Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency in a Population of Nigerian Women Resident in Akure

David Morakinyo Sanni; Oluwasegun Victor Omotoyinbo; Damilola Folajimi

doi:doi:10.11648/j.bmb.20180306.11

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Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency in a Population of Nigerian Women Resident in Akure

David Morakinyo Sanni, Oluwasegun Victor Omotoyinbo, Damilola Folajimi

Published in Biochemistry and Molecular Biology (Volume 3, Issue 6)

Received: 31 October 2018 Accepted: 17 December 2018 Published: 16 January 2019

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Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy in Sub-Saharan Africa and is particularly prevalent in historically malaria-endemic countries. This work is a preliminary study on the prevalence of G6PD deficiency in both pregnant and non-pregnant women carried out on 100 subjects consisting of 50 pregnant women and 50 non-pregnant women as well as toidentify predictors of G6PD deficiency by analyzing other parameters. Presence of G6PD, total protein, albumin, total bilirubin, aspartate transaminase, alanine transaminase and alkaline phosphatase were determined in all the subjects using spectrophotometric method. It was observed that the overall prevalence of G6PD deficiency was found in 10% of pregnant women considered. The albumin, total bilirubin, aspartate transaminase, alanine transaminase, total protein and alkaline phosphatase were not significantly different in G6PD deficient pregnant and non-pregnant women. In conclusion, the prevalence of G6PD deficiency in this Nigerian sub-population showed no association between the vital parameters considered and G6PD deficiency.

Published in	Biochemistry and Molecular Biology (Volume 3, Issue 6)
DOI	10.11648/j.bmb.20180306.11
Page(s)	71-76
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Glucose-6-Phosphate Dehydrogenase, Liver Function Test, Blood Protein, Pregnancy

References

[1]	Bacq, Y. (2013). The Liver in Normal Pregnancy. In: Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience; 2000-2013.
[2]	Bacq, Y., Zarka, O., Brechot, J. F., Mariotte, N. and Vol, S. (1996). Liver function tests in normal pregnancy: A prospective study of 103 pregnant women and 103 matched controls. Hepatology 23: 1030-1034.
[3]	Bertil, E andGlader, A. (2002). A review on genetics and Pathophysiology of Glucose-6-Phosphate Dehydrogenate deficiency. Blood 15: 150.
[4]	Beutler, E. (1994). G6PD deficiency. Blood 84 (11): 3613-3636.
[5]	Bygbjerb, L. C. and Flash, H. (2001). Effects of chloroquine on human lymphocyte proliferation. Tran Soc Tro Med Hyg 80: 231-235.
[6]	Devarbhavi, H., Alvares, J. F. and Kumar, K. S. (2005). Severe falciparum malaria simulating fulminant hepatic failure, Mayo Clin Proc 80: 355-358.
[7]	Fisayo, A. M. (2007). Plasma proteins and proteinuria in gestational malaria. Indian J Clin Biochem. 22 (2):93-5.
[8]	Glader, B. E. (2016). A review on genetics and Pathophysiology of Glucose-6-Phosphate Dehydrogenate deficiency. Wolters Kluwer; UpToDate.
[9]	Ignatius, C. M., Emeka, E. N. and Blessing, N. E. (2008). Effect of malaria parasitemia on liver enzymes tests. International Journal of Trop Med 3: 49-52.
[10]	Kawamoto, R., Ninomiya, D., Hasegawa, Y., Kasai, Y., Kusunoki, T., Ohtsuka, N., Kumagi, T. and Abe, M. (2014). Mildly Elevated Serum Bilirubin Levels Are Negatively Associated with Carotid Atherosclerosis among Elderly Persons. PLoS ONE, 9 (12), 1-14.
[11]	Kondrackiene, J. and Kupcinskas, L. (2008). Intrahepatic cholestasis of pregnancy-current achievements and unsolved problems. World Journal of Gastroenterology; 14 (38), 5781–5788.
[12]	Luzzato, L. and Mehta, A. (2001). Glucose-6-phosphate dehydrogenase deficiency. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic and Molecular Bases of Inherited Disease, 8th ed. New York: McGraw-Hill, 45: 17-53.
[13]	Mackillop, L. and Williamson, C. (2010). Liver disease in Pregnancy. Postgrad Med J. 86 (1013):160-4.
[14]	Mehta, M. A., Owen, A. M., Sahakian, B. J., Mavaddat, N., Pickard, J. D. and Robbins TW. (2000). Methylphenidate enhances working memory by modulating discrete frontal and parietal lobe regions in the human brain. J Neurosci. 20 (6):RC65.
[15]	Moss, D. W and Handerson, A. R. (1999). ClinicalEnzomology. In: Burtis, C. A. and F. R. Ashwood, (Eds.), Tietz Textbook of clinical chemistry. 3^rd Edn., Saunders Co., Philadelphia, W. B., pp: 617-721.
[16]	Nour, A. H., Nour, Ab. H., Sandanasamy, J. A. P. and Yusoff, M. M. (2012). Antibacterial Activity of Different Extracts of SwieteniaMacrophylla King. Proceedings of the 13th Seminar on Medicinal and Aromatic Plants, 25-26 September 2012, Kuala lumbur, Malaysia, pp. 17-18.
[17]	Odhiambo, C., Omolo, P., Oyaro, B., Williamson, J., Kinuthia, J., Matemo, D., Drake, A., John-Stewart, G. and Zeh, C. (2017). Establishment of reference intervals during normal pregnancy through six months postpartum in western Kenya. PLoS ONE, 12 (4): 1-11.
[18]	Owusu, R., Asante, K. P., Mahama, E., Awini, E., Anyorigiya, T., Dosoo, D., Amu, A., Jakpa, G., Ofei, E., Segbaya, S., Oduro, A. R., Gyapong, M., Hodgson, A., Bart-Plange, C. and Owusu-Agyei, S. (2015). Glucose-6-Phosphate Dehydrogenase Deficiency and Haemoglobin drop after Sulphadoxine-Pyrimethamine use for Intermittent Preventive Treatment of Malaria during Pregnancy in Ghana – A Cohort Study. PLoS ONE 10 (9): 1-17.
[19]	Peters, A. L. and Van Noorden, C. J. F. (2009). Glucose-6-phosphate Dehydrogenase Deficiency and Malaria: Cytochemical Detection of Heterozygous G6PD Deficiency in Women. J. Histochemistry and Cytochemistry, 57 (11), 1003–1011.
[20]	Prakash, J. (2012). The kidney in pregnancy: A journey of three decades. Indian Journal of Nephrology, 22 (3), 159–167.
[21]	Prchal, J. T. (2005). Polycythemia vera and other primary polycythemias. Curr. Opin. Hemat. 12: 112-116.
[22]	Reclos, G. J., Hatzidakis, C. J. and Schulpis, K. H. (2000). Glucose-6-phosphate dehydrogenase deficiency neonatal screening: Preliminary evidence that a high percentage of partially deficient female neonate are missed during routine screening. J Med Screen 7:46-51.
[23]	Seong, W. J., Chong, G. O., Hong, D. G., Lee, T. H., Lee, Y. S., Cho, Y. L., Chun, S. S. and Park, I. S. (2010). Clinical significance of serum albumin level in pregnancy-related hypertension. J Obstet Gynaecol Res. 36 (6):1165-73.
[24]	WHO Scientific Group (1967). Standarization procedures for the study of glucose-6-phosphate dehydrogenase. WHO Tech Rep. 366, 1-8.
[25]	WHO Working Group. (1989). Glucose-6-phosphate dehydrogenase deficiency. Bulletin of the World Health Organization, 67 (6), 601–611.
[26]	Zaffanello, M., Rugolotto, S., Zamboni, G., Gaudino, R. and Tatò, L. (2004). Eur J Epidemiol. 19: 255-257.

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David Morakinyo Sanni, Oluwasegun Victor Omotoyinbo, Damilola Folajimi. (2019). Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency in a Population of Nigerian Women Resident in Akure. Biochemistry and Molecular Biology, 3(6), 71-76. https://doi.org/10.11648/j.bmb.20180306.11

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ACS Style

David Morakinyo Sanni; Oluwasegun Victor Omotoyinbo; Damilola Folajimi. Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency in a Population of Nigerian Women Resident in Akure. Biochem. Mol. Biol. 2019, 3(6), 71-76. doi: 10.11648/j.bmb.20180306.11

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AMA Style

David Morakinyo Sanni, Oluwasegun Victor Omotoyinbo, Damilola Folajimi. Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency in a Population of Nigerian Women Resident in Akure. Biochem Mol Biol. 2019;3(6):71-76. doi: 10.11648/j.bmb.20180306.11

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@article{10.11648/j.bmb.20180306.11,
  author = {David Morakinyo Sanni and Oluwasegun Victor Omotoyinbo and Damilola Folajimi},
  title = {Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency in a Population of Nigerian Women Resident in Akure},
  journal = {Biochemistry and Molecular Biology},
  volume = {3},
  number = {6},
  pages = {71-76},
  doi = {10.11648/j.bmb.20180306.11},
  url = {https://doi.org/10.11648/j.bmb.20180306.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bmb.20180306.11},
  abstract = {Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy in Sub-Saharan Africa and is particularly prevalent in historically malaria-endemic countries. This work is a preliminary study on the prevalence of G6PD deficiency in both pregnant and non-pregnant women carried out on 100 subjects consisting of 50 pregnant women and 50 non-pregnant women as well as toidentify predictors of G6PD deficiency by analyzing other parameters. Presence of G6PD, total protein, albumin, total bilirubin, aspartate transaminase, alanine transaminase and alkaline phosphatase were determined in all the subjects using spectrophotometric method. It was observed that the overall prevalence of G6PD deficiency was found in 10% of pregnant women considered. The albumin, total bilirubin, aspartate transaminase, alanine transaminase, total protein and alkaline phosphatase were not significantly different in G6PD deficient pregnant and non-pregnant women. In conclusion, the prevalence of G6PD deficiency in this Nigerian sub-population showed no association between the vital parameters considered and G6PD deficiency.},
 year = {2019}
}

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TY  - JOUR
T1  - Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency in a Population of Nigerian Women Resident in Akure
AU  - David Morakinyo Sanni
AU  - Oluwasegun Victor Omotoyinbo
AU  - Damilola Folajimi
Y1  - 2019/01/16
PY  - 2019
N1  - https://doi.org/10.11648/j.bmb.20180306.11
DO  - 10.11648/j.bmb.20180306.11
T2  - Biochemistry and Molecular Biology
JF  - Biochemistry and Molecular Biology
JO  - Biochemistry and Molecular Biology
SP  - 71
EP  - 76
PB  - Science Publishing Group
SN  - 2575-5048
UR  - https://doi.org/10.11648/j.bmb.20180306.11
AB  - Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy in Sub-Saharan Africa and is particularly prevalent in historically malaria-endemic countries. This work is a preliminary study on the prevalence of G6PD deficiency in both pregnant and non-pregnant women carried out on 100 subjects consisting of 50 pregnant women and 50 non-pregnant women as well as toidentify predictors of G6PD deficiency by analyzing other parameters. Presence of G6PD, total protein, albumin, total bilirubin, aspartate transaminase, alanine transaminase and alkaline phosphatase were determined in all the subjects using spectrophotometric method. It was observed that the overall prevalence of G6PD deficiency was found in 10% of pregnant women considered. The albumin, total bilirubin, aspartate transaminase, alanine transaminase, total protein and alkaline phosphatase were not significantly different in G6PD deficient pregnant and non-pregnant women. In conclusion, the prevalence of G6PD deficiency in this Nigerian sub-population showed no association between the vital parameters considered and G6PD deficiency.
VL  - 3
IS  - 6
ER  -

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Author Information

David Morakinyo Sanni

Department of Biochemistry, Federal University of Technology, Akure, Nigeria
Oluwasegun Victor Omotoyinbo

Department of Biological Sciences, Wesley University, Ondo, Nigeria
Damilola Folajimi

Department of Biochemistry, Federal University of Technology, Akure, Nigeria

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APA Style

David Morakinyo Sanni, Oluwasegun Victor Omotoyinbo, Damilola Folajimi. (2019). Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency in a Population of Nigerian Women Resident in Akure. Biochemistry and Molecular Biology, 3(6), 71-76. https://doi.org/10.11648/j.bmb.20180306.11

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ACS Style

David Morakinyo Sanni; Oluwasegun Victor Omotoyinbo; Damilola Folajimi. Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency in a Population of Nigerian Women Resident in Akure. Biochem. Mol. Biol. 2019, 3(6), 71-76. doi: 10.11648/j.bmb.20180306.11

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AMA Style

David Morakinyo Sanni, Oluwasegun Victor Omotoyinbo, Damilola Folajimi. Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency in a Population of Nigerian Women Resident in Akure. Biochem Mol Biol. 2019;3(6):71-76. doi: 10.11648/j.bmb.20180306.11

Copy | Download

@article{10.11648/j.bmb.20180306.11,
  author = {David Morakinyo Sanni and Oluwasegun Victor Omotoyinbo and Damilola Folajimi},
  title = {Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency in a Population of Nigerian Women Resident in Akure},
  journal = {Biochemistry and Molecular Biology},
  volume = {3},
  number = {6},
  pages = {71-76},
  doi = {10.11648/j.bmb.20180306.11},
  url = {https://doi.org/10.11648/j.bmb.20180306.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bmb.20180306.11},
  abstract = {Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy in Sub-Saharan Africa and is particularly prevalent in historically malaria-endemic countries. This work is a preliminary study on the prevalence of G6PD deficiency in both pregnant and non-pregnant women carried out on 100 subjects consisting of 50 pregnant women and 50 non-pregnant women as well as toidentify predictors of G6PD deficiency by analyzing other parameters. Presence of G6PD, total protein, albumin, total bilirubin, aspartate transaminase, alanine transaminase and alkaline phosphatase were determined in all the subjects using spectrophotometric method. It was observed that the overall prevalence of G6PD deficiency was found in 10% of pregnant women considered. The albumin, total bilirubin, aspartate transaminase, alanine transaminase, total protein and alkaline phosphatase were not significantly different in G6PD deficient pregnant and non-pregnant women. In conclusion, the prevalence of G6PD deficiency in this Nigerian sub-population showed no association between the vital parameters considered and G6PD deficiency.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency in a Population of Nigerian Women Resident in Akure
AU  - David Morakinyo Sanni
AU  - Oluwasegun Victor Omotoyinbo
AU  - Damilola Folajimi
Y1  - 2019/01/16
PY  - 2019
N1  - https://doi.org/10.11648/j.bmb.20180306.11
DO  - 10.11648/j.bmb.20180306.11
T2  - Biochemistry and Molecular Biology
JF  - Biochemistry and Molecular Biology
JO  - Biochemistry and Molecular Biology
SP  - 71
EP  - 76
PB  - Science Publishing Group
SN  - 2575-5048
UR  - https://doi.org/10.11648/j.bmb.20180306.11
AB  - Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy in Sub-Saharan Africa and is particularly prevalent in historically malaria-endemic countries. This work is a preliminary study on the prevalence of G6PD deficiency in both pregnant and non-pregnant women carried out on 100 subjects consisting of 50 pregnant women and 50 non-pregnant women as well as toidentify predictors of G6PD deficiency by analyzing other parameters. Presence of G6PD, total protein, albumin, total bilirubin, aspartate transaminase, alanine transaminase and alkaline phosphatase were determined in all the subjects using spectrophotometric method. It was observed that the overall prevalence of G6PD deficiency was found in 10% of pregnant women considered. The albumin, total bilirubin, aspartate transaminase, alanine transaminase, total protein and alkaline phosphatase were not significantly different in G6PD deficient pregnant and non-pregnant women. In conclusion, the prevalence of G6PD deficiency in this Nigerian sub-population showed no association between the vital parameters considered and G6PD deficiency.
VL  - 3
IS  - 6
ER  -

Copy | Download