Fundamentals to Diagnosing Polycystic Ovary Syndrome in Adolescents: A Critical Literature Review

Sebastião Freitas de Medeiros; Ana Karine Lin Winck Yamamoto de Medeiros; Letícia Ferreira de Magalhães; Márcia Marly Winck Yamamoto; Matheus Antônio Souto de Medeiros

doi:doi:10.11648/j.jgo.20241204.12

Review Article |

| Peer-Reviewed

Fundamentals to Diagnosing Polycystic Ovary Syndrome in Adolescents: A Critical Literature Review

Sebastião Freitas de Medeiros^*

, Ana Karine Lin Winck Yamamoto de Medeiros

, Letícia Ferreira de Magalhães

, Márcia Marly Winck Yamamoto

, Matheus Antônio Souto de Medeiros

Published in Journal of Gynecology and Obstetrics (Volume 12, Issue 4)

Received: 23 July 2024 Accepted: 14 August 2024 Published: 30 August 2024

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Abstract

Background: Because of this prevalence and frequent association with various comorbidites, the diagnosis of polycystic ovary syndrome (PCOS) must be performed as early as possible. Despite conflicting findings, many studies have been published on adolescents with a diagnosis of polycystic ovary syndrome. Methods: The Google Scholar and PubMed data bases were searched for publications in the English language reporting on PCOS diagnosis in adolescents. Results: A comprehensive analysis of data regarding the overlay of physiological ripening of menstrual cycle characteristics, androgen levels, and ovary aspects during puberty with the established criteria to diagnose PCOS in adults revealed that are liable diagnosis of PCOS in adolescence is possibleas soon as 2-3 years postmenarche. Persistant menstrual cycle intervals shorter than 21 days or longer than 45 days, total testosterone levels >1.9-2.0 nmol/l and ovary volume >10cm³after 15-16 years of age can be used to diagnose PCOS. Conclusion: When combined, any persistent deviation of physiological parameters in adolescents as a criterion to diagnose PCOS in adults allows a certain diagnosis of PCOS in adolescents.

Published in	Journal of Gynecology and Obstetrics (Volume 12, Issue 4)
DOI	10.11648/j.jgo.20241204.12
Page(s)	67-80
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Polycystic Ovary Syndrome, Adolescents, Puberty, Menstrual Cycle, Androgens, Ultrasonic Diagnosis

References

[1]	Zawadski JS, Dunaif A. Diagnostic criteria for polycystic ovary syndrome: toward a rational approach. In: Dunaif A, Givens JR, Haseltine FP. Polycystic Ovary Syndrome. Boston: Blackwell Scientifc. 1992: 377-384.
[2]	The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004; 19(1): 41-47. https://doi.org/10.1093/humrep/deh098
[3]	Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE, Witchel SF, Androgen Excess Society. Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline. J Clin Endocrinol Metabol. 2006; 91(11): 4237-4245. https://doi.org/10.1210/jc.2006-0178
[4]	Legro RS, Arsalanian SA, Ehrmann DA, Hoeger KM, Murad MH, Pasquali R, Welt CK, Endocrine Society. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2013; 98(12): 4565-4592. https://doi.org/10.1210/jc.2013-2350
[5]	Pediatric Endocrine Society (PES) Annual Meeting. Horm Res Paediatr. 2020; 93(Suppl 1): 1-185.
[6]	Witchel SF, Oberfield S, Rosenfield RL, Codner E, Bonny A, Ibañez L, Peña A, Horikawa R, Gomez-Lobo V, Joel D, Tfayli H, Arslanian S, Dabadghao P, Rudaz CG, Lee PA. The diagnosis of polycystic ovary syndrome during adolescence. Horm Res Paediatr, 2015; 83(6): 376–389. https://doi.org/10.1159/000375530
[7]	Fauser BC, Tarlatzis BC, Rebar RW. Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group. Fertil Steril. 2012; 97(1): 28-38. E25. https://doi.org/10.1016/j.fertnstert.2011.09.024
[8]	Elene A, Jenaro K. Ovarian morphology by ultrasound imaging in adolescents with PCOS and age-matched controls. J Endocrinol Thyroid Res. 2019; 5(1): 1. https://doi.org/10.19080/JETR.2019.05.555653
[9]	Hasewaga Y, Kitahara Y, Kobayashi M, Miida M, Nenoi H, Tsukui Y, Iizuka M, Hiraishi H, Nakazato S, Iwase A. Impact of the difference in diagnostic criteria for adolescent polycystic ovary syndrome excluding polycystic ovarian morphology. J Obstet Gynaecol Res. 2024. https://doi.org/10.1111/jog.15975
[10]	Teede HJ, Tay CT, Laven J, Dokras A, Moran LJ, Piltonen TT, Costello MF, Boivin J, Redman LM, Boyle JA, Norman RJ, Mousa A, Joham AE, International PCOS Network. Recommendations from the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. Fertil Steril. 2023; 120(4): 767-793. https://doi.org/10.1210/clinem/dgad463
[11]	Peña AS, Witchel SF, Hoeger KM, Oberfield SE, Vogiatzi MG, Misso RG, Dadabghao P, Teede H. Adolescent polycystic ovary syndrome according to the international evidence-based guideline. BMC Medicine. 2020; 18(1): 72. https://doi.org/10.1186/s12916-020-01516-x
[12]	Kelsey TW, Dodwell SK, Wilkinson AG, Greve T, Andersen CY, Anderson RA, Wallace HB. Ovarian volume throughout life: a validated normative model. PLoS One. 2013; 8(9): e71465. https://doi.org/10.1371/journal.pone.0071465.
[13]	Tehrani FR, Amiri M. Polycystic Ovary Syndrome in adolescents: Challenges in diagnosis and treatment. Int J Endocrinol Metab. 2019; 17(3): e91554. https://doi.org/10.5812/ijem.91554
[14]	Meczelaski B, Niwczyk O, Kostrzak A, Maciejewska-Jeske M. PCOS in adolescents-ongoing riddles in diagnosis and treatment. J Clin Med. 2023; 12(3): 1221. https://doi.org/10.3390/jcm12031221
[15]	Codner E, Villarroel C, Eyzaguirre FC, López P, Merino PM, Pérez-Bravo F, Iñiguez G, Cassorla F. Polycystic ovarian morphology in postmenarchal adolescents. Fertil Steril. 2011; 95(2): 702–706. e2. https://doi.org/10.1016/j.fertnstert.2010.06.015
[16]	Wild, R. Androgens in the adolescent. In: Lavery, J. P., Sanfilippo, J. S. (eds) Pediatric and Adolescent Obstetrics and Gynecology. Clinical Perspective in Obstetrics and Gynecology, New York, NY. Springer. 1985, 84-95 https://doi.org/10.1007/978-1-4612-5064-7_7
[17]	Sonak M, Rathod PD, Patankar US. A prospective observational study of polycystic ovarian syndrome among adolescent and young girls at tertiary care hospital. J Reprod Contracept Obstetric Gynecol. 2022; 11(9): 2487. https://doi.org/10.18203/2320-1770.ijrcog20222315.
[18]	Sizonenko PC, Paunier L, Carmignac D. Hormonal changes during puberty. IV. Longitudinal study of adrenal androgen secretions. Horm Res. 1976; 7(4-5): 288-302. https://doi.org/10.1159/000178740
[19]	Sizonenko, PC. Endocrinology in preadolescents and adolescents. I. Hormonal changes during normal puberty. Am J Dis Children.1978; 132(7): 704-712. https://doi.org/10.1001/archpedi.1978.02120320064015
[20]	Houghton LC, Knight JA, Wei Y, Romeo RD, Goldberg M, Andrulis IL, Bradbury AR, Buys SS, Daly MB, John EM, Chung WK, Santella RM, Stanczyk FZ, Terry MB. Association of prepubertal and adolescent androgen concentrations with timing of breast development and family history of breast cancer. J Am Med Assoc. 2019; 2(2): e190083. https://doi.org/10.1001/jamanetworkopen.2019.0083
[21]	Santi M, Graf S, Zeino M, Cools M, Van de Vijver K, Trippel M, Aliu, Fluck CE. Approach to the virilizing girl at puberty. J Clin Endocrinol Metab. 2021; 106(5): 1530-1539. https://doi.org/10.1210/clinem/dgaa948
[22]	Rosenfield RL, Ghai K, Ehrmann DA, Barnes RB. Diagnosis of the polycystic ovary syndrome in adolescence: comparison of adolescent and adult hyperandrogenism. J Pediatr Endocrinol Metabol. 2000; 13(5): 1285-1289.
[23]	De Medeiros SF, Yamamoto MMW, Souto de Medeiros MA, Barbosa BB, Soares JM, Baracat EC. Changes in clinical and biochemical characteristics of polycystic ovary syndrome with advancing age. Endocr Connect. 2020a; 9(2): 74-89. https://doi.org/10.1530/EC-19-0496
[24]	Carmina E, Stanczyk FZ, Lobo RA. Evaluation of hormonal status. Yen and Jaffe's Reprod Endocrinol. 9th ed. Philadelphia: Elsever-Saunders, 2009. Chapter 31, pg 742-771. https://doi.org/ 10.1016/B978-0-323-47912-7.00034-2.
[25]	Sopher AB, Oberfiels SE, Witchel SF. Puberty: gonadarche and menarche. Yen an Jaff's reprod endocrinol. Yen and Jaffe’s Reprod Endocrinol. 9th ed. Philadelphia: Elsevier-Saunders, 2009, Chapter 18, pg 395-448.
[26]	Siegberg R, Nilsson CG, Stenman UH, Widholm O. Endocrinologic features of oligomenorrheic adolescent girls. Fertil Steril. 1986; 46(5): 852-857.
[27]	Kulle AE, Reinehr T, Simic-Schleicher G, Horning NC, Holterhus PM. Determination of 17OHPreg and DHEAS by LC-MS/MS: impact of age, sex, pubertal stage, and BMI on the Δ5 steroid pathway. J Clin Endocrinol Metab. 2017; 102(1): 232-241. https://doi.org/10.1210/jc.2016-2849
[28]	Venturoli S, Porcu E, Pluchinotta V, Ruggeri S, Macrelli S, Paradisi R, Flamigni C. Longitudinal change of sonographic ovarian aspects and endocrine parameters in irregular cycles of adolescence. Pediatr Research. 1995; 38(6): 974-980. https://doi.org/10.1203/00006450-199512000-00024
[29]	de Medeiros SF, de Medeiros MAS, Barbosa BB, Yamamoto MMW, Maciel GAR. Comparison of metabolic and obesity biomarkers between adolescent and adult women with polycystic ovary syndrome. Arch Gynecol Obstet. 2020b; 303(3): 739-749. https://doi.org/10.1007/s00404-020-05867-x
[30]	Merino PM, Pereira A, Iñiguez G, Corvalan C, Mericq V. High DHEAS level in girls is associated with earlier pubertal maturation and mild increase in androgens throughout puberty whithout affecting postmenarche ovarian morphology. Horm Res Paediatr. 2019; 92(6): 357-364. https://doi.org/10.1159/000506632
[31]	Kulle AE, Riepe FG, Melchior D, Hiort O, Holterhus PM. A novel ultrapressure liquid chromatography tandem mass spectrometry method for the simultaneous determination of androstenedione, testosterone, and dihydrotestosterone in pediatric blood samples: age- and sex-specific reference data. J Clin Endocrinol Metabol. 2010; 95(5): 2399-409. https://doi.org/10.1210/jc.2009-1670
[32]	Villarroel C, Merino PM, López P, Eyzaguirre, Velzen AV, Iñiguez G, Codner E. Polycystic ovarian morphology in adolescents with regular menstrual cycles is associated with elevated anti-Mullerian hormone. Hum Reprod. 2011; 26(10): 2861-2868. https://doi.org/10.1093/humrep/der223
[33]	Van Hoof MH, Voorhorst FJ, Kaptein MB, Hirasing RA, Koppenaal C, Schoemaker J. Polycystic ovaries in adolescents and the relationship with menstrual cycle patterns, luteinizing hormone, androgens, and insulin. Fertil Steril. 2000; 74(1): 49-58. https://doi.org/10.1016/s0015-0282(00)00584-7
[34]	van Hoof MHA, Voorhosrt FJ, Kaptein MBH, Hirasing RA, Koppenaal C, Schoemaker J. Predictive value of menstrual cycle pattern, body mass index, hormone levels and polycystic ovaries at age 15 years for oligo-amenorrhoea at age 18 years. Hum Reprod. 2004; 19(2): 383-392. https://doi.org/10.1093/humrep/deh079
[35]	Mouritsen A, Aksglaede L, Soerensen K, Hagen CP, Petersen JH, Main KM, Juul A. The pubertal transition in 179 healthy Danish children: associations between pubarche, adrenarche, gonadarche, and body composition. Eur J Endocrinol. 2013; 168: 129-136. https://doi.org/10.1530/EJE-12-0191
[36]	Moll GW Jr, Rosenfield RL. Plasma free testosterone in the diagnosis of adolescent polycystic ovary syndrome. J Pediatr. 1983; 102(3): 461-464. https://doi.org/10.1016/s0022-3476(83)80678-7
[37]	Senefeld JW, Coleman DL, Johnson PW, Carter RE, Clayurn AJ, Joyner M. Divergence in timing and magnitude of testosterone levels between male and female youths. J Am Med Assoc. 2020; 324(1): 99-101. https://doi.org/10.1001/jama.2020.5655
[38]	Ankarberg C, Norjavaara E. Diurnal rhythm of testosterone secretion before and throughout puberty in healthy girls: correlation with 17beta-estradiol and dehydroepiandrosterone sulfate. J Clinic Endocrinol Metab. 1999; 84(3): 975-984. https://doi.org/10.1210/jcem.84.3.5524
[39]	McCartney CR, Blank SK, Prendergast KA, Chhabra S, Eagleson CA, Helm KD, Yoo R, Chang J, Foster CM, Caprio S, Marshall JC. Obesity and sex steroid changes across puberty: evidence for marked hyperandrogenemia in pre- and early pubertal obese girls. J Clin Endocrinol Metabol. 2007; 92(2): 430-436. https://doi.org/10.1210/jc.2006-2002
[40]	Akgul S, Duzçeker Y, Kanbur N, Derman O. Do different diagnostic criteria impact polycystic ovary syndrome diagnosis for adolescents? J Pediatr Adolesc Gynecol. 2018; 31(3): 258-262. https://doi.org/10.1016/j.jpag.2017.12.002
[41]	Fanelli F, Gambineri A, Belluomo I, Repaci A, Di Lallo VD, Di Dalmazi G, Mezzullo M, Prontera O, Cuomo G, Zanotti L, Paccapelo A, Morselli-Labate A, Pagotto U, Pasquali R. Androgen profiling by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in healthy normal-weight ovulatory and anovulatory late adolescent and young women. J Clin Endocrinol Metabol. 2013; 98(7): 3058-3067. https://doi.org/10.1210/jc.2013-1381
[42]	Milczarek M, Kucharska A, Borowiec A. Difficulties in diagnostics of polycystic ovary syndrome in adolescents - a preliminary study. Pediatr Endocrinol Diabet Metabol. 2019; 25(3): 122-126. https://doi.org//pedm.2019.87177
[43]	Patel S, Pushpalatha K, Singh B, Shrisvastava R, Singh G, Deepti D. Evaluation of hormonal profile and ovarian morphology among adolescent girls with menstrual irregularities in a tertiary care centre at central India. Scient World J. 2022. https://doi.org/10.1155/2022.304.76.56
[44]	Ortega MT, McGrath JA, Carlson L, Poccia VF, Larson G, Douglas C, Sun BZ, Zhao S, Beery B, Vesper HW, Duke L, Botelho JC, Filie AC, Shaw ND. Longitudinal investigation of pubertal milestones and hormones as a function of body fat in girls. J Clin Endocrinol Metab. 2021; 106(6): 1668-1683. https://doi.org/10.1210/clinem/dgab092
[45]	Jain S, Jain M, Shukla RC. Correlation of clinical, hormonal, biochemical and ultrasound parameters between adult and adolescent polycystic ovarian syndrome: adult and adolescent PCOS. J Obstet Gynaecol India. 2022; 72(1): 274-280. https://doi.org/10.1007/s13224-021-01557-z
[46]	Hillard PJA. Menstruation in adolescents: what do we know? And what do we do with the information?. J PediatrAdolesc Gynecol. 2014; 27(6): 309-19. https://doi.org/10.1016/j.jpag.2013.12.001
[47]	Frank D, Williams T. Attitudes about menstruation among fifth-, sixth-, and seventh-grade pre- and post-menarcheal girls. J Sch Nursing. 1999; 15(4): 25-31. https://doi.org/10.1177/105984059901500405
[48]	Chumlea WC, Schubert CM, Roche AF, Kulin HE, Lee PA, Himes JH, Sun SS. Age at menarche and racial comparisons in US girls. Pedriatrics. 2003; 111(1): 110-113. https://doi.org/10.1542/peds.111.1.110
[49]	Demerath EW, Towne B, Chumlea WC, Sun SS, Czerwinski SA, Remsberg KE, Siervogel RM. Recent decline in age at menarche: the FELS longitudinal study. Am J Hum Biol. 2004; 16(4): 453-457. https://doi.org/10.1002/ajhb.20039
[50]	Freedman DS, Khan LK, Serdula MK, Dietz WH, Srinivasan SR, Berenson GS. Relation of age at menarche to race, time period, and anthropometric dimensions: the Bogalusa Heart Study. Pediatrics. 2002; 110(4): e43. https://doi.org/10.1542/peds.110.4.e43
[51]	Treloar AE, Boyton RE, Behn BG, Brown BW. Variation of the human menstrual cycle through reproductive life. Int J Fertil. 1967; 12(1 Pt 2): 77-126.
[52]	World Health Organization. Multicenter study on menstrual and ovulatory patterns in adolescent girls: II. Longitudinal study of menstrual patterns in the early postmenarcheal period, duration of bleeding episodes and menstrual cycles. Sci Direct 1986; 7(4): 236-244.
[53]	American Academy of Pediatrics, Committee on Adolescence, American College of Obstetricians Gynecologists and Committee on Adolescent Health Care. Menstruation in girls and adolescents: usin the menstrual cycle as a vital sign. Pediatrics . 2006; 118(5): 2245-2250. https://doi.org/10.1097/AOG.0000000000001215
[54]	Vollman RF. The menstrual cycle. Major Probl Obstet Gynecol. 1977; 7(1): 1-193.
[55]	Vihko R, Apter D. Endocrine characteristics of adolescent menstrual cycles: impact of early menarche. J Steroid Biochem. 1984; 20(1): 231-236. https://doi.org/10.1016/0022-4731(84)90209-7
[56]	Committee on Adolescent Health Care Services and Models of Care for Treatment, Prevention, and Healthy Development, NIH. Adolescent Health Services: Missing Opportunities. National Academies Press (US), 2009. https://doi.org/10.17226/12063
[57]	Carlson LJ, Shaw ND. Development of ovulatory menstrual cycles in adolescent girls. J Pediatr Adolesc Gynecol. 2019; 32(3): 249-253. https://doi.org/10.1016/j.jpag.2019.02.119
[58]	Metcalf MG, Skidmore DS, Lowry GF, Mackenzie JA. Incidence of ovulation in the years after the menarche. J Endocrinol. 1983; 97(2): 213-219. https://doi.org/10.1677/joe.0.0970213
[59]	Widholm O, Kantero RL: A statistical analysis of the menstrual patterns of 8.000 Finnish girls and their mothers. Acta Obstet Gynecol Scand. 1971; 14(Suppl 14): 1-36.
[60]	Apter D, Viinikka L, Vihko R. Hormonal pattern of adolescent menstrual cycles. J Clin Endocrinol Metabol. 1978; 47(5): 944-954. https://doi.org/10.1210/jcem-47-5-944
[61]	Rigon F, Bianchin L, Bernasconi S, Bona G, Bozzola M, Buzi F, Cicogani A, De Sanctis C, De Sanctis V, Radetti G, Tató L, Tonini G, Perissinotto E. Update on age at menarche in Italy: toward the leveling off of the secular trend. J Adolesc Health. 2010; 46(3): 238-244. https://doi.org/10.1016/j.jadohealth.2009.07.009
[62]	Rigon F, De Sanctis V, Bernasconi S, Bianchin L, Bona G, Bozzola M, Buzi F, Radetti G, Tatò L, Tonini G, De Sanctis C, Perissinotto E. Menstrual pattern and menstrual disorders among adolescents: an update of the Italian data. Ital J Pediatr. 2012; 38(1): 38. https://doi.org/10.1186/1824-7288-38-38
[63]	Legro RS, Lin HM, Demers LM, Lloyd T. Rapid maturation of the reproductive axis during perimenarche independent of body composition. J Clin Endocrinol Metab. 2000; 85(3): 1021-1025. https://doi.org/10.1210/jcem.85.3.6423
[64]	Clavel-Chapelon F. E3N-Epic group. European prospective investigation into cancer. Evolution of age at menarche and at onset of regular cycling in a large cohort of French women. Hum Reprod. 2002; 17(1): 228-232. https://doi.org/10.1093/humrep/17.1.228
[65]	Hosowaka M, Imazeki S, Mizunuma H, Kubota T, Hayashi K. Secular trends in age at menarche and time to stablish regular menstrual cycling in Japanese women born between 1930 and 1985. BMC Womens Health. 2012; 12(1): 1-6. https://doi.org/10.1186/1472-6874-12-19
[66]	Zhang K, Pollak S, Ghods A, Dicken C, Isaac B, Adel G, Zeitlian G, Santoro N. Onset of ovulation after menarche in girls: a longitudinal study. J Clin Endocrinol Metab. 2008; 93(4): 1186-1194. https://doi.org/10.1210/jc.2007-1846
[67]	Carmina E, Oberfield SE, Lobo RA. The diagnosis of polycystic ovary syndrome in adolescents. Am J Obstet Gynecol. 2010; 203(3): 201. e1-e5.
[68]	Hickey M, Doherty DA, Atkinson H, Sloboda DM, Franks S, Norman RJ, Hart R. Clinical, ultrasound and biochemical features of polycystic ovary syndrome in adolescents: implications for diagnosis. HumReprod. 2011; 26(6): 1469-1477. https://doi.org/10.1093/humrep/der102
[69]	Orsini LF, Salardi S, Pilu G, Bovicelli L, Cacciari E. Pelvic organs in premenarcheal girls: real-time ultrasonography. Radiology. 1984; 153(1): 113-116. https://doi.org/10.1148/radiology.153.1.6473771
[70]	Bentzen JG, Forman JL, Johannsen TH, Pinborg A, Larsen EC, Andersen AN. Ovarian antral follicle subclasses and anti-mullerian hormone during normal reproductive aging. J Clin Endocrinol Metab. 2013; 98(4): 1602-1611. https://doi.org/10.1210/jc.2012-1829
[71]	Chen Y, Yang D, Li L, Chen X. The role of ovarian volume as a diagnostic criterion for Chinese adolescents with polycystic ovary syndrome. J Pediatr Adolesc Gynecol. 2008; 21(6): 347-350. https://doi.org/10.1016/j.jpag.2008.01.081
[72]	Radivojevic UD, Lazaovic GB, Kravic-Stevovic TK, Puzigaca ZD, Canovic FM, Nikolic RR, Milicevic SM. Differences in anthropometric and ultrasonographic parameters between adolescent girls with regular and irregular menstrual cycles: a case-study of 835 cases. J Pediatr Adolesc Gynecol. 2014; 27(4): 227-231. https://doi.org/10.1016/j.jpag.2013.11.007
[73]	Sample WF, Lippe BM, Gyepes MT. Gray-scale ultrasonography of the normal female pelvis. Radioloy. 1977; 125(2): 477-483. https://doi.org/10.1148/125.2.477
[74]	Cohen HL, Tice HM, Mandel FS: Ovarian volumes measures by US: bigger than we think. Radiology. 1990; 177(1): 189-192. https://doi.org/10.1148/radiology.177.1.2204964
[75]	Peters H. The human ovary in childhood and early maturity. Eur J Obstet Gynecol Reprod Biol. 1979; 9(3): 137-144.
[76]	Venturoli S, Porcu E, Fabbri R. Polycystic ovarian syndrome and adolescence. In Genazzani AR, Petraglia F, Volpe A (eds) Prog Gynecol Obst. 1989; p539-544.
[77]	Webber LJ, Stubbs S, Stark J, Trew GH, Margara R, Hardy K, Franks S. Formation and early development of follicles in the polycystic ovary. Lancet. 2003; 362(9389): 1017-1021. https://doi.org/10.1016/s0140-6736(03)14410-8
[78]	Franks S, Stark J, Hardy K. Follicles dynamis and ovulation in polycystic ovary syndrome. Hum Reprod Update. 2008; 14(4): 367-368. https://doi.org/10.1093/humupd/dmn015
[79]	Hsueh AJ, Kawamura K, Cheng Y, Fauser BC. Intraovarian control of early folliculogenesis. Endocr Rev. 2015; 36(1): 1-24. https://doi.org/10.1210/er.2014-1020
[80]	Venturoli S, Porcu E, Fabbri R, ParadisiR, Orsini LF, Flamigni C. Ovaries and menstrual cycles in adolescence. Gynecol Obstet Invest. 1984; 17(4): 219-222.
[81]	Venturoli S, Porcu E, Fabbri R, Paradise R, Gammi L, Passarini M, Orsini LF, Flamigni C. Ovarian multifollicularity, high LH and androgen plasma levels, and anovulation are frequent and strongly linked in adolescent irregular cycles. Acta Endocrinol. 1986; 111(3): 368-372. https://doi.org/10.1530/acta.0.1110368
[82]	Venturoli S, Porcu E, Gammi L, Magrini O, Fabbri R, Paradisi R, Flamigni C. Different gonadotropin pulsatile fashions in anovulatory cycles of young girls indicate different maturational pathways in adolescence. J Clin Endocrinol Metab. 1987; 65(4): 785-791. https://doi.org/10.1210/jcem-65-4-785
[83]	Giorlandino C, Gleicher N, Taramanni C, Vizzone A, Gentili P, Mancuso S, Forleo R. Ovarian development of the female child and adolescent: I. Morphology. Intern J Gynaecol Obstetrics. 1989; 29(1): 57-63. https://doi.org/10.1016/0020-7292(89)90130-6
[84]	Mortensen M, Rosenfield RL, Littlejohn E. Functional significance of polycystic-size ovaries in healthy adolescents. J Clin Endocrinol Metab. 2006; 91(10): 3786-3790. https://doi.org/10.1210/jc.2006-0835
[85]	Johnstone EB, Rosen MP, Neril R, Trevithick D, Sternfeld B, Murphy R, Addauan-Andersen C, McConell D, Pera RR, Cedars MI. The polycystic ovary post-Rotterdam: a common, age-dependent finding in ovulatory women without metabolic significance. J Clin Endocrinol Metab. 2010; 95(11): 4965-4972. https://doi.org/10.1210/jc.2010-0202
[86]	Michelmore KF, Balen AH, Vessey MP. Polycystic ovaries and associated clinical and biochemical features in young women. Clin Endocrinol. 1999; 51(6): 779-786. https://doi.org/10.1046/j.1365-2265.1999.00886.x
[87]	Farqhar CM, Birdsall M, Manning P, Mitchell JM, France JT. The prevalence of polycystic ovaries on ultrasound scanning in a population of randomly selected women. J Obstetr Gynaecol. 1994; 34(1): 67-72. https://doi.org/10.1111/j.1479-828x.1994.tb01041.x
[88]	Nobels, F, Dewailly D. Puberty and polycystic ovarian syndrome: the insulin/insulin-like growth factor I hypothesis. Fertil Steril. 1992; 58(4): 655-666. https://doi.org/10.1016/s0015-0282(16)55307-2
[89]	Clayton RN, Ogden V, Hodgkinson J, Worswick L, Rodin DA, Dyer S, Meade TW. How common are polycystic ovaries in normal women and what is their significance for the fertility of the population? Clin Endocrinol. 1992; 37(2): 127-134. https://doi.org/10.1111/j.1365-2265.1992.tb02296.x
[90]	Polson D, Adams J, Wadsworth J, Franks S. Polycystic ovaries a common finding in normal women. Lancet. 1988; 1(8590): 870-872. https://doi.org/10.1016/s0140-6736(88)91612-1
[91]	Van Hooff MH, Voorhorst FJ, Kaptein MB, Hirasing RA, Koppenaal C, Schoemaker J. Relationship of the menstrual cycle pattern in 14-17 years old adolescents. Hum Reprod. 2017; 13(8): 2252-2256. https://doi.org/10.1093/humrep/13.8.2252
[92]	Fulghesu AM, Canu E, Casula L, Melis F, Gambineri A. Polycystic ovarian morphology in normocyclic non-hyperandrogenic adolescents. J Pediatr Adolesc Gynecol. 2021; 34(5): 610-616. https://doi.org/10.1016/j.jpag.2021.02.004
[93]	Tsikouras P, Spyros L, Manay B, Zervoudis S, Poiana C, Nikolaos T, Petros P, Dimitraki M, Koukouli C, Galazios G, von Tempelhoff GF. Features of polycystic ovary syndrome in adolescence. J Med Life. 2015; 8(3): 291-296.
[94]	Baker T. A quantative and cytological study of germ cells in human ovaries. Proc R SocLond B Biol Sci. 1963; 158(972): 417-433. https://doi.org/10.1098/rspb.1963.0055
[95]	Brink HV, Burget TS, Barral R, Malik A, Gadiraju M, Lujan ME. Ovarian morphology in girls longitudinal cohort study: pilot evaluation of ovarian morphology as a biomarker of reproductive and metabolic features during the first gynecological year. J Pediatr Adolesc Gynecol. 2024; 37(3): 315-322. https://doi.org/10.1016/j.jpag.2024.02.004
[96]	Assens M, Dyre L, Henriksen LS, Brocks V, Sundberg K, Jensen LN, Pedersen AT, Main KM. Menstrual pattern, reproductive hormones and transabdominal 3D ultrasound in 317 adolescent girls. J Clin Endocrinol Metab. 2022; 105(9): e3257 e 3266. https://doi.org/10.1210/clinem/dgaa355
[97]	Diamanti-Kandarakis AE, Panidis D. Unravelling the phenotypic map of polycystic ovary syndrome (PCOS): A prospective study of 634 women with PCOS. Clin Endocrinol. 2007; 67(5): 735-742. https://doi.org/10.1111/j.1365-2265.2007.02954.x
[98]	Yilmaz M, Isaoglu U, Delibas IB, Kadanali S. Anthropometric, clinical and laboratory comparison of four phenotypes of polycystic ovary syndrome based on Rotterdam criteria. J Obstet Gynaecol Res. 2011; 37(8): 1020-1026. https://doi.org/10.1111/j.1447-0756.2010.01478.x
[99]	Choi W, Park JS, Oluwatobiloba A, Morebise O. Differences of polycystic ovary syndrome (PCOS) effects among Asian and Caucasian women. Asian J Med Health. 2021; 19(8): 29-36. https://doi.org/10.9734/ajmah/2021/v19i830354
[100]	Peña AS, Teede H, Hewawasam E, Hull ML, Gibson-Helm M. Diagnosis experiences of adolescents with polycystic ovary syndrome: Cross-sectional study. Clin Endocrinol. 2022; 96(1): 62-69. https://doi.org/10.1111/cen.14604
[101]	Bronstein J, Tawdekar S, Yingua L, Pawelczak M, David R, Shah B. Age of onset of polycystic ovarian syndrome in girls may be earlier than previously thought. J Pediatr Adolesc Gynecol. 2011; 24(1): 15-20. https://doi.org/10.1016/j.jpag.2010.06.003
[102]	Yen SSC. The polycystic ovary syndrome. Clin Endocrinol. 1980; 12(2): 177-208. https://doi.org/.1111/j.1365-2265.1980.tb02132.x
[103]	Avvad CK, Holeuwerger R, Silva VC, Ordallo MA, Breitenbach MM. Menstrual irregularity in the first postmenarchal years: an early clinical sign of polycystic ovary syndrome in adolescence. Gynecol Endocrinol. 2001; 15(3); 170-177. https://doi.org/10.1080/gye.15.3.170.177
[104]	Naz MSG, Farahmand M, Dashti S, Tehrani FR. Factors affecting menstrual cycle developmental trajectory in adolescents: a narrative review. Intern J Endocrinol Metabol. 2022; 20(1); e120438-e120438. https://doi.org/10.5812/ijem.120438
[105]	Lee LK, Chen PC, Lee KK, Kaur J. Menstruation among adolescent girls in Malasyia: a cross-sectional school survey. Singapore Med J. 2006; 47(10): 869-874.
[106]	Vassalou H, Sotiraki M, Michala L. PCOS diagnosis in adolescents: the timeline of a controversy in a systematic review. J Pediatr Endocrinol Metab. 2019; 32(6): 549-559. https://doi.org/10.1515/jpem-2019-0024
[107]	Hickey M, Balen A. Menstrual disorders in adolescence: investigation and management. Hum Reprod Update. 2003; 9(2): 493-495. https://doi.org/10.1093/humupd/dmg038
[108]	Winksten-Almstromer M, Hirschberg AL, Hagenfeld K. Prospective follow-up of menstrual disorders in adolescence and prognostic factors. Acta Obstet Gynecol Scand. 2008; 87(11): 1162-1168. https://doi.org/10.1080/00016340802478166
[109]	Sultan C, Paris F. Clinical expression of polycystic ovary syndrome in adolescent girls. Fertil Steril. 2006; 86(Suppl1): S6. https://doi.org/10.1016/j.fertnstert.2006.04.015
[110]	DewaillyD, Lujan ME, Carmina E, Cedars MI, Laven J, Norman RJ, Escobar-Morreale HF: Definition and significance of polycystic ovarian morphology: a task force report from Androgen Excess and Polycystic Ovary Syndrome Society. Hum Reprod Update. 2014; 20: 334-352. https://doi.org/10.1093/humupd/dmt061
[111]	Kamboj MK, Bonny AE. Polycystic ovary syndrome in adolescence: diagnostic and therapeutic strategies. Transl Pediatr. 2017; 6(4): 248-255.
[112]	Zore T, Lizneva D, Brakta S, Walker W, Suturina L, Ricardo A. Minimal difference in phenotype between adolescents and young adults with polycystic ovary syndrome. Fertil Steril. 2019; 111(2): 389-396. https://doi.org/10.1016/j.fertnstert.2018.10.020
[113]	West S, Lashen H, Bloigu A, Franks S, Puukka K, Ruokonen A, Jarvelin MR, Tapanainen JS, Morin-Papunen L. Irregular menstruation and hyperandrogenaemia in adolescence are associated with polycystic ovary syndrome and infertility in later life: Northern Finland Birth Cohort 1986 study. Hum Reprod. 2014; 29(10): 2339-2351. https://doi.org/10.1093/humrep/deu200
[114]	Çelik HG, Çelik E, Polat I. Evaluation of Biochemical Hyperandrogenism in Adolescent Girls with Menstrual Irregularities. J Med Biochem. 2018; 37(1): 7-11. https://doi.org/10.1515/jomb-2017-0037
[115]	Russo G, Brambilla P, Beffa FD, Ferrario M, Pitea M, Mastropietro T, Marinello R, Picca M, Nizzoli G, Chiumello G. Early onset of puberty in young girls: an Italian cross-sectional study. J Endocrinol Invest. 2012; 35(9): 804-808. https://doi.org/10.3275/8062
[116]	Rosenfield RL. Normal and premature adrenarche. Endocr Rev. 2021; 42(6): 783-814. https://doi.org/10.1210/endrev/bnab009
[117]	Rotteveel J, Riedder C, Schoute E, Delemarre-van de Waal HA. Androstenedione, dehydroepiandrosterone sulfate, and estradiol levels throughout female puberty: relation to height velocity. Horm Res. 1997; 48(6): 263-267. https://doi.org/10.1159/000185532
[118]	Villarroel C, Lopez P, Merino PM, Iniguez G, Sir-Petermann T, Codner E. Hirsutism and oligomenorrhea are appropriate screening criteria for polycystic ovary syndrome in adolescents. Gynecol Endocrinol. 2015; 31: 625-629. https://doi.org/10.3109/09513590.2015.1025380
[119]	Fruzzetti F, Perini D, Lazzarini V, Parrini D, Genazzani AR. Adolescent girls with polycystic ovary syndrome showing different phenotypes have a different metabolic profile associated with increasing androgen levels. Fertil Steril. 2009a; 92(2): 626-34. https://doi.org/10.1016/j.fertnstert.2008.06.004
[120]	Gambineri A, Fanelli F, Prontera O, Repaci A, Dalmazi GD, Zanotti L, Pagotto U, Flacco ME, Guidi J, Fava GA, Manzoli L, Pasquali R. Prevalence of hyperandrogenic states in late adolescent and young women: epidemiological survey on Italian high-school students. J Clin Endocrinol Metabol. 2013; 98(4): 1641-1650. https://doi.org/10.1210/jc.2012-3537
[121]	Khashchenko E, Uvarova E, Vysokikh M, Ivanets T, Krechetova L, Tarasova N, Sukhanova I, Mamedova F, Borovikov P, Balashov I, Sukhikh G. The relevant hormonal levels and diagnostic features of polycystic ovary syndrome in adolescents. J Clin Med. 2020; 9(6): 1831. https://doi.org/10.3390/jcm9061831
[122]	Fitzgerald S, Stamoulis C, Gooding H, DiVasta AD. Characteristics of adolescents with differing polycystic ovary syndrome phenotypes. J Pediatr Adolesc Gynecol. 2020; 33(6): 697-702. https://doi.org/10.1016/j.jpag.2020.08.015
[123]	Fruzzetti F, Petrini D, Lazzarini V, Parrini D, Genazzi AR. Hyperandrogenemia influences the prevalence of the metabolic syndrome abnormalities in adolescents with the polycystic ovary syndrome. Gynecol Endocrinol. 2009b; 25(5): 335-343.
[124]	Er E, Ata A. Evaluation of clinical and laboratory findings in adolescents diagnosed with polycystic ovary syndrome. Ann Clin Analyt Med. 2023; 14(Suppl 3): S215-S219.
[125]	Adams J, Polson DW, Franks S. Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism. Brit Med J. 1986; 293(6543): 355-359. https://doi.org/10.1136/bmj.293.6543.355
[126]	Jonard S, Robert Y, Cortet-Rudelli C, Pigny P, Decanter C, Dewailly D. Ultrasound examination of polycystic ovaries: is it worth counting the follicles? Hum Reprod. 2003; 18(3): 598-603. https://doi.org/10.1093/humrep/deg115
[127]	Quinn MM, Kao CN, Ahmad A, Lenhart N, Shinkai K, Cedars MI, Huddleston HG. Raising threshold for diagnosis of polycystic ovary syndrome excludes population of patients with metabolic risk. Fertil Steril. 2016; 106(5): 1244-1251. https://doi.org/10.1016/j.fertnstert.2016.06.026
[128]	Christ JP, Willis AD, Brooks ED, Brink HV, Jarret BY, Pierson RA, Chizen DR, Lujan ME. Follicle number, not assessments of the ovarian stroma, represents the best ultrasonographic marker of polycystic ovary syndrome. Fertil Steril. 2014; 101(1): 280-287. https://doi.org/10.1016/j.fertnstert.2013.10.001
[129]	Christ JP, Cedars MI. Current guidelines for diagnosing PCOS. Diagnostic. 2023; 13(6): 1113. https://doi.org/10.3390/diagnostics13061113
[130]	Youngster M, Ward VL, Blood EA, Barnewolt CE, Emans SJ, Divasta AD. Utility of ultrasound in the diagnosis of polycystic ovary syndrome in adolescents. Fertil Steril. 2014; 102(5): 1432-1438. https://doi.org/10.1016/j.fertnstert.2014.07.1241
[131]	Hashemipour M, Faghihimani S, Zolfaghary B, Hovsepian S, Ahmadi F, Haghihi S. Prevalence of polycystic ovary syndrome in girls aged 14-18 years in Isfahan. Iran Horm Res. 2004; 62(6): 278-282. https://doi.org/10.1159/000081842
[132]	Treasure JL, Gordon PA, King EA, Wheeler M, Russell GF. Cysticovaries: a phase of anorexia nervosa. Lancet. 1985; 28; 2(8469-70): 1379-1382. https://doi.org/10.1016/s0140-6736(85)92553-x
[133]	Bridges NA, Cooke A, Healy MJ, Hindmarsh PC, Brook CG. Standards for ovarian volume in childhood and puberty. Fertil Steril. 1993; 60(3): 456-460.
[134]	Christensen SB, Black MH, Smith N, Martinez MM, Jacobsen SJ, Porter AH, Koebnick C. Prevalence of polycystic ovary syndrome in adolescents. Fertil Steril. 2013; 100(2): 470-477. https://doi.org/10.1016/j.fertnstert.2013.04.001
[135]	Panidis D, Tziomalos K, Misichronis G, Papadakis E, Betsas G, Katsikis I, Macut D. Insulin resistance and endocrine characteristics of the different phenotypes of polycystic ovary syndrome: a prospective study. Hum Reprod. 2012; 27(2): 541-549. https://doi.org/10.1093/humrep/der418
[136]	Lujan ME, Jarrett BY, Brooks ED, Reines JK, Peppin AK, Muhn N, Haider E, Pierson RA, Chizen DR. Updated ultrasound criteria for polycystic ovary syndrome: reliable thresholds for elevated follicle population and ovarian volume. Hum Reprod. 2013; 28(5): 1361-1368. https://doi.org/10.1093/humrep/det062
[137]	Herter LD, Magalháes JA, Spritzer PM. Relevance of the determination of ovarian volume in adolescents girls with menstrual disorders. J Clin Ultras. 1996; 24(5): 243-248. https://doi.org/10.1002/(SICI)1097-0096(199606)24:5<243::AID-JCU3>3.0.CO;2-E
[138]	Ibañez L, Oberfield SE, Witchel S, Auchus RJ, Chang RJ, Codner E, Dabadghao P, Darendeliler F, Elbarbary NS, Gambineri A, Rudaz CG, Hoeger KM, López-Bermejo A, Ong K, Peña AS, Reinehr T, Santoro N, Tena-Sempere M, Tao R, Yildiz BO, Alkhayyat H, Deeb A, Joel D, Horikawa R, Zegher F, Lee PA. An international consortium update: pathophysiology, diagnosis, and treatment of polycystic ovarian syndrome in adolescence. Horm Res Paediatr. 2017; 88(6): 371-395. https://doi.org/10.1159/000479371
[139]	Tay CT, Hart RJ, Hickey M, Moran LJ, Earnest A, Doherty DA, Teede HJ, Joham AE. Update adolescent diagnostic criteria for polycystic ovary syndrome: impact on prevalence and longitudinal body mass index trajectories from birth to adulthood. BMC Medicine. 2020; 18(1): 389. https://doi.org/10.1186/s12916-020-01861-x
[140]	Pereira-Eshraghi CF, Tao R, Chiuzan CC, Zhang Y, Shen W, Lerner JP, Oberfield SE, Sopher AB. Ovarian follicle count by magnetic resonance imaging is greater in adolescents and young adults with polycystic ovary syndrome than in controls. Fertil Steril. Reports 2022; 3(2): 102-109. https:/doi.org/10.1016/j.xfre.2022.01.008
[141]	Yoo RY, Sirlin C, Gottschalk M, Chang RJ. Ovarian imaging by magnetic resonance in obese adolescent females with polycystic ovary syndrome. Fertil Steril. 2005; 84(4): 985-995. https://doi.org/10.1016/j.fertnstert.2005.04.039
[142]	Brown M, Park AS, Shayya RF, Wolfson T, Su HI, Chang RJ. Ovarian imaging by magnetic resonance in adolescent girls with polycystic ovary syndrome and age-matched controls. J Magnet Reson Imaging. 2013; 38(3): 689-693. https://doi.org/10.1002/jmri.23992
[143]	Merino PM, Villarroel C, Jesam C, López P, Codner E. Newdiagnostic criteria of polycystic ovarian morphology for adolescents: Impact on prevalence and hormonal profile. Horm Res Paediatr. 2017; 88(6): 401-407. https://doi.org/10.1159/000481532

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Medeiros, S. F. D., Medeiros, A. K. L. W. Y. D., Magalhães, L. F. D., Yamamoto, M. M. W., Medeiros, M. A. S. D. (2024). Fundamentals to Diagnosing Polycystic Ovary Syndrome in Adolescents: A Critical Literature Review. Journal of Gynecology and Obstetrics, 12(4), 67-80. https://doi.org/10.11648/j.jgo.20241204.12

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Medeiros, S. F. D.; Medeiros, A. K. L. W. Y. D.; Magalhães, L. F. D.; Yamamoto, M. M. W.; Medeiros, M. A. S. D. Fundamentals to Diagnosing Polycystic Ovary Syndrome in Adolescents: A Critical Literature Review. J. Gynecol. Obstet. 2024, 12(4), 67-80. doi: 10.11648/j.jgo.20241204.12

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Medeiros SFD, Medeiros AKLWYD, Magalhães LFD, Yamamoto MMW, Medeiros MASD. Fundamentals to Diagnosing Polycystic Ovary Syndrome in Adolescents: A Critical Literature Review. J Gynecol Obstet. 2024;12(4):67-80. doi: 10.11648/j.jgo.20241204.12

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@article{10.11648/j.jgo.20241204.12,
  author = {Sebastião Freitas de Medeiros and Ana Karine Lin Winck Yamamoto de Medeiros and Letícia Ferreira de Magalhães and Márcia Marly Winck Yamamoto and Matheus Antônio Souto de Medeiros},
  title = {Fundamentals to Diagnosing Polycystic Ovary Syndrome in Adolescents: A Critical Literature Review
},
  journal = {Journal of Gynecology and Obstetrics},
  volume = {12},
  number = {4},
  pages = {67-80},
  doi = {10.11648/j.jgo.20241204.12},
  url = {https://doi.org/10.11648/j.jgo.20241204.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20241204.12},
  abstract = {Background: Because of this prevalence and frequent association with various comorbidites, the diagnosis of polycystic ovary syndrome (PCOS) must be performed as early as possible. Despite conflicting findings, many studies have been published on adolescents with a diagnosis of polycystic ovary syndrome. Methods: The Google Scholar and PubMed data bases were searched for publications in the English language reporting on PCOS diagnosis in adolescents. Results: A comprehensive analysis of data regarding the overlay of physiological ripening of menstrual cycle characteristics, androgen levels, and ovary aspects during puberty with the established criteria to diagnose PCOS in adults revealed that are liable diagnosis of PCOS in adolescence is possibleas soon as 2-3 years postmenarche. Persistant menstrual cycle intervals shorter than 21 days or longer than 45 days, total testosterone levels >1.9-2.0 nmol/l and ovary volume >10cm3 after 15-16 years of age can be used to diagnose PCOS. Conclusion: When combined, any persistent deviation of physiological parameters in adolescents as a criterion to diagnose PCOS in adults allows a certain diagnosis of PCOS in adolescents.
},
 year = {2024}
}

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TY  - JOUR
T1  - Fundamentals to Diagnosing Polycystic Ovary Syndrome in Adolescents: A Critical Literature Review

AU  - Sebastião Freitas de Medeiros
AU  - Ana Karine Lin Winck Yamamoto de Medeiros
AU  - Letícia Ferreira de Magalhães
AU  - Márcia Marly Winck Yamamoto
AU  - Matheus Antônio Souto de Medeiros
Y1  - 2024/08/30
PY  - 2024
N1  - https://doi.org/10.11648/j.jgo.20241204.12
DO  - 10.11648/j.jgo.20241204.12
T2  - Journal of Gynecology and Obstetrics
JF  - Journal of Gynecology and Obstetrics
JO  - Journal of Gynecology and Obstetrics
SP  - 67
EP  - 80
PB  - Science Publishing Group
SN  - 2376-7820
UR  - https://doi.org/10.11648/j.jgo.20241204.12
AB  - Background: Because of this prevalence and frequent association with various comorbidites, the diagnosis of polycystic ovary syndrome (PCOS) must be performed as early as possible. Despite conflicting findings, many studies have been published on adolescents with a diagnosis of polycystic ovary syndrome. Methods: The Google Scholar and PubMed data bases were searched for publications in the English language reporting on PCOS diagnosis in adolescents. Results: A comprehensive analysis of data regarding the overlay of physiological ripening of menstrual cycle characteristics, androgen levels, and ovary aspects during puberty with the established criteria to diagnose PCOS in adults revealed that are liable diagnosis of PCOS in adolescence is possibleas soon as 2-3 years postmenarche. Persistant menstrual cycle intervals shorter than 21 days or longer than 45 days, total testosterone levels >1.9-2.0 nmol/l and ovary volume >10cm3 after 15-16 years of age can be used to diagnose PCOS. Conclusion: When combined, any persistent deviation of physiological parameters in adolescents as a criterion to diagnose PCOS in adults allows a certain diagnosis of PCOS in adolescents.

VL  - 12
IS  - 4
ER  -

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Sebastião Freitas de Medeiros

Department of Gynecology and Obstetrics, Medical School, Federal University of Mato Grosso, Cuiabá, Brazil; Tropical Institute of Reproductive Medicine, Cuiabá, Brazil

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http://orcid.org/0000-0003-1292-2515
Ana Karine Lin Winck Yamamoto de Medeiros

Departament of Medicine, University of Cuiabá, Cuiabá, Brazil

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http://orcid.org/0000-0002-5207-8307
Letícia Ferreira de Magalhães

Tropical Institute of Reproductive Medicine, Cuiabá, Brazil

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http://orcid.org/0009-0009-4895-7454
Márcia Marly Winck Yamamoto

Tropical Institute of Reproductive Medicine, Cuiabá, Brazil

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http://orcid.org/0000-0002-4845-4226
Matheus Antônio Souto de Medeiros

Tropical Institute of Reproductive Medicine, Cuiabá, Brazil

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http://orcid.org/0000-0003-4069-7490

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Medeiros, S. F. D., Medeiros, A. K. L. W. Y. D., Magalhães, L. F. D., Yamamoto, M. M. W., Medeiros, M. A. S. D. (2024). Fundamentals to Diagnosing Polycystic Ovary Syndrome in Adolescents: A Critical Literature Review. Journal of Gynecology and Obstetrics, 12(4), 67-80. https://doi.org/10.11648/j.jgo.20241204.12

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ACS Style

Medeiros, S. F. D.; Medeiros, A. K. L. W. Y. D.; Magalhães, L. F. D.; Yamamoto, M. M. W.; Medeiros, M. A. S. D. Fundamentals to Diagnosing Polycystic Ovary Syndrome in Adolescents: A Critical Literature Review. J. Gynecol. Obstet. 2024, 12(4), 67-80. doi: 10.11648/j.jgo.20241204.12

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AMA Style

Medeiros SFD, Medeiros AKLWYD, Magalhães LFD, Yamamoto MMW, Medeiros MASD. Fundamentals to Diagnosing Polycystic Ovary Syndrome in Adolescents: A Critical Literature Review. J Gynecol Obstet. 2024;12(4):67-80. doi: 10.11648/j.jgo.20241204.12

Copy | Download

@article{10.11648/j.jgo.20241204.12,
  author = {Sebastião Freitas de Medeiros and Ana Karine Lin Winck Yamamoto de Medeiros and Letícia Ferreira de Magalhães and Márcia Marly Winck Yamamoto and Matheus Antônio Souto de Medeiros},
  title = {Fundamentals to Diagnosing Polycystic Ovary Syndrome in Adolescents: A Critical Literature Review
},
  journal = {Journal of Gynecology and Obstetrics},
  volume = {12},
  number = {4},
  pages = {67-80},
  doi = {10.11648/j.jgo.20241204.12},
  url = {https://doi.org/10.11648/j.jgo.20241204.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20241204.12},
  abstract = {Background: Because of this prevalence and frequent association with various comorbidites, the diagnosis of polycystic ovary syndrome (PCOS) must be performed as early as possible. Despite conflicting findings, many studies have been published on adolescents with a diagnosis of polycystic ovary syndrome. Methods: The Google Scholar and PubMed data bases were searched for publications in the English language reporting on PCOS diagnosis in adolescents. Results: A comprehensive analysis of data regarding the overlay of physiological ripening of menstrual cycle characteristics, androgen levels, and ovary aspects during puberty with the established criteria to diagnose PCOS in adults revealed that are liable diagnosis of PCOS in adolescence is possibleas soon as 2-3 years postmenarche. Persistant menstrual cycle intervals shorter than 21 days or longer than 45 days, total testosterone levels >1.9-2.0 nmol/l and ovary volume >10cm3 after 15-16 years of age can be used to diagnose PCOS. Conclusion: When combined, any persistent deviation of physiological parameters in adolescents as a criterion to diagnose PCOS in adults allows a certain diagnosis of PCOS in adolescents.
},
 year = {2024}
}

Copy | Download

TY  - JOUR
T1  - Fundamentals to Diagnosing Polycystic Ovary Syndrome in Adolescents: A Critical Literature Review

AU  - Sebastião Freitas de Medeiros
AU  - Ana Karine Lin Winck Yamamoto de Medeiros
AU  - Letícia Ferreira de Magalhães
AU  - Márcia Marly Winck Yamamoto
AU  - Matheus Antônio Souto de Medeiros
Y1  - 2024/08/30
PY  - 2024
N1  - https://doi.org/10.11648/j.jgo.20241204.12
DO  - 10.11648/j.jgo.20241204.12
T2  - Journal of Gynecology and Obstetrics
JF  - Journal of Gynecology and Obstetrics
JO  - Journal of Gynecology and Obstetrics
SP  - 67
EP  - 80
PB  - Science Publishing Group
SN  - 2376-7820
UR  - https://doi.org/10.11648/j.jgo.20241204.12
AB  - Background: Because of this prevalence and frequent association with various comorbidites, the diagnosis of polycystic ovary syndrome (PCOS) must be performed as early as possible. Despite conflicting findings, many studies have been published on adolescents with a diagnosis of polycystic ovary syndrome. Methods: The Google Scholar and PubMed data bases were searched for publications in the English language reporting on PCOS diagnosis in adolescents. Results: A comprehensive analysis of data regarding the overlay of physiological ripening of menstrual cycle characteristics, androgen levels, and ovary aspects during puberty with the established criteria to diagnose PCOS in adults revealed that are liable diagnosis of PCOS in adolescence is possibleas soon as 2-3 years postmenarche. Persistant menstrual cycle intervals shorter than 21 days or longer than 45 days, total testosterone levels >1.9-2.0 nmol/l and ovary volume >10cm3 after 15-16 years of age can be used to diagnose PCOS. Conclusion: When combined, any persistent deviation of physiological parameters in adolescents as a criterion to diagnose PCOS in adults allows a certain diagnosis of PCOS in adolescents.

VL  - 12
IS  - 4
ER  -

Copy | Download