Dilated Cardiopathy Associated with Sickle Cell Disease in a 68 Years Old Female: An Emerging Complication in Sub-sahara Africa

Sylvie Ndongo Amougou; Mary Anne Ngam; Murielle Helles Lema; Mazou Ngou Temgoua; Aicha Yap Mefire; Anderson Ngouo Tchiffo; Samuel Kingue

doi:doi:10.11648/j.ccr.20190303.15

Dilated Cardiopathy Associated with Sickle Cell Disease in a 68 Years Old Female: An Emerging Complication in Sub-sahara Africa

Sylvie Ndongo Amougou, Mary Anne Ngam, Murielle Helles Lema, Mazou Ngou Temgoua, Aicha Yap Mefire, Anderson Ngouo Tchiffo, Samuel Kingue

Published in Cardiology and Cardiovascular Research (Volume 3, Issue 3)

Received: 23 August 2019 Accepted: 9 September 2019 Published: 21 September 2019

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Sickle Cell Anemia (SCA) is an autosomal recessive disease caused by a point mutation in the hemoglobin beta gene found on chromosome 11p15.5 [1]. Specifically, it occurs when a single base from A to T in the codon for glutamic acid at position 6 is changed to valine of the beta globin and thus disrupts the tertiary structure and stability of the hemoglobin molecule [2]. Sickle hemoglobin is responsible for wide spectrum of disorders which vary with respect to severity of anemia, frequency of crises and duration of survival [3]. We present the case of a dilated cardiopathy in an elderly female sickle cell patient. A 68 years old female sickle cell patient with no known major cardiovascular risk factor presented with progressive onset of dyspnea. Clinical examination showed signs of left ventricular failure; an electrocardiogram showed a sinus regular rhythm, left ventricular hypertrophy with systolic overload, Q waves in the anteroseptal leads. Cardiac ultrasound showed a dilated cardiopathy with a preserved left ventricular systolic function at 57%, normal regional wall motion and normal pulmonary pressure. We concluded of heart failure due to probable chronic anemia or anischemic cardiopathy with a conserved systolic function in an elderly sickle cell patient but we were not able to confirm the main etiology without CT Coronary Angiogram or coronarography. Sickle cell anemia is a common genetic condition in sub-Saharan Africa associated with early death. This case is special because we have an elderly female presenting with heart failure on a dilated cardiopathy. This enhances the necessity of strict cardiovascular follow up of Sickle cell patient.

Published in	Cardiology and Cardiovascular Research (Volume 3, Issue 3)
DOI	10.11648/j.ccr.20190303.15
Page(s)	65-70
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Sickle Cell Disease, Dilated Cardiopathy, Older Female, Sub-Sahara Africa

References

[1]	Bethesda, National Center for Biotechnology Information (US), Gene and Disease. 1998.
[2]	Reis F, Narmin A, Vladimir N. Understanding the role of intrinsic disorder in subunits of hemoglobin and the disease prosess of sickle cell anemia. Intrinsically Protein Disordered 2016.
[3]	Hemalat L, Pradeep R, Rajesheka M. Spectrum of sickle cell disease im patients diagnosed at a tertiary care center in Karnataka with special emphasis on their Clincoheamatological profile. Journal of Clinical and Diagnostic Research 2016 10 (2) EC 09-EC11.
[4]	Saunthararajah Y, Vichinsky EP. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, PA: Saunders Elsevier; 2012. Sickle Cell Disease: Clinical features and management. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, Weitz JI, editors. Ch. 40.
[5]	Aziza S, Noah P. Sickle cell Disease. StatPearls Publishing 2019.
[6]	Gossman W, Ehsan M, Maruvda S. Anemia, Sickle cell. StatPearls Publishing 2019.
[7]	Gladwin M, Sachdev V. Cardiovascular Abnormalities in Sickle cell Disease. Journal of American College of Cardiology 2014 59 (13).
[8]	Brousseau DC, Panepinto JA, Nimmer M, Hoffmann RG. The number of people with sickle-cell disease in the United States: national and state estimates. American Journal of Hematology. 2010; 85: 77–8.
[9]	Julie M, Sharon E, Deogratias S, et al, Mortality in Sickle Cell Anemia in Africa: A prospective Cohort study in Tanzania. PLoS One 2011, 6 (2): e 14699.
[10]	Prati D. Transmission of hepatitis C virus by blood transfusions and other medical procedures: a global review. Journal of Hepatology. 2006: 45 (4): 607-16.
[11]	Kato GJ, Gladwin MT, Steinberg MH. Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes. Blood Review. 2007; 21: 37–47.
[12]	Platt OS, Brambilla DJ, Rosse WF et al. Mortality in sickle cell disease. Life expectancy and risk factors for early death. N Engl J Med. 1994; 330 (23): 1639-44.
[13]	Sophie Lanzkron, Patrick Carroll, Carlton Haywood. Mortality rayes and age at death from sickle cell disease: U.S., 1979-2005. Public Health Rep. 2013; 128 (2): 110-116.
[14]	Graham R Serjeant. Mortality from sickle cell disease in Africa. BMJ. 2005; 330 (7489): 432-433.
[15]	Ahmed S. Manifestations hépatiques et extra-hépatique liées au VHC. Hépato-Gastro., 2012, 19, (8): 649-60.
[16]	Nicolas Goossens, Francesco Negro et al. Cardiovascular manifestations of hepatitis C virus. Clin Liver Dis. 2017. 1089-3261.
[17]	Recommendations for prevention and control of hepatitis C virus (HCV) infection and HCV-related chronic disease. Centers for Disease Control and Prevention. MMWR Recomm Rep. 1998 Oct 16; 47 (RR-19): 1-39. PubMed \| Google Scholar.
[18]	Ersi Voskaridou, Dimitrios Christoulas and Evangelos Terpos. Sickle-cell disease and the heart: review of the current literature. British Journal of Haematology, 2012, 157, 664–673.

Cite This Article

Plain Text BibTeX RIS

APA Style

Sylvie Ndongo Amougou, Mary Anne Ngam, Murielle Helles Lema, Mazou Ngou Temgoua, Aicha Yap Mefire, et al. (2019). Dilated Cardiopathy Associated with Sickle Cell Disease in a 68 Years Old Female: An Emerging Complication in Sub-sahara Africa. Cardiology and Cardiovascular Research, 3(3), 65-70. https://doi.org/10.11648/j.ccr.20190303.15

Copy | Download

ACS Style

Sylvie Ndongo Amougou; Mary Anne Ngam; Murielle Helles Lema; Mazou Ngou Temgoua; Aicha Yap Mefire, et al. Dilated Cardiopathy Associated with Sickle Cell Disease in a 68 Years Old Female: An Emerging Complication in Sub-sahara Africa. Cardiol. Cardiovasc. Res. 2019, 3(3), 65-70. doi: 10.11648/j.ccr.20190303.15

Copy | Download

AMA Style

Sylvie Ndongo Amougou, Mary Anne Ngam, Murielle Helles Lema, Mazou Ngou Temgoua, Aicha Yap Mefire, et al. Dilated Cardiopathy Associated with Sickle Cell Disease in a 68 Years Old Female: An Emerging Complication in Sub-sahara Africa. Cardiol Cardiovasc Res. 2019;3(3):65-70. doi: 10.11648/j.ccr.20190303.15

Copy | Download

@article{10.11648/j.ccr.20190303.15,
  author = {Sylvie Ndongo Amougou and Mary Anne Ngam and Murielle Helles Lema and Mazou Ngou Temgoua and Aicha Yap Mefire and Anderson Ngouo Tchiffo and Samuel Kingue},
  title = {Dilated Cardiopathy Associated with Sickle Cell Disease in a 68 Years Old Female: An Emerging Complication in Sub-sahara Africa},
  journal = {Cardiology and Cardiovascular Research},
  volume = {3},
  number = {3},
  pages = {65-70},
  doi = {10.11648/j.ccr.20190303.15},
  url = {https://doi.org/10.11648/j.ccr.20190303.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ccr.20190303.15},
  abstract = {Sickle Cell Anemia (SCA) is an autosomal recessive disease caused by a point mutation in the hemoglobin beta gene found on chromosome 11p15.5 [1]. Specifically, it occurs when a single base from A to T in the codon for glutamic acid at position 6 is changed to valine of the beta globin and thus disrupts the tertiary structure and stability of the hemoglobin molecule [2]. Sickle hemoglobin is responsible for wide spectrum of disorders which vary with respect to severity of anemia, frequency of crises and duration of survival [3]. We present the case of a dilated cardiopathy in an elderly female sickle cell patient. A 68 years old female sickle cell patient with no known major cardiovascular risk factor presented with progressive onset of dyspnea. Clinical examination showed signs of left ventricular failure; an electrocardiogram showed a sinus regular rhythm, left ventricular hypertrophy with systolic overload, Q waves in the anteroseptal leads. Cardiac ultrasound showed a dilated cardiopathy with a preserved left ventricular systolic function at 57%, normal regional wall motion and normal pulmonary pressure. We concluded of heart failure due to probable chronic anemia or anischemic cardiopathy with a conserved systolic function in an elderly sickle cell patient but we were not able to confirm the main etiology without CT Coronary Angiogram or coronarography. Sickle cell anemia is a common genetic condition in sub-Saharan Africa associated with early death. This case is special because we have an elderly female presenting with heart failure on a dilated cardiopathy. This enhances the necessity of strict cardiovascular follow up of Sickle cell patient.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Dilated Cardiopathy Associated with Sickle Cell Disease in a 68 Years Old Female: An Emerging Complication in Sub-sahara Africa
AU  - Sylvie Ndongo Amougou
AU  - Mary Anne Ngam
AU  - Murielle Helles Lema
AU  - Mazou Ngou Temgoua
AU  - Aicha Yap Mefire
AU  - Anderson Ngouo Tchiffo
AU  - Samuel Kingue
Y1  - 2019/09/21
PY  - 2019
N1  - https://doi.org/10.11648/j.ccr.20190303.15
DO  - 10.11648/j.ccr.20190303.15
T2  - Cardiology and Cardiovascular Research
JF  - Cardiology and Cardiovascular Research
JO  - Cardiology and Cardiovascular Research
SP  - 65
EP  - 70
PB  - Science Publishing Group
SN  - 2578-8914
UR  - https://doi.org/10.11648/j.ccr.20190303.15
AB  - Sickle Cell Anemia (SCA) is an autosomal recessive disease caused by a point mutation in the hemoglobin beta gene found on chromosome 11p15.5 [1]. Specifically, it occurs when a single base from A to T in the codon for glutamic acid at position 6 is changed to valine of the beta globin and thus disrupts the tertiary structure and stability of the hemoglobin molecule [2]. Sickle hemoglobin is responsible for wide spectrum of disorders which vary with respect to severity of anemia, frequency of crises and duration of survival [3]. We present the case of a dilated cardiopathy in an elderly female sickle cell patient. A 68 years old female sickle cell patient with no known major cardiovascular risk factor presented with progressive onset of dyspnea. Clinical examination showed signs of left ventricular failure; an electrocardiogram showed a sinus regular rhythm, left ventricular hypertrophy with systolic overload, Q waves in the anteroseptal leads. Cardiac ultrasound showed a dilated cardiopathy with a preserved left ventricular systolic function at 57%, normal regional wall motion and normal pulmonary pressure. We concluded of heart failure due to probable chronic anemia or anischemic cardiopathy with a conserved systolic function in an elderly sickle cell patient but we were not able to confirm the main etiology without CT Coronary Angiogram or coronarography. Sickle cell anemia is a common genetic condition in sub-Saharan Africa associated with early death. This case is special because we have an elderly female presenting with heart failure on a dilated cardiopathy. This enhances the necessity of strict cardiovascular follow up of Sickle cell patient.
VL  - 3
IS  - 3
ER  -

Copy | Download

Author Information

Sylvie Ndongo Amougou

Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Mary Anne Ngam

Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Murielle Helles Lema

Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Mazou Ngou Temgoua

Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Aicha Yap Mefire

Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Anderson Ngouo Tchiffo

Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Samuel Kingue

Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Sylvie Ndongo Amougou, Mary Anne Ngam, Murielle Helles Lema, Mazou Ngou Temgoua, Aicha Yap Mefire, et al. (2019). Dilated Cardiopathy Associated with Sickle Cell Disease in a 68 Years Old Female: An Emerging Complication in Sub-sahara Africa. Cardiology and Cardiovascular Research, 3(3), 65-70. https://doi.org/10.11648/j.ccr.20190303.15

Copy | Download

ACS Style

Sylvie Ndongo Amougou; Mary Anne Ngam; Murielle Helles Lema; Mazou Ngou Temgoua; Aicha Yap Mefire, et al. Dilated Cardiopathy Associated with Sickle Cell Disease in a 68 Years Old Female: An Emerging Complication in Sub-sahara Africa. Cardiol. Cardiovasc. Res. 2019, 3(3), 65-70. doi: 10.11648/j.ccr.20190303.15

Copy | Download

AMA Style

Sylvie Ndongo Amougou, Mary Anne Ngam, Murielle Helles Lema, Mazou Ngou Temgoua, Aicha Yap Mefire, et al. Dilated Cardiopathy Associated with Sickle Cell Disease in a 68 Years Old Female: An Emerging Complication in Sub-sahara Africa. Cardiol Cardiovasc Res. 2019;3(3):65-70. doi: 10.11648/j.ccr.20190303.15

Copy | Download

@article{10.11648/j.ccr.20190303.15,
  author = {Sylvie Ndongo Amougou and Mary Anne Ngam and Murielle Helles Lema and Mazou Ngou Temgoua and Aicha Yap Mefire and Anderson Ngouo Tchiffo and Samuel Kingue},
  title = {Dilated Cardiopathy Associated with Sickle Cell Disease in a 68 Years Old Female: An Emerging Complication in Sub-sahara Africa},
  journal = {Cardiology and Cardiovascular Research},
  volume = {3},
  number = {3},
  pages = {65-70},
  doi = {10.11648/j.ccr.20190303.15},
  url = {https://doi.org/10.11648/j.ccr.20190303.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ccr.20190303.15},
  abstract = {Sickle Cell Anemia (SCA) is an autosomal recessive disease caused by a point mutation in the hemoglobin beta gene found on chromosome 11p15.5 [1]. Specifically, it occurs when a single base from A to T in the codon for glutamic acid at position 6 is changed to valine of the beta globin and thus disrupts the tertiary structure and stability of the hemoglobin molecule [2]. Sickle hemoglobin is responsible for wide spectrum of disorders which vary with respect to severity of anemia, frequency of crises and duration of survival [3]. We present the case of a dilated cardiopathy in an elderly female sickle cell patient. A 68 years old female sickle cell patient with no known major cardiovascular risk factor presented with progressive onset of dyspnea. Clinical examination showed signs of left ventricular failure; an electrocardiogram showed a sinus regular rhythm, left ventricular hypertrophy with systolic overload, Q waves in the anteroseptal leads. Cardiac ultrasound showed a dilated cardiopathy with a preserved left ventricular systolic function at 57%, normal regional wall motion and normal pulmonary pressure. We concluded of heart failure due to probable chronic anemia or anischemic cardiopathy with a conserved systolic function in an elderly sickle cell patient but we were not able to confirm the main etiology without CT Coronary Angiogram or coronarography. Sickle cell anemia is a common genetic condition in sub-Saharan Africa associated with early death. This case is special because we have an elderly female presenting with heart failure on a dilated cardiopathy. This enhances the necessity of strict cardiovascular follow up of Sickle cell patient.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Dilated Cardiopathy Associated with Sickle Cell Disease in a 68 Years Old Female: An Emerging Complication in Sub-sahara Africa
AU  - Sylvie Ndongo Amougou
AU  - Mary Anne Ngam
AU  - Murielle Helles Lema
AU  - Mazou Ngou Temgoua
AU  - Aicha Yap Mefire
AU  - Anderson Ngouo Tchiffo
AU  - Samuel Kingue
Y1  - 2019/09/21
PY  - 2019
N1  - https://doi.org/10.11648/j.ccr.20190303.15
DO  - 10.11648/j.ccr.20190303.15
T2  - Cardiology and Cardiovascular Research
JF  - Cardiology and Cardiovascular Research
JO  - Cardiology and Cardiovascular Research
SP  - 65
EP  - 70
PB  - Science Publishing Group
SN  - 2578-8914
UR  - https://doi.org/10.11648/j.ccr.20190303.15
AB  - Sickle Cell Anemia (SCA) is an autosomal recessive disease caused by a point mutation in the hemoglobin beta gene found on chromosome 11p15.5 [1]. Specifically, it occurs when a single base from A to T in the codon for glutamic acid at position 6 is changed to valine of the beta globin and thus disrupts the tertiary structure and stability of the hemoglobin molecule [2]. Sickle hemoglobin is responsible for wide spectrum of disorders which vary with respect to severity of anemia, frequency of crises and duration of survival [3]. We present the case of a dilated cardiopathy in an elderly female sickle cell patient. A 68 years old female sickle cell patient with no known major cardiovascular risk factor presented with progressive onset of dyspnea. Clinical examination showed signs of left ventricular failure; an electrocardiogram showed a sinus regular rhythm, left ventricular hypertrophy with systolic overload, Q waves in the anteroseptal leads. Cardiac ultrasound showed a dilated cardiopathy with a preserved left ventricular systolic function at 57%, normal regional wall motion and normal pulmonary pressure. We concluded of heart failure due to probable chronic anemia or anischemic cardiopathy with a conserved systolic function in an elderly sickle cell patient but we were not able to confirm the main etiology without CT Coronary Angiogram or coronarography. Sickle cell anemia is a common genetic condition in sub-Saharan Africa associated with early death. This case is special because we have an elderly female presenting with heart failure on a dilated cardiopathy. This enhances the necessity of strict cardiovascular follow up of Sickle cell patient.
VL  - 3
IS  - 3
ER  -

Copy | Download