The Effect of the Combined Use of Mechanical and Drug Revascularization in Acute Coronary Syndrome in Patients Working in Environmentally Polluted Conditions
Tarana Mammadhasan Javadova,
Mammadhasan Mammadhuseyn Agayev
Issue:
Volume 10, Issue 5, September 2022
Pages:
107-114
Received:
6 July 2022
Accepted:
8 August 2022
Published:
14 September 2022
DOI:
10.11648/j.ajcem.20221005.11
Downloads:
Views:
Abstract: The aim of the study was to evaluate the effect of the complex use of cardiotex (meldonium), obzidan (propranolol), cyto-mac, cardiket, preductal OD, ARBII, in combination with percutaneous intervention (PCI) and separately performed PCI on ecoendotoxicosis (AMP), on hemodynamics, cardiodynamics and clinical course of non-ST elevation acute coronary syndrome (NSTE ACS). The results of complex medical and mechanical revascularization and separately performed PCI were compared. The study included 63 patients with NSTE ACS aged 35 to 65 years (56.7 ± 1.20) (50 (79.4%) men, 13 (20.6%) women) and randomized into 3 groups (21 people each). 1st group got cardiotex, cyto-mac, obzidan (propranolol) were given anti-ischemic, isosorbidedinitrate (cardiket), antihypoxant - a biologically active food supplement vascard and PCI was performed. In group 2, cytomac and obzidan (propranolol), cardiotex were administered, anti-ischemic, antihypoxant –vascard, preductal OD, ARBII - losartan were given and PCI was performed a day later; in the 3rd group, only PCI was performed. All patients got heparin according to the schemes. During hospitalization and within a year after discharge drug therapy was carried out, including aspirin-cardio+clopidogril. At the same time, 2 times a year for 3 months, one capsule of vascard was taken once a day, one tablet of preductal OD once a day+losartan 12.5 (25) mg once a day, cardiotex was administered intravenously at 500 mg once per day for 15 days. In all groups, the degree of ecoendotoxicosis was determined in the blood, using echocardiography and Doppler echocardiography, the values of end systolic (ESV) and end diastolic (EDV) volumes, ejection fraction (EF), stroke index (SI), cardiac index (CI), local contractility disorder index (LCDI) of the left ventricle, restenosis-with the help of repeated coronary angiography, ECG for ST-segment elevation and repeated anginal pain. The dynamics of BPs and BPd and the clinical course of NSTE ACS were established. In patients of all groups the dynamics of BPs and BPd was recorded, indicators stabilized central hemodynamics. By reducing the degree of ecoendotoxicosis, EDV and ESV, LCDI, LV systolic function improves, EF increases (group 1-2). However, in the first and third groups, single ventricular extrasystoles were recorded in one patient. AHF was recorded in one patient In patients of 1st group. In the PCI-only group, 2 patients developed recurrent NT ACS, 3 had restenosis, 3 had AHF, and 2 patients died. The results of this study show that the complex use of drug therapy with PCI allows to get a prognostically positive result, in contrast to a separate PCI therapy.
Abstract: The aim of the study was to evaluate the effect of the complex use of cardiotex (meldonium), obzidan (propranolol), cyto-mac, cardiket, preductal OD, ARBII, in combination with percutaneous intervention (PCI) and separately performed PCI on ecoendotoxicosis (AMP), on hemodynamics, cardiodynamics and clinical course of non-ST elevation acute coronar...
Show More
Mysterious “Wave of Death” Could Mark Critical Divide Between Life and Death
Issue:
Volume 10, Issue 5, September 2022
Pages:
115-123
Received:
20 August 2022
Accepted:
5 September 2022
Published:
16 September 2022
DOI:
10.11648/j.ajcem.20221005.12
Downloads:
Views:
Abstract: Despite modern advances in medical science, the critical divide between life and death remains a mystery. The ability to more accurately determine when death occurs would be of enormous clinical and practical benefit in the care of dying patients. In both animals and humans, a peculiar spike of highly coherent electroencephalographic (EEG) activity during the dying process has been observed by several research groups. Some researchers believe that this spike of activity could be the brain’s last burst of normal signaling prior to death and may also provide a neuropsychological explanation for the puzzling phenomenon of near-death experiences (NDEs). This analysis offers an entirely new perspective on end-of-life electrical surges. Based on available clinical and electrophysiological evidence, it contends that the so-called "wave of death" is not initiated by the brain but rather mediated by the brain as the departing soul leaves the body at the time of death. Hypothetically, the head of the soul (the mind), upon separating from the dying brain, experiences a burst of enhanced awareness, and the associated magnetic fields drive a corresponding burst of neurological activity until the soul passes outside the physical proximity in which its electromagnetic activity can induce neuronal signals. To my knowledge, this is the first anatomically, psychophysiologically, and electrophysiologically-based explanation that links end-of-life EEG activity to NDEs without discounting the seeming extracorporeal nature of those experiences. If this hypothesis is correct, then end-of-life electrical surges could be highly precise objective markers of the transition from life to death. Beyond the benefits that this would offer to dying patients and their caregivers, it would offer a new form of scientific validation for near-death and end-of-life experiences, which have increasingly become a source of inspiration, wisdom, and hope for the dying, their loved ones, and people all over the world.
Abstract: Despite modern advances in medical science, the critical divide between life and death remains a mystery. The ability to more accurately determine when death occurs would be of enormous clinical and practical benefit in the care of dying patients. In both animals and humans, a peculiar spike of highly coherent electroencephalographic (EEG) activity...
Show More
