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Design, Synthesis of New Amino Acid Derivatives and Evaluate DNA Binding Activity, Anticancer and Antimicrobial Activity
Issue:
Volume 2, Issue 2, June 2017
Pages:
36-50
Received:
23 December 2016
Accepted:
10 January 2017
Published:
2 March 2017
DOI:
10.11648/j.ijbc.20170202.11
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Abstract: The present review covers the recent synthetic amino acid derivatives with chemical transformations to peptide derivatives. The amino acids were used as starting keys for synthesis peptides and pseudopeptides derived from pyridinine, coumarine, imaddizole, pyrazole phthalyl, qunolinine and sulfonamide rings. these biomolecules have diverse biological and pharmacological actions, as antimicrobial, anti-cancer targeting human carbonic anhydrase (CA) and DNA binding activities.
Abstract: The present review covers the recent synthetic amino acid derivatives with chemical transformations to peptide derivatives. The amino acids were used as starting keys for synthesis peptides and pseudopeptides derived from pyridinine, coumarine, imaddizole, pyrazole phthalyl, qunolinine and sulfonamide rings. these biomolecules have diverse biologic...
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Interaction Between Chitosan Solutions, Cellulose Carriers and Some of the Multi-enzyme Complexes
Elina Eldarovna Dosadina,
Alexey Alexeevich Belov
Issue:
Volume 2, Issue 2, June 2017
Pages:
51-60
Received:
30 January 2017
Accepted:
22 February 2017
Published:
9 March 2017
DOI:
10.11648/j.ijbc.20170202.12
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Abstract: This research is devoted to create and investigate the wound healing medical materials that contain proteolytic enzymes. The aim of the study is to propose a new wound dressing design “Multiferm”TM, that is based on modified cellulose, chitosan gel and proteolytic enzymes, and represent the interaction between all of the drug components for the wound treatment such as: chitosan, modified cellulose (dialdehyde cellulose, cellulose phosphor ester) and different polyenzyme complexes (proteolytic complex from hepatopancreas of crab and bromelain). The research will also propose the scheme of the obtained materials and the components interaction mechanism. This scheme is supposed to create new materials with the special properties such as: minimal loss of biological activity during the process of dressings', obtaining, and using; minimal doze of therapeutic agent; and controlled drug release. The article and the results might be useful for everyone who is interested in cellulose chemistry, properties of proteolytic enzymes and drug development for wound healing.
Abstract: This research is devoted to create and investigate the wound healing medical materials that contain proteolytic enzymes. The aim of the study is to propose a new wound dressing design “Multiferm”TM, that is based on modified cellulose, chitosan gel and proteolytic enzymes, and represent the interaction between all of the drug components for the wou...
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Interactions of Photosynthetic Reaction Centers with Bc1 Complexes from Rhodobacter Sphaeroides Studied Using SEIRAS on a Nano-Structured Gold Surface
Vedran Nedelkovski,
Andreas Schwaighofer,
Andreas F. Geiss,
Christina Bliem,
Renate L. C. Naumann
Issue:
Volume 2, Issue 2, June 2017
Pages:
61-69
Received:
29 January 2017
Accepted:
21 February 2017
Published:
22 March 2017
DOI:
10.11648/j.ijbc.20170202.13
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Abstract: Inter-protein reactions of photosynthetic reaction centers (RCs) with bc1 complexes from R. sphaeroides, have been investigated using surface-enhanced Infrared-absorption spectroscopy (SEIRAS). Surface enhancement was achieved by a nano-structured gold surface. The proteins were immobilized via his-tags attached to the P side of the RC and the C-terminal end of the cytochrome (cyt) b subunit and co-reconstituted into a lipid bilayer by in-situ dialysis. In this configuration, the cyt c binding site of the two proteins is located on opposite sides of the membrane. Light-minus-dark absorbance spectra under continuous illumination in the absence of an electron donor indicated a slow quinone/semiquinone exchange, allowing release of ubiquinol (QH2) into the membrane. The interaction of the bc1 with QH2 was indicated by the stationary state obtained but only in the presence of cyt c. The interaction is discussed in terms of a semiquinone species formed in the course of the Q cycle mechanism of the bc1.
Abstract: Inter-protein reactions of photosynthetic reaction centers (RCs) with bc1 complexes from R. sphaeroides, have been investigated using surface-enhanced Infrared-absorption spectroscopy (SEIRAS). Surface enhancement was achieved by a nano-structured gold surface. The proteins were immobilized via his-tags attached to the P side of the RC and the C-te...
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Removal of Organic Pesticides by Carbon Nanoparticle Synthesized from Pomegranate Peel
Issue:
Volume 2, Issue 2, June 2017
Pages:
70-76
Received:
9 February 2017
Accepted:
4 March 2017
Published:
24 March 2017
DOI:
10.11648/j.ijbc.20170202.14
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Abstract: Organic Pesticides are toxic to humans on consumption if disposed with inefficient treatment facilities in water bodies or on land. The present study is aimed to investigate the removal of agricultural pesticides including three herbicides Trifluralin, Glyphosate and 2,4 Dichlorophenoxyacetic acid from aqueous solution by carbon nanoparticles synthesized from pomegranate. The synthesized nanoparticles provide high specific surface area, more capacity and faster uptake kinetics. nanoparticles have an average size of approximately 30-50 nm. Particle size distribution is equal and homogeneous and shows the good synthesis of nanoparticles with the same size. Various physico-chemical parameters such as pH (5-9), initial concentration (50-250 mg/L), and adsorbent dosage (0.1-0.5gr) level and equilibrium contact time (0-40 min) were studied. The results showed that removal of the agricultural pesticides Trifluralin, Glyphosate and 2,4D depends on pH such that the optimal removal efficiency observed for pesticides Trifluralin, Glyphosate and 2,4D in pH=9 was 92.6, 78 and 92% respectively. Optimal adsorbent weight was 0.5 g for pesticides Trifluralin, Glyphosate and 2,4D so that the removal efficiency was equal to 97, 98.8 and 98.4% within 20 minutes. In the initial concentration of 50 mg/L, the removal efficiency was respectively equal to 88, 94 and 92% for Trifluralin, Glyphosate and 2,4D.
Abstract: Organic Pesticides are toxic to humans on consumption if disposed with inefficient treatment facilities in water bodies or on land. The present study is aimed to investigate the removal of agricultural pesticides including three herbicides Trifluralin, Glyphosate and 2,4 Dichlorophenoxyacetic acid from aqueous solution by carbon nanoparticles synth...
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A Comparative Analysis of Some Essential Oil Plant Species, Composition, Antimicrobial Properties and Their Applicability in the Field of Drug Discovery - A Review
E. Talebi,
I. Nasrollahi,
M. Khosravinezhad,
Shivakumar,
Z. Nemati
Issue:
Volume 2, Issue 2, June 2017
Pages:
77-82
Received:
9 February 2017
Accepted:
3 March 2017
Published:
24 March 2017
DOI:
10.11648/j.ijbc.20170202.15
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Abstract: The purpose of present study was to understand the background knowledge, benefits, applicability and important medicinal properties of selected plants of pycnocycla, oliveria decumbens and anvillea that the three essential oil plants are available in different parts of the world and consists of different variability in leaves, essential oil content, etc. Moreover, they are seven species of plant pycnocycla, two species of anvillea and oliveria consists of one species alone are reviewed and their effective utilization of all the parts of the plants, i.e., radiate being utilized in folk medicine to treat various infectious diseases and may contribute to the development of novel antimicrobial agents for the treatment of infections caused by these drug-resistant microorganisms (in vitro cytotoxicity and in vivo antitumor activity for both compounds) are reported by several researchers. Hence, It is important to underline that, the information survey being made in this review may generate a new avenue in the fields of pharmaceutical, etc. for drug discovery and the efficiency of its essential oil and applicability for several purposes like, antimicrobial and antioxidant activities, disorders, diseases controls, diseases management and beauty cosmetics, etc are reviewed and discussed in depth herein this review article.
Abstract: The purpose of present study was to understand the background knowledge, benefits, applicability and important medicinal properties of selected plants of pycnocycla, oliveria decumbens and anvillea that the three essential oil plants are available in different parts of the world and consists of different variability in leaves, essential oil content...
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