Archive:: Computational Biology and Bioinformatics:: Science Publishing Group

Volume 2, Issue 2, April 2014

On the Investigation of Biological Phenomena through Computational Intelligence

Jyotsana Pandey, B. K. Tripathi

Issue: Volume 2, Issue 2, April 2014

Pages: 19-24

Received: 8 January 2014

Accepted: 16 April 2014

Published: 20 April 2014

DOI: 10.11648/j.cbb.20140202.11

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Abstract: This paper presents the approach towards understanding and building integrative system to explain biological phenomena like splicing, promoter gene identification, disease and disorder identification through artificial neural network based computational intelligence technique. Bioinformatics and computational intelligence are new research area whic... Show More

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QSAR Studies, Design, Synthesis and Antimicrobial Evaluation of Azole Derivatives

Vasyl Kovalishyn, Iryna Kopernyk, Svitlana Chumachenko, Oleg Shablykin, Kostyantyn Kondratyuk, Stepan Pil’o, Volodymyr Prokopenko, Volodymyr Brovarets, Larysa Metelytsia

Issue: Volume 2, Issue 2, April 2014

Pages: 25-32

Received: 29 April 2014

Accepted: 14 May 2014

Published: 30 May 2014

DOI: 10.11648/j.cbb.20140202.12

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Abstract: QSAR analysis of a set of previously synthesized azole derivatives tested for growth inhibitory activity against Candida albicans was performed by using Associative Neural Network. To overcome the problem of overfitting due to descriptor selection, 5-fold cross-validation with variable selection in each step of the analysis was used. The predictive... Show More

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