    AU  - Nana Mamoudou Baba
    AU  - Wade Adama
    AU  - Mbaye Serigne Abdou Khadr
    AU  - Diack Mamadou
    AU  - Berthé Adama
    AU  - Touré Papa Souleymane
    AU  - Diop Madoky Magatte
    AU  - Ka Mamadou Mourtalla
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    JO  - American Journal of Internal Medicine
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    AB  - Buerger's disease is a systemic vasculitis strongly correlated with tobacco use. It entails a heavy socio-occupational impact. We report the case of a 26-year-old patient with ischemia of the lower limbs revealing Buerger’s disease. He is known smoker with passive exposure to Indian hemp. He was seen for ischemic foot pain that had been progressing for a year. Involvement began in the left big toe. Subsequently, hyperalgesic necrotic lesions were observed on the 3rd, 4th and 5th toes of the foot. Biological investigations revealed an inflammatory syndrome with normocytic anemia and increased C-reactive protein. Retroviral, syphilitic, Hepatitis B and C viruses and SARS-CoV-2 serologies were negative. Antinuclear antibodies were initially borderline at 100 IU with speckled fluorescence, then negative on control. Neutrophil cytoplasmic antibodies and antiphospholipid antibodies were negative. Investigation of thrombophilia was non-contributory, notably factor V mutation testing, antithrombin III assay, proteins C and S and fibrinogen. An arterial ultrasound revealed extensive arterial thrombosis with thickening of the femoral arterial vessel walls. Thromboangiitis obliterans was confirmed and the patient was put on corticosteroids and adjuvant therapy. Surgical treatment was performed 4 months later. Buerger's disease is a serious vascular disorder which must be diagnosed very early in order to prevent complications. Early smoking cessation leads to remission in the early phase.
    
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Author Information
  • Department of Internal Medicine, Abdou Aziz Sy Hospital, Tivaouane, Senegal

  • Department of Internal Medicine, Mamadou Diop Hospital, Dakar, Senegal

  • School of Medicine, Thies Regional Hospital, Thies, Senegal

  • School of Medicine, Alioune Diop University in Bambey, Bambey, Senegal

  • Department of Internal Medicine, Abdou Aziz Sy Hospital, Tivaouane, Senegal

  • Department of Internal Medicine, Abdou Aziz Sy Hospital, Tivaouane, Senegal

  • School of Medicine, Thies Regional Hospital, Thies, Senegal

  • Department of Internal Medicine, Abdou Aziz Sy Hospital, Tivaouane, Senegal

  • Department of Internal Medicine, Abdou Aziz Sy Hospital, Tivaouane, Senegal

  • Department of Internal Medicine, Abdou Aziz Sy Hospital, Tivaouane, Senegal

  • School of Medicine, Thies Regional Hospital, Thies, Senegal

  • Department of Internal Medicine, Abdou Aziz Sy Hospital, Tivaouane, Senegal

  • School of Medicine, Thies Regional Hospital, Thies, Senegal

  • School of Medicine, Iba Der Thiam University, Thies, Senegal

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