Synthesis, Characterization and Biological Study of Some (<i>E</i>)-3-(5-Bromothiophen-2-yl)-1-phenylprop-2-en-1-ones

P. Christuraj; P. R. Rajakumar; C. Geetha; G. Vanangamudi; R. Arulkumran; R. Sundararajan; G. Thirunarayanan

doi:doi:10.11648/j.ijbc.20160101.13

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Synthesis, Characterization and Biological Study of Some (E)-3-(5-Bromothiophen-2-yl)-1-phenylprop-2-en-1-ones

P. Christuraj, P. R. Rajakumar, C. Geetha, G. Vanangamudi, R. Arulkumran, R. Sundararajan, G. Thirunarayanan

Published in International Journal of Bioorganic Chemistry (Volume 1, Issue 1)

Received: 9 December 2016 Accepted: 4 January 2017 Published: 24 January 2017

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Abstract

About eleven substituted (E)-3-(5-bromothiophen-2-yl)-1-phenylprop-2-en-1-ones have been synthesized by Crossed-Aldol condensation using simple stirring of 5-bromo-2-thiophen aldehyde and various substituted acetophenones at room temperature. The obtained yields of this condensation was more than 89%. They are characterized by their analytical, UV, FT-IR and NMR spectral data. The antimicrobial activities of all synthesized chalcones have been evaluated by Bauer-Kirby disc diffusion method using gram positive and gram negative bacterial and fungal strains. From the mm of zone of inhibition values the anti-bacterial and antifungal activities of all ketones have been discussed.

Published in	International Journal of Bioorganic Chemistry (Volume 1, Issue 1)
DOI	10.11648/j.ijbc.20160101.13
Page(s)	21-30
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

(E)-3-(5-Bromothiophen-2-yl)-1-phenylprop-2-en-1-Ones, IR Spectra, NMR Spectra, Antibacterial and Antifungal Activities

References

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P. Christuraj, P. R. Rajakumar, C. Geetha, G. Vanangamudi, R. Arulkumran, et al. (2017). Synthesis, Characterization and Biological Study of Some (E)-3-(5-Bromothiophen-2-yl)-1-phenylprop-2-en-1-ones. International Journal of Bioorganic Chemistry, 1(1), 21-30. https://doi.org/10.11648/j.ijbc.20160101.13

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ACS Style

P. Christuraj; P. R. Rajakumar; C. Geetha; G. Vanangamudi; R. Arulkumran, et al. Synthesis, Characterization and Biological Study of Some (E)-3-(5-Bromothiophen-2-yl)-1-phenylprop-2-en-1-ones. Int. J. Bioorg. Chem. 2017, 1(1), 21-30. doi: 10.11648/j.ijbc.20160101.13

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AMA Style

P. Christuraj, P. R. Rajakumar, C. Geetha, G. Vanangamudi, R. Arulkumran, et al. Synthesis, Characterization and Biological Study of Some (E)-3-(5-Bromothiophen-2-yl)-1-phenylprop-2-en-1-ones. Int J Bioorg Chem. 2017;1(1):21-30. doi: 10.11648/j.ijbc.20160101.13

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@article{10.11648/j.ijbc.20160101.13,
  author = {P. Christuraj and P. R. Rajakumar and C. Geetha and G. Vanangamudi and R. Arulkumran and R. Sundararajan and G. Thirunarayanan},
  title = {Synthesis, Characterization and Biological Study of Some (E)-3-(5-Bromothiophen-2-yl)-1-phenylprop-2-en-1-ones},
  journal = {International Journal of Bioorganic Chemistry},
  volume = {1},
  number = {1},
  pages = {21-30},
  doi = {10.11648/j.ijbc.20160101.13},
  url = {https://doi.org/10.11648/j.ijbc.20160101.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbc.20160101.13},
  abstract = {About eleven substituted (E)-3-(5-bromothiophen-2-yl)-1-phenylprop-2-en-1-ones have been synthesized by Crossed-Aldol condensation using simple stirring of 5-bromo-2-thiophen aldehyde and various substituted acetophenones at room temperature. The obtained yields of this condensation was more than 89%. They are characterized by their analytical, UV, FT-IR and NMR spectral data. The antimicrobial activities of all synthesized chalcones have been evaluated by Bauer-Kirby disc diffusion method using gram positive and gram negative bacterial and fungal strains. From the mm of zone of inhibition values the anti-bacterial and antifungal activities of all ketones have been discussed.},
 year = {2017}
}

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TY  - JOUR
T1  - Synthesis, Characterization and Biological Study of Some (E)-3-(5-Bromothiophen-2-yl)-1-phenylprop-2-en-1-ones
AU  - P. Christuraj
AU  - P. R. Rajakumar
AU  - C. Geetha
AU  - G. Vanangamudi
AU  - R. Arulkumran
AU  - R. Sundararajan
AU  - G. Thirunarayanan
Y1  - 2017/01/24
PY  - 2017
N1  - https://doi.org/10.11648/j.ijbc.20160101.13
DO  - 10.11648/j.ijbc.20160101.13
T2  - International Journal of Bioorganic Chemistry
JF  - International Journal of Bioorganic Chemistry
JO  - International Journal of Bioorganic Chemistry
SP  - 21
EP  - 30
PB  - Science Publishing Group
SN  - 2578-9392
UR  - https://doi.org/10.11648/j.ijbc.20160101.13
AB  - About eleven substituted (E)-3-(5-bromothiophen-2-yl)-1-phenylprop-2-en-1-ones have been synthesized by Crossed-Aldol condensation using simple stirring of 5-bromo-2-thiophen aldehyde and various substituted acetophenones at room temperature. The obtained yields of this condensation was more than 89%. They are characterized by their analytical, UV, FT-IR and NMR spectral data. The antimicrobial activities of all synthesized chalcones have been evaluated by Bauer-Kirby disc diffusion method using gram positive and gram negative bacterial and fungal strains. From the mm of zone of inhibition values the anti-bacterial and antifungal activities of all ketones have been discussed.
VL  - 1
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ER  -

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Author Information

P. Christuraj

Post Graduate and Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram, India
P. R. Rajakumar

Post Graduate and Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram, India
C. Geetha

Post Graduate and Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram, India
G. Vanangamudi

Post Graduate and Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram, India
R. Arulkumran

Post Graduate and Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram, India
R. Sundararajan

Post Graduate and Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram, India
G. Thirunarayanan

Chemistry Department, Annamalai University, Annamalainagar, India

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APA Style

P. Christuraj, P. R. Rajakumar, C. Geetha, G. Vanangamudi, R. Arulkumran, et al. (2017). Synthesis, Characterization and Biological Study of Some (E)-3-(5-Bromothiophen-2-yl)-1-phenylprop-2-en-1-ones. International Journal of Bioorganic Chemistry, 1(1), 21-30. https://doi.org/10.11648/j.ijbc.20160101.13

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ACS Style

P. Christuraj; P. R. Rajakumar; C. Geetha; G. Vanangamudi; R. Arulkumran, et al. Synthesis, Characterization and Biological Study of Some (E)-3-(5-Bromothiophen-2-yl)-1-phenylprop-2-en-1-ones. Int. J. Bioorg. Chem. 2017, 1(1), 21-30. doi: 10.11648/j.ijbc.20160101.13

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AMA Style

P. Christuraj, P. R. Rajakumar, C. Geetha, G. Vanangamudi, R. Arulkumran, et al. Synthesis, Characterization and Biological Study of Some (E)-3-(5-Bromothiophen-2-yl)-1-phenylprop-2-en-1-ones. Int J Bioorg Chem. 2017;1(1):21-30. doi: 10.11648/j.ijbc.20160101.13

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@article{10.11648/j.ijbc.20160101.13,
  author = {P. Christuraj and P. R. Rajakumar and C. Geetha and G. Vanangamudi and R. Arulkumran and R. Sundararajan and G. Thirunarayanan},
  title = {Synthesis, Characterization and Biological Study of Some (E)-3-(5-Bromothiophen-2-yl)-1-phenylprop-2-en-1-ones},
  journal = {International Journal of Bioorganic Chemistry},
  volume = {1},
  number = {1},
  pages = {21-30},
  doi = {10.11648/j.ijbc.20160101.13},
  url = {https://doi.org/10.11648/j.ijbc.20160101.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbc.20160101.13},
  abstract = {About eleven substituted (E)-3-(5-bromothiophen-2-yl)-1-phenylprop-2-en-1-ones have been synthesized by Crossed-Aldol condensation using simple stirring of 5-bromo-2-thiophen aldehyde and various substituted acetophenones at room temperature. The obtained yields of this condensation was more than 89%. They are characterized by their analytical, UV, FT-IR and NMR spectral data. The antimicrobial activities of all synthesized chalcones have been evaluated by Bauer-Kirby disc diffusion method using gram positive and gram negative bacterial and fungal strains. From the mm of zone of inhibition values the anti-bacterial and antifungal activities of all ketones have been discussed.},
 year = {2017}
}

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TY  - JOUR
T1  - Synthesis, Characterization and Biological Study of Some (E)-3-(5-Bromothiophen-2-yl)-1-phenylprop-2-en-1-ones
AU  - P. Christuraj
AU  - P. R. Rajakumar
AU  - C. Geetha
AU  - G. Vanangamudi
AU  - R. Arulkumran
AU  - R. Sundararajan
AU  - G. Thirunarayanan
Y1  - 2017/01/24
PY  - 2017
N1  - https://doi.org/10.11648/j.ijbc.20160101.13
DO  - 10.11648/j.ijbc.20160101.13
T2  - International Journal of Bioorganic Chemistry
JF  - International Journal of Bioorganic Chemistry
JO  - International Journal of Bioorganic Chemistry
SP  - 21
EP  - 30
PB  - Science Publishing Group
SN  - 2578-9392
UR  - https://doi.org/10.11648/j.ijbc.20160101.13
AB  - About eleven substituted (E)-3-(5-bromothiophen-2-yl)-1-phenylprop-2-en-1-ones have been synthesized by Crossed-Aldol condensation using simple stirring of 5-bromo-2-thiophen aldehyde and various substituted acetophenones at room temperature. The obtained yields of this condensation was more than 89%. They are characterized by their analytical, UV, FT-IR and NMR spectral data. The antimicrobial activities of all synthesized chalcones have been evaluated by Bauer-Kirby disc diffusion method using gram positive and gram negative bacterial and fungal strains. From the mm of zone of inhibition values the anti-bacterial and antifungal activities of all ketones have been discussed.
VL  - 1
IS  - 1
ER  -

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