Case Report
Anecdotal Report: Resolution of Purported mRNA
Vaccine-Induced Arrhythmia Following Novavax Administration
Russell Hill*
,
Jill Panitch
Issue:
Volume 14, Issue 4, August 2026
Pages:
53-60
Received:
8 June 2026
Accepted:
22 June 2026
Published:
11 July 2026
Abstract: This case report and clinical overview examines rare but persistent post-vaccination cardiac complications associated with mRNA COVID-19 vaccine platforms, which exhibit a higher incidence rate ratio of post-vaccination arrhythmia compared to traditional or vector-based designs. Currently, there is a distinct clinical gap regarding the management of long-term, vaccine-associated arrhythmias that remain refractory over multiple years. We present the case of a 77-year-old male with no prior cardiac history who developed persistent ventricular bigeminy and frequent premature ventricular contractions (PVCs) following a primary mRNA vaccination series (Moderna). The arrhythmia continuously recurred through subsequent mRNA booster doses (Moderna and Pfizer) over a three-year period. Extensive clinical evaluations, including echocardiography and myocardial perfusion stress testing, ruled out structural heart disease, ischemia, or metabolic abnormalities. Because the overall arrhythmia burden was measured at a low 6%, below the standard 15% clinical treatment threshold, no antiarrhythmic medications or invasive interventions were initiated. However, following a self-initiated platform switch to a single dose of the protein-based recombinant adjuvanted vaccine (Novavax), the patient’s multi-year arrhythmia resolved completely within days, and normal sinus rhythm has been continuously documented for over a year. Putative mechanisms for mRNA-induced myocardial electrical instability include prolonged intracellular processing of encoded spike proteins within host cardiomyocytes, lipid nanoparticle-mediated systemic inflammation, and autoimmune molecular mimicry—cascades that are entirely avoided by recombinant protein vaccines. Ultimately, this case highlights a profound temporal association between long-term ventricular arrhythmia and mRNA vaccines, followed by rapid, sustained resolution upon switching platforms. Clinicians should consider enhanced, long-term arrhythmia monitoring for select patients presenting with post-mRNA palpitations, and therapeutic platform-switching to non-mRNA configurations warrants immediate further investigation as a safe, highly viable mitigation strategy for persistent vaccine-associated cardiac symptoms.
Abstract: This case report and clinical overview examines rare but persistent post-vaccination cardiac complications associated with mRNA COVID-19 vaccine platforms, which exhibit a higher incidence rate ratio of post-vaccination arrhythmia compared to traditional or vector-based designs. Currently, there is a distinct clinical gap regarding the management o...
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Research Article
Advances in Rapid Nucleic Acid Diagnostics for Disease Prevention and Control
Jinhui Sun,
Baosheng Sun,
Xiuli Ruan,
Yinzhen Sheng*
Issue:
Volume 14, Issue 4, August 2026
Pages:
61-75
Received:
23 April 2026
Accepted:
25 June 2026
Published:
6 August 2026
DOI:
10.11648/j.ajbls.20261404.12
Downloads:
Views:
Abstract: Animal diseases present a major challenge to sustainable livestock production and global public health security. Rapid nucleic acid diagnostics, characterized by high specificity, sensitivity, and speed, have emerged as indispensable tools for early disease detection and precise control. This review provides a comprehensive overview of the recent advancements in rapid nucleic acid diagnostic technologies for animal diseases. We systematically categorize and evaluate current platforms, focusing on isothermal amplification techniques, CRISPR-based assays, and microfluidic micro-systems. Particular attention is given to how modern iterations have revolutionized the diagnostic process, pushing sensitivity toward the single-molecule realm and reducing turnaround times from hours to minutes. Furthermore, this paper analyzes the critical roles of these rapid-response systems in pandemic surveillance, vaccine efficacy assessment, and cross-border biosecurity risk management. Finally, we address current technical bottlenecks, such as sample preparation complexity and field-deployability constraints. We conclude that the integration of functional nanomaterials and artificial intelligence (AI) will be the driving force behind the next generation of intelligent, sample-in-answer-out, and field-deployable diagnostic tools, ultimately shaping the future of smart veterinary medicine.
Abstract: Animal diseases present a major challenge to sustainable livestock production and global public health security. Rapid nucleic acid diagnostics, characterized by high specificity, sensitivity, and speed, have emerged as indispensable tools for early disease detection and precise control. This review provides a comprehensive overview of the recent a...
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