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Short-Term Weight Changes in Treated Primary Hypothyroid Subjects
Abul Kalam Mohammad Aminul Islam,
Abul Bashar Mohammad Kamrul Hasan,
Moinul Islam,
Mohammad Asaduzzaman,
Mohammad Rafiq Uddin,
Shiropa Islam,
Mohammed Fariduddin
Issue:
Volume 4, Issue 1, March 2019
Pages:
1-5
Received:
15 December 2018
Accepted:
28 December 2018
Published:
29 January 2019
Abstract: Weight loss due to diuresis is an early clinical response of treatment with levothyroxine in primary hypothyroidism. The objective of this study was to evaluate weight changes in patients with primary hypothyroidism after 6 weeks of initiation of treatment with levothyroxine. This prospective observational follow up study included 99 newly diagnosed primary hypothyroid patients of 18-60 years of age of both sexes. The weight and height of each patient were measured and body mass index (BMI) was calculated both at the time of enrollment and at the end of 6 weeks of treatment with levothyroxine, and variables at the baseline and at follow up were compared. 93 patients out of 99 completed follow-up at 6±1 weeks. There were significant reduction in TSH level (85.1±51.6 vs. 1.87±0.9 µIU/mL, mean±SD) and increase in FT4 level (0.49±0.19 vs. 1.4±0.78 ng/dL, mean±SD) at follow up in comparison to their baseline values. Among the participants, 90.3% lost body weight while 5.4% gained weight and 4.3% of subjects didn’t show any change in their weight at the end of the study. The mean body weight and mean BMI after levothyroxine replacement were significantly lower (weight 62.2±13.7 vs. 59.0±12.1 kg, BMI 25.1±4.6 vs. 23.8±4.1 Kg/M2, mean±SD) than the pretreatment values. The mean changes in body weight and BMI were 3.19±0.32 Kg (mean±SEM) and 1.31±0.14 Kg/M2 (mean±SEM) respectively. The mean changes in body weight and BMI did not differ significantly among subjects with different TSH categories. No statistically significant effect of any individual predictors like age, gender, and socioeconomic status, weight at baseline, baseline TSH, baseline FT4 and presence of thyroid autoimmunity was observed on weight change. Levothyroxine replacement was associated with a significant reduction of mean body weight and BMI at short-term follow up in our study, though not all patients experienced weight loss.
Abstract: Weight loss due to diuresis is an early clinical response of treatment with levothyroxine in primary hypothyroidism. The objective of this study was to evaluate weight changes in patients with primary hypothyroidism after 6 weeks of initiation of treatment with levothyroxine. This prospective observational follow up study included 99 newly diagnose...
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Parent-Reported Diabetic-Specific Health Related Quality of Life in Children Treated with Multiple Daily Injection, Continuous Subcutaneous Insulin Infusion and Flexible Multiple Daily Injection: A Comparative Study
Anutosh Shee,
Sarah Prior,
Nicole Reeves,
Maria Smith,
Sharon Luccisano
Issue:
Volume 4, Issue 1, March 2019
Pages:
6-12
Received:
16 December 2018
Accepted:
5 January 2019
Published:
29 January 2019
Abstract: Aims: This study aims to identify differences in diabetes specific health related quality of life (HRQoL) in children and adolescents with type 1 diabetes mellitus (T1D) treated with three distinct types of intensive insulin therapy-multiple daily injection (MDI), continuous subcutaneous insulin infusion (CSII) and flexible multiple daily injection (fMDI). Materials and Methods: This survey was conducted in north west Tasmania over a 6-month period, during quarterly clinic visits. A well-known, reliable and validated survey tool -Paediatric Quality of life (PedsQL) Diabetes Module 3.0 was used to capture information about the diabetic specific HRQoL in children and adolescents. The parent-proxy version of the forms was completed by the parents electronically using iSurvey application to secure information regarding their children’s diabetes related symptoms (11 items), treatment barriers (4 items), treatment adherence (7 items), worry (3 items) and communication (3 items). All de-identified information was downloaded into an excel spreadsheet and SPSS V24.0 for further analysis. Results: 34 parents completed the electronic data forms on iSurvey. There were no statistically significant differences in HRQoL among the CSII, MDI and fMDI groups as determined by one-way ANOVA in diabetes {F (2, 31) = 0.517, p = 0.601}, treatment {F (2, 31) = 0.385, p = 0.684}, worry {F (2, 31) = 0.076, p = 0.927}, and communication {F (2, 31) = 0.672, p = 0.518}. Conclusion: Although, the impact of T1D on the HRQoL in children and adolescents is higher than the children without T1D, it appears to be independent of the types of three intensive insulin therapy generally used- CSII, MDI and fMDI, suggesting type of insulin therapy may not be the major influencing factor for children’ quality of life as revealed in this first of its kind study. A further study with higher number of participants and the additional impact of various glucose monitoring systems on the HRQoL is highly recommended, which may influence the decision of right therapy suitable for the entire family.
Abstract: Aims: This study aims to identify differences in diabetes specific health related quality of life (HRQoL) in children and adolescents with type 1 diabetes mellitus (T1D) treated with three distinct types of intensive insulin therapy-multiple daily injection (MDI), continuous subcutaneous insulin infusion (CSII) and flexible multiple daily injection...
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A Review of Contemporary Markers of Insulin Resistance
Ekpe Lawson,
Onuche Lawrence
Issue:
Volume 4, Issue 1, March 2019
Pages:
13-17
Received:
29 November 2018
Accepted:
2 January 2019
Published:
19 February 2019
Abstract: Backgrounnd: The era of non-communicable diseases has been here with us for a while. Diabetes mellitus, pre-diabetes, insulin resistance, metabolic syndrome and associated complications; have been the centre of interest for many researchers lately. Insulin resistance (IR) has taken a forefront position in this regard. Aim: Insulin resistance has been implicated in the pathogenesis of many metabolic disorders. It heralds the onset of many of these diseases many years before the clinical signs and symptoms. Method: A thorough literature search was done using internet academic search engines and indexation such Google scholar, hinari, Ebsco, Scorpus, etc. Results: Insulin resistance (IR), an independent risk factor for the development of Type 2 diabetes and metabolic syndrome is assessed by several biomarkers. From the historical perspective till date, the authors assess the implication, connection and relevance from various studies to contemporary scientific breakthroughs in this regard for diagnosis and clinical application of markers of insulin resistance in patient management. Conclusion: It is hoped that with the advancement in medical research, more markers of insulin resistance will be discovered that will help in patient managements.
Abstract: Backgrounnd: The era of non-communicable diseases has been here with us for a while. Diabetes mellitus, pre-diabetes, insulin resistance, metabolic syndrome and associated complications; have been the centre of interest for many researchers lately. Insulin resistance (IR) has taken a forefront position in this regard. Aim: Insulin resistance has be...
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Ethnobotanical and Ecological Studies of Plants Used in the Treatment of Diabetes in Kwango, Kongo Central and Kinshasa in the Democratic Republic of the Congo
Adrien Tuwisana Masunda,
Clement Liyongo Inkoto,
Gédéon Ngiala Bongo,
Joseph Desiré Oleko Wa Oloko,
Koto-Te-Nyiwa Ngbolua,
Damien ShaTshibey Tshibangu,
Dorothée Dinangayi Tshilanda,
Pius Tshimankinda Mpiana
Issue:
Volume 4, Issue 1, March 2019
Pages:
18-25
Received:
28 December 2018
Accepted:
31 January 2019
Published:
28 February 2019
Abstract: Non-communicable diseases represent new challenges for the mankind in the fight for health improvement. Among these diseases, diabetes is a major contributor. Diabetes is a serious chronic disease that occurs when the pancreas does not produce enough insulin or when the body is unable to use the insulin produced effectively. This survey was performed in Kwango, Kongo-Central and Kinshasa provinces respectively between October 2016 and September 2017. A questionnaire was administered to the target population in order to collect relevant data. Plant identification was carried out at the herbarium of University of Kinshasa. The findings revealed that the inventoried medicinal flora is made up of 68 species which are divided into 34 families of 58 genera; the leaf is the most commonly used part in the treatment of diabetes while maceration is the most commonly used method of preparation. The use of medicinal plants is reported in almost all age groups from 20-89 years of age but with a predominance among people aged 40-49 years. Trees and phanerophyte species predominate in the flora studied; the majority of users of these medicinal plants have a primary level of education. In-depth phytochemical and pharmacological studies need to be carried out on these plants with a view to their scientific validation in the diabetes management.
Abstract: Non-communicable diseases represent new challenges for the mankind in the fight for health improvement. Among these diseases, diabetes is a major contributor. Diabetes is a serious chronic disease that occurs when the pancreas does not produce enough insulin or when the body is unable to use the insulin produced effectively. This survey was perform...
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Hypoglycemic and Antioxidant Capacity of Curcuma Longa and Viscum Album in Alloxan Induced Diabetic Male Wistar Rats
Nwozo Sarah Onyenibe,
Nyam Augustine Nathaniel,
Nwawuba Stanley Udogadi,
Olukotun Oluwakemi Iyanu
Issue:
Volume 4, Issue 1, March 2019
Pages:
26-34
Received:
29 December 2018
Accepted:
16 January 2019
Published:
6 May 2019
Abstract: Plant based therapies may be a potent means of managing and preventing diabetes and currently, combination therapies are employed for the treatment of critical diseases. In view of this, the objectives of the present study was to investigate the hypoglycemic and antioxidant capacity C. longa, V. album and co-treatment with C. longa + V. album on diabetes and its related complication. Qualitative phytochemical analysis of C. longa and V. album were examined using standard procedures and the result revealed the presence of alkaloids, cardiac glycosides, flavonoids, phenols, saponins, tannins, terpenoids and steroids respectively. Thirty six (36) male albino rats with the mean weight between 120-135g were divided into six (6) groups (n=6), group one (1) served as the normal control and there experimental groups were diabetic, induced with 150 mg/kg intraperitoneal alloxan injection. Body weight, blood sugar level, glycated hemoglobin, glucose-6-phosphate dehydrogenase, α-amylase, lipid profile, liver function and antioxidant markers were determined using standard procedures and the results revealed that, co-treatment with C. longa + V. album demonstrated an excellent weight reduction ability, hypoglycemic capacity, modulation of G6PDH, HBA1C and lipid profile, inhibition of α-amylase and enhancement of liver function and antioxidant levels. Therefore, co-treatment with C. longa + V. ablum can be a good therapeutic choice for the management of diabetes and its related conditions.
Abstract: Plant based therapies may be a potent means of managing and preventing diabetes and currently, combination therapies are employed for the treatment of critical diseases. In view of this, the objectives of the present study was to investigate the hypoglycemic and antioxidant capacity C. longa, V. album and co-treatment with C. longa + V. album on di...
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