Diuretics are used to manage fluid excess as part of a treatment strategy. Withania coagulans has long been utilised in traditional medicine. Including some slight modifications and by using furosemide as a standard drug, in vitro cell Lipchitz test model was used to examine a diuretic effectiveness of Withania coagulans fruit aqueous extract. Results demonstrated that only one unique route of oral dosage delivery of hydroalcoholicextract of fruit of Withania Coagulans as 500 mg/kg/b. w. and 750 mg/Kg and standard Furosemide (10 mg/kg) have enhanced the amount of urine produced as well as an increase in the amounts of sodium, potassium, and chloride ions in urine. Hydro alcoholic extract of fruit of Withania Coagulans 750 mg/kg produced a higher diuretic activity equivalent to that low dose extract and lower diuretic effect when comparable with furosemide (10 mg/kg) as a standard. The herb is utilised in traditional medicine for its diuretic properties. Thus, our study backs up and validates the logic for the folkloric usage of roots of Hydro alcoholic extract of fruit of Withania Coagulans for its diuretic activity. Withanolides isolated from ethanolic extract demonstrated antifungal, antibiotic, and anti-tumor activity. Comparing Withania species, withanolides are more polar in nature.
| Published in | Clinical Medicine Research (Volume 13, Issue 1) |
| DOI | 10.11648/j.cmr.20241301.11 |
| Page(s) | 1-5 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2024. Published by Science Publishing Group |
Hydro Alcoholic Extract (Withania Coagulans), Furosemide, Active Diurnal, Urinary Output
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APA Style
Sharma, R. K., Chandolia, P., Sundram, R. S., Isha, K., Soni, S. (2024). Therapeutic Effect of Hydroalcoholic Extract for Withania Coagulans for Diuretic Activity in Rodents. Clinical Medicine Research, 13(1), 1-5. https://doi.org/10.11648/j.cmr.20241301.11
ACS Style
Sharma, R. K.; Chandolia, P.; Sundram, R. S.; Isha, K.; Soni, S. Therapeutic Effect of Hydroalcoholic Extract for Withania Coagulans for Diuretic Activity in Rodents. Clin. Med. Res. 2024, 13(1), 1-5. doi: 10.11648/j.cmr.20241301.11
AMA Style
Sharma RK, Chandolia P, Sundram RS, Isha K, Soni S. Therapeutic Effect of Hydroalcoholic Extract for Withania Coagulans for Diuretic Activity in Rodents. Clin Med Res. 2024;13(1):1-5. doi: 10.11648/j.cmr.20241301.11
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Download@article{10.11648/j.cmr.20241301.11,
author = {Rajesh Kumar Sharma and Priyanka Chandolia and Ravi Shankar Sundram and Kumari Isha and Sanjana Soni},
title = {Therapeutic Effect of Hydroalcoholic Extract for Withania Coagulans for Diuretic Activity in Rodents},
journal = {Clinical Medicine Research},
volume = {13},
number = {1},
pages = {1-5},
doi = {10.11648/j.cmr.20241301.11},
url = {https://doi.org/10.11648/j.cmr.20241301.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20241301.11},
abstract = {Diuretics are used to manage fluid excess as part of a treatment strategy. Withania coagulans has long been utilised in traditional medicine. Including some slight modifications and by using furosemide as a standard drug, in vitro cell Lipchitz test model was used to examine a diuretic effectiveness of Withania coagulans fruit aqueous extract. Results demonstrated that only one unique route of oral dosage delivery of hydroalcoholicextract of fruit of Withania Coagulans as 500 mg/kg/b. w. and 750 mg/Kg and standard Furosemide (10 mg/kg) have enhanced the amount of urine produced as well as an increase in the amounts of sodium, potassium, and chloride ions in urine. Hydro alcoholic extract of fruit of Withania Coagulans 750 mg/kg produced a higher diuretic activity equivalent to that low dose extract and lower diuretic effect when comparable with furosemide (10 mg/kg) as a standard. The herb is utilised in traditional medicine for its diuretic properties. Thus, our study backs up and validates the logic for the folkloric usage of roots of Hydro alcoholic extract of fruit of Withania Coagulans for its diuretic activity. Withanolides isolated from ethanolic extract demonstrated antifungal, antibiotic, and anti-tumor activity. Comparing Withania species, withanolides are more polar in nature.
},
year = {2024}
}
TY - JOUR T1 - Therapeutic Effect of Hydroalcoholic Extract for Withania Coagulans for Diuretic Activity in Rodents AU - Rajesh Kumar Sharma AU - Priyanka Chandolia AU - Ravi Shankar Sundram AU - Kumari Isha AU - Sanjana Soni Y1 - 2024/01/08 PY - 2024 N1 - https://doi.org/10.11648/j.cmr.20241301.11 DO - 10.11648/j.cmr.20241301.11 T2 - Clinical Medicine Research JF - Clinical Medicine Research JO - Clinical Medicine Research SP - 1 EP - 5 PB - Science Publishing Group SN - 2326-9057 UR - https://doi.org/10.11648/j.cmr.20241301.11 AB - Diuretics are used to manage fluid excess as part of a treatment strategy. Withania coagulans has long been utilised in traditional medicine. Including some slight modifications and by using furosemide as a standard drug, in vitro cell Lipchitz test model was used to examine a diuretic effectiveness of Withania coagulans fruit aqueous extract. Results demonstrated that only one unique route of oral dosage delivery of hydroalcoholicextract of fruit of Withania Coagulans as 500 mg/kg/b. w. and 750 mg/Kg and standard Furosemide (10 mg/kg) have enhanced the amount of urine produced as well as an increase in the amounts of sodium, potassium, and chloride ions in urine. Hydro alcoholic extract of fruit of Withania Coagulans 750 mg/kg produced a higher diuretic activity equivalent to that low dose extract and lower diuretic effect when comparable with furosemide (10 mg/kg) as a standard. The herb is utilised in traditional medicine for its diuretic properties. Thus, our study backs up and validates the logic for the folkloric usage of roots of Hydro alcoholic extract of fruit of Withania Coagulans for its diuretic activity. Withanolides isolated from ethanolic extract demonstrated antifungal, antibiotic, and anti-tumor activity. Comparing Withania species, withanolides are more polar in nature. VL - 13 IS - 1 ER -
Department of Pharmacology, NIMS Institute of Pharmacy, Nims University, Jaipur, India
Department of Pharmacology, NIMS Institute of Pharmacy, Nims University, Jaipur, India
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