Introduction: The stomach wall is made up of smooth muscles which are arranged in three layers: outer longitudinal, inner circular and innermost oblique layers. The mucosa is made up of simple columnar epithelium and is made up of several cell types which include: mucous cells which secrete alkaline mucous that protects the epithelium against acid and shear stress. Gastritis can involve the whole of the stomach, or a specific part of the stomach such as the fundus, body or the antrum and the distribution of gastritis may be related to an aetiologic factor. H. pylori causes passive inflammation inside the gastric epithelium and alters signal transduction pathways that serve as a platform for the pathogenesis, but it also develops antimicrobial resistance via genetic changes and biofilm development. The bacterium floats in the direction of the epithelial membrane when it enters the stomach, taking advantage of areas of the stomach wall that are injured. Method: The study was conducted in Kano, Nigeria from April 2021 to October 2021 and it is a Hospital-based Cross-sectional Descriptive study. Patients with dyspepsia referred for oesophagogastroduodenoscopy (OGD) at the endoscopy suite of the hospital constitute the study population, 197 patients that met the inclusion criteria were recruited and underwent OGD. Each patient were biopsied in accordance with the updated Sydney protocol. Data were collected and the report of both endoscopy and histological assessment for the presence of gastritis and H. pylori were documented and analyzed using the SPSS 20. Result: H. pylori was detected in 137 patients out of the 197 gastric biopsies sample of gastritis, the prevalence was 69.5%. Also, There was a statistically significant relationship between H. pylori and those aged 31-40years (p = 0.025), however, the relationship was not significant for the other age groups and no significant relationship was found between sex (p = 0.512). The most common site affected by histologic gastritis in this study was the antrum (99.4%) and the high predominance of antral involvement is probably due to the high rate of H. pylori infection in the study subjects which is known to be associated with antral affectation. Conclusion: The most predominant pattern of histologic gastritis was chronic H. pylori gastritis located in the antrum. The prevalence of H. pylori infection was 69.5%, and it had significant association with both endoscopic and histologic gastritis. Therefore, prevention and eradication program for the H. pylori infection are necessary in our environment.
Published in | Clinical Medicine Research (Volume 13, Issue 6) |
DOI | 10.11648/j.cmr.20241306.12 |
Page(s) | 77-82 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Oesophagogastroduodenoscopy, Endoscopic Gastritis, Histologic Gastritis, Helicobacter Pylori, Proton Pump Inhibitors, Potassium-competitive Acid Blocker
Characteristics | H. pylori | No H. pylori | p-value |
---|---|---|---|
Age group (years) | 0.025 | ||
18-20 | 12(70.6) | 5(29.4) | |
21-30 | 36(69.2) | 16(30.8) | |
31-40 | 41(83.7) | 8(16.3) | |
41-50 | 29(72.5) | 11(27.5) | |
51-60 | 11(47.8) | 12(52.2) | |
>60 | 8(50.0) | 8(50.0) | |
Mean±SD | 37.7±14.1 | 43.5±15.2 | 0.070 |
Sex | 0.512 | ||
Male | 64(71.9) | 25(28.1) | |
Female | 73(67.6) | 35(32.4) | |
Type of education | 0.338 | ||
Formal | 111(71.2) | 45(28.8) | |
Non-formal | 26(63.4) | 15(36.6) | |
Level of education | 0.297 | ||
Nil | 26(63.4) | 15(36.6) | |
Primary | 5(62.5) | 3(37.5) | |
Secondary | 30(62.5) | 18(37.5) | |
Tertiary | 76(76.0) | 24(24.0) |
Characteristics | Gastritis | No gastritis | p-value |
---|---|---|---|
H. pylori | <0.001 | ||
Yes | 137(100) | 0(0) | |
No | 32(53.3) | 28(46.7) |
OGD | Oesophagogastroduodenscopy |
H. pylori | Helicobacter pylori |
HCL | Hydrochloric Acid |
AKTH | Aminu Kano Teaching Hospital |
DPX | Dibutylphthalate Polystyrene Xylene |
SPSS | Statistical Package for the Social Science |
M:F | Male:Female Ratio |
CI | Confidence Interval |
[1] | James Lindsay, Louise Langmead SLP. Clinical Medicine. 9th ed. Parveen Kumar MC, editor. Edinbugh: elsevier; 2017. 376–381 p. |
[2] | Schubert ML, Peura DA. Control of Gastric Acid Secretion in Health and Disease. Gastroenterology 2008; 134(7): 1842–60. |
[3] | Cinti S, De Matteis R, Picó C, Ceresi E, Obrador A, Maffeis C, et al. Secretory granules of endocrine and chief cells of human stomach mucosa contain leptin. Int J Obes Relat Metab Disord. 2000 Jun; 24(6): 789-93. |
[4] | Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau JP, Bortoluzzi MN, et al. The stomach is a source of leptin. Nature. 1998 Aug 20; 394(6695): 790-3. |
[5] | Zaki M, Koduru S, McCuen R, Vuyyuru L, Schubert ML. Amylin, released from the gastric fundus, stimulates somatostatin and thus inhibits histamine and acid secretion in mice. Gastroenterology. 2002 Jul; 123(1): 247-55. |
[6] | Bizzozero, G.; der Eidechsen, D. Ueber die schlauchförmigen Drüsen des Magendarmkanals und die Beziehungen ihres. Arch. Mikrosk. Anat. 1893, 42, 82. |
[7] | Stefano, K.; Marco, M.; Federica, G.; Laura, B.; Barbara, B.; Gioacchino, L.; Gian, L. d. A. Helicobacter pylori, transmission routes and recurrence of infection: State of the art. Acta Biomed. 2018 Dec 17; 89(8-S): 72-76. |
[8] | Camilo, V.; Sugiyama, T.; Touati, E. Pathogenesis of Helicobacter pylori infection. Helicobacter 2017, 22, e12405. |
[9] | Denic, M.; Touati, E.; De Reuse, H. Pathogenesis of Helicobacter pylori infection. Helicobacter 2020, 25, e12736. |
[10] | Hanyu, H.; Engevik, K. A.; Matthis, A. L.; Ottemann, K. M.; Montrose, M. H.; Aihara, E. Helicobacter pylori uses the TlpB receptor to sense sites of gastric injury. Infect. Immun. 2019, 87, e00202–e00219. |
[11] | Idowu, S.; Bertrand, P. P.; Walduck, A. K. Gastric organoids: Advancing the study of H. pylori pathogenesis and inflammation. Helicobacter 2022, 27, e12891. |
[12] | Feyisa ZT, Woldeamanuel BT. Prevalence and associated risk factors of gastritis among patients visiting Saint Paul Hospital Millennium Medical College, Addis Ababa, Ethiopia. PLoS One. 2021 Feb 9; 16(2): e0246619. |
[13] | Jemilohun A, Otegbayo J, Ola S, Oluwasola A, Akere A. Correlation Between Endoscopic and Histological Gastritis in South-Western Nigerians With Dyspepsia. Niger J Gastroenterol Hepatol 2010; 2(2): 73–6. |
[14] | Ajayi AO, Ajayi EA, Solomon OA, Duduyemi B, Omonisi EA, Taiwo OJ. Corelation between the Endoscopic and Histologic Diagnosis of Gastritis at the Ekiti State University Teaching Hospital, Ado Ekiti, Nigeria. Int J Intern Med 2015; 4(1): 9–13. |
[15] | Mustapha SK, Kida IM, Dayar A, Gundiri LB. Indications for upper gastrointestinal endoscopy in maiduguri. BOMJ. 2010; 7(2): 2008–11. |
[16] | Bojuwoye MO, Olokoba AB, Ibrahim OOK, Ogunlaja AO, Bojuwoye BJ. Relationship between helicobacter pylori infection and endoscopic findings among patients with dyspepsia in north central, Nigeria. Sjms 2016; 11(4): 56–9. |
[17] | Harun DO, Kes M, Hakim AF, Kep S, Suwandiana W, Kep S. The Correlation Of Knowledge And Education Level Of The Patients With The Gastritis Incident At Sindangbarang Public Health Center Cianjur. Int J Sci Technol Res 2015; 4(8): 6–13. |
[18] | Genta RM, Turner KO, Sonnenberg A. Demographic and socioeconomic influences on Helicobacter pylori gastritis and its pre-neoplastic lesions amongst US residents. Aliment Pharmacol Ther. 2017 Aug; 46(3): 322-330. |
[19] | Udoh MO, Obaseki DE. Histopathological evaluation of H. Pylori associated gastric lesions in benin city, Nigeria. East Afr Med J 2012; 89(12): 408–13. |
[20] | Duduyemi B, Ojo B, Olaomi O, Atiba A. Histopathological Pattern of Endoscopic Gastric Biopsy in a District Hospital in Nigeria: A Review of 118 Consecutive Cases. Am J Med Biol Res 2014; 2(3): 83–6. |
[21] | Bello AK, Umar AB, Borodo MM. Prevalence and Risk Factors for Helicobacter pylori Infection in Gastroduodenal Diseases in Kano, Nigeria. African J Med Heal Sci 2017; 16: 12–8. |
[22] | Tijjani B, Umar A. Peptic ulcer disease and Helicobacter pylori infection. Curr Opin Gastroenterol 1994; 10(1): 98–104. |
[23] | Olokoba AB, Gashau W, Bwala S, Adamu A, Salawu FK. Helicobacter Pylori Infection in Nigerians with Dyspepsia. Ghana Med J 2013; 47(2): 79-81. |
[24] | Olokoba AB, Apari E, Salawu FK, Nggada HA. Helicobacter pylori in dyspeptic Nigerians. West Afr J Med 2013; 32(4): 277–80. |
[25] | Bello U, S Maiyaki A. Morphologic Pattern of Diseases in Gastric Biopsies and Role of Helicobacter Pylori in Chronic Gastritis at a Nigerian Teaching Hospital. Saudi J Pathol Microbiol 2021; 6(2): 71–5. |
[26] | Sarfras T, Hafeez M, Shafiq H, Azhar M, Ahmed K, Jamal N. Histopathological analysis of gastric mucosal bioppsies in non-ulcer dyspepsia. PAMJ 2016; 66(6) 875-6. |
[27] | Dehesa M, Dooley CP, Cohen H, Fitzgibbons PL, Perez-perez GI, Blaser MJ. High Prevalence of Helicobacter pylori Infection and Histologic Gastritis in Asymptomatic Hispanics. J Clin Microbiol. 1991 Jun; 29(6): 1128-31. |
[28] | Dixon MF, O’Connor HJ, Axon AT. Reflux gastritis: distinct histopathological entity? J Clin Pathol. 1986 May; 39(5): 524-30. |
APA Style
Ewa, A. M., Abdulkadir, Y. M., Ibrahim, Y. (2024). Prevalence of Helicobacter Pylori Among Patients with Chronic Gastritis in Nigeria. Clinical Medicine Research, 13(6), 77-82. https://doi.org/10.11648/j.cmr.20241306.12
ACS Style
Ewa, A. M.; Abdulkadir, Y. M.; Ibrahim, Y. Prevalence of Helicobacter Pylori Among Patients with Chronic Gastritis in Nigeria. Clin. Med. Res. 2024, 13(6), 77-82. doi: 10.11648/j.cmr.20241306.12
AMA Style
Ewa AM, Abdulkadir YM, Ibrahim Y. Prevalence of Helicobacter Pylori Among Patients with Chronic Gastritis in Nigeria. Clin Med Res. 2024;13(6):77-82. doi: 10.11648/j.cmr.20241306.12
@article{10.11648/j.cmr.20241306.12, author = {Adamu Mohammad Ewa and Yussuf Maisuna Abdulkadir and Yusuf Ibrahim}, title = {Prevalence of Helicobacter Pylori Among Patients with Chronic Gastritis in Nigeria }, journal = {Clinical Medicine Research}, volume = {13}, number = {6}, pages = {77-82}, doi = {10.11648/j.cmr.20241306.12}, url = {https://doi.org/10.11648/j.cmr.20241306.12}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20241306.12}, abstract = {Introduction: The stomach wall is made up of smooth muscles which are arranged in three layers: outer longitudinal, inner circular and innermost oblique layers. The mucosa is made up of simple columnar epithelium and is made up of several cell types which include: mucous cells which secrete alkaline mucous that protects the epithelium against acid and shear stress. Gastritis can involve the whole of the stomach, or a specific part of the stomach such as the fundus, body or the antrum and the distribution of gastritis may be related to an aetiologic factor. H. pylori causes passive inflammation inside the gastric epithelium and alters signal transduction pathways that serve as a platform for the pathogenesis, but it also develops antimicrobial resistance via genetic changes and biofilm development. The bacterium floats in the direction of the epithelial membrane when it enters the stomach, taking advantage of areas of the stomach wall that are injured. Method: The study was conducted in Kano, Nigeria from April 2021 to October 2021 and it is a Hospital-based Cross-sectional Descriptive study. Patients with dyspepsia referred for oesophagogastroduodenoscopy (OGD) at the endoscopy suite of the hospital constitute the study population, 197 patients that met the inclusion criteria were recruited and underwent OGD. Each patient were biopsied in accordance with the updated Sydney protocol. Data were collected and the report of both endoscopy and histological assessment for the presence of gastritis and H. pylori were documented and analyzed using the SPSS 20. Result: H. pylori was detected in 137 patients out of the 197 gastric biopsies sample of gastritis, the prevalence was 69.5%. Also, There was a statistically significant relationship between H. pylori and those aged 31-40years (p = 0.025), however, the relationship was not significant for the other age groups and no significant relationship was found between sex (p = 0.512). The most common site affected by histologic gastritis in this study was the antrum (99.4%) and the high predominance of antral involvement is probably due to the high rate of H. pylori infection in the study subjects which is known to be associated with antral affectation. Conclusion: The most predominant pattern of histologic gastritis was chronic H. pylori gastritis located in the antrum. The prevalence of H. pylori infection was 69.5%, and it had significant association with both endoscopic and histologic gastritis. Therefore, prevention and eradication program for the H. pylori infection are necessary in our environment. }, year = {2024} }
TY - JOUR T1 - Prevalence of Helicobacter Pylori Among Patients with Chronic Gastritis in Nigeria AU - Adamu Mohammad Ewa AU - Yussuf Maisuna Abdulkadir AU - Yusuf Ibrahim Y1 - 2024/12/12 PY - 2024 N1 - https://doi.org/10.11648/j.cmr.20241306.12 DO - 10.11648/j.cmr.20241306.12 T2 - Clinical Medicine Research JF - Clinical Medicine Research JO - Clinical Medicine Research SP - 77 EP - 82 PB - Science Publishing Group SN - 2326-9057 UR - https://doi.org/10.11648/j.cmr.20241306.12 AB - Introduction: The stomach wall is made up of smooth muscles which are arranged in three layers: outer longitudinal, inner circular and innermost oblique layers. The mucosa is made up of simple columnar epithelium and is made up of several cell types which include: mucous cells which secrete alkaline mucous that protects the epithelium against acid and shear stress. Gastritis can involve the whole of the stomach, or a specific part of the stomach such as the fundus, body or the antrum and the distribution of gastritis may be related to an aetiologic factor. H. pylori causes passive inflammation inside the gastric epithelium and alters signal transduction pathways that serve as a platform for the pathogenesis, but it also develops antimicrobial resistance via genetic changes and biofilm development. The bacterium floats in the direction of the epithelial membrane when it enters the stomach, taking advantage of areas of the stomach wall that are injured. Method: The study was conducted in Kano, Nigeria from April 2021 to October 2021 and it is a Hospital-based Cross-sectional Descriptive study. Patients with dyspepsia referred for oesophagogastroduodenoscopy (OGD) at the endoscopy suite of the hospital constitute the study population, 197 patients that met the inclusion criteria were recruited and underwent OGD. Each patient were biopsied in accordance with the updated Sydney protocol. Data were collected and the report of both endoscopy and histological assessment for the presence of gastritis and H. pylori were documented and analyzed using the SPSS 20. Result: H. pylori was detected in 137 patients out of the 197 gastric biopsies sample of gastritis, the prevalence was 69.5%. Also, There was a statistically significant relationship between H. pylori and those aged 31-40years (p = 0.025), however, the relationship was not significant for the other age groups and no significant relationship was found between sex (p = 0.512). The most common site affected by histologic gastritis in this study was the antrum (99.4%) and the high predominance of antral involvement is probably due to the high rate of H. pylori infection in the study subjects which is known to be associated with antral affectation. Conclusion: The most predominant pattern of histologic gastritis was chronic H. pylori gastritis located in the antrum. The prevalence of H. pylori infection was 69.5%, and it had significant association with both endoscopic and histologic gastritis. Therefore, prevention and eradication program for the H. pylori infection are necessary in our environment. VL - 13 IS - 6 ER -