Review Article
Phytochemical and Pharmacological Properties of Calpurnia Aurea, Review
Gebretsadik Tebabal*
Issue:
Volume 12, Issue 1, March 2026
Pages:
1-10
Received:
29 November 2025
Accepted:
19 December 2025
Published:
24 February 2026
DOI:
10.11648/j.jdmp.20261201.11
Downloads:
Views:
Abstract: Calpurnia aurea plant belongs to in the fabaceae family and in the general of Calpurnia is a widely consumed medicinal plant in east Africa such as Ethiopia and Eritrea. It used to treat diseases like amoebiasis, giardiasis, dysentery, syphilis, malaria, exoparasite, diarrhea and snake bite. Many scientific papers available about it’s phytochemical and pharmacological activities. This review was focused on the Ethnobotay, phytochemistry and the biological activities of Calpurnia aurea plant using different scientific articles, books and reports available online in academic searching sites such as Google scholar, PubMed, Scoups, ProQuest and Web of science. Based on the review all parts of the plant reported to have secondary metabolites such as flavonoids, terpenoids , alkaloids, glycosides, tannins and steroids and, biological activities such as antioxidant, antibacterial, anticancer, antimalarial, anti-diarrheal, antiextoparasite and insecticidal activities. Bioactive chemical compounds also reported from stem, leaves, bark and seeds of Calpurnia aurea plant in different classes such as alkaloids, flavonoids, glycosides and terpenoids. Based on the information gathered from the chemical constituent and pharmacological properties of the plant part Calpurnia aurea is confirmed the traditional medicinal use but further work is required related to isolation of more bioactive compounds and to investigate biological activities in advanced techniques including Insilco methods to contribute for modern drug discovery.
Abstract: Calpurnia aurea plant belongs to in the fabaceae family and in the general of Calpurnia is a widely consumed medicinal plant in east Africa such as Ethiopia and Eritrea. It used to treat diseases like amoebiasis, giardiasis, dysentery, syphilis, malaria, exoparasite, diarrhea and snake bite. Many scientific papers available about it’s phytochemical...
Show More
Research Article
Talinum fruticosum (L.) Juss. (Talinaceae), an Edible and Medicinal Plant, Enhances the Activity of Antibiotics Against Multidrug-Resistant Gram-Negative Bacteria
Issue:
Volume 12, Issue 1, March 2026
Pages:
11-19
Received:
12 January 2026
Accepted:
2 February 2026
Published:
25 February 2026
DOI:
10.11648/j.jdmp.20261201.12
Downloads:
Views:
Abstract: The rapid acquisition of multidrug-resistant (MDR) phenotypes by bacteria creates life-threatening complications in infection control. Accordingly, this study aims to investigate the antibacterial activity of the methanol extract of Talinum fruticosum leaves and its interaction effects with antibiotics against MDR Gram-negative bacteria. The broth microdilution method was used to evaluate the antibacterial activity and antibiotic-resistance modulation effects of the extract. The interaction between antibiotics and T. fruticosum leaf extract (TFLE) was conducted using the checkerboard assay. Phytochemical screening was assessed using standardized qualitative tests. TFLE displayed low antibacterial activity, with MICs ranging from 512 to 2048 µg/mL against the tested bacteria. Interestingly, TFLE at its subinhibitory concentration (MIC/8) enhanced the efficacy of antibiotics by 2-to 64-fold, particularly tetracycline, doxycycline, imipenem, kanamycin, and ciprofloxacin, against at least one of the examined MDR bacteria. In addition, TFLE displayed a synergistic effect (ƩFIC < 0.5) with kanamycin and doxycycline against K. pneumoniae K2 and E. aerogenes EA298. The phytochemical screening indicated that TFLE contained flavonoids, saponins, tannins, terpenoids, phenols, and anthocyanins. Overall, this study shows that T. fruticosum leaf extract could be used in combination with commonly used antibiotics to fight infections involving MDR bacteria. Therefore, further studies are needed to identify in this plant a likely nontoxic antibiotic modulator.
Abstract: The rapid acquisition of multidrug-resistant (MDR) phenotypes by bacteria creates life-threatening complications in infection control. Accordingly, this study aims to investigate the antibacterial activity of the methanol extract of Talinum fruticosum leaves and its interaction effects with antibiotics against MDR Gram-negative bacteria. The broth ...
Show More
