The Pattern of Risk Factor Profile and Dutch Lipid Clinic Network Criteria of Familial Hypercholesterolemia in Egyptian Patients with Premature Coronary Heart Disease

Ahmed Ellaien; Ashraf Reda; Ahmed Elkersh

doi:doi:10.11648/j.ccr.20200404.16

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The Pattern of Risk Factor Profile and Dutch Lipid Clinic Network Criteria of Familial Hypercholesterolemia in Egyptian Patients with Premature Coronary Heart Disease

Ahmed Ellaien, Ashraf Reda, Ahmed Elkersh

Published in Cardiology and Cardiovascular Research (Volume 4, Issue 4)

Received: 11 October 2020 Accepted: 21 October 2020 Published: 30 October 2020

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Abstract

Background: Traditional risk factors (RFs), such as obesity, family history of premature coronary heart disease (CHD), hypertension, diabetes mellitus, and cigarette smoking have been shown to be significantly associated with early-onset CHD. Familial hypercholesterolemia (FH) is also a major genetic risk factor of premature CHD. Methods: This study was conducted on 100 patients with premature CHD (age<55 years in males and<60 years in females) who were admitted to hospital with acute coronary syndrome or stable coronary artery disease referred for coronary angiography, with a focus on RFs. Results: Male patients constituted 74% of the patients. In all patients, smoking (64%), obesity (64%), abdominal obesity (71%), increased LDL cholesterol (67%), hypertension (54%), positive family history of CHD (43%), and diabetes mellitus (34%) were the most prevalent risk factors. There were 26 patients diagnosed as having definite/probable FH (26%) using DLCNC score. The most common diagnosis was St-elevation myocardial infarction (STEMI) (53%) which was more prevalent in males compared to females [(60.8%) vs (30.8%), (p<0.001)]. Female patients had higher prevalence of hypertension [(73.1%) vs (47.3%), (p=0.023)], diabetes mellitus [(53.8%) vs (27%), (p=0.013)], Obesity [(80.8%) vs (58.1%), (P=0.038)] and definite/probable FH [(46.1%) vs (18.9%), (p=0.024)] as compared to male patients. On the other hand, male patients had higher prevalence of smoking [(85.1%) vs (3.8%), (p<0.001)] and reduced HDL cholesterol levels [(73%) vs (42.3%), (p=0.005)] compared to female patients. Conclusions: Traditional risk factors and FH were significantly related to premature CHD. Significant sex differences were also observed for multiple RFs.

Published in	Cardiology and Cardiovascular Research (Volume 4, Issue 4)
DOI	10.11648/j.ccr.20200404.16
Page(s)	203-209
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Risk Factors, Premature Coronary Heart Disease, Young, Familial Hypercholesterolemia

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APA Style

Ahmed Ellaien, Ashraf Reda, Ahmed Elkersh. (2020). The Pattern of Risk Factor Profile and Dutch Lipid Clinic Network Criteria of Familial Hypercholesterolemia in Egyptian Patients with Premature Coronary Heart Disease. Cardiology and Cardiovascular Research, 4(4), 203-209. https://doi.org/10.11648/j.ccr.20200404.16

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ACS Style

Ahmed Ellaien; Ashraf Reda; Ahmed Elkersh. The Pattern of Risk Factor Profile and Dutch Lipid Clinic Network Criteria of Familial Hypercholesterolemia in Egyptian Patients with Premature Coronary Heart Disease. Cardiol. Cardiovasc. Res. 2020, 4(4), 203-209. doi: 10.11648/j.ccr.20200404.16

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AMA Style

Ahmed Ellaien, Ashraf Reda, Ahmed Elkersh. The Pattern of Risk Factor Profile and Dutch Lipid Clinic Network Criteria of Familial Hypercholesterolemia in Egyptian Patients with Premature Coronary Heart Disease. Cardiol Cardiovasc Res. 2020;4(4):203-209. doi: 10.11648/j.ccr.20200404.16

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@article{10.11648/j.ccr.20200404.16,
  author = {Ahmed Ellaien and Ashraf Reda and Ahmed Elkersh},
  title = {The Pattern of Risk Factor Profile and Dutch Lipid Clinic Network Criteria of Familial Hypercholesterolemia in Egyptian Patients with Premature Coronary Heart Disease},
  journal = {Cardiology and Cardiovascular Research},
  volume = {4},
  number = {4},
  pages = {203-209},
  doi = {10.11648/j.ccr.20200404.16},
  url = {https://doi.org/10.11648/j.ccr.20200404.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ccr.20200404.16},
  abstract = {Background: Traditional risk factors (RFs), such as obesity, family history of premature coronary heart disease (CHD), hypertension, diabetes mellitus, and cigarette smoking have been shown to be significantly associated with early-onset CHD. Familial hypercholesterolemia (FH) is also a major genetic risk factor of premature CHD. Methods: This study was conducted on 100 patients with premature CHD (agepp=0.023)], diabetes mellitus [(53.8%) vs (27%), (p=0.013)], Obesity [(80.8%) vs (58.1%), (P=0.038)] and definite/probable FH [(46.1%) vs (18.9%), (p=0.024)] as compared to male patients. On the other hand, male patients had higher prevalence of smoking [(85.1%) vs (3.8%), (pp=0.005)] compared to female patients. Conclusions: Traditional risk factors and FH were significantly related to premature CHD. Significant sex differences were also observed for multiple RFs.},
 year = {2020}
}

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TY  - JOUR
T1  - The Pattern of Risk Factor Profile and Dutch Lipid Clinic Network Criteria of Familial Hypercholesterolemia in Egyptian Patients with Premature Coronary Heart Disease
AU  - Ahmed Ellaien
AU  - Ashraf Reda
AU  - Ahmed Elkersh
Y1  - 2020/10/30
PY  - 2020
N1  - https://doi.org/10.11648/j.ccr.20200404.16
DO  - 10.11648/j.ccr.20200404.16
T2  - Cardiology and Cardiovascular Research
JF  - Cardiology and Cardiovascular Research
JO  - Cardiology and Cardiovascular Research
SP  - 203
EP  - 209
PB  - Science Publishing Group
SN  - 2578-8914
UR  - https://doi.org/10.11648/j.ccr.20200404.16
AB  - Background: Traditional risk factors (RFs), such as obesity, family history of premature coronary heart disease (CHD), hypertension, diabetes mellitus, and cigarette smoking have been shown to be significantly associated with early-onset CHD. Familial hypercholesterolemia (FH) is also a major genetic risk factor of premature CHD. Methods: This study was conducted on 100 patients with premature CHD (agepp=0.023)], diabetes mellitus [(53.8%) vs (27%), (p=0.013)], Obesity [(80.8%) vs (58.1%), (P=0.038)] and definite/probable FH [(46.1%) vs (18.9%), (p=0.024)] as compared to male patients. On the other hand, male patients had higher prevalence of smoking [(85.1%) vs (3.8%), (pp=0.005)] compared to female patients. Conclusions: Traditional risk factors and FH were significantly related to premature CHD. Significant sex differences were also observed for multiple RFs.
VL  - 4
IS  - 4
ER  -

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Author Information

Ahmed Ellaien

Cardiology Department, Faculty of Medicine, Menofia University, Menofia, Egypt
Ashraf Reda

Cardiology Department, Faculty of Medicine, Menofia University, Menofia, Egypt
Ahmed Elkersh

Cardiology Department, Faculty of Medicine, Menofia University, Menofia, Egypt

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APA Style

Ahmed Ellaien, Ashraf Reda, Ahmed Elkersh. (2020). The Pattern of Risk Factor Profile and Dutch Lipid Clinic Network Criteria of Familial Hypercholesterolemia in Egyptian Patients with Premature Coronary Heart Disease. Cardiology and Cardiovascular Research, 4(4), 203-209. https://doi.org/10.11648/j.ccr.20200404.16

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ACS Style

Ahmed Ellaien; Ashraf Reda; Ahmed Elkersh. The Pattern of Risk Factor Profile and Dutch Lipid Clinic Network Criteria of Familial Hypercholesterolemia in Egyptian Patients with Premature Coronary Heart Disease. Cardiol. Cardiovasc. Res. 2020, 4(4), 203-209. doi: 10.11648/j.ccr.20200404.16

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AMA Style

Ahmed Ellaien, Ashraf Reda, Ahmed Elkersh. The Pattern of Risk Factor Profile and Dutch Lipid Clinic Network Criteria of Familial Hypercholesterolemia in Egyptian Patients with Premature Coronary Heart Disease. Cardiol Cardiovasc Res. 2020;4(4):203-209. doi: 10.11648/j.ccr.20200404.16

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@article{10.11648/j.ccr.20200404.16,
  author = {Ahmed Ellaien and Ashraf Reda and Ahmed Elkersh},
  title = {The Pattern of Risk Factor Profile and Dutch Lipid Clinic Network Criteria of Familial Hypercholesterolemia in Egyptian Patients with Premature Coronary Heart Disease},
  journal = {Cardiology and Cardiovascular Research},
  volume = {4},
  number = {4},
  pages = {203-209},
  doi = {10.11648/j.ccr.20200404.16},
  url = {https://doi.org/10.11648/j.ccr.20200404.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ccr.20200404.16},
  abstract = {Background: Traditional risk factors (RFs), such as obesity, family history of premature coronary heart disease (CHD), hypertension, diabetes mellitus, and cigarette smoking have been shown to be significantly associated with early-onset CHD. Familial hypercholesterolemia (FH) is also a major genetic risk factor of premature CHD. Methods: This study was conducted on 100 patients with premature CHD (agepp=0.023)], diabetes mellitus [(53.8%) vs (27%), (p=0.013)], Obesity [(80.8%) vs (58.1%), (P=0.038)] and definite/probable FH [(46.1%) vs (18.9%), (p=0.024)] as compared to male patients. On the other hand, male patients had higher prevalence of smoking [(85.1%) vs (3.8%), (pp=0.005)] compared to female patients. Conclusions: Traditional risk factors and FH were significantly related to premature CHD. Significant sex differences were also observed for multiple RFs.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - The Pattern of Risk Factor Profile and Dutch Lipid Clinic Network Criteria of Familial Hypercholesterolemia in Egyptian Patients with Premature Coronary Heart Disease
AU  - Ahmed Ellaien
AU  - Ashraf Reda
AU  - Ahmed Elkersh
Y1  - 2020/10/30
PY  - 2020
N1  - https://doi.org/10.11648/j.ccr.20200404.16
DO  - 10.11648/j.ccr.20200404.16
T2  - Cardiology and Cardiovascular Research
JF  - Cardiology and Cardiovascular Research
JO  - Cardiology and Cardiovascular Research
SP  - 203
EP  - 209
PB  - Science Publishing Group
SN  - 2578-8914
UR  - https://doi.org/10.11648/j.ccr.20200404.16
AB  - Background: Traditional risk factors (RFs), such as obesity, family history of premature coronary heart disease (CHD), hypertension, diabetes mellitus, and cigarette smoking have been shown to be significantly associated with early-onset CHD. Familial hypercholesterolemia (FH) is also a major genetic risk factor of premature CHD. Methods: This study was conducted on 100 patients with premature CHD (agepp=0.023)], diabetes mellitus [(53.8%) vs (27%), (p=0.013)], Obesity [(80.8%) vs (58.1%), (P=0.038)] and definite/probable FH [(46.1%) vs (18.9%), (p=0.024)] as compared to male patients. On the other hand, male patients had higher prevalence of smoking [(85.1%) vs (3.8%), (pp=0.005)] compared to female patients. Conclusions: Traditional risk factors and FH were significantly related to premature CHD. Significant sex differences were also observed for multiple RFs.
VL  - 4
IS  - 4
ER  -

Copy | Download