Effect of TCM Combined with Western Medicine on CD19+ B Lymphocytes in Children with IgA Vasculitis with Nephritis

Liu Jun-chao; Xu Hong; Shen Qian; Sun Li; Yu Jian; Liu Hai-mei; Li Guo-min

doi:doi:10.11648/j.ijpc.20220804.11

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Effect of TCM Combined with Western Medicine on CD19+ B Lymphocytes in Children with IgA Vasculitis with Nephritis

Liu Jun-chao, Xu Hong, Shen Qian, Sun Li, Yu Jian, Liu Hai-mei, Li Guo-min

Published in International Journal of Pharmacy and Chemistry (Volume 8, Issue 4)

Received: 9 March 2022 Accepted: 25 March 2022 Published: 14 September 2022

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Abstract

Introduction: Children with IgA vasculitis with nephritis (IgAVN) usually accepted TCM combined with western medicine therapy, but its effect on immune function is not clear, here is to analyze the change of peripheral blood CD19+ B lymphocytes in children with IgAVN after treatment of TCM combined with AECI or/and immunosuppressive agents. Methods: 46 children with IgAVN diagnosed from April 2016 to April 2017 were included and followed up in out-patient department till Dec 2021. All children with IgAVN were treated with TCM combined with ACEI or/and glucocorticoid steroids, with/without glucocorticoid-sparing agents. During treatment, urinary erythrocytes / urinary protein, peripheral blood CD (cluster of differentiation) of lymphocytes and serum immunoglobulins were tested before and after treatment. Results: All children with IgAVN except one were complete remission and no child progressed to CKD after 5-6 years follow-up. The counts of CD19+ B lymphocytes and CD19+ % in children with complete remission were significantly reduced after TCM combined with ACEI or/and glucocorticoid steroids with/without glucocorticoid-sparing agent (P < 0.01), the levels of serum IgA in children with complete remission and partial remission after 6 month combined therapy were significantly decreased (P < 0.01, P < 0.05), and IgM in partial remission children after 6 month combined therapy was significantly lower (P < 0.05). Conclusion: Peripheral blood CD19+ B lymphocytes in children with IgAVN decreased when it gained remission with treatment of TCM combined with ACEI or/and glucocorticoid steroids with/without glucocorticoid-sparing agent, suggesting that change of peripheral blood CD19+ B lymphocytes could be used to evaluate effect of therapy.

Published in	International Journal of Pharmacy and Chemistry (Volume 8, Issue 4)
DOI	10.11648/j.ijpc.20220804.11
Page(s)	39-43
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

IgA Vasculitis with Nephritis, Traditional Chinese Medicine (TCM), CD19+ B Lymphocytes

References

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[3]	Licia Peruzzi, Rosanna Coppo, IgA vasculitis nephritis in children and adults: one or different entities?, Pediatr Nephrol. 36 (2021) 2615-2625, doi: 10.1007/s00467-020-04818-7.
[4]	S Hu, A Birg, M Hovaida, M W Gavin, D McCarthy, Avoiding "Rash" Conclusions: Challenge of IgA Vasculitis in Adults, Dig Dis Sci. 62 (2017) 874-878, doi: 10.1007/s10620-017-4505-2.
[5]	Janet M M Gardner-Medwin, Pavla Dolezalova, Carole Cummins, Taunton R Southwood, Incidence of Henoch-Schönlein purpura, Kawasaki disease, and rare vasculitides in children of different ethnic origins, Lancet. 360 (2002) 1197-202, doi: 10.1016/S0140-6736(02)11279-7.
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[8]	Delbet JD, Parmentier C, Herbez Rea C, et al., Management of IgA Vasculitis with Nephritis, Paediatr Drugs. 23 (2021): 425-435, doi: 10.1007/s40272-021-00464-0.
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[14]	Delbet JD, Geslain G, Auger M, et al., Histological prognostic factors in children with Henoch-Schonlein purpura nephritis, Pediatr Nephrol. 35 (2020): 313-320, doi: 10.1007/s00467-019-04363-y.
[15]	Oni L, Sampath S, Childhood IgA Vasculitis (Henoch Schonlein Purpura)-Advances and Knowledge Gaps, Front Pediatr. 7 (2019) 257, doi: 10.3389 / fped. 2019. 00257.
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APA Style

Liu Jun-chao, Xu Hong, Shen Qian, Sun Li, Yu Jian, et al. (2022). Effect of TCM Combined with Western Medicine on CD19+ B Lymphocytes in Children with IgA Vasculitis with Nephritis. International Journal of Pharmacy and Chemistry, 8(4), 39-43. https://doi.org/10.11648/j.ijpc.20220804.11

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ACS Style

Liu Jun-chao; Xu Hong; Shen Qian; Sun Li; Yu Jian, et al. Effect of TCM Combined with Western Medicine on CD19+ B Lymphocytes in Children with IgA Vasculitis with Nephritis. Int. J. Pharm. Chem. 2022, 8(4), 39-43. doi: 10.11648/j.ijpc.20220804.11

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AMA Style

Liu Jun-chao, Xu Hong, Shen Qian, Sun Li, Yu Jian, et al. Effect of TCM Combined with Western Medicine on CD19+ B Lymphocytes in Children with IgA Vasculitis with Nephritis. Int J Pharm Chem. 2022;8(4):39-43. doi: 10.11648/j.ijpc.20220804.11

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@article{10.11648/j.ijpc.20220804.11,
  author = {Liu Jun-chao and Xu Hong and Shen Qian and Sun Li and Yu Jian and Liu Hai-mei and Li Guo-min},
  title = {Effect of TCM Combined with Western Medicine on CD19+ B Lymphocytes in Children with IgA Vasculitis with Nephritis},
  journal = {International Journal of Pharmacy and Chemistry},
  volume = {8},
  number = {4},
  pages = {39-43},
  doi = {10.11648/j.ijpc.20220804.11},
  url = {https://doi.org/10.11648/j.ijpc.20220804.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20220804.11},
  abstract = {Introduction: Children with IgA vasculitis with nephritis (IgAVN) usually accepted TCM combined with western medicine therapy, but its effect on immune function is not clear, here is to analyze the change of peripheral blood CD19+ B lymphocytes in children with IgAVN after treatment of TCM combined with AECI or/and immunosuppressive agents. Methods: 46 children with IgAVN diagnosed from April 2016 to April 2017 were included and followed up in out-patient department till Dec 2021. All children with IgAVN were treated with TCM combined with ACEI or/and glucocorticoid steroids, with/without glucocorticoid-sparing agents. During treatment, urinary erythrocytes / urinary protein, peripheral blood CD (cluster of differentiation) of lymphocytes and serum immunoglobulins were tested before and after treatment. Results: All children with IgAVN except one were complete remission and no child progressed to CKD after 5-6 years follow-up. The counts of CD19+ B lymphocytes and CD19+ % in children with complete remission were significantly reduced after TCM combined with ACEI or/and glucocorticoid steroids with/without glucocorticoid-sparing agent (P < 0.01), the levels of serum IgA in children with complete remission and partial remission after 6 month combined therapy were significantly decreased (P < 0.01, P < 0.05), and IgM in partial remission children after 6 month combined therapy was significantly lower (P < 0.05). Conclusion: Peripheral blood CD19+ B lymphocytes in children with IgAVN decreased when it gained remission with treatment of TCM combined with ACEI or/and glucocorticoid steroids with/without glucocorticoid-sparing agent, suggesting that change of peripheral blood CD19+ B lymphocytes could be used to evaluate effect of therapy.},
 year = {2022}
}

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TY  - JOUR
T1  - Effect of TCM Combined with Western Medicine on CD19+ B Lymphocytes in Children with IgA Vasculitis with Nephritis
AU  - Liu Jun-chao
AU  - Xu Hong
AU  - Shen Qian
AU  - Sun Li
AU  - Yu Jian
AU  - Liu Hai-mei
AU  - Li Guo-min
Y1  - 2022/09/14
PY  - 2022
N1  - https://doi.org/10.11648/j.ijpc.20220804.11
DO  - 10.11648/j.ijpc.20220804.11
T2  - International Journal of Pharmacy and Chemistry
JF  - International Journal of Pharmacy and Chemistry
JO  - International Journal of Pharmacy and Chemistry
SP  - 39
EP  - 43
PB  - Science Publishing Group
SN  - 2575-5749
UR  - https://doi.org/10.11648/j.ijpc.20220804.11
AB  - Introduction: Children with IgA vasculitis with nephritis (IgAVN) usually accepted TCM combined with western medicine therapy, but its effect on immune function is not clear, here is to analyze the change of peripheral blood CD19+ B lymphocytes in children with IgAVN after treatment of TCM combined with AECI or/and immunosuppressive agents. Methods: 46 children with IgAVN diagnosed from April 2016 to April 2017 were included and followed up in out-patient department till Dec 2021. All children with IgAVN were treated with TCM combined with ACEI or/and glucocorticoid steroids, with/without glucocorticoid-sparing agents. During treatment, urinary erythrocytes / urinary protein, peripheral blood CD (cluster of differentiation) of lymphocytes and serum immunoglobulins were tested before and after treatment. Results: All children with IgAVN except one were complete remission and no child progressed to CKD after 5-6 years follow-up. The counts of CD19+ B lymphocytes and CD19+ % in children with complete remission were significantly reduced after TCM combined with ACEI or/and glucocorticoid steroids with/without glucocorticoid-sparing agent (P < 0.01), the levels of serum IgA in children with complete remission and partial remission after 6 month combined therapy were significantly decreased (P < 0.01, P < 0.05), and IgM in partial remission children after 6 month combined therapy was significantly lower (P < 0.05). Conclusion: Peripheral blood CD19+ B lymphocytes in children with IgAVN decreased when it gained remission with treatment of TCM combined with ACEI or/and glucocorticoid steroids with/without glucocorticoid-sparing agent, suggesting that change of peripheral blood CD19+ B lymphocytes could be used to evaluate effect of therapy.
VL  - 8
IS  - 4
ER  -

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Author Information

Liu Jun-chao

Department of Traditional Chinese Medicine, Children’s Hospital of Fudan University, Shanghai, China
Xu Hong

Department of Nephrology, Children's Hospital of Fudan University, Shanghai, China
Shen Qian

Department of Nephrology, Children's Hospital of Fudan University, Shanghai, China
Sun Li

Department of Rheumatology, Children’s Hospital of Fudan University, Shanghai, China
Yu Jian

Department of Traditional Chinese Medicine, Children’s Hospital of Fudan University, Shanghai, China
Liu Hai-mei

Department of Rheumatology, Children’s Hospital of Fudan University, Shanghai, China
Li Guo-min

Department of Rheumatology, Children’s Hospital of Fudan University, Shanghai, China

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Plain Text BibTeX RIS

APA Style

Liu Jun-chao, Xu Hong, Shen Qian, Sun Li, Yu Jian, et al. (2022). Effect of TCM Combined with Western Medicine on CD19+ B Lymphocytes in Children with IgA Vasculitis with Nephritis. International Journal of Pharmacy and Chemistry, 8(4), 39-43. https://doi.org/10.11648/j.ijpc.20220804.11

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ACS Style

Liu Jun-chao; Xu Hong; Shen Qian; Sun Li; Yu Jian, et al. Effect of TCM Combined with Western Medicine on CD19+ B Lymphocytes in Children with IgA Vasculitis with Nephritis. Int. J. Pharm. Chem. 2022, 8(4), 39-43. doi: 10.11648/j.ijpc.20220804.11

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AMA Style

Liu Jun-chao, Xu Hong, Shen Qian, Sun Li, Yu Jian, et al. Effect of TCM Combined with Western Medicine on CD19+ B Lymphocytes in Children with IgA Vasculitis with Nephritis. Int J Pharm Chem. 2022;8(4):39-43. doi: 10.11648/j.ijpc.20220804.11

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@article{10.11648/j.ijpc.20220804.11,
  author = {Liu Jun-chao and Xu Hong and Shen Qian and Sun Li and Yu Jian and Liu Hai-mei and Li Guo-min},
  title = {Effect of TCM Combined with Western Medicine on CD19+ B Lymphocytes in Children with IgA Vasculitis with Nephritis},
  journal = {International Journal of Pharmacy and Chemistry},
  volume = {8},
  number = {4},
  pages = {39-43},
  doi = {10.11648/j.ijpc.20220804.11},
  url = {https://doi.org/10.11648/j.ijpc.20220804.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20220804.11},
  abstract = {Introduction: Children with IgA vasculitis with nephritis (IgAVN) usually accepted TCM combined with western medicine therapy, but its effect on immune function is not clear, here is to analyze the change of peripheral blood CD19+ B lymphocytes in children with IgAVN after treatment of TCM combined with AECI or/and immunosuppressive agents. Methods: 46 children with IgAVN diagnosed from April 2016 to April 2017 were included and followed up in out-patient department till Dec 2021. All children with IgAVN were treated with TCM combined with ACEI or/and glucocorticoid steroids, with/without glucocorticoid-sparing agents. During treatment, urinary erythrocytes / urinary protein, peripheral blood CD (cluster of differentiation) of lymphocytes and serum immunoglobulins were tested before and after treatment. Results: All children with IgAVN except one were complete remission and no child progressed to CKD after 5-6 years follow-up. The counts of CD19+ B lymphocytes and CD19+ % in children with complete remission were significantly reduced after TCM combined with ACEI or/and glucocorticoid steroids with/without glucocorticoid-sparing agent (P < 0.01), the levels of serum IgA in children with complete remission and partial remission after 6 month combined therapy were significantly decreased (P < 0.01, P < 0.05), and IgM in partial remission children after 6 month combined therapy was significantly lower (P < 0.05). Conclusion: Peripheral blood CD19+ B lymphocytes in children with IgAVN decreased when it gained remission with treatment of TCM combined with ACEI or/and glucocorticoid steroids with/without glucocorticoid-sparing agent, suggesting that change of peripheral blood CD19+ B lymphocytes could be used to evaluate effect of therapy.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Effect of TCM Combined with Western Medicine on CD19+ B Lymphocytes in Children with IgA Vasculitis with Nephritis
AU  - Liu Jun-chao
AU  - Xu Hong
AU  - Shen Qian
AU  - Sun Li
AU  - Yu Jian
AU  - Liu Hai-mei
AU  - Li Guo-min
Y1  - 2022/09/14
PY  - 2022
N1  - https://doi.org/10.11648/j.ijpc.20220804.11
DO  - 10.11648/j.ijpc.20220804.11
T2  - International Journal of Pharmacy and Chemistry
JF  - International Journal of Pharmacy and Chemistry
JO  - International Journal of Pharmacy and Chemistry
SP  - 39
EP  - 43
PB  - Science Publishing Group
SN  - 2575-5749
UR  - https://doi.org/10.11648/j.ijpc.20220804.11
AB  - Introduction: Children with IgA vasculitis with nephritis (IgAVN) usually accepted TCM combined with western medicine therapy, but its effect on immune function is not clear, here is to analyze the change of peripheral blood CD19+ B lymphocytes in children with IgAVN after treatment of TCM combined with AECI or/and immunosuppressive agents. Methods: 46 children with IgAVN diagnosed from April 2016 to April 2017 were included and followed up in out-patient department till Dec 2021. All children with IgAVN were treated with TCM combined with ACEI or/and glucocorticoid steroids, with/without glucocorticoid-sparing agents. During treatment, urinary erythrocytes / urinary protein, peripheral blood CD (cluster of differentiation) of lymphocytes and serum immunoglobulins were tested before and after treatment. Results: All children with IgAVN except one were complete remission and no child progressed to CKD after 5-6 years follow-up. The counts of CD19+ B lymphocytes and CD19+ % in children with complete remission were significantly reduced after TCM combined with ACEI or/and glucocorticoid steroids with/without glucocorticoid-sparing agent (P < 0.01), the levels of serum IgA in children with complete remission and partial remission after 6 month combined therapy were significantly decreased (P < 0.01, P < 0.05), and IgM in partial remission children after 6 month combined therapy was significantly lower (P < 0.05). Conclusion: Peripheral blood CD19+ B lymphocytes in children with IgAVN decreased when it gained remission with treatment of TCM combined with ACEI or/and glucocorticoid steroids with/without glucocorticoid-sparing agent, suggesting that change of peripheral blood CD19+ B lymphocytes could be used to evaluate effect of therapy.
VL  - 8
IS  - 4
ER  -

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