Research Article
Synthesis of Copper: 2-Anisidine: Cyclodextrin Nanomaterials and Characterization of 2-Anisidine–Cyclodextrin Inclusion Complexes at Various pH Conditions
Issue:
Volume 14, Issue 2, April 2026
Pages:
38-48
Received:
11 March 2026
Accepted:
23 March 2026
Published:
10 April 2026
Abstract: Absorption, emission, time resolved fluorescence spectra and molecular modelling of 2-anisidine (2AS) with α-CD and β-CD in pH~2, pH~7 and pH~11 solutions were examined. Cu: 2AS: CD nanomaterials were investigated by SEM, DSC, FTIR, XRD and 1H NMR techniques. The absorption and emission maxima and spectral shape of 2AS in all the pH solutions and solvents are different from each other. 2AS gave a single broad emission spectrum in all the solvents while dual emission noticed at pH~11. The lifetimes of the inclusion complexes were longer than that of the free 2AS molecule. The geometrical restriction of the α-CD cavity likely limits the free rotation of the amino and methoxy groups, thereby enhancing the emission intensity. The calculated HOMO–LUMO energy gap, total energy, free energy, enthalpy, entropy, dipole moment, and zero-point vibrational energy of the CD: 2AS complex differed significantly from those of the isolated 2AS, α-CD and β-CD molecules, and both the vertical and horizontal bond lengths between the amino and methoxy groups are smaller than the β-CD cavity size confirming the formation of an inclusion complex. In FTIR, most of the peaks are not appeared and a substantial decrease in intensity was noted in the Cu: 2AS: CD nano. The chemical shift value of 2AS protons are shifts to up field and down field and the peak intensities are very low in the nano copper with CD nanomaterials. SEM image of the nanomaterials are different from isolated 2AS molecule.
Abstract: Absorption, emission, time resolved fluorescence spectra and molecular modelling of 2-anisidine (2AS) with α-CD and β-CD in pH~2, pH~7 and pH~11 solutions were examined. Cu: 2AS: CD nanomaterials were investigated by SEM, DSC, FTIR, XRD and 1H NMR techniques. The absorption and emission maxima and spectral shape of 2AS in all the pH solutions and s...
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Research Article
Synthesis, Characterization, Biocidal and Molecular Docking Profiles of Zn(II) Complex Derived from Schiff Base Ligands
Patience Dooshima Iorungwa*
,
Hilary Abuh,
Moses Saviour Iorungwa,
Ambrose Nwigwe Njokunwogbu
Issue:
Volume 14, Issue 2, April 2026
Pages:
49-59
Received:
11 March 2026
Accepted:
2 April 2026
Published:
21 April 2026
DOI:
10.11648/j.sjc.20261402.12
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Abstract: Ligand, oroaniline were combined to synthesize Zn(II) complex. Characterization was performed through determining parameters such as melting point, solubility, molar conductivity, electronic and FTIR spectra studies, thermal analysis, scanning electron microscopy (SEM), profiled for their biocidal effects, and performed docking calculations to determine protein binding ability of the metal complex. Results of melting points was in the range of 188 – 194°C, indicating thermal stability, their insoluble nature in polar solvents and narrow range of conductivity indices (5.6 – 18 Ω/cm-2) highlights their non-electrolytic nature in solutions. Comparing the UV-Vis spectra of the compounds revealed major shifts which were backed up by the FTIR spectra. This confirmed coordination through nitrogen and oxygen donor atoms of the ligands. The thermal results of the ligands revealed good stability with multiple non-spontaneous decomposition steps evident from the energy of activation data. The enhanced biocidal effect of the complex in comparison with the ligand confirms chelation with increased rigid structure. Molecular docking analysis of the metal complex gave binding affinity score of -172.67 in comparison with chloroquine as the reference antimalarial medication with score of -120.36. The result indicate stronger binding interaction with the target protein. The biological function and binding interaction of the Schiff base Zn(II) complex are essential for its application as biocidal agent in therapy upon optimization and functionalization.
Abstract: Ligand, oroaniline were combined to synthesize Zn(II) complex. Characterization was performed through determining parameters such as melting point, solubility, molar conductivity, electronic and FTIR spectra studies, thermal analysis, scanning electron microscopy (SEM), profiled for their biocidal effects, and performed docking calculations to dete...
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