Synthesis, Spectral Characterization, Theoretical Evaluation of New Cu(II) and Ni(II) Complexes of Flavon

Omar H. Al-Obaidi

doi:doi:10.11648/j.ijpc.20160202.12

| Peer-Reviewed

Synthesis, Spectral Characterization, Theoretical Evaluation of New Cu(II) and Ni(II) Complexes of Flavon

Omar H. Al-Obaidi

Published in International Journal of Pharmacy and Chemistry (Volume 2, Issue 2)

Received: 17 September 2016 Accepted: 12 October 2016 Published: 21 October 2016

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

A new series of Cu(II) and Ni(II) complexes with the Flavone ligand were prepared and spectroscopic method and elemental analysis verified their structures. All the prepared complexes have been identified by available spectroscopic tools (UV-Visible and IR) in addition the structure of complexes was characterized by magnetic moments and molar conductance in DMSO solution. From the above of these studies and measurements suggest an tetrahedral geometry around Cu(II) and Ni(II). A theoretical treatment of the formation of complexes in the gas phase was studied; this was done using the HYPERCHEM-6 program for the Molecular mechanics and Semi-empirical calculations.

Published in	International Journal of Pharmacy and Chemistry (Volume 2, Issue 2)
DOI	10.11648/j.ijpc.20160202.12
Page(s)	15-19
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Flavone, Metal Complexes, Synthesis, Spectral, Theoretical Evaluation

References

[1]	Hertog, M. G. L.; Feskens, E. J.; Hollman, P. C.; Katan, M. B.; Kromhout, D. Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen Elderly Study. Lancet 1993, 342, 1007-1011.
[2]	Knekt, P.; Kumpulainen, J.; Jarvinen, R.; Rissanen, H.; Heliovaara, M.; Reunanen, A.; Hakulinen, T.; Aromaa, A. Flavonoid intake and risk of chronic diseases. Am. J. Clin. Nutr. 2002, 76,560-568.
[3]	Cushnie, T.; Lamb, A. Antimicrobial activity of flavonoids. Int. J. Antimicrob. Agents, 2005, 26,343-356. And Maria M. Kasprzak, Andrea Erxleben and Justyn Ochocki, “Properties and applications of flavonoid metal complexes,” Review Article 2015. DOI: 10.1039/C5RA05069C
[4]	Ferguson, P. J.; Kurowska, E. M.; Freeman, D. J. In vivo inhibition of growth of human tumor lines by flavonoid fractions from cranberry extract. Nutr. Cancer 2006, 56, 86-94.
[5]	Jovanovic, S. V.; Steenken, S.; Simic, M. G.; Hara, Y.; Antioxidant properties of flavonoids: Reduction potentials and electron transfer reactions of flavonoid radicals. In Flavonoids in Health and Disease; Rice-Evans, C. A., Packer, L., Eds.; Marcel Dekker, Inc.: New York, NY, 1998; pp. 137-161.
[6]	Teixeira S.; Siquet, C.; Aloes, C.; Boal, I.; Marques, M. P.; Borges, F.; Lima, J. L. F. C.; Reis, S. Structure-property studies on the antioxidant activity of flavonoids present in diet. Free Radic. Biol. Med. 2005, 39, 1099-1108.
[7]	Pietta, P. G. Flavonoids as Antioxidants. J. Nat. Prod. 2000, 63, 1035-1042. And Yuanzhen Liu 1 and Mingquan Guo,” Studies on Transition Metal-Quercetin Complexes Using Electrospray Ionization Tandem Mass Spectrometry”, Molecules 2015, 20, 8583-8594; doi:10.3390/molecules20058583.
[8]	Van Acker, S. A. B. E.; van Den Berg, D.-J.; Tromp, M. N. J. L.; Griffioen, D. H.; van Bennekom, W. P.; van der Vijgh, W. J. F.; Bast, A. Structural aspects of antioxidant activity of flavonoids. Free Radic. Biol. Med. 1996, 20, 331-342.
[9]	van Acker, S. A. B.; van Balen, G. P.; van den Berg, D. J.; Bast, A.; van der Vijgh, W.F.F. Influence of iron chelation on the antioxidant activity of flavonoids. Biochem. Pharmacol. 1998, 56, 935-943.
[10]	Grazul, M.; Budzisz, E. Biological activity of metal ions complexes of chromones, coumarins and flavones. Coord. Chem. Rev. 2009, 253, 2588–2598.
[11]	Cazarolli, L. H.; Zanatta, L.; Jorge, A. P.; de Sousa, E.; Horst, H.; Woehl, V. M.; Pizzolatti, M. G.; Szpoganicz, B.; Silva, F. R. M. B. Follow-up studies on glycosylated flavonoids and their complexes with vanadium: Their anti- hyperglycemic potential role in diabetes. Chemico-Biol. Interact. 2006, 163, 177–191.
[12]	Pereira, R. M. S.; Andrades, N. E. D.; Paulino, N.; Sawaya, A. C. H. F.; Eberlin, M. N.; Marcucci M.C.; Favero, G. M.; Novak, E. M.; Bydlowski, S. P. Synthesis and Characterization of a Metal Complex Containing Naringin and Cu, and its Antioxidant, Antimicrobial, Antiinflammatory and Tumor Cell Cytotoxicity, Molecules 2007, 12, 1352-1366.
[13]	Jun, T.; Bochu, W.; Liancai, Z. Hydrolytic cleavage of DNA by quercetin zinc (II) complex. Bioorg. Med. Chem. Lett. 2007, 17, 1197-1199.
[14]	Lever, A. B. P. Inorganic Electronic Spectroscopy; Elsevier: Amsterdam, the Netherlands, 1986; pp. 385–392.
[15]	K. Nakmato, Infarred and Raman spectra of Inorganic and coordination compounds, 4th ed., Wiley, New York (1986). Omar H. Al-Obaidi.,” Synthesis, Spectral Characterization, Theoretical Evaluation Of New Cr (III), Co (II), Fe(III) And Cu(II) Complexes”, App. Sci. Report.,12 (1), 2015: 41-45
[16]	Malesev, D., Kuntic, V. Investigation of metal-flavonoid chelates and determination of flavonoids via metal-flavonoid complexing reactions. J. Serb. Chem. Soc. 2007, 72, pp 921-939.
[17]	Job, P. Recherches sur la formation de complexes mineraux en solution, et sur leur stabilite (in Paris). Ann. Chim. 1928, 9, pp 113-203.
[18]	Irving H. and Williams R. S. P., J. Chem. Soc., 3192 (1953).
[19]	Birt, F. D, Hendrich, S, Wang, W., “Dietary Agents in Cancer Prevention Flavonoids and Isoflavonoids Pharmacology and Therapeutics”, USA, pp 157-177, 2001.
[20]	Ikeda NE, Novak EM, Maria DA, Velosa AS, Pereira RM. “Synthesis, characterization and biological evaluation of Rutin-zinc(II) flavonoid -metal complex,” Chem Biol Interact. 2015. 5; 239: 184-91.

Cite This Article

Plain Text BibTeX RIS

APA Style

Omar H. Al-Obaidi. (2016). Synthesis, Spectral Characterization, Theoretical Evaluation of New Cu(II) and Ni(II) Complexes of Flavon. International Journal of Pharmacy and Chemistry, 2(2), 15-19. https://doi.org/10.11648/j.ijpc.20160202.12

Copy | Download

ACS Style

Omar H. Al-Obaidi. Synthesis, Spectral Characterization, Theoretical Evaluation of New Cu(II) and Ni(II) Complexes of Flavon. Int. J. Pharm. Chem. 2016, 2(2), 15-19. doi: 10.11648/j.ijpc.20160202.12

Copy | Download

AMA Style

Omar H. Al-Obaidi. Synthesis, Spectral Characterization, Theoretical Evaluation of New Cu(II) and Ni(II) Complexes of Flavon. Int J Pharm Chem. 2016;2(2):15-19. doi: 10.11648/j.ijpc.20160202.12

Copy | Download

@article{10.11648/j.ijpc.20160202.12,
  author = {Omar H. Al-Obaidi},
  title = {Synthesis, Spectral Characterization, Theoretical Evaluation of New Cu(II) and Ni(II) Complexes of Flavon},
  journal = {International Journal of Pharmacy and Chemistry},
  volume = {2},
  number = {2},
  pages = {15-19},
  doi = {10.11648/j.ijpc.20160202.12},
  url = {https://doi.org/10.11648/j.ijpc.20160202.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20160202.12},
  abstract = {A new series of Cu(II) and Ni(II) complexes with the Flavone ligand were prepared and spectroscopic method and elemental analysis verified their structures. All the prepared complexes have been identified by available spectroscopic tools (UV-Visible and IR) in addition the structure of complexes was characterized by magnetic moments and molar conductance in DMSO solution. From the above of these studies and measurements suggest an tetrahedral geometry around Cu(II) and Ni(II). A theoretical treatment of the formation of complexes in the gas phase was studied; this was done using the HYPERCHEM-6 program for the Molecular mechanics and Semi-empirical calculations.},
 year = {2016}
}

Copy | Download

TY  - JOUR
T1  - Synthesis, Spectral Characterization, Theoretical Evaluation of New Cu(II) and Ni(II) Complexes of Flavon
AU  - Omar H. Al-Obaidi
Y1  - 2016/10/21
PY  - 2016
N1  - https://doi.org/10.11648/j.ijpc.20160202.12
DO  - 10.11648/j.ijpc.20160202.12
T2  - International Journal of Pharmacy and Chemistry
JF  - International Journal of Pharmacy and Chemistry
JO  - International Journal of Pharmacy and Chemistry
SP  - 15
EP  - 19
PB  - Science Publishing Group
SN  - 2575-5749
UR  - https://doi.org/10.11648/j.ijpc.20160202.12
AB  - A new series of Cu(II) and Ni(II) complexes with the Flavone ligand were prepared and spectroscopic method and elemental analysis verified their structures. All the prepared complexes have been identified by available spectroscopic tools (UV-Visible and IR) in addition the structure of complexes was characterized by magnetic moments and molar conductance in DMSO solution. From the above of these studies and measurements suggest an tetrahedral geometry around Cu(II) and Ni(II). A theoretical treatment of the formation of complexes in the gas phase was studied; this was done using the HYPERCHEM-6 program for the Molecular mechanics and Semi-empirical calculations.
VL  - 2
IS  - 2
ER  -

Copy | Download

Author Information

Omar H. Al-Obaidi

Chemistry Department, Education College for Girls, Al-Anbar University, Ramadi, Iraq

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Omar H. Al-Obaidi. (2016). Synthesis, Spectral Characterization, Theoretical Evaluation of New Cu(II) and Ni(II) Complexes of Flavon. International Journal of Pharmacy and Chemistry, 2(2), 15-19. https://doi.org/10.11648/j.ijpc.20160202.12

Copy | Download

ACS Style

Omar H. Al-Obaidi. Synthesis, Spectral Characterization, Theoretical Evaluation of New Cu(II) and Ni(II) Complexes of Flavon. Int. J. Pharm. Chem. 2016, 2(2), 15-19. doi: 10.11648/j.ijpc.20160202.12

Copy | Download

AMA Style

Omar H. Al-Obaidi. Synthesis, Spectral Characterization, Theoretical Evaluation of New Cu(II) and Ni(II) Complexes of Flavon. Int J Pharm Chem. 2016;2(2):15-19. doi: 10.11648/j.ijpc.20160202.12

Copy | Download

@article{10.11648/j.ijpc.20160202.12,
  author = {Omar H. Al-Obaidi},
  title = {Synthesis, Spectral Characterization, Theoretical Evaluation of New Cu(II) and Ni(II) Complexes of Flavon},
  journal = {International Journal of Pharmacy and Chemistry},
  volume = {2},
  number = {2},
  pages = {15-19},
  doi = {10.11648/j.ijpc.20160202.12},
  url = {https://doi.org/10.11648/j.ijpc.20160202.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20160202.12},
  abstract = {A new series of Cu(II) and Ni(II) complexes with the Flavone ligand were prepared and spectroscopic method and elemental analysis verified their structures. All the prepared complexes have been identified by available spectroscopic tools (UV-Visible and IR) in addition the structure of complexes was characterized by magnetic moments and molar conductance in DMSO solution. From the above of these studies and measurements suggest an tetrahedral geometry around Cu(II) and Ni(II). A theoretical treatment of the formation of complexes in the gas phase was studied; this was done using the HYPERCHEM-6 program for the Molecular mechanics and Semi-empirical calculations.},
 year = {2016}
}

Copy | Download

TY  - JOUR
T1  - Synthesis, Spectral Characterization, Theoretical Evaluation of New Cu(II) and Ni(II) Complexes of Flavon
AU  - Omar H. Al-Obaidi
Y1  - 2016/10/21
PY  - 2016
N1  - https://doi.org/10.11648/j.ijpc.20160202.12
DO  - 10.11648/j.ijpc.20160202.12
T2  - International Journal of Pharmacy and Chemistry
JF  - International Journal of Pharmacy and Chemistry
JO  - International Journal of Pharmacy and Chemistry
SP  - 15
EP  - 19
PB  - Science Publishing Group
SN  - 2575-5749
UR  - https://doi.org/10.11648/j.ijpc.20160202.12
AB  - A new series of Cu(II) and Ni(II) complexes with the Flavone ligand were prepared and spectroscopic method and elemental analysis verified their structures. All the prepared complexes have been identified by available spectroscopic tools (UV-Visible and IR) in addition the structure of complexes was characterized by magnetic moments and molar conductance in DMSO solution. From the above of these studies and measurements suggest an tetrahedral geometry around Cu(II) and Ni(II). A theoretical treatment of the formation of complexes in the gas phase was studied; this was done using the HYPERCHEM-6 program for the Molecular mechanics and Semi-empirical calculations.
VL  - 2
IS  - 2
ER  -

Copy | Download