Association of Leptin Receptor Gene Polymorphisms with Blood Glucose Concentration and Obesity
Mo Mo Than,
Yan Naing Soe,
Zaw Myo Lwin,
Ye Wint Kyaw,
Kyaw Thet Paing,
Khine Kyaw Oo,
Phyo Thaw Htun,
Aung Lin Oo,
Min Thein,
Ye Myat Kyaw,
Zaw Min Htut
Issue:
Volume 7, Issue 3, September 2022
Pages:
54-60
Received:
22 June 2022
Accepted:
9 July 2022
Published:
18 July 2022
DOI:
10.11648/j.bmb.20220703.11
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Abstract: Obesity has become a global epidemic and is a known risk factor for several adverse health outcomes. Single Nucleotide Polymorphism (SNP) in leptin receptor genes become interesting candidates as susceptibility genes for obesity and glucose homeostasis. The present study intended to explore the genetic analysis of LEPR gene K109, Q223R, and K656N polymorphisms and their relation to obesity and fasting plasma glucose (FPG) concentration in the Myanmar population. One hundred and fifty diagnosed obese subjects and 150 healthy non-obese controls were included. Fasting plasma glucose (FPG) was measured and LEPR gene K109R, Q223R, and K656N polymorphisms were detected by DNA analysis. Data were analyzed by chi-square and one-way ANOVA tests. Each genotype frequency distribution of LEPR gene (K109R, Q223R, and K656N) polymorphisms was not associated with obesity (p > 0.05), as well as each allele frequency distribution also similar outcome (p > 0.05). FPG levels of the study population showed no significant differences between each genotype of LEPR gene polymorphisms (p > 0.05). The K109R, Q223R, and K656N polymorphisms of the LEPR gene were not linked to obesity or FPG levels in the population of Myanmar, according to our findings. Therefore, it does not seem that these polymorphisms have an equivalently significant role for the people of Myanmar. To completely understand the unique genetic variables that predispose to obesity in humans, an ongoing study of diverse obesity phenotypes and related gene mutations is necessary as our understanding of the genes causing obesity increases as a result of new findings.
Abstract: Obesity has become a global epidemic and is a known risk factor for several adverse health outcomes. Single Nucleotide Polymorphism (SNP) in leptin receptor genes become interesting candidates as susceptibility genes for obesity and glucose homeostasis. The present study intended to explore the genetic analysis of LEPR gene K109, Q223R, and K656N p...
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Antimicrobial and Structural Investigation of Green Synthesized ZnO Nanostructures from Bougainvillea glabra Leaves Extract
Anam Khushi,
Syeda Mona Hassan,
Shahzad Sharif Mughal
Issue:
Volume 7, Issue 3, September 2022
Pages:
61-69
Received:
5 December 2021
Accepted:
25 August 2022
Published:
5 September 2022
DOI:
10.11648/j.bmb.20220703.12
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Views:
Abstract: The aim of this study is to develop the environmentally friendly green synthesized ZnO nanostructures. Green synthesis approaches are acquiring importance due to their environmentally safe, versatility, cost-effectiveness, simplicity and efficiency in large scale synthesis. Plants extract consist of numerous biochemical and phytochemical compounds that serve as capping and reducing agent that facilitates the production of non-toxic nanoparticles that are useful for pharmaceutical and biological applications. The goal of this study to see how bacteria (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa) and parasites reacted to an unrefined concentration of locally available plants, Musa paradisiaca (flower) and Bougainvillea glabra (bloom), in vitro (Candida albicans, Candida tropicalis, Aspergillus niger). In the present study, the extract of Bougainvillea glabra was used for the synthesis of ZnO nanoparticles. Zinc oxide is a magical substance because of its wide range of applications and ability to be manufactured in a variety of morphologies and with a variety of properties. Zinc oxide's small particles have a deodorizing and antimicrobial impact. The biosynthesized zinc oxide nanostructures may provide a viable approach in the bio-clinical field. Zinc oxide has a wide range of uses, including cosmetics, optical, food packaging, piezoelectric, beautifiers, and gas detection. In addition to these uses, zinc oxide nanostructures are used in biological applications such as anticancer therapy.
Abstract: The aim of this study is to develop the environmentally friendly green synthesized ZnO nanostructures. Green synthesis approaches are acquiring importance due to their environmentally safe, versatility, cost-effectiveness, simplicity and efficiency in large scale synthesis. Plants extract consist of numerous biochemical and phytochemical compounds ...
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