International Journal of Pharmacy and Chemistry

Volume 10, Issue 4, August 2024

  • Research Article

    Clinical Therapy Dose Optimization of Sublingual Buprenorphine in Poorly Adherent Pregnant Patients: A PBPK Translational Modelling Study

    Tobechi Brendan Nnanna*

    Issue: Volume 10, Issue 4, August 2024
    Pages: 46-79
    Received: 21 November 2024
    Accepted: 6 December 2024
    Published: 31 December 2024
    DOI: 10.11648/j.ijpc.20241004.11
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    Abstract: Plasma levels of sublingual buprenorphine utilized in the therapy of opioid use disorder, has been demonstrated to undergo gestation-associated decline in vivo, to an extent influenced by upheavals physiologically across gestational trimesters. However, based on extant literature, a dearth of knowledge exists in the optimization of buprenorphine th... Show More