Benefit Absence of Therapeutic Moderate Hypothermia in the Treatment of Cardiac Arrest: A Systematic Review and Meta-Analysis

García García Miguel Ángel; Rosero Arenas María de los Ángeles; Pérez Lluna Leticia; Martínez Cornejo Alfonso; Arizo León David

doi:doi:10.11648/j.ccr.20180202.13

Benefit Absence of Therapeutic Moderate Hypothermia in the Treatment of Cardiac Arrest: A Systematic Review and Meta-Analysis

García García Miguel Ángel, Rosero Arenas María de los Ángeles, Pérez Lluna Leticia, Martínez Cornejo Alfonso, Arizo León David

Published in Cardiology and Cardiovascular Research (Volume 2, Issue 2)

Received: 10 August 2018 Accepted: 30 August 2018 Published: 25 September 2018

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Abstract

Background: Hyperthermia is frequent after cardiac arrest, and is associated with poor vital and neurological prognosis. In the last few years there have been published some studies that show benefits with moderate hypothermia in these patients, and other studies haven´t shown such benefits. Aim: To collect all clinical trials evaluating the utility of moderate therapeutic hypothermia in survivors of a cardiac arrest. Method: A comprehensive search of clinical trials evaluating moderate hypothermia in patients who survive a cardiac arrest was carried out. The mortality and quality of life of the survivors were evaluated. The quality of the included studies, the publication bias and the heterogeneity of the results were evaluated. Results: there is no significant reduction in mortality (RR 0.97, 95% CI 0.93-1.01) or increase in quality of life (RR 1.07, 95% CI 0.94-1.21) of the patients undergoing moderate hypothermia versus those not treated with that. There are no different results in patients with cardiac arrest with defibrillable and non – defibrillable rhythms, with the different used cooling methods, or even with the induction of intra – cardiac arrest hypothermia. The mortality of these patients is high, and there are no significant differences in relation to the age or sex of them. Conclusion: In patients who survive a cardiac arrest, the induction of moderate hypothermia is not recommended.

Published in	Cardiology and Cardiovascular Research (Volume 2, Issue 2)
DOI	10.11648/j.ccr.20180202.13
Page(s)	29-48
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Therapeutic Hypothermia, Cardiac Arrest, Mortality, Survival with Good Neurological Prognosis

References

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APA Style

García García Miguel Ángel, Rosero Arenas María de los Ángeles, Pérez Lluna Leticia, Martínez Cornejo Alfonso, Arizo León David. (2018). Benefit Absence of Therapeutic Moderate Hypothermia in the Treatment of Cardiac Arrest: A Systematic Review and Meta-Analysis. Cardiology and Cardiovascular Research, 2(2), 29-48. https://doi.org/10.11648/j.ccr.20180202.13

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ACS Style

García García Miguel Ángel; Rosero Arenas María de los Ángeles; Pérez Lluna Leticia; Martínez Cornejo Alfonso; Arizo León David. Benefit Absence of Therapeutic Moderate Hypothermia in the Treatment of Cardiac Arrest: A Systematic Review and Meta-Analysis. Cardiol. Cardiovasc. Res. 2018, 2(2), 29-48. doi: 10.11648/j.ccr.20180202.13

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AMA Style

García García Miguel Ángel, Rosero Arenas María de los Ángeles, Pérez Lluna Leticia, Martínez Cornejo Alfonso, Arizo León David. Benefit Absence of Therapeutic Moderate Hypothermia in the Treatment of Cardiac Arrest: A Systematic Review and Meta-Analysis. Cardiol Cardiovasc Res. 2018;2(2):29-48. doi: 10.11648/j.ccr.20180202.13

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@article{10.11648/j.ccr.20180202.13,
  author = {García García Miguel Ángel and Rosero Arenas María de los Ángeles and Pérez Lluna Leticia and Martínez Cornejo Alfonso and Arizo León David},
  title = {Benefit Absence of Therapeutic Moderate Hypothermia in the Treatment of Cardiac Arrest: A Systematic Review and Meta-Analysis},
  journal = {Cardiology and Cardiovascular Research},
  volume = {2},
  number = {2},
  pages = {29-48},
  doi = {10.11648/j.ccr.20180202.13},
  url = {https://doi.org/10.11648/j.ccr.20180202.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ccr.20180202.13},
  abstract = {Background: Hyperthermia is frequent after cardiac arrest, and is associated with poor vital and neurological prognosis. In the last few years there have been published some studies that show benefits with moderate hypothermia in these patients, and other studies haven´t shown such benefits. Aim: To collect all clinical trials evaluating the utility of moderate therapeutic hypothermia in survivors of a cardiac arrest. Method: A comprehensive search of clinical trials evaluating moderate hypothermia in patients who survive a cardiac arrest was carried out. The mortality and quality of life of the survivors were evaluated. The quality of the included studies, the publication bias and the heterogeneity of the results were evaluated. Results: there is no significant reduction in mortality (RR 0.97, 95% CI 0.93-1.01) or increase in quality of life (RR 1.07, 95% CI 0.94-1.21) of the patients undergoing moderate hypothermia versus those not treated with that. There are no different results in patients with cardiac arrest with defibrillable and non – defibrillable rhythms, with the different used cooling methods, or even with the induction of intra – cardiac arrest hypothermia. The mortality of these patients is high, and there are no significant differences in relation to the age or sex of them. Conclusion: In patients who survive a cardiac arrest, the induction of moderate hypothermia is not recommended.},
 year = {2018}
}

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TY  - JOUR
T1  - Benefit Absence of Therapeutic Moderate Hypothermia in the Treatment of Cardiac Arrest: A Systematic Review and Meta-Analysis
AU  - García García Miguel Ángel
AU  - Rosero Arenas María de los Ángeles
AU  - Pérez Lluna Leticia
AU  - Martínez Cornejo Alfonso
AU  - Arizo León David
Y1  - 2018/09/25
PY  - 2018
N1  - https://doi.org/10.11648/j.ccr.20180202.13
DO  - 10.11648/j.ccr.20180202.13
T2  - Cardiology and Cardiovascular Research
JF  - Cardiology and Cardiovascular Research
JO  - Cardiology and Cardiovascular Research
SP  - 29
EP  - 48
PB  - Science Publishing Group
SN  - 2578-8914
UR  - https://doi.org/10.11648/j.ccr.20180202.13
AB  - Background: Hyperthermia is frequent after cardiac arrest, and is associated with poor vital and neurological prognosis. In the last few years there have been published some studies that show benefits with moderate hypothermia in these patients, and other studies haven´t shown such benefits. Aim: To collect all clinical trials evaluating the utility of moderate therapeutic hypothermia in survivors of a cardiac arrest. Method: A comprehensive search of clinical trials evaluating moderate hypothermia in patients who survive a cardiac arrest was carried out. The mortality and quality of life of the survivors were evaluated. The quality of the included studies, the publication bias and the heterogeneity of the results were evaluated. Results: there is no significant reduction in mortality (RR 0.97, 95% CI 0.93-1.01) or increase in quality of life (RR 1.07, 95% CI 0.94-1.21) of the patients undergoing moderate hypothermia versus those not treated with that. There are no different results in patients with cardiac arrest with defibrillable and non – defibrillable rhythms, with the different used cooling methods, or even with the induction of intra – cardiac arrest hypothermia. The mortality of these patients is high, and there are no significant differences in relation to the age or sex of them. Conclusion: In patients who survive a cardiac arrest, the induction of moderate hypothermia is not recommended.
VL  - 2
IS  - 2
ER  -

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Author Information

García García Miguel Ángel
Rosero Arenas María de los Ángeles
Pérez Lluna Leticia

Internal Medicine Department, Hospital de Sagunto, Valencia, Spain
Martínez Cornejo Alfonso

ICU Department, Hospital de Sagunto, Valencia, Spain
Arizo León David

ICU Department, Hospital de Sagunto, Valencia, Spain

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APA Style

García García Miguel Ángel, Rosero Arenas María de los Ángeles, Pérez Lluna Leticia, Martínez Cornejo Alfonso, Arizo León David. (2018). Benefit Absence of Therapeutic Moderate Hypothermia in the Treatment of Cardiac Arrest: A Systematic Review and Meta-Analysis. Cardiology and Cardiovascular Research, 2(2), 29-48. https://doi.org/10.11648/j.ccr.20180202.13

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ACS Style

García García Miguel Ángel; Rosero Arenas María de los Ángeles; Pérez Lluna Leticia; Martínez Cornejo Alfonso; Arizo León David. Benefit Absence of Therapeutic Moderate Hypothermia in the Treatment of Cardiac Arrest: A Systematic Review and Meta-Analysis. Cardiol. Cardiovasc. Res. 2018, 2(2), 29-48. doi: 10.11648/j.ccr.20180202.13

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AMA Style

García García Miguel Ángel, Rosero Arenas María de los Ángeles, Pérez Lluna Leticia, Martínez Cornejo Alfonso, Arizo León David. Benefit Absence of Therapeutic Moderate Hypothermia in the Treatment of Cardiac Arrest: A Systematic Review and Meta-Analysis. Cardiol Cardiovasc Res. 2018;2(2):29-48. doi: 10.11648/j.ccr.20180202.13

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@article{10.11648/j.ccr.20180202.13,
  author = {García García Miguel Ángel and Rosero Arenas María de los Ángeles and Pérez Lluna Leticia and Martínez Cornejo Alfonso and Arizo León David},
  title = {Benefit Absence of Therapeutic Moderate Hypothermia in the Treatment of Cardiac Arrest: A Systematic Review and Meta-Analysis},
  journal = {Cardiology and Cardiovascular Research},
  volume = {2},
  number = {2},
  pages = {29-48},
  doi = {10.11648/j.ccr.20180202.13},
  url = {https://doi.org/10.11648/j.ccr.20180202.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ccr.20180202.13},
  abstract = {Background: Hyperthermia is frequent after cardiac arrest, and is associated with poor vital and neurological prognosis. In the last few years there have been published some studies that show benefits with moderate hypothermia in these patients, and other studies haven´t shown such benefits. Aim: To collect all clinical trials evaluating the utility of moderate therapeutic hypothermia in survivors of a cardiac arrest. Method: A comprehensive search of clinical trials evaluating moderate hypothermia in patients who survive a cardiac arrest was carried out. The mortality and quality of life of the survivors were evaluated. The quality of the included studies, the publication bias and the heterogeneity of the results were evaluated. Results: there is no significant reduction in mortality (RR 0.97, 95% CI 0.93-1.01) or increase in quality of life (RR 1.07, 95% CI 0.94-1.21) of the patients undergoing moderate hypothermia versus those not treated with that. There are no different results in patients with cardiac arrest with defibrillable and non – defibrillable rhythms, with the different used cooling methods, or even with the induction of intra – cardiac arrest hypothermia. The mortality of these patients is high, and there are no significant differences in relation to the age or sex of them. Conclusion: In patients who survive a cardiac arrest, the induction of moderate hypothermia is not recommended.},
 year = {2018}
}

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TY  - JOUR
T1  - Benefit Absence of Therapeutic Moderate Hypothermia in the Treatment of Cardiac Arrest: A Systematic Review and Meta-Analysis
AU  - García García Miguel Ángel
AU  - Rosero Arenas María de los Ángeles
AU  - Pérez Lluna Leticia
AU  - Martínez Cornejo Alfonso
AU  - Arizo León David
Y1  - 2018/09/25
PY  - 2018
N1  - https://doi.org/10.11648/j.ccr.20180202.13
DO  - 10.11648/j.ccr.20180202.13
T2  - Cardiology and Cardiovascular Research
JF  - Cardiology and Cardiovascular Research
JO  - Cardiology and Cardiovascular Research
SP  - 29
EP  - 48
PB  - Science Publishing Group
SN  - 2578-8914
UR  - https://doi.org/10.11648/j.ccr.20180202.13
AB  - Background: Hyperthermia is frequent after cardiac arrest, and is associated with poor vital and neurological prognosis. In the last few years there have been published some studies that show benefits with moderate hypothermia in these patients, and other studies haven´t shown such benefits. Aim: To collect all clinical trials evaluating the utility of moderate therapeutic hypothermia in survivors of a cardiac arrest. Method: A comprehensive search of clinical trials evaluating moderate hypothermia in patients who survive a cardiac arrest was carried out. The mortality and quality of life of the survivors were evaluated. The quality of the included studies, the publication bias and the heterogeneity of the results were evaluated. Results: there is no significant reduction in mortality (RR 0.97, 95% CI 0.93-1.01) or increase in quality of life (RR 1.07, 95% CI 0.94-1.21) of the patients undergoing moderate hypothermia versus those not treated with that. There are no different results in patients with cardiac arrest with defibrillable and non – defibrillable rhythms, with the different used cooling methods, or even with the induction of intra – cardiac arrest hypothermia. The mortality of these patients is high, and there are no significant differences in relation to the age or sex of them. Conclusion: In patients who survive a cardiac arrest, the induction of moderate hypothermia is not recommended.
VL  - 2
IS  - 2
ER  -

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