Archive:: American Journal of Biomedical and Life Sciences:: Science Publishing Group

Volume 12, Issue 3, June 2024

Research Article
Reversal of P-glycoprotein Mediated Multidrug Resistance in MCF-7/R Cancer Cells by Esculetin Derivatives: Experimental and MD Simulation Studies

Navanath Kumbhar, Neelofar Khan, Rohit Bavi, Sagar Barage, Ayesha Khan^*

Issue: Volume 12, Issue 3, June 2024

Pages: 30-48

Received: 1 July 2024

Accepted: 29 July 2024

Published: 27 August 2024

DOI: 10.11648/j.ajbls.20241203.12

Downloads:

Views:

Abstract: Coumarins of natural origin have been explored as potential inhibitors of P-glycoprotein (P-gp). Esculetin which belongs to the class of coumarin has been derivatized with known hydrazine pharmacophores viz; benzoyl hydrazine (BH), isonicotinyl hydrazine (INH), and hydrazino benzoic acid. The homology modeling approach was used to predict the three... Show More

Download PDF

View Online
Review Article
The Role of Exosomal Long Non-Coding RNAs in Tumors and Tumour Metabolism

Yaomin Luo, Yanhong Liu, Zhen Jiang^*

Issue: Volume 12, Issue 3, June 2024

Pages: 49-56

Received: 10 July 2024

Accepted: 12 August 2024

Published: 27 August 2024

DOI: 10.11648/j.ajbls.20241203.13

Downloads:

Views:

Abstract: Long non-coding RNAs (lncRNAs) are RNAs that do not have protein-coding functions and are involved in a wide range of important regulatory processes through four modes of (1) signaling (2) guidance (3) structural backbone (4) decoying, which regulate gene expression at epigenetic, transcriptional and post-transcriptional levels. Exosomes are extrac... Show More

Download PDF

View Online