Anabolic Steroids Effects on Bone Regeneration

José Carlos Pansieri; Alessandra Esteves; Wagner Costa Rossi Junior

doi:doi:10.11648/j.ajss.20190703.12

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Anabolic Steroids Effects on Bone Regeneration

José Carlos Pansieri, Alessandra Esteves, Wagner Costa Rossi Junior

Published in American Journal of Sports Science (Volume 7, Issue 3)

Received: 9 June 2019 Accepted: 16 July 2019 Published: 30 July 2019

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Abstract

In recent decades, the importance given to body appearance has grown dramatically, as has the consumption of so-called "body image drugs," which include androgenic anabolic steroids (AAS), synthetic substances derived from testosterone. Although the therapeutic use of anabolic steroids are beneficial and necessary to body when there is reduction or depletion of these substances, the excessive use is related to negative interference in fracture healing process. Thus, the objective of study was to verify if there is influence of AAS in process of bone repair. For this, twenty Wistar rats were used, in which a fracture with bone loss was performed on left fibular diaphysis. Subsequently, they were divided into four groups and the animals were treated for one (1) month, with physiological solution (0.02 ml), Durateston® (83.3 mg / kg [0.02 ml]) and Deca Durabolin® (16.6 mg / kg [0.02 ml]), applied once a week. The results showed that there was a significant loss in bone healing on groups treated with AAS, since there was no regeneration in fractured fibula, besides increasing resorption process at the ends of fracture stumps. For this reason it is possible to conclude that the misuse of AAS interferes negatively in metabolism of bone tissue reinforcing the danger of indiscriminate use for health, warning that, addition other biological tissues, the bone may be affected by abuse of these substances.

Published in	American Journal of Sports Science (Volume 7, Issue 3)
DOI	10.11648/j.ajss.20190703.12
Page(s)	88-93
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Anabolic Steroids, Testosterone, Fracture Fibula, Bone Regeneration

References

[1]	S. Oryan, A. Monazzah, A. Bigham-Sadegh. Bone Injury and Fracture Healing Biology. Biomed Environ Sci, 2015; 28 (1): 57-71. doi: 10.3967/bes2015.006.
[2]	J. G. M. P. Isola, P. C. Moraes. Estrutura e regeneração óssea – revisão de literatura. Revista Científica Eletrônica de Medicina Veterinária, 18 (2012).
[3]	L. C. Junqueira, J. Carneiro. Histologia Básica. 12.ed. Rio de Janeiro: Guanabara Koogan, 2013.
[4]	T. S. Cunha, A. P. Tanno, F. K. Marcondes, S. E. A. Perez. A administração de nandrolona não promove hipertrofia do músculo sóleo em ratos. Arq Bras Endocrinol Metab, 50 (2006): 532-540. doi: 10.1590/S0004-27302006000300017.
[5]	M. A. S. Marques, H. M. G. Pereira, F. R. Aquino Neto. Controle de dopagem de anabolizantes: o perfil esteroidal e suas regulações. Bras Med Esporte, 9 (2003): 15-24. http://dx.doi.org/10.1590/S1517-86922003000100004.
[6]	F. C. Cruz, S. A. Engi, R. M. Leão, C. S. Planeta, C. C. Crestani. Influence of the single or combined administration of cocaine and testosterone in autonomic and neuroendocrine responses to acutere straint stress. J. Psychopharmacol, 26 (2012): 1366-74. doi: 10.1177/0269881112453210.
[7]	A. G. Fragkaki, Y. S. Angelis, M. Koupparis, A. Tsantili-Kakoulidou, G. Kokotos, C. Georgakopoulos. Structural characteristics of anabolic androgenic steroids contributing to binding to the androgen receptor and to their anabolic andandrogenic activities applied modifications in the steroidal structure. Rev Steroids, 74 (2009): 172–197. doi: 10.1016/j.steroids.2008.10.016.
[8]	P. D. Venâncio. Esteroides anabolizantes e seu efeito sobre as variáveis bioquímicas e neuroendócrinas em indivíduos que praticam exercício resistido. Revista Brasileira de Medicina do Esporte, 16 (2010): 191-195. doi: 10.1590/S1517-86922010000300007.
[9]	F. Cecchetto, D. R. Moraes, P. S. Farias. Distintos enfoques sobre esteroides anabolizantes: riscos à saúde e hipermasculinidade. Interface-Comunicação, Saúde, Educação, 16 (2012): 369-82. http://dx.doi.org/10.1590/S1414-32832012005000008.
[10]	M. R. Laurent, L. Dedeyne, J. Dupont, B. Mellaerts, M. Dejaeger, E. Gielen. Age-related bone loss and sarcopenia in men. Maturitas, 122 (2019): 51–56. https://doi.org/10.1016/j.maturitas.2019.01.006
[11]	M. Hedström, K. Sjöberg, E. Brosjö, K. Åström, H. Sjöberg, N. Dalén. Positive effects of anabolic steroids, vitamin D and calcium on muscle mass, bone mineral density and clinical function after a hip fracture. A randomised study of 63 women. J Bone Joint Surg, 84 (2002): 497-503.
[12]	V. Farooqi, M. E. Van Den Berg, I. D. Cameron, M. Crotty. Anabolic steroids for rehabilitation after hip fracture in older people. Cochrane Database Syst Ver, 10 (2014): 467-468. http://dx.doi.org/10.1590/1516-3180.20161345t2
[13]	J. A. B. Iriart, J. C. Chaves, R. G. Orlean. Culto ao corpo e uso de anabolizantes entre praticantes de musculação. Cad. Saúde Pública, 25 (2009): 773-782. http://dx.doi.org/10.1590/S0102-311X2009000400008
[14]	A. T. Kicman. Pharmacology of anabolic steroids. British Journal of Pharmacology, 154 (2008): 502–521. doi: 10.1038/bjp.2008.165.
[15]	R. C. Agis-Balboa, N. Maria, F. Pibiri, G. Pinna. Enhanced fear responses in mice treated with anabolic androgenic steroids. Neuroreport, 20 (2009): 617-21. doi: 10.1097/WNR.0b013e32832a2393.
[16]	J. Corrêa, V. Amorin, D. A. Nogueira, E. A. Soares, F. R. Guerra, G. J. M. Fernandes, W. C. Rossi Junior, A. Esteves. Neuronal quantification in mice cerebral cortex under use of Ayahuasca tea. Revista Neurociências, 22 (2014): 388-391. DOI: 10.4181/RNC.2014.22.03.933.4p.
[17]	C. Ribeiro, D. K. Silva, B. Damião, D. M. Alves, A. Freitas, W. C. Rossi Junior, A. Esteves. Quantitative analysis of mices purkinje cells under the use by anabolic steroids. Revista Neurociências, 22 (2014): 432-437. DOI: 10.4181/RNC.2014.22.03.969.6p.
[18]	A. C. Freitas, B. Damião, D. M. Alves, M. Ribeiro, G. J. M. Fernandes, W. C. Rossi Junior, A. Esteves. Effects of anabolic agents on the neuron density of the basal nuclei. Rev Bras Med Esporte, 23 (2017): 213-216. doi: 10.1590/1517-869220172303151688.
[19]	M. F. Sant’anna. Capacidade osteogênica de enxertos periosteais livres. [Tese]. Universidade Estadual Paulista (UNESP). 1997.
[20]	W. C. Rossi Junior. Influência de uma membrana de colágeno associada a extrato etanólico de própolis na consolidação de fraturas com perda óssea. [Tese]. Faculdade de Odontologia de Piracicaba – Universidade Estadual de Campinas (UNICAMP). 2002.
[21]	G. Kanayama, J. I. Hudson, H. G. Pope Jr. Illicit Anabolic Androgenic Steroid Use. Horm Behav, 58 (2010): 111–121. doi: 10.1016/j.yhbeh.2009.09.006
[22]	E. Tasgin, S. Lok, N. Demir. Combined usage of testosterone and nandrolone may cause heart damage. African Journal of Biotechnology, 10 (2011): 3766-3768. DOI: 10.5897/AJB10.2714
[23]	M. D. C. Dandoy, R. S. M. D. Gereige. Performance-enhancing drugs. Pediatr Rev, 33 (2012): 265-272. doi: 10.1542/pir.33-6-265.
[24]	B. Laurence, K. Björn, H. D. Rande. Goodman & Gilman's the pharmacological basis of therapeutics. 13. ed. New York: McGraw Hill Medical, 2018.
[25]	DEF Dicionário de especialidades farmacêuticas. 42ª edição, Editora EPUC, 2014.
[26]	P. C. P. Ribeiro. The substances abuse: anabolizant steroids and energy drugs. Adolesc. Latinoam, 2 (2001): 97-101.
[27]	P. R. P. Silva, R. Danielski, M. A. Czepielewski. Esteroides anabolizantes no esporte. Rev. Bras. Med. Esporte, 8 (2002): 235-243. http://dx.doi.org/10.1590/S1517-86922002000600005
[28]	F. C. W. Wu. Endocrine aspects of anabolic steroids. Clin. Chem, 43 (1997): 1289-92.
[29]	R. S. Fortunato; D. Rosenthal; D. P. De Carvalho. Abuso de Esteroides Anabolizantes e seu Impacto sobre a Função Tireóidea. Arq Bras Endocrinol Metab 2007; 51/9:1417-1424. Doi.org/10.1590/S0004-27302007000900003.
[30]	S. K. Banu, J. A. Arosh, P. Govingarajulu, M. M. Aruldhas. Testosterone and estradiol differentially regulate thyroid growth in wistar rats from immature to adult age. Endocr Res, 27 (2001): 447-63.
[31]	R. C. Daly, T. P. Su, P. J. Schmidt, M. Pagliaro, D. Pickar, D. R. Rubinow. Neuroendocrine and behavioral effects of high dose anabolis steroid administration in male normal volunteers. Psychoneuroendocrinology, 28 (2003): 317-331.
[32]	S. O. Abde-Allh, S. A. Rahim. Anabolic Androgenic Steroid in male adult mice induced: Hypothyroidism, Oxidative stress. Euphrates Journal of Agriculture Science, 2014; 6 (4): 16-29.

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APA Style

José Carlos Pansieri, Alessandra Esteves, Wagner Costa Rossi Junior. (2019). Anabolic Steroids Effects on Bone Regeneration. American Journal of Sports Science, 7(3), 88-93. https://doi.org/10.11648/j.ajss.20190703.12

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ACS Style

José Carlos Pansieri; Alessandra Esteves; Wagner Costa Rossi Junior. Anabolic Steroids Effects on Bone Regeneration. Am. J. Sports Sci. 2019, 7(3), 88-93. doi: 10.11648/j.ajss.20190703.12

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AMA Style

José Carlos Pansieri, Alessandra Esteves, Wagner Costa Rossi Junior. Anabolic Steroids Effects on Bone Regeneration. Am J Sports Sci. 2019;7(3):88-93. doi: 10.11648/j.ajss.20190703.12

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@article{10.11648/j.ajss.20190703.12,
  author = {José Carlos Pansieri and Alessandra Esteves and Wagner Costa Rossi Junior},
  title = {Anabolic Steroids Effects on Bone Regeneration},
  journal = {American Journal of Sports Science},
  volume = {7},
  number = {3},
  pages = {88-93},
  doi = {10.11648/j.ajss.20190703.12},
  url = {https://doi.org/10.11648/j.ajss.20190703.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajss.20190703.12},
  abstract = {In recent decades, the importance given to body appearance has grown dramatically, as has the consumption of so-called "body image drugs," which include androgenic anabolic steroids (AAS), synthetic substances derived from testosterone. Although the therapeutic use of anabolic steroids are beneficial and necessary to body when there is reduction or depletion of these substances, the excessive use is related to negative interference in fracture healing process. Thus, the objective of study was to verify if there is influence of AAS in process of bone repair. For this, twenty Wistar rats were used, in which a fracture with bone loss was performed on left fibular diaphysis. Subsequently, they were divided into four groups and the animals were treated for one (1) month, with physiological solution (0.02 ml), Durateston® (83.3 mg / kg [0.02 ml]) and Deca Durabolin® (16.6 mg / kg [0.02 ml]), applied once a week. The results showed that there was a significant loss in bone healing on groups treated with AAS, since there was no regeneration in fractured fibula, besides increasing resorption process at the ends of fracture stumps. For this reason it is possible to conclude that the misuse of AAS interferes negatively in metabolism of bone tissue reinforcing the danger of indiscriminate use for health, warning that, addition other biological tissues, the bone may be affected by abuse of these substances.},
 year = {2019}
}

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TY  - JOUR
T1  - Anabolic Steroids Effects on Bone Regeneration
AU  - José Carlos Pansieri
AU  - Alessandra Esteves
AU  - Wagner Costa Rossi Junior
Y1  - 2019/07/30
PY  - 2019
N1  - https://doi.org/10.11648/j.ajss.20190703.12
DO  - 10.11648/j.ajss.20190703.12
T2  - American Journal of Sports Science
JF  - American Journal of Sports Science
JO  - American Journal of Sports Science
SP  - 88
EP  - 93
PB  - Science Publishing Group
SN  - 2330-8540
UR  - https://doi.org/10.11648/j.ajss.20190703.12
AB  - In recent decades, the importance given to body appearance has grown dramatically, as has the consumption of so-called "body image drugs," which include androgenic anabolic steroids (AAS), synthetic substances derived from testosterone. Although the therapeutic use of anabolic steroids are beneficial and necessary to body when there is reduction or depletion of these substances, the excessive use is related to negative interference in fracture healing process. Thus, the objective of study was to verify if there is influence of AAS in process of bone repair. For this, twenty Wistar rats were used, in which a fracture with bone loss was performed on left fibular diaphysis. Subsequently, they were divided into four groups and the animals were treated for one (1) month, with physiological solution (0.02 ml), Durateston® (83.3 mg / kg [0.02 ml]) and Deca Durabolin® (16.6 mg / kg [0.02 ml]), applied once a week. The results showed that there was a significant loss in bone healing on groups treated with AAS, since there was no regeneration in fractured fibula, besides increasing resorption process at the ends of fracture stumps. For this reason it is possible to conclude that the misuse of AAS interferes negatively in metabolism of bone tissue reinforcing the danger of indiscriminate use for health, warning that, addition other biological tissues, the bone may be affected by abuse of these substances.
VL  - 7
IS  - 3
ER  -

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Author Information

José Carlos Pansieri

Institute of Biomedical Sciences, Department of Anatomy, Federal University of Alfenas, Alfenas, Brazil
Alessandra Esteves

Institute of Biomedical Sciences, Department of Anatomy, Federal University of Alfenas, Alfenas, Brazil
Wagner Costa Rossi Junior

Institute of Biomedical Sciences, Department of Anatomy, Federal University of Alfenas, Alfenas, Brazil

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APA Style

José Carlos Pansieri, Alessandra Esteves, Wagner Costa Rossi Junior. (2019). Anabolic Steroids Effects on Bone Regeneration. American Journal of Sports Science, 7(3), 88-93. https://doi.org/10.11648/j.ajss.20190703.12

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ACS Style

José Carlos Pansieri; Alessandra Esteves; Wagner Costa Rossi Junior. Anabolic Steroids Effects on Bone Regeneration. Am. J. Sports Sci. 2019, 7(3), 88-93. doi: 10.11648/j.ajss.20190703.12

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AMA Style

José Carlos Pansieri, Alessandra Esteves, Wagner Costa Rossi Junior. Anabolic Steroids Effects on Bone Regeneration. Am J Sports Sci. 2019;7(3):88-93. doi: 10.11648/j.ajss.20190703.12

Copy | Download

@article{10.11648/j.ajss.20190703.12,
  author = {José Carlos Pansieri and Alessandra Esteves and Wagner Costa Rossi Junior},
  title = {Anabolic Steroids Effects on Bone Regeneration},
  journal = {American Journal of Sports Science},
  volume = {7},
  number = {3},
  pages = {88-93},
  doi = {10.11648/j.ajss.20190703.12},
  url = {https://doi.org/10.11648/j.ajss.20190703.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajss.20190703.12},
  abstract = {In recent decades, the importance given to body appearance has grown dramatically, as has the consumption of so-called "body image drugs," which include androgenic anabolic steroids (AAS), synthetic substances derived from testosterone. Although the therapeutic use of anabolic steroids are beneficial and necessary to body when there is reduction or depletion of these substances, the excessive use is related to negative interference in fracture healing process. Thus, the objective of study was to verify if there is influence of AAS in process of bone repair. For this, twenty Wistar rats were used, in which a fracture with bone loss was performed on left fibular diaphysis. Subsequently, they were divided into four groups and the animals were treated for one (1) month, with physiological solution (0.02 ml), Durateston® (83.3 mg / kg [0.02 ml]) and Deca Durabolin® (16.6 mg / kg [0.02 ml]), applied once a week. The results showed that there was a significant loss in bone healing on groups treated with AAS, since there was no regeneration in fractured fibula, besides increasing resorption process at the ends of fracture stumps. For this reason it is possible to conclude that the misuse of AAS interferes negatively in metabolism of bone tissue reinforcing the danger of indiscriminate use for health, warning that, addition other biological tissues, the bone may be affected by abuse of these substances.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Anabolic Steroids Effects on Bone Regeneration
AU  - José Carlos Pansieri
AU  - Alessandra Esteves
AU  - Wagner Costa Rossi Junior
Y1  - 2019/07/30
PY  - 2019
N1  - https://doi.org/10.11648/j.ajss.20190703.12
DO  - 10.11648/j.ajss.20190703.12
T2  - American Journal of Sports Science
JF  - American Journal of Sports Science
JO  - American Journal of Sports Science
SP  - 88
EP  - 93
PB  - Science Publishing Group
SN  - 2330-8540
UR  - https://doi.org/10.11648/j.ajss.20190703.12
AB  - In recent decades, the importance given to body appearance has grown dramatically, as has the consumption of so-called "body image drugs," which include androgenic anabolic steroids (AAS), synthetic substances derived from testosterone. Although the therapeutic use of anabolic steroids are beneficial and necessary to body when there is reduction or depletion of these substances, the excessive use is related to negative interference in fracture healing process. Thus, the objective of study was to verify if there is influence of AAS in process of bone repair. For this, twenty Wistar rats were used, in which a fracture with bone loss was performed on left fibular diaphysis. Subsequently, they were divided into four groups and the animals were treated for one (1) month, with physiological solution (0.02 ml), Durateston® (83.3 mg / kg [0.02 ml]) and Deca Durabolin® (16.6 mg / kg [0.02 ml]), applied once a week. The results showed that there was a significant loss in bone healing on groups treated with AAS, since there was no regeneration in fractured fibula, besides increasing resorption process at the ends of fracture stumps. For this reason it is possible to conclude that the misuse of AAS interferes negatively in metabolism of bone tissue reinforcing the danger of indiscriminate use for health, warning that, addition other biological tissues, the bone may be affected by abuse of these substances.
VL  - 7
IS  - 3
ER  -

Copy | Download