Association of Leptin Receptor Gene Polymorphisms with Blood Glucose Concentration and Obesity

Mo Mo Than; Yan Naing Soe; Zaw Myo Lwin; Ye Wint Kyaw; Kyaw Thet Paing; Khine Kyaw Oo; Phyo Thaw Htun; Aung Lin Oo; Min Thein; Ye Myat Kyaw; Zaw Min Htut

doi:doi:10.11648/j.bmb.20220703.11

Association of Leptin Receptor Gene Polymorphisms with Blood Glucose Concentration and Obesity

Mo Mo Than, Yan Naing Soe, Zaw Myo Lwin, Ye Wint Kyaw, Kyaw Thet Paing, Khine Kyaw Oo, Phyo Thaw Htun, Aung Lin Oo, Min Thein, Ye Myat Kyaw, Zaw Min Htut

Published in Biochemistry and Molecular Biology (Volume 7, Issue 3)

Received: 22 June 2022 Accepted: 9 July 2022 Published: 18 July 2022

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Abstract

Obesity has become a global epidemic and is a known risk factor for several adverse health outcomes. Single Nucleotide Polymorphism (SNP) in leptin receptor genes become interesting candidates as susceptibility genes for obesity and glucose homeostasis. The present study intended to explore the genetic analysis of LEPR gene K109, Q223R, and K656N polymorphisms and their relation to obesity and fasting plasma glucose (FPG) concentration in the Myanmar population. One hundred and fifty diagnosed obese subjects and 150 healthy non-obese controls were included. Fasting plasma glucose (FPG) was measured and LEPR gene K109R, Q223R, and K656N polymorphisms were detected by DNA analysis. Data were analyzed by chi-square and one-way ANOVA tests. Each genotype frequency distribution of LEPR gene (K109R, Q223R, and K656N) polymorphisms was not associated with obesity (p > 0.05), as well as each allele frequency distribution also similar outcome (p > 0.05). FPG levels of the study population showed no significant differences between each genotype of LEPR gene polymorphisms (p > 0.05). The K109R, Q223R, and K656N polymorphisms of the LEPR gene were not linked to obesity or FPG levels in the population of Myanmar, according to our findings. Therefore, it does not seem that these polymorphisms have an equivalently significant role for the people of Myanmar. To completely understand the unique genetic variables that predispose to obesity in humans, an ongoing study of diverse obesity phenotypes and related gene mutations is necessary as our understanding of the genes causing obesity increases as a result of new findings.

Published in	Biochemistry and Molecular Biology (Volume 7, Issue 3)
DOI	10.11648/j.bmb.20220703.11
Page(s)	54-60
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Obesity, Fasting Plasma Glucose, LEPR Gene K109R SNP, LEPR Gene Q223R SNP, LEPR Gene K656N SNP

References

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APA Style

Mo Mo Than, Yan Naing Soe, Zaw Myo Lwin, Ye Wint Kyaw, Kyaw Thet Paing, et al. (2022). Association of Leptin Receptor Gene Polymorphisms with Blood Glucose Concentration and Obesity. Biochemistry and Molecular Biology, 7(3), 54-60. https://doi.org/10.11648/j.bmb.20220703.11

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ACS Style

Mo Mo Than; Yan Naing Soe; Zaw Myo Lwin; Ye Wint Kyaw; Kyaw Thet Paing, et al. Association of Leptin Receptor Gene Polymorphisms with Blood Glucose Concentration and Obesity. Biochem. Mol. Biol. 2022, 7(3), 54-60. doi: 10.11648/j.bmb.20220703.11

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AMA Style

Mo Mo Than, Yan Naing Soe, Zaw Myo Lwin, Ye Wint Kyaw, Kyaw Thet Paing, et al. Association of Leptin Receptor Gene Polymorphisms with Blood Glucose Concentration and Obesity. Biochem Mol Biol. 2022;7(3):54-60. doi: 10.11648/j.bmb.20220703.11

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@article{10.11648/j.bmb.20220703.11,
  author = {Mo Mo Than and Yan Naing Soe and Zaw Myo Lwin and Ye Wint Kyaw and Kyaw Thet Paing and Khine Kyaw Oo and Phyo Thaw Htun and Aung Lin Oo and Min Thein and Ye Myat Kyaw and Zaw Min Htut},
  title = {Association of Leptin Receptor Gene Polymorphisms with Blood Glucose Concentration and Obesity},
  journal = {Biochemistry and Molecular Biology},
  volume = {7},
  number = {3},
  pages = {54-60},
  doi = {10.11648/j.bmb.20220703.11},
  url = {https://doi.org/10.11648/j.bmb.20220703.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bmb.20220703.11},
  abstract = {Obesity has become a global epidemic and is a known risk factor for several adverse health outcomes. Single Nucleotide Polymorphism (SNP) in leptin receptor genes become interesting candidates as susceptibility genes for obesity and glucose homeostasis. The present study intended to explore the genetic analysis of LEPR gene K109, Q223R, and K656N polymorphisms and their relation to obesity and fasting plasma glucose (FPG) concentration in the Myanmar population. One hundred and fifty diagnosed obese subjects and 150 healthy non-obese controls were included. Fasting plasma glucose (FPG) was measured and LEPR gene K109R, Q223R, and K656N polymorphisms were detected by DNA analysis. Data were analyzed by chi-square and one-way ANOVA tests. Each genotype frequency distribution of LEPR gene (K109R, Q223R, and K656N) polymorphisms was not associated with obesity (p > 0.05), as well as each allele frequency distribution also similar outcome (p > 0.05). FPG levels of the study population showed no significant differences between each genotype of LEPR gene polymorphisms (p > 0.05). The K109R, Q223R, and K656N polymorphisms of the LEPR gene were not linked to obesity or FPG levels in the population of Myanmar, according to our findings. Therefore, it does not seem that these polymorphisms have an equivalently significant role for the people of Myanmar. To completely understand the unique genetic variables that predispose to obesity in humans, an ongoing study of diverse obesity phenotypes and related gene mutations is necessary as our understanding of the genes causing obesity increases as a result of new findings.},
 year = {2022}
}

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TY  - JOUR
T1  - Association of Leptin Receptor Gene Polymorphisms with Blood Glucose Concentration and Obesity
AU  - Mo Mo Than
AU  - Yan Naing Soe
AU  - Zaw Myo Lwin
AU  - Ye Wint Kyaw
AU  - Kyaw Thet Paing
AU  - Khine Kyaw Oo
AU  - Phyo Thaw Htun
AU  - Aung Lin Oo
AU  - Min Thein
AU  - Ye Myat Kyaw
AU  - Zaw Min Htut
Y1  - 2022/07/18
PY  - 2022
N1  - https://doi.org/10.11648/j.bmb.20220703.11
DO  - 10.11648/j.bmb.20220703.11
T2  - Biochemistry and Molecular Biology
JF  - Biochemistry and Molecular Biology
JO  - Biochemistry and Molecular Biology
SP  - 54
EP  - 60
PB  - Science Publishing Group
SN  - 2575-5048
UR  - https://doi.org/10.11648/j.bmb.20220703.11
AB  - Obesity has become a global epidemic and is a known risk factor for several adverse health outcomes. Single Nucleotide Polymorphism (SNP) in leptin receptor genes become interesting candidates as susceptibility genes for obesity and glucose homeostasis. The present study intended to explore the genetic analysis of LEPR gene K109, Q223R, and K656N polymorphisms and their relation to obesity and fasting plasma glucose (FPG) concentration in the Myanmar population. One hundred and fifty diagnosed obese subjects and 150 healthy non-obese controls were included. Fasting plasma glucose (FPG) was measured and LEPR gene K109R, Q223R, and K656N polymorphisms were detected by DNA analysis. Data were analyzed by chi-square and one-way ANOVA tests. Each genotype frequency distribution of LEPR gene (K109R, Q223R, and K656N) polymorphisms was not associated with obesity (p > 0.05), as well as each allele frequency distribution also similar outcome (p > 0.05). FPG levels of the study population showed no significant differences between each genotype of LEPR gene polymorphisms (p > 0.05). The K109R, Q223R, and K656N polymorphisms of the LEPR gene were not linked to obesity or FPG levels in the population of Myanmar, according to our findings. Therefore, it does not seem that these polymorphisms have an equivalently significant role for the people of Myanmar. To completely understand the unique genetic variables that predispose to obesity in humans, an ongoing study of diverse obesity phenotypes and related gene mutations is necessary as our understanding of the genes causing obesity increases as a result of new findings.
VL  - 7
IS  - 3
ER  -

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Author Information

Mo Mo Than

Department of Biochemistry, Defence Services Medical Academy, Yangon, Myanmar
Yan Naing Soe

Department of Biochemistry, Defence Services Medical Academy, Yangon, Myanmar
Zaw Myo Lwin

Department of Biochemistry, Defence Services Medical Academy, Yangon, Myanmar
Ye Wint Kyaw

Department of Biochemistry, Defence Services Medical Academy, Yangon, Myanmar
Kyaw Thet Paing

Department of Biochemistry, Defence Services Medical Academy, Yangon, Myanmar
Khine Kyaw Oo

Department of Biochemistry, Defence Services Medical Academy, Yangon, Myanmar
Phyo Thaw Htun

Department of Biochemistry, Defence Services Medical Academy, Yangon, Myanmar
Aung Lin Oo

Department of Biochemistry, Defence Services Medical Academy, Yangon, Myanmar
Min Thein

Department of Biochemistry, Defence Services Medical Academy, Yangon, Myanmar
Ye Myat Kyaw

Department of Biochemistry, Defence Services Medical Academy, Yangon, Myanmar
Zaw Min Htut

Department of Biochemistry, Defence Services Medical Academy, Yangon, Myanmar

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APA Style

Mo Mo Than, Yan Naing Soe, Zaw Myo Lwin, Ye Wint Kyaw, Kyaw Thet Paing, et al. (2022). Association of Leptin Receptor Gene Polymorphisms with Blood Glucose Concentration and Obesity. Biochemistry and Molecular Biology, 7(3), 54-60. https://doi.org/10.11648/j.bmb.20220703.11

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ACS Style

Mo Mo Than; Yan Naing Soe; Zaw Myo Lwin; Ye Wint Kyaw; Kyaw Thet Paing, et al. Association of Leptin Receptor Gene Polymorphisms with Blood Glucose Concentration and Obesity. Biochem. Mol. Biol. 2022, 7(3), 54-60. doi: 10.11648/j.bmb.20220703.11

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AMA Style

Mo Mo Than, Yan Naing Soe, Zaw Myo Lwin, Ye Wint Kyaw, Kyaw Thet Paing, et al. Association of Leptin Receptor Gene Polymorphisms with Blood Glucose Concentration and Obesity. Biochem Mol Biol. 2022;7(3):54-60. doi: 10.11648/j.bmb.20220703.11

Copy | Download

@article{10.11648/j.bmb.20220703.11,
  author = {Mo Mo Than and Yan Naing Soe and Zaw Myo Lwin and Ye Wint Kyaw and Kyaw Thet Paing and Khine Kyaw Oo and Phyo Thaw Htun and Aung Lin Oo and Min Thein and Ye Myat Kyaw and Zaw Min Htut},
  title = {Association of Leptin Receptor Gene Polymorphisms with Blood Glucose Concentration and Obesity},
  journal = {Biochemistry and Molecular Biology},
  volume = {7},
  number = {3},
  pages = {54-60},
  doi = {10.11648/j.bmb.20220703.11},
  url = {https://doi.org/10.11648/j.bmb.20220703.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bmb.20220703.11},
  abstract = {Obesity has become a global epidemic and is a known risk factor for several adverse health outcomes. Single Nucleotide Polymorphism (SNP) in leptin receptor genes become interesting candidates as susceptibility genes for obesity and glucose homeostasis. The present study intended to explore the genetic analysis of LEPR gene K109, Q223R, and K656N polymorphisms and their relation to obesity and fasting plasma glucose (FPG) concentration in the Myanmar population. One hundred and fifty diagnosed obese subjects and 150 healthy non-obese controls were included. Fasting plasma glucose (FPG) was measured and LEPR gene K109R, Q223R, and K656N polymorphisms were detected by DNA analysis. Data were analyzed by chi-square and one-way ANOVA tests. Each genotype frequency distribution of LEPR gene (K109R, Q223R, and K656N) polymorphisms was not associated with obesity (p > 0.05), as well as each allele frequency distribution also similar outcome (p > 0.05). FPG levels of the study population showed no significant differences between each genotype of LEPR gene polymorphisms (p > 0.05). The K109R, Q223R, and K656N polymorphisms of the LEPR gene were not linked to obesity or FPG levels in the population of Myanmar, according to our findings. Therefore, it does not seem that these polymorphisms have an equivalently significant role for the people of Myanmar. To completely understand the unique genetic variables that predispose to obesity in humans, an ongoing study of diverse obesity phenotypes and related gene mutations is necessary as our understanding of the genes causing obesity increases as a result of new findings.},
 year = {2022}
}

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TY  - JOUR
T1  - Association of Leptin Receptor Gene Polymorphisms with Blood Glucose Concentration and Obesity
AU  - Mo Mo Than
AU  - Yan Naing Soe
AU  - Zaw Myo Lwin
AU  - Ye Wint Kyaw
AU  - Kyaw Thet Paing
AU  - Khine Kyaw Oo
AU  - Phyo Thaw Htun
AU  - Aung Lin Oo
AU  - Min Thein
AU  - Ye Myat Kyaw
AU  - Zaw Min Htut
Y1  - 2022/07/18
PY  - 2022
N1  - https://doi.org/10.11648/j.bmb.20220703.11
DO  - 10.11648/j.bmb.20220703.11
T2  - Biochemistry and Molecular Biology
JF  - Biochemistry and Molecular Biology
JO  - Biochemistry and Molecular Biology
SP  - 54
EP  - 60
PB  - Science Publishing Group
SN  - 2575-5048
UR  - https://doi.org/10.11648/j.bmb.20220703.11
AB  - Obesity has become a global epidemic and is a known risk factor for several adverse health outcomes. Single Nucleotide Polymorphism (SNP) in leptin receptor genes become interesting candidates as susceptibility genes for obesity and glucose homeostasis. The present study intended to explore the genetic analysis of LEPR gene K109, Q223R, and K656N polymorphisms and their relation to obesity and fasting plasma glucose (FPG) concentration in the Myanmar population. One hundred and fifty diagnosed obese subjects and 150 healthy non-obese controls were included. Fasting plasma glucose (FPG) was measured and LEPR gene K109R, Q223R, and K656N polymorphisms were detected by DNA analysis. Data were analyzed by chi-square and one-way ANOVA tests. Each genotype frequency distribution of LEPR gene (K109R, Q223R, and K656N) polymorphisms was not associated with obesity (p > 0.05), as well as each allele frequency distribution also similar outcome (p > 0.05). FPG levels of the study population showed no significant differences between each genotype of LEPR gene polymorphisms (p > 0.05). The K109R, Q223R, and K656N polymorphisms of the LEPR gene were not linked to obesity or FPG levels in the population of Myanmar, according to our findings. Therefore, it does not seem that these polymorphisms have an equivalently significant role for the people of Myanmar. To completely understand the unique genetic variables that predispose to obesity in humans, an ongoing study of diverse obesity phenotypes and related gene mutations is necessary as our understanding of the genes causing obesity increases as a result of new findings.
VL  - 7
IS  - 3
ER  -

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