Screening Investigation of Novel 1,2,4-Triazole-3-Thione Derivatives on Anticonvulsant Activity

Dmitryi Pavlovich Kavraiskyi; Sergey Yurievich Shtrygol'; Victoria Akopovna Georgiyants; Narzullo Boboevich Saidov

doi:doi:10.11648/j.ijpc.20160202.18

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Screening Investigation of Novel 1,2,4-Triazole-3-Thione Derivatives on Anticonvulsant Activity

Dmitryi Pavlovich Kavraiskyi, Sergey Yurievich Shtrygol', Victoria Akopovna Georgiyants, Narzullo Boboevich Saidov

Published in International Journal of Pharmacy and Chemistry (Volume 2, Issue 2)

Received: 30 August 2016 Accepted: 19 October 2016 Published: 10 January 2017

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Abstract

1,2,4-triazole and its derivatives are present in many biologically active aromatic compounds that have different biological properties and clinical applications including anticonvulsant activity. The number of studies in this direction is increasing. Therefore, based on the results of previous computer predictions, 8 novel 1,2,4-triazole-3-thione derivatives have been synthesized in the Department of Pharmaceutical Chemistry at the National Pharmacy University of Ukraine. The screening test of novel 1,2,4-triazole-3-thione derivatives on anticonvulsant activity in PTZ-induced seizures was conducted on mice. Among test substances revealed were those, which in the dose of 100 mg/kg showed moderate anticonvulsive effect and which were non-inferior to "reference drug" sodium valproate by some parameters. Screening results have confirmed the reasonability of in-depth anticonvulsive activity study of substances-leaders, pharmacological study of their mechanism of action, spectrum of anticonvulsant activity, concurrent types of pharmacological activity, dose-dependence of effect and safety.

Published in	International Journal of Pharmacy and Chemistry (Volume 2, Issue 2)
DOI	10.11648/j.ijpc.20160202.18
Page(s)	47-51
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Pharmacological Screening, Anticonvulsant Activity, Triazole Derivatives, PASS-Software, Pentylenetetrazole-Induced Seizures

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APA Style

Dmitryi Pavlovich Kavraiskyi, Sergey Yurievich Shtrygol', Victoria Akopovna Georgiyants, Narzullo Boboevich Saidov. (2017). Screening Investigation of Novel 1,2,4-Triazole-3-Thione Derivatives on Anticonvulsant Activity. International Journal of Pharmacy and Chemistry, 2(2), 47-51. https://doi.org/10.11648/j.ijpc.20160202.18

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ACS Style

Dmitryi Pavlovich Kavraiskyi; Sergey Yurievich Shtrygol'; Victoria Akopovna Georgiyants; Narzullo Boboevich Saidov. Screening Investigation of Novel 1,2,4-Triazole-3-Thione Derivatives on Anticonvulsant Activity. Int. J. Pharm. Chem. 2017, 2(2), 47-51. doi: 10.11648/j.ijpc.20160202.18

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AMA Style

Dmitryi Pavlovich Kavraiskyi, Sergey Yurievich Shtrygol', Victoria Akopovna Georgiyants, Narzullo Boboevich Saidov. Screening Investigation of Novel 1,2,4-Triazole-3-Thione Derivatives on Anticonvulsant Activity. Int J Pharm Chem. 2017;2(2):47-51. doi: 10.11648/j.ijpc.20160202.18

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@article{10.11648/j.ijpc.20160202.18,
  author = {Dmitryi Pavlovich Kavraiskyi and Sergey Yurievich Shtrygol' and Victoria Akopovna Georgiyants and Narzullo Boboevich Saidov},
  title = {Screening Investigation of Novel 1,2,4-Triazole-3-Thione Derivatives on Anticonvulsant Activity},
  journal = {International Journal of Pharmacy and Chemistry},
  volume = {2},
  number = {2},
  pages = {47-51},
  doi = {10.11648/j.ijpc.20160202.18},
  url = {https://doi.org/10.11648/j.ijpc.20160202.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20160202.18},
  abstract = {1,2,4-triazole and its derivatives are present in many biologically active aromatic compounds that have different biological properties and clinical applications including anticonvulsant activity. The number of studies in this direction is increasing. Therefore, based on the results of previous computer predictions, 8 novel 1,2,4-triazole-3-thione derivatives have been synthesized in the Department of Pharmaceutical Chemistry at the National Pharmacy University of Ukraine. The screening test of novel 1,2,4-triazole-3-thione derivatives on anticonvulsant activity in PTZ-induced seizures was conducted on mice. Among test substances revealed were those, which in the dose of 100 mg/kg showed moderate anticonvulsive effect and which were non-inferior to "reference drug" sodium valproate by some parameters. Screening results have confirmed the reasonability of in-depth anticonvulsive activity study of substances-leaders, pharmacological study of their mechanism of action, spectrum of anticonvulsant activity, concurrent types of pharmacological activity, dose-dependence of effect and safety.},
 year = {2017}
}

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TY  - JOUR
T1  - Screening Investigation of Novel 1,2,4-Triazole-3-Thione Derivatives on Anticonvulsant Activity
AU  - Dmitryi Pavlovich Kavraiskyi
AU  - Sergey Yurievich Shtrygol'
AU  - Victoria Akopovna Georgiyants
AU  - Narzullo Boboevich Saidov
Y1  - 2017/01/10
PY  - 2017
N1  - https://doi.org/10.11648/j.ijpc.20160202.18
DO  - 10.11648/j.ijpc.20160202.18
T2  - International Journal of Pharmacy and Chemistry
JF  - International Journal of Pharmacy and Chemistry
JO  - International Journal of Pharmacy and Chemistry
SP  - 47
EP  - 51
PB  - Science Publishing Group
SN  - 2575-5749
UR  - https://doi.org/10.11648/j.ijpc.20160202.18
AB  - 1,2,4-triazole and its derivatives are present in many biologically active aromatic compounds that have different biological properties and clinical applications including anticonvulsant activity. The number of studies in this direction is increasing. Therefore, based on the results of previous computer predictions, 8 novel 1,2,4-triazole-3-thione derivatives have been synthesized in the Department of Pharmaceutical Chemistry at the National Pharmacy University of Ukraine. The screening test of novel 1,2,4-triazole-3-thione derivatives on anticonvulsant activity in PTZ-induced seizures was conducted on mice. Among test substances revealed were those, which in the dose of 100 mg/kg showed moderate anticonvulsive effect and which were non-inferior to "reference drug" sodium valproate by some parameters. Screening results have confirmed the reasonability of in-depth anticonvulsive activity study of substances-leaders, pharmacological study of their mechanism of action, spectrum of anticonvulsant activity, concurrent types of pharmacological activity, dose-dependence of effect and safety.
VL  - 2
IS  - 2
ER  -

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Author Information

Dmitryi Pavlovich Kavraiskyi

Department of Pharmacology, National Pharmacy University, Kharkiv, Ukraine
Sergey Yurievich Shtrygol'

Department of Pharmacology, National Pharmacy University, Kharkiv, Ukraine
Victoria Akopovna Georgiyants

Department of Pharmaceutical Chemistry, National Pharmacy University, Kharkiv, Ukraine
Narzullo Boboevich Saidov

Department of Pharmaceutical Chemistry, National Pharmacy University, Kharkiv, Ukraine

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Plain Text BibTeX RIS

APA Style

Dmitryi Pavlovich Kavraiskyi, Sergey Yurievich Shtrygol', Victoria Akopovna Georgiyants, Narzullo Boboevich Saidov. (2017). Screening Investigation of Novel 1,2,4-Triazole-3-Thione Derivatives on Anticonvulsant Activity. International Journal of Pharmacy and Chemistry, 2(2), 47-51. https://doi.org/10.11648/j.ijpc.20160202.18

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ACS Style

Dmitryi Pavlovich Kavraiskyi; Sergey Yurievich Shtrygol'; Victoria Akopovna Georgiyants; Narzullo Boboevich Saidov. Screening Investigation of Novel 1,2,4-Triazole-3-Thione Derivatives on Anticonvulsant Activity. Int. J. Pharm. Chem. 2017, 2(2), 47-51. doi: 10.11648/j.ijpc.20160202.18

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AMA Style

Dmitryi Pavlovich Kavraiskyi, Sergey Yurievich Shtrygol', Victoria Akopovna Georgiyants, Narzullo Boboevich Saidov. Screening Investigation of Novel 1,2,4-Triazole-3-Thione Derivatives on Anticonvulsant Activity. Int J Pharm Chem. 2017;2(2):47-51. doi: 10.11648/j.ijpc.20160202.18

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@article{10.11648/j.ijpc.20160202.18,
  author = {Dmitryi Pavlovich Kavraiskyi and Sergey Yurievich Shtrygol' and Victoria Akopovna Georgiyants and Narzullo Boboevich Saidov},
  title = {Screening Investigation of Novel 1,2,4-Triazole-3-Thione Derivatives on Anticonvulsant Activity},
  journal = {International Journal of Pharmacy and Chemistry},
  volume = {2},
  number = {2},
  pages = {47-51},
  doi = {10.11648/j.ijpc.20160202.18},
  url = {https://doi.org/10.11648/j.ijpc.20160202.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20160202.18},
  abstract = {1,2,4-triazole and its derivatives are present in many biologically active aromatic compounds that have different biological properties and clinical applications including anticonvulsant activity. The number of studies in this direction is increasing. Therefore, based on the results of previous computer predictions, 8 novel 1,2,4-triazole-3-thione derivatives have been synthesized in the Department of Pharmaceutical Chemistry at the National Pharmacy University of Ukraine. The screening test of novel 1,2,4-triazole-3-thione derivatives on anticonvulsant activity in PTZ-induced seizures was conducted on mice. Among test substances revealed were those, which in the dose of 100 mg/kg showed moderate anticonvulsive effect and which were non-inferior to "reference drug" sodium valproate by some parameters. Screening results have confirmed the reasonability of in-depth anticonvulsive activity study of substances-leaders, pharmacological study of their mechanism of action, spectrum of anticonvulsant activity, concurrent types of pharmacological activity, dose-dependence of effect and safety.},
 year = {2017}
}

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TY  - JOUR
T1  - Screening Investigation of Novel 1,2,4-Triazole-3-Thione Derivatives on Anticonvulsant Activity
AU  - Dmitryi Pavlovich Kavraiskyi
AU  - Sergey Yurievich Shtrygol'
AU  - Victoria Akopovna Georgiyants
AU  - Narzullo Boboevich Saidov
Y1  - 2017/01/10
PY  - 2017
N1  - https://doi.org/10.11648/j.ijpc.20160202.18
DO  - 10.11648/j.ijpc.20160202.18
T2  - International Journal of Pharmacy and Chemistry
JF  - International Journal of Pharmacy and Chemistry
JO  - International Journal of Pharmacy and Chemistry
SP  - 47
EP  - 51
PB  - Science Publishing Group
SN  - 2575-5749
UR  - https://doi.org/10.11648/j.ijpc.20160202.18
AB  - 1,2,4-triazole and its derivatives are present in many biologically active aromatic compounds that have different biological properties and clinical applications including anticonvulsant activity. The number of studies in this direction is increasing. Therefore, based on the results of previous computer predictions, 8 novel 1,2,4-triazole-3-thione derivatives have been synthesized in the Department of Pharmaceutical Chemistry at the National Pharmacy University of Ukraine. The screening test of novel 1,2,4-triazole-3-thione derivatives on anticonvulsant activity in PTZ-induced seizures was conducted on mice. Among test substances revealed were those, which in the dose of 100 mg/kg showed moderate anticonvulsive effect and which were non-inferior to "reference drug" sodium valproate by some parameters. Screening results have confirmed the reasonability of in-depth anticonvulsive activity study of substances-leaders, pharmacological study of their mechanism of action, spectrum of anticonvulsant activity, concurrent types of pharmacological activity, dose-dependence of effect and safety.
VL  - 2
IS  - 2
ER  -

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