Dechi Jean-Jacques Renaud,Toni Thomas D'Aquin,Cisse-Camara Massara,N'din Jean-Louis Philippe,Ake Aya Jeanne Armande,Siransy Kouabla Liliane,Sekongo Yassongui Mamadou,Gogbe Leto Olivier,Brou Emmanuel,Fieni Flore,Wawa Amedee Junior,Aby Roland,Kouakou Kouadio,Chenal Henri
Issue:
Volume 7, Issue 4, December 2022
Pages:
70-74
Received:
15 September 2022
Accepted:
4 October 2022
Published:
17 October 2022
DOI:
10.11648/j.bmb.20220704.11
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Abstract: Switching to dolutegravir (DTG)-based triple therapy is done without taking into account the level of viral replication and resistance developed by the virus against nucleoside reverse transcriptase inhibitors (NRTIs). The objective of the study was to evaluate the resistance to NRTIs in children and adults with virological failure in Côte d'Ivoire in a context of systematic switching to a DTG-based combination. The study population was constituted at the Abidjan Integrated Bioclinical Research Center (CIRBA) from a cohort of children in virological failure from 2012 to 2013 and HIV-1 infected adults with an indication for genotypic resistance testing from 2015 to 2017. Biological analyses were performed using ANRS techniques and algorithm (www.hivfrenchresistance.org). A total of 243 children and adults with virological failure were included in the study. The frequency of resistance to NRTIs was 65% (n = 159/243). It was 92% (n = 146/159) to lamivudine/emtricitabine (3TC/FTC), 52% (n= 82/159) to zidovudine (ZDV), 45% (n = 71/159) to abacavir (ABC) and 18% (n = 29/159) to tenofovir (TDF). Commonly encountered mutations were M184V/I (90%; n = 143/159) for 3TC/FTC, T215I/N/V/Y/F (42%; n = 67/159) for ZDV, L74V/I (22%; n = 35/159) for ABC. K65R (4%; n = 6/159) and K70E (6%; n = 9/159) for TDF. This study highlights the need to guide the switch to triple therapy containing two NRTIs and one dolutegravir molecule by genotypic resistance testing.Abstract: Switching to dolutegravir (DTG)-based triple therapy is done without taking into account the level of viral replication and resistance developed by the virus against nucleoside reverse transcriptase inhibitors (NRTIs). The objective of the study was to evaluate the resistance to NRTIs in children and adults with virological failure in Côte d'Ivoire...Show More
