Synthesis of Some Novel Heterocyclic Compounds Containing Benzofuran Moiety of Potential Antimicrobial Activity

Mahmoud M. Abdelall; Ahmed H. Bedair; Fawzy M. Ali; Ahmed M. El-Agrody; Esam S. Khattab; Ahmed H. Halawa; Ahmed M. Abou Warda

doi:doi:10.11648/j.ijbc.20170201.11

Synthesis of Some Novel Heterocyclic Compounds Containing Benzofuran Moiety of Potential Antimicrobial Activity

Mahmoud M. Abdelall, Ahmed H. Bedair, Fawzy M. Ali, Ahmed M. El-Agrody, Esam S. Khattab, Ahmed H. Halawa, Ahmed M. Abou Warda

Published in International Journal of Bioorganic Chemistry (Volume 2, Issue 1)

Received: 6 December 2016 Accepted: 12 January 2017 Published: 13 February 2017

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Imidazotriazole, thiazoles, quinoxaline, benzothiazine, imidazo-thiadiazole, imidazopyridine, imidazothiazole were synthesized via reaction of 3-bromoacetyl-5-bromobenzofuran with each of thiourea, phenylthiourea, thiocetamide, thiocarbamoyl pyrazole, o-phenylenediamine, o-aminothiophenol, 2-aminothia-diazole, aminotriazole, 2-aminopyridine and 2-aminothiazole. The structure of the newly synthesized compounds was confirmed by elemental analysis, IR, 1H NMR, and mass spectral data. All compounds were evaluated for their antimicrobial activities, compound 2 gave excellent results.

Published in	International Journal of Bioorganic Chemistry (Volume 2, Issue 1)
DOI	10.11648/j.ijbc.20170201.11
Page(s)	1-9
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Thiazole, Benzofuran, Quinoxaline, Antimicrobial

References

[1]	Rudocph, J. M.; Illig, R. C.; Sabasinghe, I. N.; Biorgan. Med. Chem. Lett. 12 (2002) 491.
[2]	Xue, S. T.; Guo, H. F.; Liu, M. J.; Jin, J.; Ju, D. H.; Liu, Z. Y.; Li, Z. R. Eur. J. Med. Chem. 96 (2015) 151.
[3]	Hassan, G. S.; Abou-Seri, S. M.; Kamel, G.; Ali, M. M. Eur. J. Med. Chem. 76 (2014) 482.
[4]	Carrër, A.; Brinet, D.; Florent, J. C.; Rousselle, P.; Bertounesque, E. J. Org. Chem. 77 (2012) 1316.
[5]	Watanabe, H.; Kawasaki, A.; Sano, K.; Ono, M.; Saji, H. Bioorg. Med. Chem. 24 (2016) 3618.
[6]	Tian, Y.; Liang, Z.; Xu, H.; Mou, Y.; Guo, C. Molecules, 21 (2016) 758.
[7]	Liang, Z.; Xu, H.; Tian, Y.; Guo, M.; Su, X.; Guo, C., Molecules 21 (2016) 732.
[8]	Stephen, E. C.; Tanious, F., Kim, S.; Wilson, W. D.; Schell, A. W.; Prefect, R. J.; Franzblau, G. S.; Boykin, W. D.; J. Med. Chem. 44 (2001) 1741.
[9]	Siclccki, M. T.; Liu, J.; Mousa, A. S.; Racanclli, A. L.; IIausncr, A. E.; Wexler, R. R.; Olson, E. R., Bioorgan. Med. Chem. Lett. 11 (2001) 2201.
[10]	Canto-Cavacheiro, M. M.; Echevarria, A.; De Souza, S. A. M.; Cysne-Finkeistein, L.; Torres, D. A. M.; Leon, L. L., Arzncimittel. Forschung 50 (2000) 925.
[11]	Al- Ashry, H. S. E.; Rashed, N., Shobier, S. H. A.; Pharmazie 55 (2000) 403.
[12]	Ewing, R. W.; Becker, R. M.; Manetta, E. V., Davis, S. R.; J. Med. Chem. 42 (1999) 3557.
[13]	Okumura, K., Shimazaki, T., Aoki, Y.; Yamashita, II. J. Med. Chem. 41 (1998) 4036.
[14]	Hranjec, M.; Gadisa, M., Pavelic, K., Boykin, W. D.; Karminski- Zamola, G., IL Farmaco 58 (2003) 1319.
[15]	Lee, H. K.; Huang, R. B.; Eur. J. Med. Chem. 37 (2002) 333.
[16]	Ward, S. R.; Nat. Prod. Rep. 14 (1997) 43.
[17]	Bedeschi, A.; Cabri, W.; Candiani, J., Debernardinis, S.; Marchi, M., Eur. Pat. Appl., EP496064 (1990/92); (Chem. Abstr., 117, (1992) 233838.
[18]	Ashraf, H. F.; Fawzy, M. A.; Ahmed, H. B.; Ahmed, H. A.; Ahmed, M. E.; Gamal, M. E.; Al-Azhar Bull. Sci., 18 (2), (2007) 141.
[19]	Ashraf, H. F.; Fawzy, M. A.; Ahmed, H. B.; Ahmed, H. A.; Ahmed, M. E.; Gamal, M. E.; J. Serb. Chem. Sco., 71 (5), (2006) 459.
[20]	Hanamanthsa, S. B. and Virupax, V. B.; J. Heterocycl. Chem. 19 (1982) 69.
[21]	S. M. Hassan, H. A. Emam, and M. M. Abdel All,; J. Chem. Res. (S), (2000) 544.
[22]	Pradeep, Mishra, Asho, K. Shakya, R. K. Agrawal, G. K. Patnalk, J. Indian. Chem. Soc., 67 (1990) 520.
[23]	Ho, Y. W. and Wang, I. J. J. Heterocyclic Chem., 32 (1995) 819.
[24]	R. Harode and T. C. Sharma. J. Indian Chem. Soc., 66 (1989) 282.
[25]	European Committee for Antimicrobial Susceptibility Testing (EUCAST) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID). Determination of minimum inhibitory concentrations (MICs) of antibacterial agents by agar dilution, Clinical Microbiology and Infection, Vol. 6 Number 9, September 2000, pp: 509-515.
[26]	National Committee for Clinical Laboratory Standards. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 5th edn. Approved Standard M7-A5. Wayne, PA: NCCLS, 2000.

Cite This Article

Plain Text BibTeX RIS

APA Style

Mahmoud M. Abdelall, Ahmed H. Bedair, Fawzy M. Ali, Ahmed M. El-Agrody, Esam S. Khattab, et al. (2017). Synthesis of Some Novel Heterocyclic Compounds Containing Benzofuran Moiety of Potential Antimicrobial Activity. International Journal of Bioorganic Chemistry, 2(1), 1-9. https://doi.org/10.11648/j.ijbc.20170201.11

Copy | Download

ACS Style

Mahmoud M. Abdelall; Ahmed H. Bedair; Fawzy M. Ali; Ahmed M. El-Agrody; Esam S. Khattab, et al. Synthesis of Some Novel Heterocyclic Compounds Containing Benzofuran Moiety of Potential Antimicrobial Activity. Int. J. Bioorg. Chem. 2017, 2(1), 1-9. doi: 10.11648/j.ijbc.20170201.11

Copy | Download

AMA Style

Mahmoud M. Abdelall, Ahmed H. Bedair, Fawzy M. Ali, Ahmed M. El-Agrody, Esam S. Khattab, et al. Synthesis of Some Novel Heterocyclic Compounds Containing Benzofuran Moiety of Potential Antimicrobial Activity. Int J Bioorg Chem. 2017;2(1):1-9. doi: 10.11648/j.ijbc.20170201.11

Copy | Download

@article{10.11648/j.ijbc.20170201.11,
  author = {Mahmoud M. Abdelall and Ahmed H. Bedair and Fawzy M. Ali and Ahmed M. El-Agrody and Esam S. Khattab and Ahmed H. Halawa and Ahmed M. Abou Warda},
  title = {Synthesis of Some Novel Heterocyclic Compounds Containing Benzofuran Moiety of Potential Antimicrobial Activity},
  journal = {International Journal of Bioorganic Chemistry},
  volume = {2},
  number = {1},
  pages = {1-9},
  doi = {10.11648/j.ijbc.20170201.11},
  url = {https://doi.org/10.11648/j.ijbc.20170201.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbc.20170201.11},
  abstract = {Imidazotriazole, thiazoles, quinoxaline, benzothiazine, imidazo-thiadiazole, imidazopyridine, imidazothiazole were synthesized via reaction of 3-bromoacetyl-5-bromobenzofuran with each of thiourea, phenylthiourea, thiocetamide, thiocarbamoyl pyrazole, o-phenylenediamine, o-aminothiophenol, 2-aminothia-diazole, aminotriazole, 2-aminopyridine and 2-aminothiazole. The structure of the newly synthesized compounds was confirmed by elemental analysis, IR, 1H NMR, and mass spectral data. All compounds were evaluated for their antimicrobial activities, compound 2 gave excellent results.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Synthesis of Some Novel Heterocyclic Compounds Containing Benzofuran Moiety of Potential Antimicrobial Activity
AU  - Mahmoud M. Abdelall
AU  - Ahmed H. Bedair
AU  - Fawzy M. Ali
AU  - Ahmed M. El-Agrody
AU  - Esam S. Khattab
AU  - Ahmed H. Halawa
AU  - Ahmed M. Abou Warda
Y1  - 2017/02/13
PY  - 2017
N1  - https://doi.org/10.11648/j.ijbc.20170201.11
DO  - 10.11648/j.ijbc.20170201.11
T2  - International Journal of Bioorganic Chemistry
JF  - International Journal of Bioorganic Chemistry
JO  - International Journal of Bioorganic Chemistry
SP  - 1
EP  - 9
PB  - Science Publishing Group
SN  - 2578-9392
UR  - https://doi.org/10.11648/j.ijbc.20170201.11
AB  - Imidazotriazole, thiazoles, quinoxaline, benzothiazine, imidazo-thiadiazole, imidazopyridine, imidazothiazole were synthesized via reaction of 3-bromoacetyl-5-bromobenzofuran with each of thiourea, phenylthiourea, thiocetamide, thiocarbamoyl pyrazole, o-phenylenediamine, o-aminothiophenol, 2-aminothia-diazole, aminotriazole, 2-aminopyridine and 2-aminothiazole. The structure of the newly synthesized compounds was confirmed by elemental analysis, IR, 1H NMR, and mass spectral data. All compounds were evaluated for their antimicrobial activities, compound 2 gave excellent results.
VL  - 2
IS  - 1
ER  -

Copy | Download

Author Information

Mahmoud M. Abdelall

Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt
Ahmed H. Bedair

Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt
Fawzy M. Ali

Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt
Ahmed M. El-Agrody

Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt
Esam S. Khattab

Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt
Ahmed H. Halawa

Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt
Ahmed M. Abou Warda

Microbiology Department, National Organization for Drug Control and Research, Giza, Egypt

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Mahmoud M. Abdelall, Ahmed H. Bedair, Fawzy M. Ali, Ahmed M. El-Agrody, Esam S. Khattab, et al. (2017). Synthesis of Some Novel Heterocyclic Compounds Containing Benzofuran Moiety of Potential Antimicrobial Activity. International Journal of Bioorganic Chemistry, 2(1), 1-9. https://doi.org/10.11648/j.ijbc.20170201.11

Copy | Download

ACS Style

Mahmoud M. Abdelall; Ahmed H. Bedair; Fawzy M. Ali; Ahmed M. El-Agrody; Esam S. Khattab, et al. Synthesis of Some Novel Heterocyclic Compounds Containing Benzofuran Moiety of Potential Antimicrobial Activity. Int. J. Bioorg. Chem. 2017, 2(1), 1-9. doi: 10.11648/j.ijbc.20170201.11

Copy | Download

AMA Style

Mahmoud M. Abdelall, Ahmed H. Bedair, Fawzy M. Ali, Ahmed M. El-Agrody, Esam S. Khattab, et al. Synthesis of Some Novel Heterocyclic Compounds Containing Benzofuran Moiety of Potential Antimicrobial Activity. Int J Bioorg Chem. 2017;2(1):1-9. doi: 10.11648/j.ijbc.20170201.11

Copy | Download

@article{10.11648/j.ijbc.20170201.11,
  author = {Mahmoud M. Abdelall and Ahmed H. Bedair and Fawzy M. Ali and Ahmed M. El-Agrody and Esam S. Khattab and Ahmed H. Halawa and Ahmed M. Abou Warda},
  title = {Synthesis of Some Novel Heterocyclic Compounds Containing Benzofuran Moiety of Potential Antimicrobial Activity},
  journal = {International Journal of Bioorganic Chemistry},
  volume = {2},
  number = {1},
  pages = {1-9},
  doi = {10.11648/j.ijbc.20170201.11},
  url = {https://doi.org/10.11648/j.ijbc.20170201.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbc.20170201.11},
  abstract = {Imidazotriazole, thiazoles, quinoxaline, benzothiazine, imidazo-thiadiazole, imidazopyridine, imidazothiazole were synthesized via reaction of 3-bromoacetyl-5-bromobenzofuran with each of thiourea, phenylthiourea, thiocetamide, thiocarbamoyl pyrazole, o-phenylenediamine, o-aminothiophenol, 2-aminothia-diazole, aminotriazole, 2-aminopyridine and 2-aminothiazole. The structure of the newly synthesized compounds was confirmed by elemental analysis, IR, 1H NMR, and mass spectral data. All compounds were evaluated for their antimicrobial activities, compound 2 gave excellent results.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Synthesis of Some Novel Heterocyclic Compounds Containing Benzofuran Moiety of Potential Antimicrobial Activity
AU  - Mahmoud M. Abdelall
AU  - Ahmed H. Bedair
AU  - Fawzy M. Ali
AU  - Ahmed M. El-Agrody
AU  - Esam S. Khattab
AU  - Ahmed H. Halawa
AU  - Ahmed M. Abou Warda
Y1  - 2017/02/13
PY  - 2017
N1  - https://doi.org/10.11648/j.ijbc.20170201.11
DO  - 10.11648/j.ijbc.20170201.11
T2  - International Journal of Bioorganic Chemistry
JF  - International Journal of Bioorganic Chemistry
JO  - International Journal of Bioorganic Chemistry
SP  - 1
EP  - 9
PB  - Science Publishing Group
SN  - 2578-9392
UR  - https://doi.org/10.11648/j.ijbc.20170201.11
AB  - Imidazotriazole, thiazoles, quinoxaline, benzothiazine, imidazo-thiadiazole, imidazopyridine, imidazothiazole were synthesized via reaction of 3-bromoacetyl-5-bromobenzofuran with each of thiourea, phenylthiourea, thiocetamide, thiocarbamoyl pyrazole, o-phenylenediamine, o-aminothiophenol, 2-aminothia-diazole, aminotriazole, 2-aminopyridine and 2-aminothiazole. The structure of the newly synthesized compounds was confirmed by elemental analysis, IR, 1H NMR, and mass spectral data. All compounds were evaluated for their antimicrobial activities, compound 2 gave excellent results.
VL  - 2
IS  - 1
ER  -

Copy | Download