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Evaluation of Lipid Profile on Hypertensive Patients: An Observational Study from North Sulawesi, Indonesia

Received: 1 March 2022     Accepted: 24 March 2022     Published: 31 March 2022
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Abstract

Hypertension is a major cause of premature death worldwide and a risk factor for cardiovascular disease (CVD). The prevalence of hypertension in Indonesia is 34.11%, and about 95% of hypertension in Indonesia is essential hypertension of unknown cause and multifactorial. Dyslipidemia is characterized by an increase or decrease in the lipid fraction in plasma. Patients with hypertension who are accompanied by dyslipidemia have a risk of 18.1 times more likely to develop coronary heart disease than those without dyslipidemia. This study aimed to determine the prevalence and relationship between lipid profile levels and blood pressures of hypertensive patients in North Sulawesi, Indonesia. This was a cross-sectional study conducted on 132 inpatients and outpatients with hypertension. Physical examinations including systolic and diastolic blood pressure (SBP, DBP) and body mass index (BMI) were performed. Fasting lipids including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) were evaluated. Overall, 79.5% of the subjects had dyslipidemia, and more prevalent in females and over 45 years of age. The most common type of dyslipidemia observed was hypercholesterolemia (51.5%), followed by high LDL-C (34.1%), elevated TG (31.8%), and low HDL-C (31.1%). There were statistically significant correlations found between lipid profiles and other cardiovascular risk factors only in females, namely a positive correlation between LDL-C and DBP and a negative correlation between HDL-C and age. As conclusion, the prevalence of dyslipidemia in this study was high. A statistically significant positive correlation between lipid profile and blood pressures was found only in females.

Published in Cardiology and Cardiovascular Research (Volume 6, Issue 1)
DOI 10.11648/j.ccr.20220601.16
Page(s) 39-44
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Hypertension, Dyslipidemia, Blood Pressures

References
[1] Kannel W. Fifty years of Framingham Study contributions to understanding hypertension. J Hum Hypertens 2000; 14 (2): 83–90.
[2] Reddy KS. Cardiovascular Disease in Non-Western Countries. N Engl J Med 2004; 350 (24): 2438–40.
[3] Badan Penelitian dan Pengembangan Kesehatan. Hasil Utama RISKESDAS 2018. Kementerian Kesehatan RI; 2018.
[4] Whelton PK, Carey RM, Aronow WS, Casey DE, Collins KJ, Dennison Himmelfarb C, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults. J Am Coll Cardiol 2018; 71 (19): e127–248.
[5] Ariyanti R, Besral B. Dyslipidemia Associated with Hypertension Increases the Risks for Coronary Heart Disease: A Case-Control Study in Harapan Kita Hospital, National Cardiovascular Center, Jakarta. J Lipids 2019; 2019: 1–6.
[6] Islam S, Choudhury KN, Mainuddin A, Wahiduzzaman M. Serum lipid profile and its association with hypertension in Bangladesh. Vasc Health Risk Manag. 2014; 10: 327-32.
[7] Nayak P. Evaluation of Lipid Profile and Apolipoproteins in Essential Hypertensive Patients. J Clin Diagn Res 2016; 10 (10): BC01-04.
[8] Gebrie A, Gnanasekaran N, Menon M, Sisay M, Zegeye A. Evaluation of lipid profiles and hematological parameters in hypertensive patients: Laboratory-based cross-sectional study. SAGE Open Med 2018; 6: 205031211875666.
[9] Diana DAIAT, Astini DAAAS. Prevalence of hypertension among adults in Kintamani Subdistrict-Bali. IOP Conf Ser Mater Sci Eng 2018; 434: 012322.
[10] World Health Organization. A global brief on hypertension [Internet]. WHO Press; 2013. Available from: https://www.who.int/publications/i/item/a-global-brief-on-hypertension-silent-killer-global-public-health-crisis-world-health-day-2013
[11] Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA J Am Med Assoc 2001; 285 (19): 2486–97.
[12] Rinkūnienė E, Laucevičius A, Petrulionienė Ž, Dženkevičiūtė V, Kutkienė S, Skujaitė A, et al. The prevalence of dislipidemia and its relation to other risk factors: a nationwide survey of Lithuania. Clin Lipidol 2015; 10 (3): 219–25.
[13] Dave JA, Levitt NS, Ross IL, Lacerda M, Maartens G, Blom D. Anti-Retroviral Therapy Increases the Prevalence of Dyslipidemia in South African HIV-Infected Patients. Blackard J, editor. PLOS ONE 2016; 11 (3): e0151911.
[14] Banerjee R, Bhattacherjee S, Ray K, Roy JK, Datta S, Banerjee I. Dyslipidemia and its Relationship with Cardiovascular Risk Factors in a Selected Population of Siliguri City, West Bengal, India. Asian J Med Sci 2013; 5 (1): 1–8.
[15] Pająk A, Szafraniec K, Polak M, Polakowska M, Kozela M, Piotrowski W, et al. Changes in the prevalence, management and treatment of hypercholesterolemia and other dyslipidemias over 10 years in Poland. The WOBASZ study. Pol Arch Intern Med 2016; 126 (9): 642-52.
[16] Noubiap JJ, Bigna JJ, Nansseu JR, Nyaga UF, Balti EV, Echouffo-Tcheugui JB, et al. Prevalence of dyslipidaemia among adults in Africa: a systematic review and meta-analysis. Lancet Glob Health 2018; 6 (9): e998–1007.
[17] Najafipour H, Shokoohi M, Yousefzadeh G, Sarvar Azimzadeh B, Moshtaghi Kashanian G, Bagheri MM, et al. Prevalence of dyslipidemia and its association with other coronary artery disease risk factors among urban population in Southeast of Iran: results of the Kerman coronary artery disease risk factors study (KERCADRS). J Diabetes Metab Disord 2016; 15 (1): 49.
[18] Liu X, Yu S, Mao Z, Li Y, Zhang H, Yang K, et al. Dyslipidemia prevalence, awareness, treatment, control, and risk factors in Chinese rural population: the Henan rural cohort study. Lipids Health Dis 2018; 17 (1): 119.
[19] Sufa B, Abebe G, Cheneke W. Dyslipidemia and associated factors among women using hormonal contraceptives in Harar town, Eastern Ethiopia. BMC Res Notes 2019; 12 (1): 120.
[20] Wankhade PS, Pedhambkar RB, Pagare RS, Pedhambkar BS. Prevalence and risk factors of dyslipidemia among male industrial workers in India. Int J Community Med Public Health 2018; 5 (4): 1458.
[21] Bakesiima R, Byakika-Kibwika P, Tumwine JK, Kalyango JN, Nabaasa G, Najjingo I, et al. Dyslipidaemias in women using hormonal contraceptives: a cross sectional study in Mulago Hospital Family Planning Clinic, Kampala, Uganda. BMJ Open 2018; 8 (10): e022338.
[22] Ali I, Kharma A, Samara M, Odeh S, Jaradat N, Zaid AN, et al. Prevalence of Dyslipidemia in Undiagnosed Palestinian Men: A Cross-Sectional Study. J Lipids 2019; 2019: 1–6.
[23] Reiger S, Jardim TV, Abrahams-Gessel S, Crowther NJ, Wade A, Gomez-Olive FX, et al. Awareness, treatment, and control of dyslipidemia in rural South Africa: The HAALSI (Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in South Africa) study. Guerrero-Romero F, editor. PLOS ONE 2017; 12 (10): e0187347.
[24] Ayoade OG, Umoh I, Amadi C. Dyslipidemia and Associated Risk Factors among Nigerians with Hypertension. Dubai Med J 2020; 3 (4): 155–61.
[25] Purwanto DS, Mewo YM, Jim EL, Laloan RJ, Engka JNA, Kepel BJ. The Analysis of Electrolyte Levels on Hypertensive Patients in Noongan Regional General Hospital, North Sulawesi, Indonesia. Sci J Clin Med 2019; 8 (5): 54.
[26] Wang M, Liu M, Li F, Guo C, Liu Z, Pan Y, et al. Gender heterogeneity in dyslipidemia prevalence, trends with age and associated factors in middle age rural Chinese. Lipids Health Dis 2020; 19 (1): 135.
[27] Peters SAE, Muntner P, Woodward M. Sex Differences in the Prevalence of, and Trends in, Cardiovascular Risk Factors, Treatment, and Control in the United States, 2001 to 2016. Circulation 2019; 139 (8): 1025–35.
[28] Ettehad D, Emdin CA, Kiran A, Anderson SG, Callender T, Emberson J, et al. Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. The Lancet 2016; 387 (10022): 957–67.
[29] Hossain FB, Adhikary G, Chowdhury AB, Shawon MSR. Association between body mass index (BMI) and hypertension in south Asian population: evidence from nationally-representative surveys. Clin Hypertens 2019; 25 (1): 28.
[30] Linderman GC, Lu J, Lu Y, Sun X, Xu W, Nasir K, et al. Association of Body Mass Index With Blood Pressure Among 1.7 Million Chinese Adults. JAMA Network Open 2018; 1 (4): e181271.
[31] Ericsson S, Eriksson M, Vitols S, Einarsson K, Berglund L, Angelin B. Influence of age on the metabolism of plasma low density lipoproteins in healthy males. J Clin Invest 1991; 87 (2): 591–6.
[32] Gebreegziabiher G, Belachew T, Mehari K, Tamiru D. Prevalence of dyslipidemia and associated risk factors among adult residents of Mekelle City, Northern Ethiopia. Spradley FT, editor. PLOS ONE 2021; 16 (2): e0243103.
[33] Oda E, Kawai R. LDL Cholesterol Is Associated With Blood Pressure in Japanese Women. Diabetes Care 2009; 32 (9): e113–e113.
[34] Behradmanesh S. Serum cholesterol and LDL-C in association with level of diastolic blood pressure in type 2 diabetic patients. J Renal Inj Prev 2012; 1 (1): 23-26.
[35] Cho K-H, Park H-J, Kim J-R. Decrease in Serum HDL-C Level Is Associated with Elevation of Blood Pressure: Correlation Analysis from the Korean National Health and Nutrition Examination Survey 2017. Int J Environ Res Public Health 2020; 17 (3): 1101.
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  • APA Style

    Diana Shintawati Purwanto, Yanti Meilen Mewo, Edmond Leonard Jim. (2022). Evaluation of Lipid Profile on Hypertensive Patients: An Observational Study from North Sulawesi, Indonesia. Cardiology and Cardiovascular Research, 6(1), 39-44. https://doi.org/10.11648/j.ccr.20220601.16

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    ACS Style

    Diana Shintawati Purwanto; Yanti Meilen Mewo; Edmond Leonard Jim. Evaluation of Lipid Profile on Hypertensive Patients: An Observational Study from North Sulawesi, Indonesia. Cardiol. Cardiovasc. Res. 2022, 6(1), 39-44. doi: 10.11648/j.ccr.20220601.16

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    AMA Style

    Diana Shintawati Purwanto, Yanti Meilen Mewo, Edmond Leonard Jim. Evaluation of Lipid Profile on Hypertensive Patients: An Observational Study from North Sulawesi, Indonesia. Cardiol Cardiovasc Res. 2022;6(1):39-44. doi: 10.11648/j.ccr.20220601.16

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  • @article{10.11648/j.ccr.20220601.16,
      author = {Diana Shintawati Purwanto and Yanti Meilen Mewo and Edmond Leonard Jim},
      title = {Evaluation of Lipid Profile on Hypertensive Patients: An Observational Study from North Sulawesi, Indonesia},
      journal = {Cardiology and Cardiovascular Research},
      volume = {6},
      number = {1},
      pages = {39-44},
      doi = {10.11648/j.ccr.20220601.16},
      url = {https://doi.org/10.11648/j.ccr.20220601.16},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ccr.20220601.16},
      abstract = {Hypertension is a major cause of premature death worldwide and a risk factor for cardiovascular disease (CVD). The prevalence of hypertension in Indonesia is 34.11%, and about 95% of hypertension in Indonesia is essential hypertension of unknown cause and multifactorial. Dyslipidemia is characterized by an increase or decrease in the lipid fraction in plasma. Patients with hypertension who are accompanied by dyslipidemia have a risk of 18.1 times more likely to develop coronary heart disease than those without dyslipidemia. This study aimed to determine the prevalence and relationship between lipid profile levels and blood pressures of hypertensive patients in North Sulawesi, Indonesia. This was a cross-sectional study conducted on 132 inpatients and outpatients with hypertension. Physical examinations including systolic and diastolic blood pressure (SBP, DBP) and body mass index (BMI) were performed. Fasting lipids including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) were evaluated. Overall, 79.5% of the subjects had dyslipidemia, and more prevalent in females and over 45 years of age. The most common type of dyslipidemia observed was hypercholesterolemia (51.5%), followed by high LDL-C (34.1%), elevated TG (31.8%), and low HDL-C (31.1%). There were statistically significant correlations found between lipid profiles and other cardiovascular risk factors only in females, namely a positive correlation between LDL-C and DBP and a negative correlation between HDL-C and age. As conclusion, the prevalence of dyslipidemia in this study was high. A statistically significant positive correlation between lipid profile and blood pressures was found only in females.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Evaluation of Lipid Profile on Hypertensive Patients: An Observational Study from North Sulawesi, Indonesia
    AU  - Diana Shintawati Purwanto
    AU  - Yanti Meilen Mewo
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    PY  - 2022
    N1  - https://doi.org/10.11648/j.ccr.20220601.16
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    T2  - Cardiology and Cardiovascular Research
    JF  - Cardiology and Cardiovascular Research
    JO  - Cardiology and Cardiovascular Research
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    EP  - 44
    PB  - Science Publishing Group
    SN  - 2578-8914
    UR  - https://doi.org/10.11648/j.ccr.20220601.16
    AB  - Hypertension is a major cause of premature death worldwide and a risk factor for cardiovascular disease (CVD). The prevalence of hypertension in Indonesia is 34.11%, and about 95% of hypertension in Indonesia is essential hypertension of unknown cause and multifactorial. Dyslipidemia is characterized by an increase or decrease in the lipid fraction in plasma. Patients with hypertension who are accompanied by dyslipidemia have a risk of 18.1 times more likely to develop coronary heart disease than those without dyslipidemia. This study aimed to determine the prevalence and relationship between lipid profile levels and blood pressures of hypertensive patients in North Sulawesi, Indonesia. This was a cross-sectional study conducted on 132 inpatients and outpatients with hypertension. Physical examinations including systolic and diastolic blood pressure (SBP, DBP) and body mass index (BMI) were performed. Fasting lipids including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) were evaluated. Overall, 79.5% of the subjects had dyslipidemia, and more prevalent in females and over 45 years of age. The most common type of dyslipidemia observed was hypercholesterolemia (51.5%), followed by high LDL-C (34.1%), elevated TG (31.8%), and low HDL-C (31.1%). There were statistically significant correlations found between lipid profiles and other cardiovascular risk factors only in females, namely a positive correlation between LDL-C and DBP and a negative correlation between HDL-C and age. As conclusion, the prevalence of dyslipidemia in this study was high. A statistically significant positive correlation between lipid profile and blood pressures was found only in females.
    VL  - 6
    IS  - 1
    ER  - 

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Author Information
  • Department of Biochemistry, Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia

  • Department of Biochemistry, Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia

  • Department of Cardiovascular Medicine, Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia

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