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Correlation Between Coronary Calcium Scoring and Duke’s Treadmill Score in Patients with Normal Myocardial Perfusion Imaging SPECT

Received: 9 November 2021     Accepted: 24 November 2021     Published: 2 December 2021
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Abstract

Background: Stress myocardial perfusion imaging (MPI) is a highly valuable test in the evaluation and risk stratification of ischemic heart disease. However, negative stress MPI does not exclude coronary atherosclerosis. The Coronary artery calcium (CAC) score is a validated simple test in the evaluation of coronary atherosclerosis. Our goal was to investigate the correlation between CAC score and Duke’s treadmill score, as well as the prevalence of CAC in patients with negative MPI. Methods: A total of 926 consecutive Egyptian patients, aged 30 to 60 years without known CAD, underwent CAC score testing following normal MPI. Results: In the setting of normal MPI among Egyptian patients without known CAD, mean age 48±7 years, 325 (35%) patients had a positive CAC score, and 9% had high CAC>100. Out of CAC>0, 160 were low-risk DTS. Our study showed no correlation between CAC score and DTS (P value=0.5). Age (OR=1.119, P value=<.001 and 95% confidence interval (CI)=1.071 - 1.169), male gender (OR=2.795, P value=.001 and 95% (CI)=1.494 - 5.230), and statin therapy (OR=2.020, P value=.008 and 95% (CI)=1.199 - 3.404), were significant independent predictors of a high CAC score>100. Conclusion: In a large number of normal MPI Egyptian patients without known CAD, CAC prevalence was 35%, confirming the beneficial value of adding CAC score test to negative MPI for cardiovascular risk stratification and screening for subclinical CAD regardless of DTS. Higher CAC values and prevalence were associated with age and male gender.

Published in Cardiology and Cardiovascular Research (Volume 5, Issue 4)
DOI 10.11648/j.ccr.20210504.18
Page(s) 204-210
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

CAC Score, DTS, MPI

References
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Cite This Article
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    Abd Al Aziz Mohie Al Deen Abd Al Aziz, Mohamed Abou Mandour Ali, Ayman El Saeed Saddek, Adel Hassan Allam. (2021). Correlation Between Coronary Calcium Scoring and Duke’s Treadmill Score in Patients with Normal Myocardial Perfusion Imaging SPECT. Cardiology and Cardiovascular Research, 5(4), 204-210. https://doi.org/10.11648/j.ccr.20210504.18

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    ACS Style

    Abd Al Aziz Mohie Al Deen Abd Al Aziz; Mohamed Abou Mandour Ali; Ayman El Saeed Saddek; Adel Hassan Allam. Correlation Between Coronary Calcium Scoring and Duke’s Treadmill Score in Patients with Normal Myocardial Perfusion Imaging SPECT. Cardiol. Cardiovasc. Res. 2021, 5(4), 204-210. doi: 10.11648/j.ccr.20210504.18

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    AMA Style

    Abd Al Aziz Mohie Al Deen Abd Al Aziz, Mohamed Abou Mandour Ali, Ayman El Saeed Saddek, Adel Hassan Allam. Correlation Between Coronary Calcium Scoring and Duke’s Treadmill Score in Patients with Normal Myocardial Perfusion Imaging SPECT. Cardiol Cardiovasc Res. 2021;5(4):204-210. doi: 10.11648/j.ccr.20210504.18

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  • @article{10.11648/j.ccr.20210504.18,
      author = {Abd Al Aziz Mohie Al Deen Abd Al Aziz and Mohamed Abou Mandour Ali and Ayman El Saeed Saddek and Adel Hassan Allam},
      title = {Correlation Between Coronary Calcium Scoring and Duke’s Treadmill Score in Patients with Normal Myocardial Perfusion Imaging SPECT},
      journal = {Cardiology and Cardiovascular Research},
      volume = {5},
      number = {4},
      pages = {204-210},
      doi = {10.11648/j.ccr.20210504.18},
      url = {https://doi.org/10.11648/j.ccr.20210504.18},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ccr.20210504.18},
      abstract = {Background: Stress myocardial perfusion imaging (MPI) is a highly valuable test in the evaluation and risk stratification of ischemic heart disease. However, negative stress MPI does not exclude coronary atherosclerosis. The Coronary artery calcium (CAC) score is a validated simple test in the evaluation of coronary atherosclerosis. Our goal was to investigate the correlation between CAC score and Duke’s treadmill score, as well as the prevalence of CAC in patients with negative MPI. Methods: A total of 926 consecutive Egyptian patients, aged 30 to 60 years without known CAD, underwent CAC score testing following normal MPI. Results: In the setting of normal MPI among Egyptian patients without known CAD, mean age 48±7 years, 325 (35%) patients had a positive CAC score, and 9% had high CAC>100. Out of CAC>0, 160 were low-risk DTS. Our study showed no correlation between CAC score and DTS (P value=0.5). Age (OR=1.119, P value=100. Conclusion: In a large number of normal MPI Egyptian patients without known CAD, CAC prevalence was 35%, confirming the beneficial value of adding CAC score test to negative MPI for cardiovascular risk stratification and screening for subclinical CAD regardless of DTS. Higher CAC values and prevalence were associated with age and male gender.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Correlation Between Coronary Calcium Scoring and Duke’s Treadmill Score in Patients with Normal Myocardial Perfusion Imaging SPECT
    AU  - Abd Al Aziz Mohie Al Deen Abd Al Aziz
    AU  - Mohamed Abou Mandour Ali
    AU  - Ayman El Saeed Saddek
    AU  - Adel Hassan Allam
    Y1  - 2021/12/02
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ccr.20210504.18
    DO  - 10.11648/j.ccr.20210504.18
    T2  - Cardiology and Cardiovascular Research
    JF  - Cardiology and Cardiovascular Research
    JO  - Cardiology and Cardiovascular Research
    SP  - 204
    EP  - 210
    PB  - Science Publishing Group
    SN  - 2578-8914
    UR  - https://doi.org/10.11648/j.ccr.20210504.18
    AB  - Background: Stress myocardial perfusion imaging (MPI) is a highly valuable test in the evaluation and risk stratification of ischemic heart disease. However, negative stress MPI does not exclude coronary atherosclerosis. The Coronary artery calcium (CAC) score is a validated simple test in the evaluation of coronary atherosclerosis. Our goal was to investigate the correlation between CAC score and Duke’s treadmill score, as well as the prevalence of CAC in patients with negative MPI. Methods: A total of 926 consecutive Egyptian patients, aged 30 to 60 years without known CAD, underwent CAC score testing following normal MPI. Results: In the setting of normal MPI among Egyptian patients without known CAD, mean age 48±7 years, 325 (35%) patients had a positive CAC score, and 9% had high CAC>100. Out of CAC>0, 160 were low-risk DTS. Our study showed no correlation between CAC score and DTS (P value=0.5). Age (OR=1.119, P value=100. Conclusion: In a large number of normal MPI Egyptian patients without known CAD, CAC prevalence was 35%, confirming the beneficial value of adding CAC score test to negative MPI for cardiovascular risk stratification and screening for subclinical CAD regardless of DTS. Higher CAC values and prevalence were associated with age and male gender.
    VL  - 5
    IS  - 4
    ER  - 

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Author Information
  • Department of Cardiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

  • Department of Cardiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

  • Department of Cardiology, Faculty of Medicine, Al-Azhar University, Cairo, EgyptDepartment of Cardiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

  • Department of Cardiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

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