Research Progresses on the Relationship Between the Phthalates Exposure and Children’s Neurodevelopmental Disorders

Yu Qifan; Shen Xuezhi; Chen Hongqing; Chen Qianye; Zheng Guofe; Luo Yufeng; Li Aiqing; Ding Yuemin

doi:doi:10.11648/j.sjph.20210903.11

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Research Progresses on the Relationship Between the Phthalates Exposure and Children’s Neurodevelopmental Disorders

Yu Qifan, Shen Xuezhi, Chen Hongqing, Chen Qianye, Zheng Guofe, Luo Yufeng, Li Aiqing, Ding Yuemin

Published in Science Journal of Public Health (Volume 9, Issue 3)

Received: 6 March 2021 Published: 8 May 2021

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Abstract

Neurodevelopment, a complex multifactorial process, is influenced by genetic factors, environmental factors and the interaction between them. Among various environmental factors, prenatal or postnatal phthalate exposure are gradually attracting great attention. The plasticizers phthalate are widely used in various products. Since they do not form covalent bonds with the polymer matrix, they may leach or outgas into the environment and enter the human body, even affect the development of the fetus or newborn through the placenta or breast milk. In recent years, increasing evidences have shown that maternal phthalate exposure can interfere with the development of fetal central nervous system, resulting in neurodevelopmental disorders in postnatal children. However, the specific relationship between maternal phthalate exposure and fetal neurodevelopment and its mechanism have not been clearly studied. At present, the known possible mechanisms include disruption of thyroid homeostasis, alteration of calcium signal transduction, disturbance of lipid metabolism, interfering with the action of sex hormones, influence of the Rho-GTPase pathway, induction of epigenetic and oxidative stress, etc. As the problem has gradually become the focus of attention all over the world, new research results are still emerging. In order to provide references for further study of the etiology and pathogenesis, the latest research progresses and mechanisms of phthalate exposure on neurodevelopment were reviewed in the following article.

Published in	Science Journal of Public Health (Volume 9, Issue 3)
DOI	10.11648/j.sjph.20210903.11
Page(s)	72-76
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Phthalates, Plasticizer, Neurodevelopment, Mechanism

References

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APA Style

Yu Qifan, Shen Xuezhi, Chen Hongqing, Chen Qianye, Zheng Guofe, et al. (2021). Research Progresses on the Relationship Between the Phthalates Exposure and Children’s Neurodevelopmental Disorders. Science Journal of Public Health, 9(3), 72-76. https://doi.org/10.11648/j.sjph.20210903.11

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ACS Style

Yu Qifan; Shen Xuezhi; Chen Hongqing; Chen Qianye; Zheng Guofe, et al. Research Progresses on the Relationship Between the Phthalates Exposure and Children’s Neurodevelopmental Disorders. Sci. J. Public Health 2021, 9(3), 72-76. doi: 10.11648/j.sjph.20210903.11

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AMA Style

Yu Qifan, Shen Xuezhi, Chen Hongqing, Chen Qianye, Zheng Guofe, et al. Research Progresses on the Relationship Between the Phthalates Exposure and Children’s Neurodevelopmental Disorders. Sci J Public Health. 2021;9(3):72-76. doi: 10.11648/j.sjph.20210903.11

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@article{10.11648/j.sjph.20210903.11,
  author = {Yu Qifan and Shen Xuezhi and Chen Hongqing and Chen Qianye and Zheng Guofe and Luo Yufeng and Li Aiqing and Ding Yuemin},
  title = {Research Progresses on the Relationship Between the Phthalates Exposure and Children’s Neurodevelopmental Disorders},
  journal = {Science Journal of Public Health},
  volume = {9},
  number = {3},
  pages = {72-76},
  doi = {10.11648/j.sjph.20210903.11},
  url = {https://doi.org/10.11648/j.sjph.20210903.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20210903.11},
  abstract = {Neurodevelopment, a complex multifactorial process, is influenced by genetic factors, environmental factors and the interaction between them. Among various environmental factors, prenatal or postnatal phthalate exposure are gradually attracting great attention. The plasticizers phthalate are widely used in various products. Since they do not form covalent bonds with the polymer matrix, they may leach or outgas into the environment and enter the human body, even affect the development of the fetus or newborn through the placenta or breast milk. In recent years, increasing evidences have shown that maternal phthalate exposure can interfere with the development of fetal central nervous system, resulting in neurodevelopmental disorders in postnatal children. However, the specific relationship between maternal phthalate exposure and fetal neurodevelopment and its mechanism have not been clearly studied. At present, the known possible mechanisms include disruption of thyroid homeostasis, alteration of calcium signal transduction, disturbance of lipid metabolism, interfering with the action of sex hormones, influence of the Rho-GTPase pathway, induction of epigenetic and oxidative stress, etc. As the problem has gradually become the focus of attention all over the world, new research results are still emerging. In order to provide references for further study of the etiology and pathogenesis, the latest research progresses and mechanisms of phthalate exposure on neurodevelopment were reviewed in the following article.},
 year = {2021}
}

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TY  - JOUR
T1  - Research Progresses on the Relationship Between the Phthalates Exposure and Children’s Neurodevelopmental Disorders
AU  - Yu Qifan
AU  - Shen Xuezhi
AU  - Chen Hongqing
AU  - Chen Qianye
AU  - Zheng Guofe
AU  - Luo Yufeng
AU  - Li Aiqing
AU  - Ding Yuemin
Y1  - 2021/05/08
PY  - 2021
N1  - https://doi.org/10.11648/j.sjph.20210903.11
DO  - 10.11648/j.sjph.20210903.11
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 72
EP  - 76
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20210903.11
AB  - Neurodevelopment, a complex multifactorial process, is influenced by genetic factors, environmental factors and the interaction between them. Among various environmental factors, prenatal or postnatal phthalate exposure are gradually attracting great attention. The plasticizers phthalate are widely used in various products. Since they do not form covalent bonds with the polymer matrix, they may leach or outgas into the environment and enter the human body, even affect the development of the fetus or newborn through the placenta or breast milk. In recent years, increasing evidences have shown that maternal phthalate exposure can interfere with the development of fetal central nervous system, resulting in neurodevelopmental disorders in postnatal children. However, the specific relationship between maternal phthalate exposure and fetal neurodevelopment and its mechanism have not been clearly studied. At present, the known possible mechanisms include disruption of thyroid homeostasis, alteration of calcium signal transduction, disturbance of lipid metabolism, interfering with the action of sex hormones, influence of the Rho-GTPase pathway, induction of epigenetic and oxidative stress, etc. As the problem has gradually become the focus of attention all over the world, new research results are still emerging. In order to provide references for further study of the etiology and pathogenesis, the latest research progresses and mechanisms of phthalate exposure on neurodevelopment were reviewed in the following article.
VL  - 9
IS  - 3
ER  -

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Author Information

Yu Qifan

Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou, China
Shen Xuezhi

Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou, China
Chen Hongqing

Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou, China
Chen Qianye

Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou, China
Zheng Guofe

Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou, China
Luo Yufeng

Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou, China
Li Aiqing

Gastroenterology Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
Ding Yuemin

Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou, China

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APA Style

Yu Qifan, Shen Xuezhi, Chen Hongqing, Chen Qianye, Zheng Guofe, et al. (2021). Research Progresses on the Relationship Between the Phthalates Exposure and Children’s Neurodevelopmental Disorders. Science Journal of Public Health, 9(3), 72-76. https://doi.org/10.11648/j.sjph.20210903.11

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ACS Style

Yu Qifan; Shen Xuezhi; Chen Hongqing; Chen Qianye; Zheng Guofe, et al. Research Progresses on the Relationship Between the Phthalates Exposure and Children’s Neurodevelopmental Disorders. Sci. J. Public Health 2021, 9(3), 72-76. doi: 10.11648/j.sjph.20210903.11

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AMA Style

Yu Qifan, Shen Xuezhi, Chen Hongqing, Chen Qianye, Zheng Guofe, et al. Research Progresses on the Relationship Between the Phthalates Exposure and Children’s Neurodevelopmental Disorders. Sci J Public Health. 2021;9(3):72-76. doi: 10.11648/j.sjph.20210903.11

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@article{10.11648/j.sjph.20210903.11,
  author = {Yu Qifan and Shen Xuezhi and Chen Hongqing and Chen Qianye and Zheng Guofe and Luo Yufeng and Li Aiqing and Ding Yuemin},
  title = {Research Progresses on the Relationship Between the Phthalates Exposure and Children’s Neurodevelopmental Disorders},
  journal = {Science Journal of Public Health},
  volume = {9},
  number = {3},
  pages = {72-76},
  doi = {10.11648/j.sjph.20210903.11},
  url = {https://doi.org/10.11648/j.sjph.20210903.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20210903.11},
  abstract = {Neurodevelopment, a complex multifactorial process, is influenced by genetic factors, environmental factors and the interaction between them. Among various environmental factors, prenatal or postnatal phthalate exposure are gradually attracting great attention. The plasticizers phthalate are widely used in various products. Since they do not form covalent bonds with the polymer matrix, they may leach or outgas into the environment and enter the human body, even affect the development of the fetus or newborn through the placenta or breast milk. In recent years, increasing evidences have shown that maternal phthalate exposure can interfere with the development of fetal central nervous system, resulting in neurodevelopmental disorders in postnatal children. However, the specific relationship between maternal phthalate exposure and fetal neurodevelopment and its mechanism have not been clearly studied. At present, the known possible mechanisms include disruption of thyroid homeostasis, alteration of calcium signal transduction, disturbance of lipid metabolism, interfering with the action of sex hormones, influence of the Rho-GTPase pathway, induction of epigenetic and oxidative stress, etc. As the problem has gradually become the focus of attention all over the world, new research results are still emerging. In order to provide references for further study of the etiology and pathogenesis, the latest research progresses and mechanisms of phthalate exposure on neurodevelopment were reviewed in the following article.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Research Progresses on the Relationship Between the Phthalates Exposure and Children’s Neurodevelopmental Disorders
AU  - Yu Qifan
AU  - Shen Xuezhi
AU  - Chen Hongqing
AU  - Chen Qianye
AU  - Zheng Guofe
AU  - Luo Yufeng
AU  - Li Aiqing
AU  - Ding Yuemin
Y1  - 2021/05/08
PY  - 2021
N1  - https://doi.org/10.11648/j.sjph.20210903.11
DO  - 10.11648/j.sjph.20210903.11
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 72
EP  - 76
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20210903.11
AB  - Neurodevelopment, a complex multifactorial process, is influenced by genetic factors, environmental factors and the interaction between them. Among various environmental factors, prenatal or postnatal phthalate exposure are gradually attracting great attention. The plasticizers phthalate are widely used in various products. Since they do not form covalent bonds with the polymer matrix, they may leach or outgas into the environment and enter the human body, even affect the development of the fetus or newborn through the placenta or breast milk. In recent years, increasing evidences have shown that maternal phthalate exposure can interfere with the development of fetal central nervous system, resulting in neurodevelopmental disorders in postnatal children. However, the specific relationship between maternal phthalate exposure and fetal neurodevelopment and its mechanism have not been clearly studied. At present, the known possible mechanisms include disruption of thyroid homeostasis, alteration of calcium signal transduction, disturbance of lipid metabolism, interfering with the action of sex hormones, influence of the Rho-GTPase pathway, induction of epigenetic and oxidative stress, etc. As the problem has gradually become the focus of attention all over the world, new research results are still emerging. In order to provide references for further study of the etiology and pathogenesis, the latest research progresses and mechanisms of phthalate exposure on neurodevelopment were reviewed in the following article.
VL  - 9
IS  - 3
ER  -

Copy | Download