An Analysis of Cumulative Selection and Random Drift in the Evolutionary Origination of Novel Protein Motifs

Joseph E. Hannon Bozorgmehr

doi:doi:10.11648/j.cbb.20130104.11

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An Analysis of Cumulative Selection and Random Drift in the Evolutionary Origination of Novel Protein Motifs

Joseph E. Hannon Bozorgmehr

Published in Computational Biology and Bioinformatics (Volume 1, Issue 4)

Received: 6 August 2013 Published: 30 August 2013

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Abstract

Despite the fact that all-important protein motifs encoded in gene sequences are generally considered to have been generated solely through a gradual and undirected process of change, the idea lacks empirical evidence and also suffers from theoretical difficulties. More recently, sudden developments such as through the exonization of non-coding DNA, as well as frameshift mutation, have been suggested as another source of evolutionary innovation. A mathematical model was used here to describe the combined action of both cumulative natural selection and random drift, relative to that of an alternative mechanism of artificial selection, in the origination of a hypothetical multi-residue sequence motif. A computer simulation of the model quantifiably demonstrates the marked inefficacy of standard forces in developing these molecular features when compared to the power of a directed or self-organizing process. An examination of how natural population shifts, including migration and isolation, as well as intragenic recombination, may serve to facilitate this particular case is also explored. An evolutionary accretion for novel motifs is concluded as being eminently feasible, although not one wholly reliant on the outcome of chance and differential reproduction.

Published in	Computational Biology and Bioinformatics (Volume 1, Issue 4)
DOI	10.11648/j.cbb.20130104.11
Page(s)	15-21
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Cumulative Selection, Protein Motifs, Functional Adaptation, Directed Evolution

References

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Joseph E. Hannon Bozorgmehr. (2013). An Analysis of Cumulative Selection and Random Drift in the Evolutionary Origination of Novel Protein Motifs. Computational Biology and Bioinformatics, 1(4), 15-21. https://doi.org/10.11648/j.cbb.20130104.11

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ACS Style

Joseph E. Hannon Bozorgmehr. An Analysis of Cumulative Selection and Random Drift in the Evolutionary Origination of Novel Protein Motifs. Comput. Biol. Bioinform. 2013, 1(4), 15-21. doi: 10.11648/j.cbb.20130104.11

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AMA Style

Joseph E. Hannon Bozorgmehr. An Analysis of Cumulative Selection and Random Drift in the Evolutionary Origination of Novel Protein Motifs. Comput Biol Bioinform. 2013;1(4):15-21. doi: 10.11648/j.cbb.20130104.11

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@article{10.11648/j.cbb.20130104.11,
  author = {Joseph E. Hannon Bozorgmehr},
  title = {An Analysis of Cumulative Selection and Random Drift in the Evolutionary Origination of Novel Protein Motifs},
  journal = {Computational Biology and Bioinformatics},
  volume = {1},
  number = {4},
  pages = {15-21},
  doi = {10.11648/j.cbb.20130104.11},
  url = {https://doi.org/10.11648/j.cbb.20130104.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cbb.20130104.11},
  abstract = {Despite the fact that all-important protein motifs encoded in gene sequences are generally considered to have been generated solely through a gradual and undirected process of change, the idea lacks empirical evidence and also suffers from theoretical difficulties. More recently, sudden developments such as through the exonization of non-coding DNA, as well as frameshift mutation, have been suggested as another source of evolutionary innovation. A mathematical model was used here to describe the combined action of both cumulative natural selection and random drift, relative to that of an alternative mechanism of artificial selection, in the origination of a hypothetical multi-residue sequence motif. A computer simulation of the model quantifiably demonstrates the marked inefficacy of standard forces in developing these molecular features when compared to the power of a directed or self-organizing process. An examination of how natural population shifts, including migration and isolation, as well as intragenic recombination, may serve to facilitate this particular case is also explored. An evolutionary accretion for novel motifs is concluded as being eminently feasible, although not one wholly reliant on the outcome of chance and differential reproduction.},
 year = {2013}
}

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TY  - JOUR
T1  - An Analysis of Cumulative Selection and Random Drift in the Evolutionary Origination of Novel Protein Motifs
AU  - Joseph E. Hannon Bozorgmehr
Y1  - 2013/08/30
PY  - 2013
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PB  - Science Publishing Group
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AB  - Despite the fact that all-important protein motifs encoded in gene sequences are generally considered to have been generated solely through a gradual and undirected process of change, the idea lacks empirical evidence and also suffers from theoretical difficulties. More recently, sudden developments such as through the exonization of non-coding DNA, as well as frameshift mutation, have been suggested as another source of evolutionary innovation. A mathematical model was used here to describe the combined action of both cumulative natural selection and random drift, relative to that of an alternative mechanism of artificial selection, in the origination of a hypothetical multi-residue sequence motif. A computer simulation of the model quantifiably demonstrates the marked inefficacy of standard forces in developing these molecular features when compared to the power of a directed or self-organizing process. An examination of how natural population shifts, including migration and isolation, as well as intragenic recombination, may serve to facilitate this particular case is also explored. An evolutionary accretion for novel motifs is concluded as being eminently feasible, although not one wholly reliant on the outcome of chance and differential reproduction.
VL  - 1
IS  - 4
ER  -

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Author Information

Joseph E. Hannon Bozorgmehr

School of Informatics, University of Manchester, Manchester M13 9PL, United Kingdom

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APA Style

Joseph E. Hannon Bozorgmehr. (2013). An Analysis of Cumulative Selection and Random Drift in the Evolutionary Origination of Novel Protein Motifs. Computational Biology and Bioinformatics, 1(4), 15-21. https://doi.org/10.11648/j.cbb.20130104.11

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ACS Style

Joseph E. Hannon Bozorgmehr. An Analysis of Cumulative Selection and Random Drift in the Evolutionary Origination of Novel Protein Motifs. Comput. Biol. Bioinform. 2013, 1(4), 15-21. doi: 10.11648/j.cbb.20130104.11

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AMA Style

Joseph E. Hannon Bozorgmehr. An Analysis of Cumulative Selection and Random Drift in the Evolutionary Origination of Novel Protein Motifs. Comput Biol Bioinform. 2013;1(4):15-21. doi: 10.11648/j.cbb.20130104.11

Copy | Download

@article{10.11648/j.cbb.20130104.11,
  author = {Joseph E. Hannon Bozorgmehr},
  title = {An Analysis of Cumulative Selection and Random Drift in the Evolutionary Origination of Novel Protein Motifs},
  journal = {Computational Biology and Bioinformatics},
  volume = {1},
  number = {4},
  pages = {15-21},
  doi = {10.11648/j.cbb.20130104.11},
  url = {https://doi.org/10.11648/j.cbb.20130104.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cbb.20130104.11},
  abstract = {Despite the fact that all-important protein motifs encoded in gene sequences are generally considered to have been generated solely through a gradual and undirected process of change, the idea lacks empirical evidence and also suffers from theoretical difficulties. More recently, sudden developments such as through the exonization of non-coding DNA, as well as frameshift mutation, have been suggested as another source of evolutionary innovation. A mathematical model was used here to describe the combined action of both cumulative natural selection and random drift, relative to that of an alternative mechanism of artificial selection, in the origination of a hypothetical multi-residue sequence motif. A computer simulation of the model quantifiably demonstrates the marked inefficacy of standard forces in developing these molecular features when compared to the power of a directed or self-organizing process. An examination of how natural population shifts, including migration and isolation, as well as intragenic recombination, may serve to facilitate this particular case is also explored. An evolutionary accretion for novel motifs is concluded as being eminently feasible, although not one wholly reliant on the outcome of chance and differential reproduction.},
 year = {2013}
}

Copy | Download

TY  - JOUR
T1  - An Analysis of Cumulative Selection and Random Drift in the Evolutionary Origination of Novel Protein Motifs
AU  - Joseph E. Hannon Bozorgmehr
Y1  - 2013/08/30
PY  - 2013
N1  - https://doi.org/10.11648/j.cbb.20130104.11
DO  - 10.11648/j.cbb.20130104.11
T2  - Computational Biology and Bioinformatics
JF  - Computational Biology and Bioinformatics
JO  - Computational Biology and Bioinformatics
SP  - 15
EP  - 21
PB  - Science Publishing Group
SN  - 2330-8281
UR  - https://doi.org/10.11648/j.cbb.20130104.11
AB  - Despite the fact that all-important protein motifs encoded in gene sequences are generally considered to have been generated solely through a gradual and undirected process of change, the idea lacks empirical evidence and also suffers from theoretical difficulties. More recently, sudden developments such as through the exonization of non-coding DNA, as well as frameshift mutation, have been suggested as another source of evolutionary innovation. A mathematical model was used here to describe the combined action of both cumulative natural selection and random drift, relative to that of an alternative mechanism of artificial selection, in the origination of a hypothetical multi-residue sequence motif. A computer simulation of the model quantifiably demonstrates the marked inefficacy of standard forces in developing these molecular features when compared to the power of a directed or self-organizing process. An examination of how natural population shifts, including migration and isolation, as well as intragenic recombination, may serve to facilitate this particular case is also explored. An evolutionary accretion for novel motifs is concluded as being eminently feasible, although not one wholly reliant on the outcome of chance and differential reproduction.
VL  - 1
IS  - 4
ER  -

Copy | Download