Influence of Oxidative Stress Markers on Coronary No-reflow After Primary Percutaneous Coronary Intervention for Patients with Acute Myocardial Infarction

Mahmoud Ragab Darwish; Walaa Farid; Ahmed Mokhtar El-Kersh

doi:doi:10.11648/j.ccr.20210501.13

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Influence of Oxidative Stress Markers on Coronary No-reflow After Primary Percutaneous Coronary Intervention for Patients with Acute Myocardial Infarction

Mahmoud Ragab Darwish, Walaa Farid, Ahmed Mokhtar El-Kersh

Published in Cardiology and Cardiovascular Research (Volume 5, Issue 1)

Received: 20 December 2020 Accepted: 30 December 2020 Published: 15 January 2021

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Abstract

Background: ST-elevation myocardial infarction (STEMI) is one of the leading causes of mortality and morbidity worldwide. However, survival after acute STEMI has considerably improved due to increasing symptom recognition, accurate diagnosis and effective timely reperfusion. This study aimed to investigate the relation between the level of oxidative stress markers and coronary no-reflow after primary percutaneous coronary intervention for patients with acute myocardial infarction. Patients & Methods: This prospective cohort study included 90 patients admitted with acute STEMI at cardiovascular medicine department Naser Institute hospital, during the period from June 2018 till 12 months. Patients were divided into 2 groups according to the post primary PCI thrombolysis in myocardial infarction (TIMI) flow score into: Group I: 45 patients with no-reflow phenomenon. Group II: 45 patients with TIMI flow ≥ 2 after primary PCI. They all underwent primary PCI within 24 hours of presentation. Results: This study showed increased concentrations of Malondialdehide (MDA) in the circulation of patients with no-reflow indicating increased lipid peroxidation which could be attributed to a deficiency of antioxidant defense mechanism. In group I, pt with coronary no-reflow MDA level ranged from 2.8-4.5 nmol/mL with mean 3.9±1.5 nmol/mL, while in group II control group, MDA level ranged from 1.1 – 2.1 nmol/mL with mean 1.55±0.4 nmol/mL, there was statistically significant difference between the two groups (P value<0.004). Conclusions: no-reflow phenomenon after primary PCI can be predicted using the oxidative stress markers.

Published in	Cardiology and Cardiovascular Research (Volume 5, Issue 1)
DOI	10.11648/j.ccr.20210501.13
Page(s)	16-24
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Oxidative Stress, Percutaneous Coronary Intervention, St-elevation Myocardial Infarction

References

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APA Style

Mahmoud Ragab Darwish, Walaa Farid, Ahmed Mokhtar El-Kersh. (2021). Influence of Oxidative Stress Markers on Coronary No-reflow After Primary Percutaneous Coronary Intervention for Patients with Acute Myocardial Infarction. Cardiology and Cardiovascular Research, 5(1), 16-24. https://doi.org/10.11648/j.ccr.20210501.13

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ACS Style

Mahmoud Ragab Darwish; Walaa Farid; Ahmed Mokhtar El-Kersh. Influence of Oxidative Stress Markers on Coronary No-reflow After Primary Percutaneous Coronary Intervention for Patients with Acute Myocardial Infarction. Cardiol. Cardiovasc. Res. 2021, 5(1), 16-24. doi: 10.11648/j.ccr.20210501.13

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AMA Style

Mahmoud Ragab Darwish, Walaa Farid, Ahmed Mokhtar El-Kersh. Influence of Oxidative Stress Markers on Coronary No-reflow After Primary Percutaneous Coronary Intervention for Patients with Acute Myocardial Infarction. Cardiol Cardiovasc Res. 2021;5(1):16-24. doi: 10.11648/j.ccr.20210501.13

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@article{10.11648/j.ccr.20210501.13,
  author = {Mahmoud Ragab Darwish and Walaa Farid and Ahmed Mokhtar El-Kersh},
  title = {Influence of Oxidative Stress Markers on Coronary No-reflow After Primary Percutaneous Coronary Intervention for Patients with Acute Myocardial Infarction},
  journal = {Cardiology and Cardiovascular Research},
  volume = {5},
  number = {1},
  pages = {16-24},
  doi = {10.11648/j.ccr.20210501.13},
  url = {https://doi.org/10.11648/j.ccr.20210501.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ccr.20210501.13},
  abstract = {Background: ST-elevation myocardial infarction (STEMI) is one of the leading causes of mortality and morbidity worldwide. However, survival after acute STEMI has considerably improved due to increasing symptom recognition, accurate diagnosis and effective timely reperfusion. This study aimed to investigate the relation between the level of oxidative stress markers and coronary no-reflow after primary percutaneous coronary intervention for patients with acute myocardial infarction. Patients & Methods: This prospective cohort study included 90 patients admitted with acute STEMI at cardiovascular medicine department Naser Institute hospital, during the period from June 2018 till 12 months. Patients were divided into 2 groups according to the post primary PCI thrombolysis in myocardial infarction (TIMI) flow score into: Group I: 45 patients with no-reflow phenomenon. Group II: 45 patients with TIMI flow ≥ 2 after primary PCI. They all underwent primary PCI within 24 hours of presentation. Results: This study showed increased concentrations of Malondialdehide (MDA) in the circulation of patients with no-reflow indicating increased lipid peroxidation which could be attributed to a deficiency of antioxidant defense mechanism. In group I, pt with coronary no-reflow MDA level ranged from 2.8-4.5 nmol/mL with mean 3.9±1.5 nmol/mL, while in group II control group, MDA level ranged from 1.1 – 2.1 nmol/mL with mean 1.55±0.4 nmol/mL, there was statistically significant difference between the two groups (P value<0.004). Conclusions: no-reflow phenomenon after primary PCI can be predicted using the oxidative stress markers.},
 year = {2021}
}

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TY  - JOUR
T1  - Influence of Oxidative Stress Markers on Coronary No-reflow After Primary Percutaneous Coronary Intervention for Patients with Acute Myocardial Infarction
AU  - Mahmoud Ragab Darwish
AU  - Walaa Farid
AU  - Ahmed Mokhtar El-Kersh
Y1  - 2021/01/15
PY  - 2021
N1  - https://doi.org/10.11648/j.ccr.20210501.13
DO  - 10.11648/j.ccr.20210501.13
T2  - Cardiology and Cardiovascular Research
JF  - Cardiology and Cardiovascular Research
JO  - Cardiology and Cardiovascular Research
SP  - 16
EP  - 24
PB  - Science Publishing Group
SN  - 2578-8914
UR  - https://doi.org/10.11648/j.ccr.20210501.13
AB  - Background: ST-elevation myocardial infarction (STEMI) is one of the leading causes of mortality and morbidity worldwide. However, survival after acute STEMI has considerably improved due to increasing symptom recognition, accurate diagnosis and effective timely reperfusion. This study aimed to investigate the relation between the level of oxidative stress markers and coronary no-reflow after primary percutaneous coronary intervention for patients with acute myocardial infarction. Patients & Methods: This prospective cohort study included 90 patients admitted with acute STEMI at cardiovascular medicine department Naser Institute hospital, during the period from June 2018 till 12 months. Patients were divided into 2 groups according to the post primary PCI thrombolysis in myocardial infarction (TIMI) flow score into: Group I: 45 patients with no-reflow phenomenon. Group II: 45 patients with TIMI flow ≥ 2 after primary PCI. They all underwent primary PCI within 24 hours of presentation. Results: This study showed increased concentrations of Malondialdehide (MDA) in the circulation of patients with no-reflow indicating increased lipid peroxidation which could be attributed to a deficiency of antioxidant defense mechanism. In group I, pt with coronary no-reflow MDA level ranged from 2.8-4.5 nmol/mL with mean 3.9±1.5 nmol/mL, while in group II control group, MDA level ranged from 1.1 – 2.1 nmol/mL with mean 1.55±0.4 nmol/mL, there was statistically significant difference between the two groups (P value<0.004). Conclusions: no-reflow phenomenon after primary PCI can be predicted using the oxidative stress markers.
VL  - 5
IS  - 1
ER  -

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Author Information

Mahmoud Ragab Darwish

Cardiology Department, Health Insurance, Tanta, Egypt
Walaa Farid

Cardiology Department, Menoufia University, Shebin Elkom, Egypt
Ahmed Mokhtar El-Kersh

Cardiology Department, Faculty of Medicine, Menofia University, Shebin Elkom, Egypt

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APA Style

Mahmoud Ragab Darwish, Walaa Farid, Ahmed Mokhtar El-Kersh. (2021). Influence of Oxidative Stress Markers on Coronary No-reflow After Primary Percutaneous Coronary Intervention for Patients with Acute Myocardial Infarction. Cardiology and Cardiovascular Research, 5(1), 16-24. https://doi.org/10.11648/j.ccr.20210501.13

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ACS Style

Mahmoud Ragab Darwish; Walaa Farid; Ahmed Mokhtar El-Kersh. Influence of Oxidative Stress Markers on Coronary No-reflow After Primary Percutaneous Coronary Intervention for Patients with Acute Myocardial Infarction. Cardiol. Cardiovasc. Res. 2021, 5(1), 16-24. doi: 10.11648/j.ccr.20210501.13

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AMA Style

Mahmoud Ragab Darwish, Walaa Farid, Ahmed Mokhtar El-Kersh. Influence of Oxidative Stress Markers on Coronary No-reflow After Primary Percutaneous Coronary Intervention for Patients with Acute Myocardial Infarction. Cardiol Cardiovasc Res. 2021;5(1):16-24. doi: 10.11648/j.ccr.20210501.13

Copy | Download

@article{10.11648/j.ccr.20210501.13,
  author = {Mahmoud Ragab Darwish and Walaa Farid and Ahmed Mokhtar El-Kersh},
  title = {Influence of Oxidative Stress Markers on Coronary No-reflow After Primary Percutaneous Coronary Intervention for Patients with Acute Myocardial Infarction},
  journal = {Cardiology and Cardiovascular Research},
  volume = {5},
  number = {1},
  pages = {16-24},
  doi = {10.11648/j.ccr.20210501.13},
  url = {https://doi.org/10.11648/j.ccr.20210501.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ccr.20210501.13},
  abstract = {Background: ST-elevation myocardial infarction (STEMI) is one of the leading causes of mortality and morbidity worldwide. However, survival after acute STEMI has considerably improved due to increasing symptom recognition, accurate diagnosis and effective timely reperfusion. This study aimed to investigate the relation between the level of oxidative stress markers and coronary no-reflow after primary percutaneous coronary intervention for patients with acute myocardial infarction. Patients & Methods: This prospective cohort study included 90 patients admitted with acute STEMI at cardiovascular medicine department Naser Institute hospital, during the period from June 2018 till 12 months. Patients were divided into 2 groups according to the post primary PCI thrombolysis in myocardial infarction (TIMI) flow score into: Group I: 45 patients with no-reflow phenomenon. Group II: 45 patients with TIMI flow ≥ 2 after primary PCI. They all underwent primary PCI within 24 hours of presentation. Results: This study showed increased concentrations of Malondialdehide (MDA) in the circulation of patients with no-reflow indicating increased lipid peroxidation which could be attributed to a deficiency of antioxidant defense mechanism. In group I, pt with coronary no-reflow MDA level ranged from 2.8-4.5 nmol/mL with mean 3.9±1.5 nmol/mL, while in group II control group, MDA level ranged from 1.1 – 2.1 nmol/mL with mean 1.55±0.4 nmol/mL, there was statistically significant difference between the two groups (P value<0.004). Conclusions: no-reflow phenomenon after primary PCI can be predicted using the oxidative stress markers.},
 year = {2021}
}

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TY  - JOUR
T1  - Influence of Oxidative Stress Markers on Coronary No-reflow After Primary Percutaneous Coronary Intervention for Patients with Acute Myocardial Infarction
AU  - Mahmoud Ragab Darwish
AU  - Walaa Farid
AU  - Ahmed Mokhtar El-Kersh
Y1  - 2021/01/15
PY  - 2021
N1  - https://doi.org/10.11648/j.ccr.20210501.13
DO  - 10.11648/j.ccr.20210501.13
T2  - Cardiology and Cardiovascular Research
JF  - Cardiology and Cardiovascular Research
JO  - Cardiology and Cardiovascular Research
SP  - 16
EP  - 24
PB  - Science Publishing Group
SN  - 2578-8914
UR  - https://doi.org/10.11648/j.ccr.20210501.13
AB  - Background: ST-elevation myocardial infarction (STEMI) is one of the leading causes of mortality and morbidity worldwide. However, survival after acute STEMI has considerably improved due to increasing symptom recognition, accurate diagnosis and effective timely reperfusion. This study aimed to investigate the relation between the level of oxidative stress markers and coronary no-reflow after primary percutaneous coronary intervention for patients with acute myocardial infarction. Patients & Methods: This prospective cohort study included 90 patients admitted with acute STEMI at cardiovascular medicine department Naser Institute hospital, during the period from June 2018 till 12 months. Patients were divided into 2 groups according to the post primary PCI thrombolysis in myocardial infarction (TIMI) flow score into: Group I: 45 patients with no-reflow phenomenon. Group II: 45 patients with TIMI flow ≥ 2 after primary PCI. They all underwent primary PCI within 24 hours of presentation. Results: This study showed increased concentrations of Malondialdehide (MDA) in the circulation of patients with no-reflow indicating increased lipid peroxidation which could be attributed to a deficiency of antioxidant defense mechanism. In group I, pt with coronary no-reflow MDA level ranged from 2.8-4.5 nmol/mL with mean 3.9±1.5 nmol/mL, while in group II control group, MDA level ranged from 1.1 – 2.1 nmol/mL with mean 1.55±0.4 nmol/mL, there was statistically significant difference between the two groups (P value<0.004). Conclusions: no-reflow phenomenon after primary PCI can be predicted using the oxidative stress markers.
VL  - 5
IS  - 1
ER  -

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