Back ground: Tumor necrosis factor-alpha (TNF-α), adiponectin (ADP) and C-reactive protein (CRP) are associated with the risk of cardiovascular or non communicable diseases. Aims: To evaluate the association between TNF-α, ADP, CRP and metabolic markers in Congelese Bantu from Brazzaville. Methods: A cross-sectional case-control study was conducted during the period from July 2018 to February 2021. A total of 233 participants were recruited then divided into 130 healthy participants (control group) and 103 insulin resistant patients (case group). The Spearman correlation coefficient was calculated in order to search for an association between TNFα, ADP and the metabolic markers. An exponential nonlinear regression was used for the analysis of the association between TNFα (dependent variable) and CRP. Results: Participants were aged of 45.5 ± 13.1 years with a median BMI of 25.4 kg/m2, were included in this study. The median values of TNFα, CRP, ADP and HOMA-IR were 96.2 pg/mL, 12.3 mg/L, 8.6 ng/mL and 2.3, respectively. TNFα was positively correlated with anthropometric parameters, CRP and insulin resistance. In contrast, ADP was negatively correlated with anthropometric parameters, CRP and insulin resistance. In control group, the equation was written as TNF alpha = 187 * (1 - 0.96CRP). The model shows that CRP explains 84.62% of the variability of TNFα in healthy participants. In case group, the equation was written as TNF alpha = 186.4 * (1 - 0.95CRP). The model shows that CRP explains 93.65% of the variability of TNFα in insulin-resistant participants. Conclusion: TNF alpha and ADP are associated at NC, WC, WHR, WHtR, LDL, CRP and insulin resistance in Congolese Bantu from Brazzaville.
| Published in | Cardiology and Cardiovascular Research (Volume 6, Issue 2) |
| DOI | 10.11648/j.ccr.20220602.12 |
| Page(s) | 55-59 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2022. Published by Science Publishing Group |
TNF Alpha, Adiponectin, Obesity, Insulin Resistance, Bantu, Brazzaville
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APA Style
Danny Mafuta-Munganga, Benjamin Longo-Mbenza, Reine Freudlendrich Eboka-Loumingou Sakou, Etienne Mokondjimobe, Gombet Thierry Raoul Alexis, et al. (2022). Relationship BetweenTumor Necrosis Factor Alpha, Adiponectin and Metabolic Parameters in Bantu Congolese at Brazzaville with and Without Insulin Resistance. Cardiology and Cardiovascular Research, 6(2), 55-59. https://doi.org/10.11648/j.ccr.20220602.12
ACS Style
Danny Mafuta-Munganga; Benjamin Longo-Mbenza; Reine Freudlendrich Eboka-Loumingou Sakou; Etienne Mokondjimobe; Gombet Thierry Raoul Alexis, et al. Relationship BetweenTumor Necrosis Factor Alpha, Adiponectin and Metabolic Parameters in Bantu Congolese at Brazzaville with and Without Insulin Resistance. Cardiol. Cardiovasc. Res. 2022, 6(2), 55-59. doi: 10.11648/j.ccr.20220602.12
AMA Style
Danny Mafuta-Munganga, Benjamin Longo-Mbenza, Reine Freudlendrich Eboka-Loumingou Sakou, Etienne Mokondjimobe, Gombet Thierry Raoul Alexis, et al. Relationship BetweenTumor Necrosis Factor Alpha, Adiponectin and Metabolic Parameters in Bantu Congolese at Brazzaville with and Without Insulin Resistance. Cardiol Cardiovasc Res. 2022;6(2):55-59. doi: 10.11648/j.ccr.20220602.12
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author = {Danny Mafuta-Munganga and Benjamin Longo-Mbenza and Reine Freudlendrich Eboka-Loumingou Sakou and Etienne Mokondjimobe and Gombet Thierry Raoul Alexis and Moise Mvitu and Mireille Nganga and Christian Kisoka Lusunsi},
title = {Relationship BetweenTumor Necrosis Factor Alpha, Adiponectin and Metabolic Parameters in Bantu Congolese at Brazzaville with and Without Insulin Resistance},
journal = {Cardiology and Cardiovascular Research},
volume = {6},
number = {2},
pages = {55-59},
doi = {10.11648/j.ccr.20220602.12},
url = {https://doi.org/10.11648/j.ccr.20220602.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ccr.20220602.12},
abstract = {Back ground: Tumor necrosis factor-alpha (TNF-α), adiponectin (ADP) and C-reactive protein (CRP) are associated with the risk of cardiovascular or non communicable diseases. Aims: To evaluate the association between TNF-α, ADP, CRP and metabolic markers in Congelese Bantu from Brazzaville. Methods: A cross-sectional case-control study was conducted during the period from July 2018 to February 2021. A total of 233 participants were recruited then divided into 130 healthy participants (control group) and 103 insulin resistant patients (case group). The Spearman correlation coefficient was calculated in order to search for an association between TNFα, ADP and the metabolic markers. An exponential nonlinear regression was used for the analysis of the association between TNFα (dependent variable) and CRP. Results: Participants were aged of 45.5 ± 13.1 years with a median BMI of 25.4 kg/m2, were included in this study. The median values of TNFα, CRP, ADP and HOMA-IR were 96.2 pg/mL, 12.3 mg/L, 8.6 ng/mL and 2.3, respectively. TNFα was positively correlated with anthropometric parameters, CRP and insulin resistance. In contrast, ADP was negatively correlated with anthropometric parameters, CRP and insulin resistance. In control group, the equation was written as TNF alpha = 187 * (1 - 0.96CRP). The model shows that CRP explains 84.62% of the variability of TNFα in healthy participants. In case group, the equation was written as TNF alpha = 186.4 * (1 - 0.95CRP). The model shows that CRP explains 93.65% of the variability of TNFα in insulin-resistant participants. Conclusion: TNF alpha and ADP are associated at NC, WC, WHR, WHtR, LDL, CRP and insulin resistance in Congolese Bantu from Brazzaville.},
year = {2022}
}
TY - JOUR T1 - Relationship BetweenTumor Necrosis Factor Alpha, Adiponectin and Metabolic Parameters in Bantu Congolese at Brazzaville with and Without Insulin Resistance AU - Danny Mafuta-Munganga AU - Benjamin Longo-Mbenza AU - Reine Freudlendrich Eboka-Loumingou Sakou AU - Etienne Mokondjimobe AU - Gombet Thierry Raoul Alexis AU - Moise Mvitu AU - Mireille Nganga AU - Christian Kisoka Lusunsi Y1 - 2022/04/26 PY - 2022 N1 - https://doi.org/10.11648/j.ccr.20220602.12 DO - 10.11648/j.ccr.20220602.12 T2 - Cardiology and Cardiovascular Research JF - Cardiology and Cardiovascular Research JO - Cardiology and Cardiovascular Research SP - 55 EP - 59 PB - Science Publishing Group SN - 2578-8914 UR - https://doi.org/10.11648/j.ccr.20220602.12 AB - Back ground: Tumor necrosis factor-alpha (TNF-α), adiponectin (ADP) and C-reactive protein (CRP) are associated with the risk of cardiovascular or non communicable diseases. Aims: To evaluate the association between TNF-α, ADP, CRP and metabolic markers in Congelese Bantu from Brazzaville. Methods: A cross-sectional case-control study was conducted during the period from July 2018 to February 2021. A total of 233 participants were recruited then divided into 130 healthy participants (control group) and 103 insulin resistant patients (case group). The Spearman correlation coefficient was calculated in order to search for an association between TNFα, ADP and the metabolic markers. An exponential nonlinear regression was used for the analysis of the association between TNFα (dependent variable) and CRP. Results: Participants were aged of 45.5 ± 13.1 years with a median BMI of 25.4 kg/m2, were included in this study. The median values of TNFα, CRP, ADP and HOMA-IR were 96.2 pg/mL, 12.3 mg/L, 8.6 ng/mL and 2.3, respectively. TNFα was positively correlated with anthropometric parameters, CRP and insulin resistance. In contrast, ADP was negatively correlated with anthropometric parameters, CRP and insulin resistance. In control group, the equation was written as TNF alpha = 187 * (1 - 0.96CRP). The model shows that CRP explains 84.62% of the variability of TNFα in healthy participants. In case group, the equation was written as TNF alpha = 186.4 * (1 - 0.95CRP). The model shows that CRP explains 93.65% of the variability of TNFα in insulin-resistant participants. Conclusion: TNF alpha and ADP are associated at NC, WC, WHR, WHtR, LDL, CRP and insulin resistance in Congolese Bantu from Brazzaville. VL - 6 IS - 2 ER -
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