@article{10.11648/j.ijg.20230702.16,
  author = {Md. Mawla Ali Sheikh and Md. Anisur Rahman and Tareq Mahmud Bhuiyan and Md. Golam Azam},
  title = {Anthropometric and Biochemical Findings in Non-Alcoholic Fatty Liver Disease with or Without Diabetes},
  journal = {International Journal of Gastroenterology},
  volume = {7},
  number = {2},
  pages = {77-86},
  doi = {10.11648/j.ijg.20230702.16},
  url = {https://doi.org/10.11648/j.ijg.20230702.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijg.20230702.16},
  abstract = {Background: Non-alcoholic fatty liver disease (NAFLD) has emerged as a prevalent cause of chronic liver diseases globally in the past decade, posing significant risks to liver health, cardiovascular well-being, and even warranting consideration for liver transplantation. There is limited research on the clinical, anthropometric, biochemical, and metabolic characteristics of NAFLD patients, both with and without diabetes, in Bangladesh. Aim of the study: This study aimed to assess the prevalence of diabetes and non-diabetes among a group of NAFLD patients and to investigate the anthropometric, biochemical, and metabolic profiles of NAFLD patients with diabetes compared to those without diabetes. Methods: This prospective observational study was conducted at the Department of Gastrointestinal Hepatobiliary & Pancreatic Disorder (GHPD), BIRDEM General Hospital, Dhaka, from April 2014 to April 2015. A total of 111 individuals with ultrasonographically diagnosed NAFLD were included in the study. Participants underwent assessments for various parameters, including anthropometric measurements, biochemical assays (including blood glucose levels, liver function tests, lipid profiles, and HOMA-IR), and the presence of diabetes or metabolic syndrome (as defined by IDF criteria). The patients were categorized and analyzed based on the presence or absence of diabetes. Statistical analysis was performed using SPSS version 16.0. Results: Among the 111 NAFLD patients, 71 (63.96%) were diagnosed with diabetes, while 40 (36.04%) did not have diabetes. In comparison to those without diabetes, NAFLD patients with diabetes tended to be older (47.15±10.26 vs. 43.35±10.7 years) and included a higher proportion of females (61.98% vs. 57.50%). They also had a significantly higher prevalence of hypertension (77.47% vs. 40.0%; pConclusion: NAFLD patients with diabetes exhibit greater metabolic risk factors, including higher BMI, central obesity, hypertension, elevated triglyceride levels, and increased insulin resistance, all of which may contribute to the progression of non-alcoholic steatohepatitis (NASH) and advanced fibrosis. Notably, a substantial proportion of NAFLD patients without diabetes also display metabolic risk factors, highlighting the importance of recognizing NAFLD in individuals without diabetes.
},
 year = {2023}
}

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TY  - JOUR
T1  - Anthropometric and Biochemical Findings in Non-Alcoholic Fatty Liver Disease with or Without Diabetes
AU  - Md. Mawla Ali Sheikh
AU  - Md. Anisur Rahman
AU  - Tareq Mahmud Bhuiyan
AU  - Md. Golam Azam
Y1  - 2023/12/22
PY  - 2023
N1  - https://doi.org/10.11648/j.ijg.20230702.16
DO  - 10.11648/j.ijg.20230702.16
T2  - International Journal of Gastroenterology
JF  - International Journal of Gastroenterology
JO  - International Journal of Gastroenterology
SP  - 77
EP  - 86
PB  - Science Publishing Group
SN  - 2640-169X
UR  - https://doi.org/10.11648/j.ijg.20230702.16
AB  - Background: Non-alcoholic fatty liver disease (NAFLD) has emerged as a prevalent cause of chronic liver diseases globally in the past decade, posing significant risks to liver health, cardiovascular well-being, and even warranting consideration for liver transplantation. There is limited research on the clinical, anthropometric, biochemical, and metabolic characteristics of NAFLD patients, both with and without diabetes, in Bangladesh. Aim of the study: This study aimed to assess the prevalence of diabetes and non-diabetes among a group of NAFLD patients and to investigate the anthropometric, biochemical, and metabolic profiles of NAFLD patients with diabetes compared to those without diabetes. Methods: This prospective observational study was conducted at the Department of Gastrointestinal Hepatobiliary & Pancreatic Disorder (GHPD), BIRDEM General Hospital, Dhaka, from April 2014 to April 2015. A total of 111 individuals with ultrasonographically diagnosed NAFLD were included in the study. Participants underwent assessments for various parameters, including anthropometric measurements, biochemical assays (including blood glucose levels, liver function tests, lipid profiles, and HOMA-IR), and the presence of diabetes or metabolic syndrome (as defined by IDF criteria). The patients were categorized and analyzed based on the presence or absence of diabetes. Statistical analysis was performed using SPSS version 16.0. Results: Among the 111 NAFLD patients, 71 (63.96%) were diagnosed with diabetes, while 40 (36.04%) did not have diabetes. In comparison to those without diabetes, NAFLD patients with diabetes tended to be older (47.15±10.26 vs. 43.35±10.7 years) and included a higher proportion of females (61.98% vs. 57.50%). They also had a significantly higher prevalence of hypertension (77.47% vs. 40.0%; pConclusion: NAFLD patients with diabetes exhibit greater metabolic risk factors, including higher BMI, central obesity, hypertension, elevated triglyceride levels, and increased insulin resistance, all of which may contribute to the progression of non-alcoholic steatohepatitis (NASH) and advanced fibrosis. Notably, a substantial proportion of NAFLD patients without diabetes also display metabolic risk factors, highlighting the importance of recognizing NAFLD in individuals without diabetes.

VL  - 7
IS  - 2
ER  - 

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