Abstract: Introduction: This study focuses on the persistence of urogenital schistosomiasis (8%) in the Tambacounda health district, despite mass treatment efforts with praziquantel among 5-14-year-olds in 2023. The primary objective is to evaluate the current prevalence of the disease, identify the factors contributing to its persistence, and assess the acceptability of preventive measures implemented. Methods: We conducted a descriptive and analytical study in August 2024. The target population consisted of mothers or guardians of children under 10 years old. Data were collected using Kobo Collect, and analysis was performed with R 4.4.1. Binary logistic regression was used to identify the factors associated with the occurrence of urogenital schistosomiasis. Results: The majority (93.5%) accepted preventive measures, and 9.2% showed hematuria. Among 5-10-year-olds, 84.44% received treatment. Urine test strips were positive for 14.2% of them, and 6.1% were carrying Schistosoma haematobium eggs. The prevalence of urogenital schistosomiasis in 5-10-year-olds was 7.88%, compared to 3.7% in those under 5 years old. The factors significantly associated with the occurrence of urogenital schistosomiasis were: seeking healthcare for children by mothers or guardians (ORa = 5.6 [1.11; 32.8]; p = 0.04) and positive urine test strips (p = 0.004, ORa = 71.13 [17.84; 49.49]; p = 0.004). Conclusion: This study highlights the persistence of urogenital schistosomiasis in the Tambacounda health district, despite mass treatment campaigns. Although the acceptability of preventive measures is high, these results underscore the need to strengthen prevention, awareness, and treatment strategies.Abstract: Introduction: This study focuses on the persistence of urogenital schistosomiasis (8%) in the Tambacounda health district, despite mass treatment efforts with praziquantel among 5-14-year-olds in 2023. The primary objective is to evaluate the current prevalence of the disease, identify the factors contributing to its persistence, and assess the acc...Show More