HAART Use and Cardiovascular Risk Among HIV Patients in Rivers State, Nigeria

Ajala Aisha Oluwabunmi; Ofori Sandra Nnedinma; Odia Osarentin James

doi:doi:10.11648/j.ccr.20190303.11

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HAART Use and Cardiovascular Risk Among HIV Patients in Rivers State, Nigeria

Ajala Aisha Oluwabunmi, Ofori Sandra Nnedinma, Odia Osarentin James

Published in Cardiology and Cardiovascular Research (Volume 3, Issue 3)

Received: 26 June 2019 Accepted: 24 July 2019 Published: 7 August 2019

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Abstract

Cardiovascular diseases have been associated with deaths among HIV seropositive persons in low income countries. This was a cross-sectional study of cardiovascular risk among 100 HIV seropositive persons and 100 age and sex matched seropositive but HAART-naive controls in Rivers state, Nigeria. The study subjects underwent clinical examinations to determine their blood pressure and anthropometric parameters. Blood samples were taken to assess fasting blood glucose and lipid profile. Risk assessment was done using the WHO/ISH cardiovascular risk score chart. Among the subjects, 76 (76%) were on a non-PI based HAART compared with 24 (24%) on a PI-based HAART. The mean BMI and CD4 count were significantly higher among the cases than the controls (p =.0.048 and p < 0.0001 respectively). There was a statistically significant difference in the mean SBP (131.90 ± 14.33mmHg versus 127.48 ± 12.03mmHg) and DBP (83.88 ± 6.59mmHg versus 80.63 ± 6.74mmHg) between the cases and controls (p = 0.019 and 0.023 respectively). Dyslipidaemia was higher among the cases than the controls (low HDL-c was 36% vs 33%; increased TC 20% vs 7%; increased LDL-c 13% vs 4% and triglycerides 7% vs 5%. The prevalence of hypercholesterolemia and increased LDL-c was significantly higher among the cases than the controls (p = 0.007 and 0.022 respectively). The prevalence of intermediate to high CV risk score was higher among the HAART experienced HIV seropositive subjects compared to control subjects.

Published in	Cardiology and Cardiovascular Research (Volume 3, Issue 3)
DOI	10.11648/j.ccr.20190303.11
Page(s)	45-51
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Cardiovascular Risk, HAART, HIV

References

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APA Style

Ajala Aisha Oluwabunmi, Ofori Sandra Nnedinma, Odia Osarentin James. (2019). HAART Use and Cardiovascular Risk Among HIV Patients in Rivers State, Nigeria. Cardiology and Cardiovascular Research, 3(3), 45-51. https://doi.org/10.11648/j.ccr.20190303.11

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ACS Style

Ajala Aisha Oluwabunmi; Ofori Sandra Nnedinma; Odia Osarentin James. HAART Use and Cardiovascular Risk Among HIV Patients in Rivers State, Nigeria. Cardiol. Cardiovasc. Res. 2019, 3(3), 45-51. doi: 10.11648/j.ccr.20190303.11

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AMA Style

Ajala Aisha Oluwabunmi, Ofori Sandra Nnedinma, Odia Osarentin James. HAART Use and Cardiovascular Risk Among HIV Patients in Rivers State, Nigeria. Cardiol Cardiovasc Res. 2019;3(3):45-51. doi: 10.11648/j.ccr.20190303.11

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@article{10.11648/j.ccr.20190303.11,
  author = {Ajala Aisha Oluwabunmi and Ofori Sandra Nnedinma and Odia Osarentin James},
  title = {HAART Use and Cardiovascular Risk Among HIV Patients in Rivers State, Nigeria},
  journal = {Cardiology and Cardiovascular Research},
  volume = {3},
  number = {3},
  pages = {45-51},
  doi = {10.11648/j.ccr.20190303.11},
  url = {https://doi.org/10.11648/j.ccr.20190303.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ccr.20190303.11},
  abstract = {Cardiovascular diseases have been associated with deaths among HIV seropositive persons in low income countries. This was a cross-sectional study of cardiovascular risk among 100 HIV seropositive persons and 100 age and sex matched seropositive but HAART-naive controls in Rivers state, Nigeria. The study subjects underwent clinical examinations to determine their blood pressure and anthropometric parameters. Blood samples were taken to assess fasting blood glucose and lipid profile. Risk assessment was done using the WHO/ISH cardiovascular risk score chart. Among the subjects, 76 (76%) were on a non-PI based HAART compared with 24 (24%) on a PI-based HAART. The mean BMI and CD4 count were significantly higher among the cases than the controls (p =.0.048 and p < 0.0001 respectively). There was a statistically significant difference in the mean SBP (131.90 ± 14.33mmHg versus 127.48 ± 12.03mmHg) and DBP (83.88 ± 6.59mmHg versus 80.63 ± 6.74mmHg) between the cases and controls (p = 0.019 and 0.023 respectively). Dyslipidaemia was higher among the cases than the controls (low HDL-c was 36% vs 33%; increased TC 20% vs 7%; increased LDL-c 13% vs 4% and triglycerides 7% vs 5%. The prevalence of hypercholesterolemia and increased LDL-c was significantly higher among the cases than the controls (p = 0.007 and 0.022 respectively). The prevalence of intermediate to high CV risk score was higher among the HAART experienced HIV seropositive subjects compared to control subjects.},
 year = {2019}
}

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TY - JOUR
T1 - HAART Use and Cardiovascular Risk Among HIV Patients in Rivers State, Nigeria
AU - Ajala Aisha Oluwabunmi
AU - Ofori Sandra Nnedinma
AU - Odia Osarentin James
Y1 - 2019/08/07
PY - 2019
N1 - https://doi.org/10.11648/j.ccr.20190303.11
DO - 10.11648/j.ccr.20190303.11
T2 - Cardiology and Cardiovascular Research
JF - Cardiology and Cardiovascular Research
JO - Cardiology and Cardiovascular Research
SP - 45
EP - 51
PB - Science Publishing Group
SN - 2578-8914
UR - https://doi.org/10.11648/j.ccr.20190303.11
AB - Cardiovascular diseases have been associated with deaths among HIV seropositive persons in low income countries. This was a cross-sectional study of cardiovascular risk among 100 HIV seropositive persons and 100 age and sex matched seropositive but HAART-naive controls in Rivers state, Nigeria. The study subjects underwent clinical examinations to determine their blood pressure and anthropometric parameters. Blood samples were taken to assess fasting blood glucose and lipid profile. Risk assessment was done using the WHO/ISH cardiovascular risk score chart. Among the subjects, 76 (76%) were on a non-PI based HAART compared with 24 (24%) on a PI-based HAART. The mean BMI and CD4 count were significantly higher among the cases than the controls (p =.0.048 and p < 0.0001 respectively). There was a statistically significant difference in the mean SBP (131.90 ± 14.33mmHg versus 127.48 ± 12.03mmHg) and DBP (83.88 ± 6.59mmHg versus 80.63 ± 6.74mmHg) between the cases and controls (p = 0.019 and 0.023 respectively). Dyslipidaemia was higher among the cases than the controls (low HDL-c was 36% vs 33%; increased TC 20% vs 7%; increased LDL-c 13% vs 4% and triglycerides 7% vs 5%. The prevalence of hypercholesterolemia and increased LDL-c was significantly higher among the cases than the controls (p = 0.007 and 0.022 respectively). The prevalence of intermediate to high CV risk score was higher among the HAART experienced HIV seropositive subjects compared to control subjects.
VL - 3
IS - 3
ER -

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Author Information

Ajala Aisha Oluwabunmi

Department of Internal Medicine, University of Port Harcourt Teaching Hospital, Choba, Rivers State, Nigeria
Ofori Sandra Nnedinma

Department of Internal Medicine, University of Port Harcourt Teaching Hospital, Choba, Rivers State, Nigeria
Odia Osarentin James

Department of Internal Medicine, University of Port Harcourt Teaching Hospital, Choba, Rivers State, Nigeria

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APA Style

Ajala Aisha Oluwabunmi, Ofori Sandra Nnedinma, Odia Osarentin James. (2019). HAART Use and Cardiovascular Risk Among HIV Patients in Rivers State, Nigeria. Cardiology and Cardiovascular Research, 3(3), 45-51. https://doi.org/10.11648/j.ccr.20190303.11

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ACS Style

Ajala Aisha Oluwabunmi; Ofori Sandra Nnedinma; Odia Osarentin James. HAART Use and Cardiovascular Risk Among HIV Patients in Rivers State, Nigeria. Cardiol. Cardiovasc. Res. 2019, 3(3), 45-51. doi: 10.11648/j.ccr.20190303.11

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AMA Style

Ajala Aisha Oluwabunmi, Ofori Sandra Nnedinma, Odia Osarentin James. HAART Use and Cardiovascular Risk Among HIV Patients in Rivers State, Nigeria. Cardiol Cardiovasc Res. 2019;3(3):45-51. doi: 10.11648/j.ccr.20190303.11

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@article{10.11648/j.ccr.20190303.11,
  author = {Ajala Aisha Oluwabunmi and Ofori Sandra Nnedinma and Odia Osarentin James},
  title = {HAART Use and Cardiovascular Risk Among HIV Patients in Rivers State, Nigeria},
  journal = {Cardiology and Cardiovascular Research},
  volume = {3},
  number = {3},
  pages = {45-51},
  doi = {10.11648/j.ccr.20190303.11},
  url = {https://doi.org/10.11648/j.ccr.20190303.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ccr.20190303.11},
  abstract = {Cardiovascular diseases have been associated with deaths among HIV seropositive persons in low income countries. This was a cross-sectional study of cardiovascular risk among 100 HIV seropositive persons and 100 age and sex matched seropositive but HAART-naive controls in Rivers state, Nigeria. The study subjects underwent clinical examinations to determine their blood pressure and anthropometric parameters. Blood samples were taken to assess fasting blood glucose and lipid profile. Risk assessment was done using the WHO/ISH cardiovascular risk score chart. Among the subjects, 76 (76%) were on a non-PI based HAART compared with 24 (24%) on a PI-based HAART. The mean BMI and CD4 count were significantly higher among the cases than the controls (p =.0.048 and p < 0.0001 respectively). There was a statistically significant difference in the mean SBP (131.90 ± 14.33mmHg versus 127.48 ± 12.03mmHg) and DBP (83.88 ± 6.59mmHg versus 80.63 ± 6.74mmHg) between the cases and controls (p = 0.019 and 0.023 respectively). Dyslipidaemia was higher among the cases than the controls (low HDL-c was 36% vs 33%; increased TC 20% vs 7%; increased LDL-c 13% vs 4% and triglycerides 7% vs 5%. The prevalence of hypercholesterolemia and increased LDL-c was significantly higher among the cases than the controls (p = 0.007 and 0.022 respectively). The prevalence of intermediate to high CV risk score was higher among the HAART experienced HIV seropositive subjects compared to control subjects.},
 year = {2019}
}

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