Research Article
Indocyanine Green Fluorescence Imaging-guided Hepatectomy for Hepatocellular Carcinoma Following Neoadjuvant Therapy
Issue:
Volume 15, Issue 1, March 2026
Pages:
1-10
Received:
29 March 2026
Accepted:
16 April 2026
Published:
28 April 2026
Abstract: Background: Neoadjuvant therapy has improved the resectability of locally advanced hepatocellular carcinoma (HCC), but treatment-induced tumor necrosis and fibrosis often obscure tumor boundaries, making margin control challenging during non-anatomical hepatectomy (NAH). This study evaluated the efficacy of indocyanine green (ICG) fluorescence imaging for tumor delineation and resection margin control in this patient population. Methods: This retrospective observational study included 110 patients with HCC who received neoadjuvant therapy and subsequently underwent NAH between January 2018 and January 2024. After exclusions, 88 eligible patients were divided into ICG-guided (n=40) and conventional surgery (n=48) groups, with 38 matched pairs (38 vs. 38) after 1: 1 propensity score matching (PSM). Primary outcomes included adequate/positive resection margin rates and boundary identification accuracy; secondary outcomes were perioperative and oncological outcomes. Results: The ICG group demonstrated a significantly higher adequate margin rate (92.1% vs. 73.7%, p = 0.034) and improved tumor boundary identification accuracy (89.5% vs. 63.2%, p = 0.012). The positive margin rate was lower in the ICG group (2.6% vs. 18.4%, p = 0.058). Length of hospital stay was significantly shorter (7.1 ± 2.0 vs. 9.4 ± 2.7 days, p = 0.001), while operative time, blood loss, and postoperative complication rates were comparable. No significant differences in recurrence-free survival (RFS) or overall survival (OS) were observed. Conclusions: ICG fluorescence imaging enhances tumor boundary visualization and may improve resection margin quality in NAH following neoadjuvant therapy for HCC, representing a valuable intraoperative navigation tool.
Abstract: Background: Neoadjuvant therapy has improved the resectability of locally advanced hepatocellular carcinoma (HCC), but treatment-induced tumor necrosis and fibrosis often obscure tumor boundaries, making margin control challenging during non-anatomical hepatectomy (NAH). This study evaluated the efficacy of indocyanine green (ICG) fluorescence imag...
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Research Article
Prenatal Ultrasound Diagnosis of Cleft Lip and Palate:
A Case Report
Camara Mody Abdoulaye,
Mamadou Sylla Traore,
Aldjouma Yanogue*,
Bamody Sidibe,
Bagnoni Traore,
Issa Traore,
Guindo Ilias,
Tata Toure,
Siaka Sidibe
Issue:
Volume 15, Issue 1, March 2026
Pages:
11-15
Received:
13 April 2026
Accepted:
28 April 2026
Published:
30 April 2026
DOI:
10.11648/j.sjcm.20261502.12
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Abstract: Introduction: A cleft lip or palate is a congenital malformation that causes a fissure of the lips or palate, and an antenatal diagnosis is essential for its treatment. Objective: The objective of this study was to present a case of a labial cleft in prenatal diagnosis by ultrasound at the Kalaban Coro reference health center. Materials and Methods: This was a case study of a labial cleft discovered during an obstetrical ultrasound. The examination was performed using a VINNO E30 ultrasound machine. Informed consent was obtained from the patient before her participation in the study. Participation in the study was voluntary. The patient's anonymity and confidentiality were guaranteed. Results: The study focused on a 28-year-old housewife. This was her third pregnancy and second delivery, with a history of stillbirth. No medical or surgical history was found. The patient was referred for an obstetrical ultrasound to evaluate the prognosis of delivery. The examination revealed a 34-week-old intrauterine male fetus with a large cleft lip and palate with umbilical cord interposition in the cleft, which was confirmed after birth. Conclusion: Ultrasound is the method of choice for prenatal screening of cleft lip and palate.
Abstract: Introduction: A cleft lip or palate is a congenital malformation that causes a fissure of the lips or palate, and an antenatal diagnosis is essential for its treatment. Objective: The objective of this study was to present a case of a labial cleft in prenatal diagnosis by ultrasound at the Kalaban Coro reference health center. Materials and Methods...
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,
Yue Liu
