Computational Biology and Bioinformatics

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Volume 3, Issue 2, April 2015

  • HIV Tropism Prediction: Digital Signal Processing-Based Bioinformatics Approach is Non-Sequence Alignment Dependent

    Norbert Nwankwo, Michael Adikwu, Ignatus Okafor

    Issue: Volume 3, Issue 2, April 2015
    Pages: 21-30
    Received: 6 March 2015
    Accepted: 23 March 2015
    Published: 28 March 2015
    DOI: 10.11648/j.cbb.20150302.11
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    Abstract: Phenotypic and genotypic predictors forHIV/SIV tropism are available. The genotypic predictors are more rational. However, they are sequence alignment dependent only. Regrettably, non-homologous proteins are found to display common biological functionality. This indicates that sequence-dependent predictors cannot be trusted with appropriate classif... Show More
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  • Dynamics of βB2-Crystallin Motion Based on Principal Component Analysis and Normal Mode Analysis

    Alaa El-Din A. Gawad

    Issue: Volume 3, Issue 2, April 2015
    Pages: 31-39
    Received: 8 April 2015
    Accepted: 20 April 2015
    Published: 30 April 2015
    DOI: 10.11648/j.cbb.20150302.12
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    Abstract: The primary function of lens is to focus images perfectly on the retina. Lens crystallins however are flexible nanomachines that frequently accomplish their biological function by collective atomic motions in and/or out the lens. Although genetic and biochemical data on the βB2-crystallin protein are available from several sources, the correlation ... Show More
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