Abstract: Groundwater is a common drinking water resource worldwide. Understanding the distribution patterns of its chemical constituents is crucial for prioritizing sustainable management strategies. This study aims to present a holistic understanding of the spatial distribution of the physicochemical quality of groundwater in the Plateaux Region of Togo. A hydrochemical database of over 900 borehole water samples was compiled and integrated into GIS tools along with geological, hydrological, soils, land use and land cover, and other ancillary data. Comparison tests, global and local spatial autocorrelation, and hot spot analysis were performed at a confidence level of 95%. The results showed that groundwater is generally fresh and slightly acidic. Our results stress the importance of controlling physiographic features on groundwater quality. The Kruskal-Wallis test revealed statistical differences (p < 0.05) among physiographic groups for each groundwater quality parameter. The spatial statistics highlight the spatial dependence in the data and substantial variability in the chemical composition of groundwater due to association with physiographic features. In general, mountainous forest zones with higher rainfall recorded the predominance of lower conductivity values and less contamination in groundwater, probably due to the high rate of groundwater recharge and fast fluxes or circulation driven by topographic gradients. In contrast, those in the south, the center, and sometimes in the east and north present a substantially more advanced mineralization. The High-High clusters are similar and developed southwestward. Fluoride hot spots are associated with groundwater alkalinization in the North and granitoids displaying high-K calc-alkaline magnesian series in the southwest. The hotspots for nitrate concentrations are located at the southeast and northeast ends of the Region due to the affluence of contamination sources and the aquifer vulnerability. This study appears significant as a relevant contributing tool for the sustainable management of groundwater resources in the region.Abstract: Groundwater is a common drinking water resource worldwide. Understanding the distribution patterns of its chemical constituents is crucial for prioritizing sustainable management strategies. This study aims to present a holistic understanding of the spatial distribution of the physicochemical quality of groundwater in the Plateaux Region of Togo. A...Show More